{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:13:57Z","timestamp":1789928037563,"version":"4.0.1"},"reference-count":99,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007551","name":"Hallym University Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoporosis and Sarcopenia"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.afos.2025.04.003","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T07:53:24Z","timestamp":1747122804000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4962-0270","authenticated-orcid":false,"given":"Jun","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5901-4883","authenticated-orcid":false,"given":"Vivek Kumar","family":"Morya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-2560","authenticated-orcid":false,"given":"Mi-Kyung","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-185X","authenticated-orcid":false,"given":"Sin-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-2977","authenticated-orcid":false,"given":"Kyu-Cheol","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.afos.2025.04.003_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105647","article-title":"Sp7 action in the skeleton: its mode of action, functions, and relevance to skeletal diseases","volume":"23","author":"Hojo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.afos.2025.04.003_bib3","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.3390\/ijms22115445","article-title":"Regulation and role of transcription factors in osteogenesis","volume":"22","author":"Chan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107494","article-title":"Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation","volume":"300","author":"Zhu","year":"2024","journal-title":"J Biol Chem"},{"key":"10.1016\/j.afos.2025.04.003_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-024-00376-y","article-title":"Engineering bone\/cartilage organoids: strategy, progress, and application","volume":"12","author":"Bai","year":"2024","journal-title":"Bone Res"},{"key":"10.1016\/j.afos.2025.04.003_bib6","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.3390\/ijms22083989","article-title":"From stem cells to bone-forming cells","volume":"22","author":"Donsante","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41467-022-28318-4","article-title":"A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder","volume":"13","author":"Lui","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.afos.2025.04.003_bib8","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1038\/s41467-021-26571-7","article-title":"Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.afos.2025.04.003_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176574","article-title":"Osteoporosis: emerging targets on the classical signaling pathways of bone formation","volume":"973","author":"Li","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.afos.2025.04.003_bib10","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401303R","article-title":"Mechanoresponsive regulation of tissue regeneration during distraction osteogenesis","volume":"38","author":"Hu","year":"2024","journal-title":"FASEB J"},{"key":"10.1016\/j.afos.2025.04.003_bib11","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.3390\/ijms25105291","article-title":"Runx2 and polycystins in bone mechanotransduction: challenges for therapeutic opportunities","volume":"25","author":"Gargalionis","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.601224","article-title":"Recent advances of osterix transcription factor in osteoblast differentiation and bone formation","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.afos.2025.04.003_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm1270","article-title":"NFAT and Osterix cooperatively regulate bone formation","volume":"11","author":"Koga","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.afos.2025.04.003_bib14","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3390\/ijms23031500","article-title":"Genetics and epigenetics of bone remodeling and metabolic bone diseases","volume":"23","author":"Oton-Gonzalez","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s44324-024-00010-9","article-title":"Bone metabolism \u2013 an underappreciated player","volume":"2","author":"Choi","year":"2024","journal-title":"Npj Metab Health Dis"},{"key":"10.1016\/j.afos.2025.04.003_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/18735592MTA5uODcAy","article-title":"Molecular signaling pathways and essential metabolic elements in bone remodeling: an implication of therapeutic targets for bone diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.afos.2025.04.003_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11914-023-00778-7","article-title":"SP7: from bone development to skeletal disease","volume":"21","author":"Wang","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.afos.2025.04.003_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810102","article-title":"Regulation of skeletal development and maintenance by Runx2 and Sp7","volume":"25","author":"Komori","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/cells13120999","article-title":"Exploring the role of circular RNA in bone biology: a comprehensive review","volume":"13","author":"Valenti","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.afos.2025.04.003_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/osi2.1184","article-title":"Regulatory landscape of Runx2 and Sp7 in osteoblast and chondrocyte lineages: recent findings from next-generation sequencer-based studies","volume":"21","author":"Ohba","year":"2024","journal-title":"Oral Sci Int"},{"key":"10.1016\/j.afos.2025.04.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov"},{"key":"10.1016\/j.afos.2025.04.003_bib22","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.3390\/ijms24032979","article-title":"Emerging RUNX2-mediated gene regulatory mechanisms consisting of multi-layered regulatory networks in skeletal development","volume":"24","author":"Hojo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jot.2024.06.005","article-title":"Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation","volume":"47","author":"Jiang","year":"2024","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.afos.2025.04.003_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166888","article-title":"Glutathione limits RUNX2 oxidation and degradation to regulate bone formation","volume":"8","author":"Hu","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.afos.2025.04.003_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziae026","article-title":"A homozygous SP7\/OSX mutation causes osteogenesis and dentinogenesis imperfecta with craniofacial anomalies","volume":"8","author":"Al-Mutairi","year":"2024","journal-title":"JBMR Plus"},{"key":"10.1016\/j.afos.2025.04.003_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41419-021-03480-7","article-title":"BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation","volume":"12","author":"Yu","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.afos.2025.04.003_bib27","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.3390\/ijms25042162","article-title":"Periosteum containing implicit stem cells: a progressive source of inspiration for bone tissue regeneration","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib28","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.3390\/cells11203277","article-title":"DLX genes in the development and maintenance of the vertebrate skeleton: implications for human pathologies","volume":"11","author":"Levi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.afos.2025.04.