{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:55:32Z","timestamp":1791438932225,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.advms.2026.10.002","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:47:33Z","timestamp":1791319653000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transplantation of undifferentiated and differentiated neural precursors towards Schwann-like phenotype in a model of acute spinal cord injury"],"prefix":"10.1016","author":[{"given":"Marcela Mar\u00eda Jos\u00e9","family":"Rodr\u00edguez-Baeza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelinda","family":"Salgado-Ceballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia Jannette","family":"Carrillo-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Campos-Ordo\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alvarez-Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Escobar-Camberos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-6535","authenticated-orcid":false,"given":"Graciela","family":"Gudi\u00f1o-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.advms.2026.10.002_bib1","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-024-03514-9","article-title":"Global incidence and characteristics of spinal cord injury since 2000\u20132021: a systematic review and meta-analysis","volume":"22","author":"Lu","year":"2024","journal-title":"BMC Med"},{"key":"10.1016\/j.advms.2026.10.002_bib2","article-title":"Spinal Cord Injury Epidemiology and Causes: A Worldwide Analysis with 2050 Projections","volume":"13","author":"Kim","year":"2025","journal-title":"Healthcare (Switzerland)"},{"key":"10.1016\/j.advms.2026.10.002_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02787-w","article-title":"Pathological hemodynamic changes and leukocyte transmigration disrupt the blood\u2013spinal cord barrier after spinal cord injury","volume":"20","author":"Zhou","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.advms.2026.10.002_bib4","doi-asserted-by":"crossref","DOI":"10.31083\/FBL38904","article-title":"Glutamate Excitotoxicity: A Key Secondary Injury Mechanism of Traumatic Brain Injury and Spinal Cord Injury","volume":"30","author":"Hou","year":"2025","journal-title":"Frontiers in Bioscience - Landmark"},{"key":"10.1016\/j.advms.2026.10.002_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.648076","article-title":"For Better or for Worse: A Look Into Neutrophils in Traumatic Spinal Cord Injury","volume":"15","author":"Zivkovic","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.advms.2026.10.002_bib6","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.3390\/ijms26199624","article-title":"Immune Activation Following Spinal Cord Injury: A Review Focused on Inflammatory Changes in the Spinal Cord","volume":"26","author":"Nascimento","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.advms.2026.10.002_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1619337","article-title":"Regulatory effect of inflammatory mediators in spinal cord injury","volume":"16","author":"Zeng","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.advms.2026.10.002_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1186\/s13287-025-04712-9","article-title":"Spinal cord injury alters the therapeutic potential of olfactory ensheathing cells harvested in an autologous transplantation model","volume":"16","author":"Delarue","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.advms.2026.10.002_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-024-05350-9","article-title":"Human induced pluripotent stem cell\/embryonic stem cell-derived pyramidal neuronal precursors show safety and efficacy in a rat spinal cord injury model","volume":"81","author":"Li","year":"2024","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.advms.2026.10.002_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/S0169-328X(01)00044-4","article-title":"Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors","volume":"88","author":"Woodhall","year":"2001","journal-title":"Molecular Brain Research"},{"key":"10.1016\/j.advms.2026.10.002_bib11","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1523\/JNEUROSCI.0085-16.2016","article-title":"Olfactory ensheathing cell transplantation after a complete spinal cord transection mediates neuroprotective and immunomodulatory mechanisms to facilitate regeneration","volume":"36","author":"Khankan","year":"2016","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.advms.2026.10.002_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/1098-1136(200103)33:3<225::AID-GLIA1021>3.0.CO;2-Y","article-title":"Neurotrophic and migratory properties of an olfactory ensheathing cell line","volume":"33","author":"Boruch","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.advms.2026.10.002_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.20029","article-title":"Acute Transplantation of Olfactory Ensheathing Cells or Schwann Cells Promotes Recovery after Spinal Cord Injury in the Rat","volume":"75","author":"Garc\u00eda-Al\u00edas","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.advms.2026.10.002_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.773375","article-title":"Neural Stem Cells Overexpressing Nerve Growth Factor Improve Functional Recovery in Rats Following Spinal Cord Injury via Modulating Microenvironment and Enhancing Endogenous Neurogenesis","volume":"15","author":"Wang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.advms.2026.10.002_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.966866","article-title":"The roles and applications of neural stem cells in spinal cord injury repair","volume":"10","author":"Guo","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.advms.2026.10.002_bib16","doi-asserted-by":"crossref","first-page":"689","DOI":"10.25122\/jml-2022-0346","article-title":"Differentiation of neurosphere after transplantation into the damaged spinal cord","volume":"16","author":"Gramatiuk","year":"2023","journal-title":"J Med Life"},{"key":"10.1016\/j.advms.2026.10.002_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/dvdy.21489","article-title":"Microarray analysis of striatal embryonic stem cells induced to differentiate by ensheathing cell conditioned media","volume":"237","author":"Rojas-Mayorqu\u00edn","year":"2008","journal-title":"Developmental Dynamics"},{"key":"10.1016\/j.advms.2026.10.002_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ddmod.2006.11.006","article-title":"Cracking the black box \u2013 and putting it back together again: Animal models of spinal cord injury","volume":"3","author":"Br\u00f6samle","year":"2006","journal-title":"Drug Discov Today Dis Models"},{"key":"10.1016\/j.advms.2026.10.002_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/srep09640","article-title":"Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation","volume":"5","author":"Lukovic","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.advms.2026.10.002_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/exnr.2002.7909","article-title":"Anatomical Correlates of Locomotor Recovery Following Dorsal and Ventral Lesions of the Rat Spinal Cord","volume":"176","author":"Schucht","year":"2002","journal-title":"Exp Neurol"},{"issue":"1-2","key":"10.1016\/j.advms.2026.10.002_bib21","first-page":"39","article-title":"Spontaneous recovery of locomotion induced by remaining fibers after spinal cord transection in adult rats","volume":"21","author":"You","year":"2003","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.advms.2026.10.002_bib22","doi-asserted-by":"crossref","DOI":"10.1006\/exnr.1996.0098","article-title":"Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection","volume":"139","author":"Basso","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1016\/j.advms.2026.10.002_bib23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2021.12.003","article-title":"Hormesis and neural stem cells","volume":"178","author":"Calabrese","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.advms.2026.10.002_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5653787","article-title":"Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem\/Progenitor Cells","volume":"2018","author":"Deng","year":"2018","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.advms.2026.10.