{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:37:07Z","timestamp":1792456627710,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["endocrinologydiabetes.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AACE Endocrinology and Diabetes"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.aed.2025.07.012","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:55:28Z","timestamp":1754668528000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Once-Weekly IcoSema in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5681-6522","authenticated-orcid":false,"given":"A.B.M.","family":"Kamrul-Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-4412","authenticated-orcid":false,"given":"Subhankar","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-5554","authenticated-orcid":false,"given":"Lakshmi","family":"Nagendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-2722","authenticated-orcid":false,"given":"Shinjan","family":"Patra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-8805","authenticated-orcid":false,"given":"Deep","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0676-1336","authenticated-orcid":false,"given":"Asma","family":"Aljaberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-5255","authenticated-orcid":false,"given":"Joseph M.","family":"Pappachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.aed.2025.07.012_bib1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S2213-8587(25)00162-7","article-title":"IcoSema and the evolution of fixed-ratio insulin-GLP-1 receptor agonist therapies","volume":"13","author":"Umpierrez","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"10.1016\/j.aed.2025.07.012_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40261-024-01405-8","article-title":"Pharmacokinetic properties of a once-weekly fixed-ratio combination of insulin icodec and semaglutide compared with separate administration of each component in individuals with type 2 diabetes mellitus","volume":"44","author":"Westergaard","year":"2024","journal-title":"Clin Drug Investig"},{"issue":"10","key":"10.1016\/j.aed.2025.07.012_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2023.102877","article-title":"Optimal use of once weekly icodec insulin in type-2 diabetes: an updated meta-analysis of phase-2 and phase-3 randomized controlled trials","volume":"17","author":"Dutta","year":"2023","journal-title":"Diabetes Metab Syndr"},{"issue":"4","key":"10.1016\/j.aed.2025.07.012_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.eprac.2024.12.013","article-title":"Optimal use of once-weekly basal insulin Efsitora Alfa in type 1 and type 2 diabetes: a systematic review and meta-analysis","volume":"31","author":"Dutta","year":"2025","journal-title":"Endocr Pract"},{"issue":"2","key":"10.1016\/j.aed.2025.07.012_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70127","article-title":"Once-weekly semaglutide versus once-daily liraglutide for weight loss in adults: a meta-analysis of randomized controlled trials","volume":"18","author":"Hashmi","year":"2025","journal-title":"Clin Transl Sci"},{"issue":"2","key":"10.1016\/j.aed.2025.07.012_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1001\/jama.2021.23619","article-title":"STEP 8 investigators. Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial","volume":"327","author":"Rubino","year":"2022","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.aed.2025.07.012_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/dme.15414","article-title":"Insulin icodec: a novel once-weekly treatment for diabetes","volume":"41","author":"Schaffner","year":"2024","journal-title":"Diabet Med"},{"issue":"7","key":"10.1016\/j.aed.2025.07.012_bib8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S2213-8587(25)00096-8","article-title":"Once-weekly IcoSema versus once-weekly insulin icodec in type 2 diabetes management (COMBINE 1): an open-label, multicentre, treat-to-target, randomised, phase 3a trial","volume":"13","author":"Mathieu","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"10.1016\/j.aed.2025.07.012_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00125-024-06348-5","article-title":"Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial","volume":"68","author":"Lingvay","year":"2025","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.aed.2025.07.012_bib10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S2213-8587(25)00052-X","article-title":"Once-weekly IcoSema versus multiple daily insulin injections in type 2 diabetes management (COMBINE 3): an open-label, multicentre, treat-to-target, non-inferiority, randomised, phase 3a trial","volume":"13","author":"Billings","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.aed.2025.07.012_bib11","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.aed.2025.07.012_bib12","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2024"},{"key":"10.1016\/j.aed.2025.07.012_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/cob.70008","article-title":"Metabolic outcomes of bariatric surgery versus lifestyle intervention in adolescents with severe obesity: a systematic review and meta-analysis","author":"Kamrul-Hasan","year":"2025","journal-title":"Clin Obes"},{"key":"10.1016\/j.aed.2025.07.012_bib14","series-title":"Review Manager (RevMan) [Computer program]","year":"2024"},{"key":"10.1016\/j.aed.2025.07.012_bib15","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.aed.2025.07.012_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res