{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:44:31Z","timestamp":1761824671433,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.advms.2022.02.007","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T23:21:02Z","timestamp":1646868062000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytokine and LL-37 gene expression levels in Bartonella spp. seropositive and seronegative patients of a rheumatology clinic"],"prefix":"10.1016","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-7428","authenticated-orcid":false,"given":"Monika E.","family":"\u0141ysakowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2318-7923","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Szybka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-8497","authenticated-orcid":false,"given":"Brzezi\u0144ska","family":"Olga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Moskwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Konieczka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Makowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Pastuszak-Lewandoska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1128\/JCM.02827-14","article-title":"Bartonella, a common cause of endocarditis: a report on 106 cases and review","volume":"53","author":"Edouard","year":"2015","journal-title":"J\u00a0Clin Microbiol"},{"issue":"12","key":"10.1016\/j.advms.2022.02.007_bib2","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/JCM.37.12.4034-4038.1999","article-title":"Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis","volume":"37","author":"Kerkhoff","year":"1999","journal-title":"J\u00a0Clin Microbiol"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1365-2672.2010.04679.x","article-title":"Bartonellosis, an increasingly recognized zoonosis","volume":"109","author":"Chomel","year":"2010","journal-title":"J\u00a0Appl Microbiol"},{"issue":"8","key":"10.1016\/j.advms.2022.02.007_bib4","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1128\/JCM.00910-13","article-title":"Cat scratch disease caused by Bartonella grahamii in an immunocompromised patient","volume":"51","author":"Oksi","year":"2013","journal-title":"J\u00a0Clin Microbiol"},{"issue":"2\u20134","key":"10.1016\/j.advms.2022.02.007_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.vetmic.2006.08.010","article-title":"Characterization of Th1 activation by Bartonella henselae stimulation in BALB\/c mice: Inhibitory activities of interleukin-10 for the production of interferon-gamma in spleen cells","volume":"119","author":"Kabeya","year":"2007","journal-title":"Vet Microbiol"},{"issue":"9","key":"10.1016\/j.advms.2022.02.007_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1471-4906(02)02288-3","article-title":"Pathogen-specific regulatory T cells provoke a shift in the Th1\/Th2 paradigm in immunity to infectious diseases","volume":"23","author":"McGuirk","year":"2002","journal-title":"Trends Immunol"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib7","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1128\/IAI.69.10.5974-5980.2001","article-title":"Interaction of Bartonella henselae with the murine macrophage cell line J774: infection and proinflammatory response","volume":"69","author":"Musso","year":"2001","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.advms.2022.02.007_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/104454903767650694","article-title":"The role of the host immune response in pathogenesis of Bartonella henselae","volume":"22","author":"Resto-Ruiz","year":"2003","journal-title":"DNA Cell Biol"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib9","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1128\/IAI.69.10.6427-6433.2001","article-title":"Bartonella henselae-specific cell-mediated immune responses display a predominantly Th1 phenotype in experimentally infected C57BL\/6 mice","volume":"69","author":"Arvand","year":"2001","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1348-0421.2006.tb03783.x","article-title":"Predominant T helper 2 immune responses against Bartonella henselae in naturally infected cats","volume":"50","author":"Kabeya","year":"2006","journal-title":"Microbiol Immunol"},{"issue":"9","key":"10.1016\/j.advms.2022.02.007_bib11","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1128\/jcm.33.9.2445-2450.1995","article-title":"Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers","volume":"33","author":"Chomel","year":"1995","journal-title":"J\u00a0Clin Microbiol"},{"issue":"11","key":"10.1016\/j.advms.2022.02.007_bib12","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1002\/art.21411","article-title":"Cat-scratch disease\u2013associated arthropathy","volume":"52","author":"Giladi","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.advms.2022.02.007_bib13","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1086\/523587","article-title":"Musculoskeletal manifestations of cat scratch disease","volume":"45","author":"Maman","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"11","key":"10.1016\/j.advms.2022.02.007_bib14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3201\/eid1811.121226","article-title":"Bartonella spp. bacteremia and rheumatic symptoms in patients from Lyme disease-endemic region","volume":"18","author":"Maggi","year":"2012","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.advms.2022.02.007_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jbspin.2012.08.015","article-title":"Bartonella henselae