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2026.105187","article-title":"Neural stem cells and glioblastoma stem cells: Redefining concepts","volume":"220","author":"Arce","year":"2026","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.advms.2026.10.002_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061427","article-title":"Animal Models of Spinal Cord Injury","volume":"13","author":"Sobolev","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.advms.2026.10.002_bib27","doi-asserted-by":"crossref","DOI":"10.1006\/exnr.2000.7536","article-title":"Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage","volume":"167","author":"Cao","year":"2001","journal-title":"Exp Neurol"},{"issue":"4","key":"10.1016\/j.advms.2026.10.002_bib28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2174\/1874467208666150928153511","article-title":"Stem Cell Therapy and Immunological Rejection in Animal Models","volume":"9","author":"Jin","year":"2016","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.advms.2026.10.002_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100950","article-title":"Immunological aspects of RPE cell transplantation","volume":"84","author":"Sugita","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.advms.2026.10.002_bib30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/sctm.16-0434","article-title":"Concise review: Innate and adaptive immune recognition of allogeneic and xenogeneic cell transplants in the central nervous system","volume":"6","author":"Hoornaert","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.advms.2026.10.002_bib31","article-title":"Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury","volume":"19","author":"Kim","year":"2022","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.advms.2026.10.002_bib32","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-024-01465-6","article-title":"The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis","volume":"44","author":"Wang","year":"2024","journal-title":"Cell Mol Neurobiol"},{"issue":"10","key":"10.1016\/j.advms.2026.10.002_bib33","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1016\/j.ymthe.2025.07.041","article-title":"Fetal rat neural progenitor cell transplantation after spinal cord injury improves motor recovery following optogenetic stimulation","volume":"33","author":"S\u00e1nchez-Mart\u00edn","year":"2025","journal-title":"Mol Ther"},{"key":"10.1016\/j.advms.2026.10.002_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.spinee.2012.09.005","article-title":"Functional assessment of the acute local and distal transplantation of human neural stem cells after spinal cord injury","volume":"12","author":"Cheng","year":"2012","journal-title":"Spine Journal"},{"key":"10.1016\/j.advms.2026.10.002_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9807978","article-title":"High-Dose Neural Stem\/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Injury","volume":"2019","author":"Yuan","year":"2019","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.advms.2026.10.002_bib36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.13004\/kjnt.2025.21.e36","article-title":"Intramedullary Neural Stem Cell Transplantation in Spinal Cord Injury: Timing, Targets, and Techniques","volume":"21","author":"Kwon","year":"2025","journal-title":"Korean J Neurotrauma"},{"key":"10.1016\/j.advms.2026.10.002_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1108077108","article-title":"Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice","volume":"108","author":"Nori","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.advms.2026.10.002_bib38","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0654-07.2007","article-title":"p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells","volume":"27","author":"Young","year":"2007","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.advms.2026.10.002_bib39","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/ijms18030548","article-title":"Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury","volume":"18","author":"Keefe","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.advms.2026.10.002_bib40","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/brain\/awad392","article-title":"Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances","volume":"147","author":"Hosseini","year":"2024","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.advms.2026.10.002_bib41","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1523\/JNEUROSCI.23-04-01424.2003","article-title":"Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord","volume":"23","author":"Zhou","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.advms.2026.10.002_bib42","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-024-01519-9","article-title":"The Role of Inflammatory Cascade and Reactive Astrogliosis in Glial Scar Formation Post-spinal Cord Injury","volume":"44","author":"Bhatt","year":"2024","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.advms.2026.10.002_bib43","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.stemcr.2024.08.007","article-title":"Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury","volume":"19","author":"Hosseini","year":"2024","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.advms.2026.10.002_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140289","article-title":"Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice","volume":"300","author":"Tao","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.advms.2026.10.002_bib45","article-title":"Ion\u2010Engineered Microcryogels via Osteogenesis\u2010Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration","volume":"34","author":"Wang","year":"2024","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.advms.2026.10.002_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.matt.2025.102366","article-title":"Biodegradable and electroactive cryogel microspheres for neurovascularized bone regeneration","volume":"8","author":"Wang","year":"2025","journal-title":"Matter"},{"key":"10.1016\/j.advms.2026.10.002_bib47","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1177\/0963689719860128","article-title":"Neural Stem Cell Transplantation Improves Locomotor Function in Spinal Cord Transection Rats Associated with Nerve Regeneration and IGF-1 R Expression","volume":"28","author":"Zhao","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.advms.2026.10.002_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2012.08.020","article-title":"Long-distance growth and connectivity of neural stem cells after severe spinal cord injury","volume":"150","author":"Lu","year":"2012","journal-title":"Cell"}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112626000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112626000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:42:20Z","timestamp":1791438140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1896112626000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"alternative-id":["S1896112626000428"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2026.10.002","relation":{},"ISSN":["1896-1126"],"issn-type":[{"value":"1896-1126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplantation of undifferentiated and differentiated neural precursors towards Schwann-like phenotype in a model of acute spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2026.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V. on behalf of Medical University of Bialystok.","name":"copyright","label":"Copyright"}]}}