{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:36:49Z","timestamp":1791988609162,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2024R213"],"award-info":[{"award-number":["PNURSP2024R213"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.advms.2024.09.008","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T16:41:29Z","timestamp":1727368889000},"page":"463-473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reducing metastasis ability of gastric cancer cell line by targeting MMP16 using miR-193a-5p and 5-FU"],"prefix":"10.1016","volume":"69","author":[{"given":"Tahani Ahmad","family":"Almatrafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-3422","authenticated-orcid":false,"given":"Natrayan","family":"Lakshmaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailah M.","family":"Almohaimeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikumar","family":"Chakravarthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4760-5846","authenticated-orcid":false,"given":"Ayman","family":"Jafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-6309","authenticated-orcid":false,"given":"Amany I.","family":"Almars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar A.","family":"Basabrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-5161","authenticated-orcid":false,"given":"Youssef S.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1059-5780","authenticated-orcid":false,"given":"Mohamed J.","family":"Saadh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Akhavan-Sigari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.advms.2024.09.008_bib1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/jgh.15037","article-title":"Gastric cancer prevention strategies: a global perspective","volume":"35","author":"Eusebi","year":"2020","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.advms.2024.09.008_bib2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cmi.2015.06.004","article-title":"Helicobacter pylori infection and gastric carcinoma","volume":"21","author":"M\u00e9graud","year":"2015","journal-title":"Clin Microbiol Infection"},{"key":"10.1016\/j.advms.2024.09.008_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.advms.2024.09.008_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2020.102243","article-title":"Targeting non-apoptotic cell death in cancer treatment by nanomaterials: recent advances and future outlook","volume":"29","author":"Sepand","year":"2020","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"10.1016\/j.advms.2024.09.008_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115902","article-title":"The relationship between tumor metabolism and 5-fluorouracil resistance","volume":"218","author":"Hu","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.advms.2024.09.008_bib6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/acsptsci.2c00252","article-title":"Discovery of 5\u2032-substituted 5-Fluoro-2\u2032-deoxyuridine monophosphate analogs: a novel class of thymidylate synthase inhibitors","volume":"6","author":"Dasari","year":"2023","journal-title":"ACS Pharmacol Transl Sci"},{"issue":"1","key":"10.1016\/j.advms.2024.09.008_bib7","first-page":"24","article-title":"Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells","volume":"21","author":"Lee","year":"2021","journal-title":"Oncol Lett"},{"key":"10.1016\/j.advms.2024.09.008_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.advms.2024.09.008_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.advms.2024.09.008_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/ncrna9020027","article-title":"Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update","volume":"9","author":"Bayraktar","year":"2023","journal-title":"Non-Coding RNA"},{"key":"10.1016\/j.advms.2024.09.008_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121667","article-title":"An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer","volume":"322","author":"Fathi","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.advms.2024.09.008_bib12","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3390\/ijms21030877","article-title":"Mir-20b and mir-451a are involved in gastric carcinogenesis through the PI3K\/AKT\/mTOR signaling pathway: data from gastric cancer patients, cell lines and ins-gas mouse model","volume":"21","author":"Streleckiene","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.advms.2024.09.008_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/iub.2786","article-title":"miR-203a\u2014a multifaceted regulator modulating cancer hallmarks and therapy response","volume":"76","author":"Biswal","year":"2024","journal-title":"IUBMB Life"},{"key":"10.1016\/j.advms.2024.09.008_bib14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4103\/am.am_45_23","article-title":"A\u00a0systematic review: role of miRNA in gastric cancer risk, onset, and progression","volume":"20","author":"Sharma","year":"2023","journal-title":"Apollo Medicine"},{"key":"10.1016\/j.advms.2024.09.008_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130527","article-title":"Oleuropein induces apoptosis in gastric cancer cell lines by regulating mir-34a, mir-21, and related genes: an experimental and bioinformatic study","volume":"265","author":"Asghariazar","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.advms.2024.09.008_bib16","first-page":"4114","article-title":"A\u00a0meta-analysis and bioinformatics exploration of the diagnostic value and molecular mechanism of miR-193a-5p in lung cancer","volume":"16","author":"Xie","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.advms.2024.09.008_bib17","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v20.i34.12241","article-title":"Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer","volume":"20","author":"Zhang","year":"2014","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.advms.2024.09.008_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-017-0649-3","article-title":"Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel","volume":"36","author":"Yang","year":"2017","journal-title":"J\u00a0Exp