infection during tocilizumab therapy","volume":"80","author":"Milin","year":"2013","journal-title":"Joint Bone Spine"},{"issue":"1","key":"10.1016\/j.advms.2022.02.007_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/RHU.0000000000000203","article-title":"Cat-scratch fever and lymphadenopathy in a rheumatoid arthritis patient on tocilizumab","volume":"21","author":"Singh","year":"2015","journal-title":"J\u00a0Clin Rheumatol"},{"issue":"5","key":"10.1016\/j.advms.2022.02.007_bib17","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1097\/RHU.0000000000001305","article-title":"Disseminated cat-scratch disease in a patient with rheumatoid arthritis on rituximab","volume":"27","author":"Maniar","year":"2021","journal-title":"J\u00a0Clin Rheumatol"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib18","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s10067-019-04591-5","article-title":"The seroprevalence of Bartonella spp. in the blood of patients with musculoskeletal complaints and blood donors, Poland: a pilot study","volume":"38","author":"\u0141ysakowska","year":"2019","journal-title":"Clin Rheumatol"},{"issue":"5","key":"10.1016\/j.advms.2022.02.007_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12223-016-0448-9","article-title":"Development of a serum-free liquid medium for Bartonella species","volume":"61","author":"M\u00fcller","year":"2016","journal-title":"Folia Microbiol"},{"issue":"5","key":"10.1016\/j.advms.2022.02.007_bib20","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1128\/JCM.38.5.1717-1722.2000","article-title":"Rapid identification and differentiation of Bartonella species using a single-step PCR assay","volume":"38","author":"Jensen","year":"2000","journal-title":"J\u00a0Clin Microbiol"},{"issue":"7","key":"10.1016\/j.advms.2022.02.007_bib21","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/jcm.33.7.1797-1803.1995","article-title":"Differentiation of Bartonella-like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene","volume":"33","author":"Norman","year":"1995","journal-title":"J\u00a0Clin Microbiol"},{"issue":"5","key":"10.1016\/j.advms.2022.02.007_bib22","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1128\/JCM.06621-11","article-title":"Development of a novel genus-specific real-time PCR assay for detection and differentiation of Bartonella species and genotypes","volume":"50","author":"Diaz","year":"2012","journal-title":"J\u00a0Clin Microbiol"},{"issue":"7","key":"10.1016\/j.advms.2022.02.007_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/molehr\/gar011","article-title":"Apoptotic gene expression in potentially fertile and subfertile men","volume":"17","author":"Cavalcanti","year":"2011","journal-title":"Mol Hum Reprod"},{"issue":"6","key":"10.1016\/j.advms.2022.02.007_bib24","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s11033-010-0476-5","article-title":"Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of D-galactose-induced aging rats","volume":"38","author":"Chen","year":"2011","journal-title":"Mol Biol Rep"},{"issue":"4","key":"10.1016\/j.advms.2022.02.007_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaci.2008.08.020","article-title":"Administration of oral vitamin D induces cathelicidin production in atopic individuals","volume":"122","author":"Hata","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.advms.2022.02.007_bib26","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/srep02233","article-title":"H2O2-responsive molecularly engineered polymer nanoparticles as ischemia\/reperfusion-targeted nanotherapeutic agents","volume":"3","author":"Lee","year":"2013","journal-title":"Sci Rep"},{"year":"2013","series-title":"Etude des m\u00e9canismes d'action d'une immunoth\u00e9rapie par un triacyl lipide A chez l'homme. M\u00e9decine humaine et pathologie","author":"Isambert","key":"10.1016\/j.advms.2022.02.007_bib27"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib28","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3390\/pathogens10030362","article-title":"High-throughput microfluidic Real-time PCR for the detection of multiple microorganisms in Ixodid cattle ticks in Northeast Algeria","volume":"10","author":"Boularias","year":"2021","journal-title":"Pathogens"},{"issue":"15","key":"10.1016\/j.advms.2022.02.007_bib29","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1001\/archinte.1995.00430150164017","article-title":"Use of Bartonella antigens for serologic diagnosis of cat-scratch disease at a national referral center","volume":"155","author":"Dalton","year":"1995","journal-title":"Arch Intern Med"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrrheum.2012.134","article-title":"Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis","volume":"8","author":"Arend","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib31","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3390\/microorganisms8101459","article-title":"Role of infections in the pathogenesis of rheumatoid arthritis: focus on Mycobacteria","volume":"8","author":"Bo","year":"2020","journal-title":"Microorganisms"},{"issue":"9","key":"10.1016\/j.advms.2022.02.007_bib32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/biom9090501","article-title":"Immunomodulatory functions of the human cathelicidin LL-37 (aa 13\u201331)-derived peptides are associated with predicted alpha-helical propensity and hydrophobic