{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:20:57Z","timestamp":1782476457895,"version":"3.54.5"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","endocrinologydiabetes.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["AACE Endocrinology and Diabetes"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.aed.2026.02.001","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:36:18Z","timestamp":1770338178000},"page":"507-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Precipitated Adrenal Insufficiency by Osilodrostat and Fluconazole in Ectopic Adrenocorticotrophic Hormone Syndrome With a Pituitary Microadenoma and Cryptococcus Infection"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3395-8458","authenticated-orcid":false,"given":"Kristen","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Mendes","family":"Pessoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.aed.2026.02.001_bib1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.arcmed.2006.05.015","article-title":"Ectopic ACTH-secreting syndrome: a single center experience report with a high prevalence of occult tumor","volume":"37","author":"Hern\u00e1ndez","year":"2006","journal-title":"Arch Med Res"},{"issue":"4","key":"10.1016\/j.aed.2026.02.001_bib2","article-title":"Successful management of Cushing syndrome from ectopic ACTH secretion in an adolescent with osilodrostat","volume":"1","author":"Blew","year":"2023","journal-title":"JCEM Case Rep"},{"issue":"19","key":"10.1016\/j.aed.2026.02.001_bib3","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1002\/cncr.26029","article-title":"Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center Experience","volume":"117","author":"Ejaz","year":"2011","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.aed.2026.02.001_bib4","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1210\/clinem\/dgac686","article-title":"Dynamic testing for differential diagnosis of ACTH-dependent Cushing syndrome: a systematic review and meta-analysis","volume":"108","author":"Ceccato","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.aed.2026.02.001_bib5","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvac073","article-title":"The Mount Sinai clinical pathway for the diagnosis and management of hypercortisolism due to ectopic ACTH syndrome","volume":"6","author":"Alba","year":"2022","journal-title":"J Endocr Soc"},{"issue":"8","key":"10.1016\/j.aed.2026.02.001_bib6","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1210\/jc.2004-2527","article-title":"Cushing\u2019s syndrome due to ectopic corticotropin secretion: twenty years\u2019 experience at the National Institutes of Health","volume":"90","author":"Ilias","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.aed.2026.02.001_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/eje.1.02332","article-title":"The usefulness of combined biochemical tests in the diagnosis of Cushing\u2019s disease with negative pituitary magnetic resonance imaging","volume":"156","author":"Testa","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"10.1016\/j.aed.2026.02.001_bib8","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvae194","article-title":"Recognition and management of ectopic ACTH secreting tumors","volume":"9","author":"Elenius","year":"2025","journal-title":"J Endocr Soc"},{"issue":"5","key":"10.1016\/j.aed.2026.02.001_bib9","doi-asserted-by":"crossref","first-page":"L13","DOI":"10.1530\/EJE-21-0147","article-title":"Rapid control of severe ectopic Cushing\u2019s syndrome by oral osilodrostat monotherapy","volume":"184","author":"Bessi\u00e8ne","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.aed.2026.02.001_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2265.1991.tb01737.x","article-title":"Use of ketoconazole in the treatment of Cushing\u2019s disease and ectopic ACTH syndrome","volume":"34","author":"Tabarin","year":"1991","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2-3","key":"10.1016\/j.aed.2026.02.001_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12672-019-00361-6","article-title":"Effects of ketoconazole on ACTH-producing and non-ACTH-producing neuroendocrine tumor cells","volume":"10","author":"Herrera-Mart\u00ednez","year":"2019","journal-title":"Horm Cancer"},{"issue":"10418","key":"10.1016\/j.aed.2026.02.001_bib12","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/S0140-6736(23)01961-X","article-title":"Cushing\u2019s syndrome","volume":"402","author":"Gadelha","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.aed.2026.02.001_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11154-010-9139-z","article-title":"The ectopic ACTH syndrome","volume":"11","author":"Alexandraki","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"issue":"2","key":"10.1016\/j.aed.2026.02.001_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ecl.2018.01.005","article-title":"The ectopic adrenocorticotropic hormone syndrome: rarely easy, always challenging","volume":"47","author":"Hayes","year":"2018","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"9","key":"10.1016\/j.aed.2026.02.001_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.tem.2020.04.004","article-title":"The immune system in Cushing\u2019s syndrome","volume":"31","author":"Hasenmajer","year":"2020","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.aed.2026.02.001_bib16","doi-asserted-by":"crossref","first-page":"334","DOI":"10.7326\/0003-4819-101-3-334","article-title":"Opportunistic infections in endogenous Cushing\u2019s syndrome","volume":"101","author":"Graham","year":"1984","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.aed.2026.02.001_bib17","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11102-022-01268-2","article-title":"Treatment of Cushing\u2019s syndrome with osilodrostat: practical applications of recent studies with case examples","volume":"25","author":"Fleseriu","year":"2022","journal-title":"Pituitary"},{"key":"10.1016\/j.aed.2026.02.001_bib19","article-title":"Fluconazole in the treatment of Cushing\u2019s disease","volume":"1","author":"Burns","year":"2016","journal-title":"Endocrinol Diabetes Metab Case Rep"}],"container-title":["AACE Endocrinology and Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050915726000226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050915726000226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:29:02Z","timestamp":1780046942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050915726000226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S3050915726000226"],"URL":"https:\/\/doi.org\/10.1016\/j.aed.2026.02.001","relation":{},"ISSN":["3050-9157"],"issn-type":[{"value":"3050-9157","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precipitated Adrenal Insufficiency by Osilodrostat and Fluconazole in Ectopic Adrenocorticotrophic Hormone Syndrome With a Pituitary Microadenoma and Cryptococcus Infection","name":"articletitle","label":"Article Title"},{"value":"AACE Endocrinology and Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aed.2026.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Association of Clinical Endocrinology.","name":"copyright","label":"Copyright"}]}}