Clin Cancer Res"},{"key":"10.1016\/j.advms.2024.09.008_bib19","first-page":"38","article-title":"miR-193a-5p promotes pancreatic cancer cell metastasis through SRSF6-mediated alternative splicing of OGDHL and ECM1","volume":"10","author":"Li","year":"2020","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.advms.2024.09.008_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107355","article-title":"miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4","volume":"92","author":"Azar","year":"2021","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.advms.2024.09.008_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.advms.2024.09.008_bib22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/path.5225","article-title":"Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis","volume":"247","author":"Conlon","year":"2019","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.advms.2024.09.008_bib23","doi-asserted-by":"crossref","first-page":"7162","DOI":"10.1111\/febs.15701","article-title":"Multifunctional intracellular matrix metalloproteinases: implications in disease","volume":"288","author":"Bassiouni","year":"2021","journal-title":"FEBS J"},{"key":"10.1016\/j.advms.2024.09.008_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/1758835919850665","article-title":"The p53\/miR-193a\/EGFR feedback loop function as a driving force for non-small cell lung carcinoma tumorigenesis","volume":"11","author":"Wang","year":"2019","journal-title":"Therapeutic advances in medical oncology"},{"key":"10.1016\/j.advms.2024.09.008_bib25","doi-asserted-by":"crossref","first-page":"16861","DOI":"10.1002\/jcp.28368","article-title":"miR-193: a new weapon against cancer","volume":"234","author":"Khordadmehr","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.advms.2024.09.008_bib26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.15171\/apb.2020.017","article-title":"Restoration of miR-193a-5p and miR-146 a-5p expression induces G1 arrest in colorectal cancer through targeting of MDM2\/p53","volume":"10","author":"Noorolyai","year":"2020","journal-title":"Adv Pharmaceut Bull"},{"key":"10.1016\/j.advms.2024.09.008_bib27","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.biopha.2018.12.106","article-title":"Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapy","volume":"111","author":"Izadpanah","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.advms.2024.09.008_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s10585-016-9783-0","article-title":"MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR","volume":"33","author":"Pu","year":"2016","journal-title":"respectively. Clinical & experimental metastasis."},{"key":"10.1016\/j.advms.2024.09.008_bib29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.omtn.2021.01.020","article-title":"Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic","volume":"23","author":"van den Bosch","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.advms.2024.09.008_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5913195","article-title":"Biological function of MicroRNA193a-3p in health and disease","volume":"2017","author":"Grossi","year":"2017","journal-title":"International Journal of Genomics"},{"key":"10.1016\/j.advms.2024.09.008_bib31","series-title":"Practical medical oncology textbook","first-page":"587","article-title":"Gastric cancer: advanced\/metastatic disease","author":"Vita","year":"2021"},{"key":"10.1016\/j.advms.2024.09.008_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114883","article-title":"Novel targets for gastric cancer: the tumor microenvironment (TME), N6-methyladenosine (m6A), pyroptosis, autophagy, ferroptosis and cuproptosis","volume":"163","author":"Yang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.advms.2024.09.008_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes & Diseases"},{"key":"10.1016\/j.advms.2024.09.008_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512222","article-title":"Dysregulated signalling pathways driving anticancer drug resistance","volume":"24","author":"Bou Antoun","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.advms.2024.09.008_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01171-z","article-title":"Role of non-coding RNAs and RNA modifiers in cancer therapy resistance","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.advms.2024.09.008_bib36","doi-asserted-by":"crossref","first-page":"ftz039","DOI":"10.1093\/femspd\/ftz039","article-title":"The correlation between microRNAs and Helicobacter pylori in gastric cancer","volume":"77","author":"Dastmalchi","year":"2019","journal-title":"Pathogens and disease"},{"key":"10.1016\/j.advms.2024.09.008_bib37","first-page":"169","article-title":"microRNA-193a-5p suppresses the migratory ability of human KATO III gastric cancer cells through inhibition of vimentin and MMP-9","volume":"12","author":"Baghbanzadeh","year":"2022","journal-title":"Adv Pharmaceut Bull"},{"key":"10.1016\/j.advms.2024.09.008_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2019.100241","article-title":"MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2","volume":"17","author":"Wang","year":"2019","journal-title":"Journal of bone oncology"},{"key":"10.1016\/j.advms.2024.09.008_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-02962-4","article-title":"Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.advms.2024.09.008_bib40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3892\/mmr.2021.12221","article-title":"MicroRNA-193a-5p exerts a tumor suppressive role in epithelial ovarian cancer by modulating RBBP6","volume":"24","author":"Zhang","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.advms.2024.09.008_bib41","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2174\/1568009618666180308105727","article-title":"Role