Synth Methods"},{"issue":"7414","key":"10.1016\/j.aed.2025.07.012_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.aed.2025.07.012_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta4100","article-title":"Publication and related biases","volume":"4","author":"Song","year":"2000","journal-title":"Health Technol Assess"},{"issue":"4","key":"10.1016\/j.aed.2025.07.012_bib19","article-title":"Determinants of poor glycemic control among type 2 diabetes patients: a systematic review","volume":"17","author":"Ahmed","year":"2025","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.aed.2025.07.012_bib20","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/dom.16282","article-title":"A systematic literature review on the burden of diabetic ketoacidosis in type 2 diabetes mellitus","volume":"27","author":"Wysham","year":"2025","journal-title":"Diabetes Obes Metab"},{"issue":"4","key":"10.1016\/j.aed.2025.07.012_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.4239\/wjd.v14.i4.396","article-title":"Management of diabesity: current concepts","volume":"14","author":"Michaelidou","year":"2023","journal-title":"World J Diabetes"},{"issue":"52","key":"10.1016\/j.aed.2025.07.012_bib22","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000036308","article-title":"Efficacy and safety of once-weekly basal insulin versus once-daily basal insulin in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"102","author":"Wang","year":"2023","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.aed.2025.07.012_bib23","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.7326\/M23-1288","article-title":"Once-weekly insulin icodec with dosing guide app versus once-daily basal insulin analogues in insulin-naive type 2 diabetes (ONWARDS 5): a randomized trial","volume":"176","author":"Bajaj","year":"2023","journal-title":"Ann Intern Med"},{"issue":"9","key":"10.1016\/j.aed.2025.07.012_bib24","article-title":"Single-administration self-boosting microneedle patch for the treatment of obesity","volume":"7","author":"Singh","year":"2024","journal-title":"Adv Ther (Weinh)"},{"issue":"10","key":"10.1016\/j.aed.2025.07.012_bib25","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.2337\/dc19-2316","article-title":"Impact of a weekly glucagon-like peptide 1 receptor agonist, albiglutide, on glycemic control and on reducing prandial insulin use in type 2 diabetes inadequately controlled on multiple insulin therapy: a randomized trial","volume":"43","author":"Rosenstock","year":"2020","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.aed.2025.07.012_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041840","article-title":"Cost of hospitalization and length of stay of hypoglycemic events in hospitalized patients with diabetes mellitus: a cross-sectional study","volume":"104","author":"Naser","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.aed.2025.07.012_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.aap.2019.105334","article-title":"Type 2 diabetes can undermine driving performance of middle-aged male drivers through its deterioration of perceptual and cognitive functions","volume":"134","author":"Ma","year":"2020","journal-title":"Accid Anal Prev"},{"key":"10.1016\/j.aed.2025.07.012_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112175","article-title":"Neurovascular decoupling of frontoparietal cortex-putamen-cerebellum network in type 2 diabetes patient: potential biomarker for abnormal eating patterns","volume":"224","author":"Yu","year":"2025","journal-title":"Diabetes Res Clin Pract"},{"issue":"2","key":"10.1016\/j.aed.2025.07.012_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pcd.2025.01.009","article-title":"Investigation of food cravings in individuals with type 2 diabetes: a hierarchical regression analysis","volume":"19","author":"\u00c7avu\u015fo\u011flu","year":"2025","journal-title":"Prim Care Diabetes"},{"issue":"8031","key":"10.1016\/j.aed.2025.07.012_bib30","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41586-024-07922-y","article-title":"Pathogenic hypothalamic extracellular matrix promotes metabolic disease","volume":"633","author":"Beddows","year":"2024","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.aed.2025.07.012_bib31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.clnu.2024.01.013","article-title":"Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus","volume":"43","author":"Lin","year":"2024","journal-title":"Clin Nutr"}],"container-title":["AACE Endocrinology and Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050915725000700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050915725000700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:26:45Z","timestamp":1758626805000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050915725000700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S3050915725000700"],"URL":"https:\/\/doi.org\/10.1016\/j.aed.2025.07.012","relation":{},"ISSN":["3050-9157"],"issn-type":[{"value":"3050-9157","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Once-Weekly IcoSema in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"AACE Endocrinology and Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aed.2025.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Association of Clinical Endocrinologists. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}