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03404-5","article-title":"Osteomodulin positively regulates osteogenesis through interaction with BMP2","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.afos.2025.04.003_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111748","article-title":"Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration","volume":"120","author":"Bharadwaz","year":"2021","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.afos.2025.04.003_bib31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1042\/BST20200376","article-title":"BMP9 is a potential therapeutic agent for use in oral and maxillofacial bone tissue engineering","volume":"48","author":"Liu","year":"2020","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.afos.2025.04.003_bib32","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41434-021-00248-8","article-title":"Mesenchymal stem cells overexpressing BMP-9 by CRISPR-Cas9 present high in vitro osteogenic potential and enhance in vivo bone formation","volume":"28","author":"Freitas","year":"2021","journal-title":"Gene Ther"},{"key":"10.1016\/j.afos.2025.04.003_bib33","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.apsb.2022.01.012","article-title":"Drug discovery of sclerostin inhibitors","volume":"12","author":"Yu","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.afos.2025.04.003_bib34","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/jre.13134","article-title":"Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation","volume":"58","author":"Nakamura","year":"2023","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.afos.2025.04.003_bib35","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.3390\/ijms24065264","article-title":"Bone and cartilage biology","volume":"24","author":"Nishimura","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1491066","article-title":"Sclerostin as a new target of diabetes-induced osteoporosis","volume":"15","author":"Li","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.afos.2025.04.003_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116636","article-title":"Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density","volume":"167","author":"O'Donohue","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.afos.2025.04.003_bib38","series-title":"Bone regulators and osteoporosis therapy","first-page":"451","article-title":"New targets and emergent therapies for osteoporosis","author":"Brommage","year":"2020"},{"key":"10.1016\/j.afos.2025.04.003_bib39","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/jcm10040787","article-title":"Osteoporosis treatment with anti-sclerostin antibodies\u2014mechanisms of action and clinical application","volume":"10","author":"Rauner","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.afos.2025.04.003_bib40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12951-023-02020-z","article-title":"HIF-1\u03b1 increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1\u03b1\/VEGF\/AKT\/mTOR signaling pathway","volume":"21","author":"Song","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.afos.2025.04.003_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911201","article-title":"Hypoxia-inducible factors signaling in osteogenesis and skeletal repair","volume":"23","author":"Qin","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib42","article-title":"Lithium and copper induce the osteogenesis-angiogenesis coupling of bone marrow mesenchymal stem cells via crosstalk between canonical Wnt and HIF-1\u03b1 signaling pathways","volume":"2021","author":"Tan","year":"2021","journal-title":"Stem Cell Int"},{"key":"10.1016\/j.afos.2025.04.003_bib43","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.3390\/cells11223552","article-title":"HIF-1\u03b1 regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.afos.2025.04.003_bib44","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.3390\/ijms24098029","article-title":"The role of HIF-1\u03b1 in bone regeneration: a new direction and challenge in bone tissue engineering","volume":"24","author":"You","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib45","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13018-022-03162-w","article-title":"Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1\u03b1 and activating the Wnt\/\u03b2-catenin signaling pathway","volume":"17","author":"Li","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.afos.2025.04.003_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/joor.13410","article-title":"Deferoxamine mesylate enhances mandibular advancement-induced condylar osteogenesis by promoting H-type angiogenesis","volume":"50","author":"Hu","year":"2023","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.afos.2025.04.003_bib47","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3390\/jcm13195805","article-title":"Combined effects of cyclic hypoxic and mechanical stimuli on human bone marrow mesenchymal stem cell differentiation: a new approach to the treatment of bone loss","volume":"13","author":"Camacho-Cardenosa","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.afos.2025.04.003_bib48","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.scib.2023.07.032","article-title":"Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies","volume":"68","author":"Hu","year":"2023","journal-title":"Sci Bull"},{"key":"10.1016\/j.afos.2025.04.003_bib49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.14348","article-title":"Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases","volume":"1474","author":"Zhao","year":"2020","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib50","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bbrc.2011.07.009","article-title":"Akt phosphorylates and regulates the osteogenic activity of Osterix","volume":"411","author":"Choi","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.afos.2025.04.003_bib51","doi-asserted-by":"crossref","first-page":"37471","DOI":"10.18632\/oncotarget.9650","article-title":"Osterix acetylation at K307 and K312 enhances its transcriptional activity and is required for osteoblast