of miR-193a in cancer: complexity and factors control the pattern of its expression","volume":"18","author":"Mamoori","year":"2018","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.advms.2024.09.008_bib42","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.advms.2024.09.008_bib43","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1089\/scd.2011.0695","article-title":"MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5","volume":"21","author":"Wang","year":"2012","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.advms.2024.09.008_bib44","first-page":"169","article-title":"microRNA-193a-5p suppresses the migratory ability of human KATO III gastric cancer cells through inhibition of vimentin and MMP-9","volume":"12","author":"Baghbanzadeh","year":"2022","journal-title":"Adv Pharmaceut Bull"},{"key":"10.1016\/j.advms.2024.09.008_bib45","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.21873\/anticanres.12596","article-title":"MiR-193a-5p and-3p play a distinct role in gastric cancer: miR-193a-3p suppresses gastric cancer cell growth by targeting ETS1 and CCND1","volume":"38","author":"Chou","year":"2018","journal-title":"Anticancer Res"},{"key":"10.1016\/j.advms.2024.09.008_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2804478","article-title":"miR-193a directly targets PSEN1 and inhibits gastric cancer cell growth, the activation of PI3K\/akt signaling pathway, and the epithelial-to-mesenchymal transition","volume":"2021","author":"Pan","year":"2021","journal-title":"Journal of Oncology"},{"key":"10.1016\/j.advms.2024.09.008_bib47","first-page":"1011","article-title":"Chemotherapy-induced modification of microRNA expression in esophageal cancer","volume":"26","author":"Hummel","year":"2011","journal-title":"Oncol Rep"},{"key":"10.1016\/j.advms.2024.09.008_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11010-019-03598-5","article-title":"5-FU preferably induces apoptosis in BRAF V600E colorectal cancer cells via downregulation of Bcl-xL","volume":"461","author":"Shi","year":"2019","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.advms.2024.09.008_bib49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2174\/1871530320666200807115647","article-title":"Plant polyphenolic compounds potentiates therapeutic efficiency of anticancer chemotherapeutic drugs: a review. Endocrine, metabolic & immune disorders-drug targets","volume":"21","author":"Oruganti","year":"2021","journal-title":"Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders)"},{"key":"10.1016\/j.advms.2024.09.008_bib50","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1038\/emm.2017.33","article-title":"microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression","volume":"49","author":"Lee","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.advms.2024.09.008_bib51","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1159\/000490871","article-title":"Sensitization of gastric cancer cells to 5-FU by MicroRNA-204 through targeting the TGFBR2-mediated epithelial to mesenchymal transition","volume":"47","author":"Li","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.advms.2024.09.008_bib52","article-title":"CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217\/Wnt3 pathway","volume":"11","author":"Liu","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"13_Supplement","key":"10.1016\/j.advms.2024.09.008_bib53","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1158\/1538-7445.AM2018-4412","article-title":"Abstract 4412: elevated miR-193a attenuates 5-fluorouricil metabolism enzyme CMPK1, resulting in therapeutic resistance and poor survival in gastric cancer","volume":"78","author":"Chen","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.advms.2024.09.008_bib54","series-title":"Cancer invasion and metastasis: molecular and cellular perspective. Madame Curie Bioscience Database [Internet]","author":"Martin","year":"2000"},{"key":"10.1016\/j.advms.2024.09.008_bib55","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10177","article-title":"MMP16 is a marker of poor prognosis in gastric cancer promoting proliferation and invasion","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.advms.2024.09.008_bib56","first-page":"813","article-title":"miR-26a suppresses gastric cancer cell invasion by targeting MMP16","volume":"26","author":"CHEN","year":"2016","journal-title":"China Oncology"},{"key":"10.1016\/j.advms.2024.09.008_bib57","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.20060","article-title":"MMP16 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma","volume":"8","author":"Shen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.advms.2024.09.008_bib58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.21037\/atm-20-8027","article-title":"MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition","volume":"9","author":"Wang","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.advms.2024.09.008_bib59","first-page":"1","volume":"vol. 31","author":"Wang","year":"2021"}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112624000567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112624000567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T17:01:31Z","timestamp":1730739691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1896112624000567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1896112624000567"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2024.09.008","relation":{},"ISSN":["1896-1126"],"issn-type":[{"value":"1896-1126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reducing metastasis ability of gastric cancer cell line by targeting MMP16 using miR-193a-5p and 5-FU","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2024.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V. on behalf of Medical University of Bialystok.","name":"copyright","label":"Copyright"}]}}