{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:59:35Z","timestamp":1791392375291,"version":"4.3.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000035","name":"Institute of Nutrition Metabolism and Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Nutrition"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.advnut.2026.100737","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:48:22Z","timestamp":1789688902000},"page":"100737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-7757","authenticated-orcid":false,"given":"Ruslan","family":"Kubant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Harvey","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41591-025-04124-5","article-title":"The expanding landscape of GLP-1 medicines","volume":"32","author":"Drucker","year":"2026","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.advnut.2026.100737_bib2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cmet.2025.01.026","article-title":"On the causes of obesity and its treatment: the end of the beginning","volume":"37","author":"Friedman","year":"2025","journal-title":"Cell Metab."},{"issue":"8042","key":"10.1016\/j.advnut.2026.100737_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-024-08165-7","article-title":"Adipose tissue retains an epigenetic memory of obesity after weight loss","volume":"636","author":"Hinte","year":"2024","journal-title":"Nature."},{"issue":"Suppl 2","key":"10.1016\/j.advnut.2026.100737_bib4","article-title":"Physiology of weight regain: lessons from the classic Minnesota Starvation Experiment on human body composition regulation","volume":"22","author":"Dulloo","year":"2021","journal-title":"Obes. Rev."},{"issue":"5","key":"10.1016\/j.advnut.2026.100737_bib5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s11154-025-09970-9","article-title":"Adaptive thermogenesis driving catch-up fat during weight regain: a role for skeletal muscle hypothyroidism and a risk for sarcopenic obesity","volume":"26","author":"Dulloo","year":"2025","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.advnut.2026.100737_bib6","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3389\/fphys.2019.01634","article-title":"Phenotypic switching resulting from developmental plasticity: fixed or reversible?","volume":"10","author":"Burggren","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.advnut.2026.100737_bib7","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1038\/ncomms4746","article-title":"Maternal nutrition at conception modulates DNA methylation of human metastable epialleles","volume":"5","author":"Dominguez-Salas","year":"2014","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.advnut.2026.100737_bib8","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1128\/MCB.23.15.5293-5300.2003","article-title":"Transposable elements: targets for early nutritional effects on epigenetic gene regulation","volume":"23","author":"Waterland","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00125-007-0793-y","article-title":"Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study","volume":"51","author":"Yajnik","year":"2008","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.advnut.2026.100737_bib10","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1093\/nutrit\/nuac025","article-title":"Folate dose and form during pregnancy may program maternal and fetal health and disease risk","volume":"80","author":"Pannia","year":"2022","journal-title":"Nutr. Rev."},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13059-014-0569-x","article-title":"An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss","volume":"16","author":"Benton","year":"2015","journal-title":"Genome Biol"},{"issue":"6","key":"10.1016\/j.advnut.2026.100737_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003572","article-title":"A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue","volume":"9","author":"Ronn","year":"2013","journal-title":"PLoS Genet"},{"issue":"12","key":"10.1016\/j.advnut.2026.100737_bib13","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.2337\/db11-1653","article-title":"Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes","volume":"61","author":"Nitert","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3945\/an.113.004705","article-title":"Epigenetics in adipose tissue, obesity, weight loss, and diabetes","volume":"5","author":"Martinez","year":"2014","journal-title":"Adv. Nutr."},{"issue":"7472","key":"10.1016\/j.advnut.2026.100737_bib15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","article-title":"TET enzymes, TDG and the dynamics of DNA demethylation","volume":"502","author":"Kohli","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000546727","article-title":"Experimental environment is a determinant of gene methylation and one-carbon metabolism in obese adult mice","volume":"18","author":"Yang","year":"2025","journal-title":"Lifestyle Genom"},{"issue":"7635","key":"10.1016\/j.advnut.2026.100737_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature20784","article-title":"Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity","volume":"541","author":"Wahl","year":"2017","journal-title":"Nature"},{"issue":"9933","key":"10.1016\/j.advnut.2026.100737_bib18","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0140-6736(13)62674-4","article-title":"DNA methylation and body-mass index: a genome-wide analysis","volume":"383","author":"Dick","year":"2014","journal-title":"Lancet"},{"issue":"7196","key":"10.1016\/j.advnut.2026.100737_bib19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.advnut.2026.100737_bib20","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jhep.2024.12.011","article-title":"Why weight loss is only half the battle: the epigenetic memory of adipose tissue","volume":"82","author":"Chew","year":"2025","journal-title":"J. Hepatol."},{"issue":"44","key":"10.1016\/j.advnut.2026.100737_bib21","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1073\/pnas.0806560105","article-title":"Persistent epigenetic differences associated with prenatal exposure to famine in humans","volume":"105","author":"Heijmans","year":"2008","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.advnut.2026.100737_bib22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnins.2011.00074","article-title":"The selfish brain: stress and eating behavior","volume":"5","author":"Peters","year":"2011","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib23","first-page":"67","article-title":"Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake, Cell","volume":"30","author":"Hall","year":"2019","journal-title":"Metab"},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.advnut.2026.100737_bib25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmet.2014.07.003","article-title":"Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates","volume":"20","author":"Sonnenburg","year":"2014","journal-title":"Cell. Metab"},{"issue":"3","key":"10.1016\/j.advnut.2026.100737_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"Tirzepatide once weekly for the treatment of obesity","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jama.2023.24945","article-title":"Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 Randomized Clinical Trial","volume":"331","author":"Aronne","year":"2024","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.advnut.2026.100737_bib28","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/dom.14725","article-title":"Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension","volume":"24","author":"Wilding","year":"2022","journal-title":"Diabetes Obes. Metab."},{"issue":"2","key":"10.1016\/j.advnut.2026.100737_bib29","article-title":"Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity","volume":"151","author":"Hampl","year":"2023","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.advnut.2026.100737_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1139\/apnm-2014-0249","article-title":"Mealtime exposure to food advertisements while watching television increases food intake in overweight and obese girls but has a paradoxical effect in boys","volume":"40","author":"Anderson","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"1","key":"10.1016\/j.advnut.2026.100737_bib31","doi-asserted-by":"crossref","first-page":"232S","DOI":"10.3945\/an.115.009357","article-title":"Physiology of food intake control in children","volume":"7","author":"Anderson","year":"2016","journal-title":"Adv. Nutr."}],"container-title":["Advances in Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831326001511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2161831326001511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:41:27Z","timestamp":1791391287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2161831326001511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2161831326001511"],"URL":"https:\/\/doi.org\/10.1016\/j.advnut.2026.100737","relation":{},"ISSN":["2161-8313"],"issn-type":[{"value":"2161-8313","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain","name":"articletitle","label":"Article Title"},{"value":"Advances in Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advnut.2026.100737","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"100737"}}