index","volume":"9","author":"Hemshekhar","year":"2019","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.advms.2022.02.007_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molimm.2013.08.011","article-title":"Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis","volume":"57","author":"Chow","year":"2014","journal-title":"Mol Immunol"},{"issue":"10","key":"10.1016\/j.advms.2022.02.007_bib34","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/1756-185X.13919","article-title":"Salivary and serum cathelicidin LL-37 levels in subjects with rheumatoid arthritis and chronic periodontitis","volume":"23","author":"Cheah","year":"2020","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"10.1016\/j.advms.2022.02.007_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.semarthrit.2019.02.002","article-title":"Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis","volume":"49","author":"Maloley","year":"2019","journal-title":"Semin Arthritis Rheum"},{"issue":"3\u20134","key":"10.1016\/j.advms.2022.02.007_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-2427(01)00372-5","article-title":"Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs","volume":"83","author":"Pappalardo","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.chom.2020.01.015","article-title":"A\u00a0Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses","volume":"27","author":"Sorg","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"6\u20137","key":"10.1016\/j.advms.2022.02.007_bib38","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.micinf.2009.03.008","article-title":"Experimental infection of cats with Bartonella henselae resulted in rapid clearance associated with T helper 1 immune responses","volume":"11","author":"Kabeya","year":"2009","journal-title":"Microb Infect"},{"issue":"2","key":"10.1016\/j.advms.2022.02.007_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.advms.2022.02.007_bib40","first-page":"19","article-title":"Association of interleukin-12B polymorphism and serum level of interleukin-12 in a sample of egyptian patients with rheumatoid arthritis","volume":"27","author":"El-Hakeim","year":"2020","journal-title":"Egypt J Immunol"},{"issue":"6","key":"10.1016\/j.advms.2022.02.007_bib41","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1086\/322596","article-title":"Circulating cytokines in patients with cat scratch disease","volume":"33","author":"Papadopoulos","year":"2001","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.advms.2022.02.007_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005684","article-title":"Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru","volume":"11","author":"Pons","year":"2017","journal-title":"PLoS Neglected Trop Dis"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1348-0421.2006.tb03783.x","article-title":"Predominant T helper 2 immune responses against Bartonella henselae in naturally infected cats","volume":"50","author":"Kabeya","year":"2006","journal-title":"Microbiol Immunol"},{"issue":"3","key":"10.1016\/j.advms.2022.02.007_bib44","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1128\/IAI.69.3.1880-1882.2001","article-title":"Passive antibody to Bartonella henselae protects against clinical disease following homologous challenge but does not prevent bacteremia in cats","volume":"69","author":"O'Reilly","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.advms.2022.02.007_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cyto.2015.01.038","article-title":"History of interleukin-4","volume":"75","author":"Paul","year":"2015","journal-title":"Cytokine"},{"issue":"18","key":"10.1016\/j.advms.2022.02.007_bib46","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1073\/pnas.91.18.8562","article-title":"Divergent T-cell cytokine patterns in inflammatory arthritis","volume":"91","author":"Simon","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"10.1016\/j.advms.2022.02.007_bib47","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010465","article-title":"Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: a case report","volume":"97","author":"Mozayeni","year":"2018","journal-title":"Medicine (Baltim)"},{"issue":"7","key":"10.1016\/j.advms.2022.02.007_bib48","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s10067-016-3524-2","article-title":"DNA sequencing, and second harmonic generation (SHG) visualization of Bartonella henselae from a surgically excised human femoral head","volume":"36","author":"Ericson","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"7","key":"10.1016\/j.advms.2022.02.007_bib49","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1073\/pnas.072292699","article-title":"Bartonella-associated endothelial proliferation depends on inhibition of apoptosis","volume":"99","author":"Kirby","year":"2002","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112622000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112622000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:41:31Z","timestamp":1761824491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1896112622000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1896112622000116"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2022.02.007","relation":{},"ISSN":["1896-1126"],"issn-type":[{"type":"print","value":"1896-1126"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine and LL-37 gene expression levels in Bartonella spp. seropositive and seronegative patients of a rheumatology clinic","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2022.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}