differentiation","volume":"7","author":"Lu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.afos.2025.04.003_bib52","article-title":"Deubiquitinase USP17 regulates osteoblast differentiation by increasing osterix protein stability","volume":"24","author":"Kim","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib53","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.3390\/cells11172710","article-title":"SUMOylation in skeletal development, homeostasis, and disease","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.afos.2025.04.003_bib54","doi-asserted-by":"crossref","first-page":"14930","DOI":"10.1096\/fj.202001340R","article-title":"Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation","volume":"34","author":"Hoshikawa","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.afos.2025.04.003_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116391","article-title":"A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover","volume":"226","author":"Xu","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.afos.2025.04.003_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.657","article-title":"Regulation of bone homeostasis: signaling pathways and therapeutic targets","volume":"5","author":"Wu","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.afos.2025.04.003_bib57","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/s41467-018-05187-4","article-title":"SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7\/Osterix","volume":"9","author":"Fukuda","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.afos.2025.04.003_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135210","article-title":"Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases","volume":"279","author":"Li","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.afos.2025.04.003_bib59","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physiolgenomics.00229.2010","article-title":"Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway","volume":"43","author":"Xing","year":"2011","journal-title":"Physiol Genom"},{"key":"10.1016\/j.afos.2025.04.003_bib60","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1242\/jcs.005090","article-title":"PIASx\u03b2 is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts","volume":"120","author":"Ali","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib61","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.cellbio.16.1.591","article-title":"SUMO\u2014nonclassical ubiquitin","volume":"16","author":"Melchior","year":"2000","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.afos.2025.04.003_bib62","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5483\/BMBRep.2022.55.11.098","article-title":"Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells","volume":"55","author":"Yeo","year":"2022","journal-title":"BMB Rep"},{"key":"10.1016\/j.afos.2025.04.003_bib63","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/cdd.2017.113","article-title":"p53 inhibits SP7\/Osterix activity in the transcriptional program of osteoblast differentiation","volume":"24","author":"Artigas","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.afos.2025.04.003_bib64","article-title":"Sp7\/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae","volume":"44","author":"Chen","year":"2019","journal-title":"J Bio Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13008-023-00086-7","article-title":"Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis","volume":"18","author":"An","year":"2023","journal-title":"Cell Div"},{"key":"10.1016\/j.afos.2025.04.003_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713633","article-title":"A novel long noncoding RNA in osteocytes regulates bone formation through the wnt\/\u03b2-catenin signaling pathway","volume":"24","author":"Arai","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib67","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3390\/ijms22052362","article-title":"MicroRNAs modulate signaling pathways in osteogenic differentiation of mesenchymal stem cells","volume":"22","author":"Mazziotta","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib68","series-title":"Stem cells and signaling pathways","first-page":"133","article-title":"Chapter 8 - role of stem cells in osteoblastic miRNA and bone tissue regeneration","author":"Govindan","year":"2024"},{"key":"10.1016\/j.afos.2025.04.003_bib69","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/br.2020.1305","article-title":"Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)","volume":"13","author":"Sun","year":"2020","journal-title":"Biomed Rep"},{"key":"10.1016\/j.afos.2025.04.003_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2023.151998","article-title":"Non-coding RNAs regulate the BMP\/Smad pathway during osteogenic differentiation of stem cells","volume":"125","author":"Zhang","year":"2023","journal-title":"Acta Histochem"},{"key":"10.1016\/j.afos.2025.04.003_bib71","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s13577-023-00888-5","article-title":"Long non-coding RNAs in osteoporosis: from mechanisms of action to therapeutic potential","volume":"36","author":"Hou","year":"2023","journal-title":"Hum Cell"},{"key":"10.1016\/j.afos.2025.04.003_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.682581","article-title":"An overview of RNA-based scaffolds for osteogenesis","volume":"8","author":"Damiati","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.afos.2025.04.003_bib73","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.febslet.2015.02.021","article-title":"Phosphorylation of Serine422 increases the stability and transactivation activities of human Osterix","volume":"589","author":"Xu","year":"2015","journal-title":"FEBS (Fed Eur Biochem Soc) Lett"},{"key":"10.1016\/j.afos.2025.04.003_bib74","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mce.2015.03.010","article-title":"Src enhances osteogenic differentiation through phosphorylation of Osterix","volume":"407","author":"Choi","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.afos.2025.04.003_bib75","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/j.apsb.2023.06.016","article-title":"The role of E3 ubiquitin ligases in bone homeostasis and related diseases","volume":"13","author":"Dong","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.afos.2025.04.003_bib76","doi-asserted-by":"crossref","first-page":"205","DOI":"10.18632\/aging.100728","article-title":"The p53\/miR-17\/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells","volume":"7","author":"Liu","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.afos.2025.04.003_bib77","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.scib.2017.01.009","article-title":"Zinc finger transcription factor Sp7\/Osterix acts on bone formation and regulates col10a1a expression in zebrafish","volume":"62","author":"Niu","year":"2017","journal-title":"Sci Bull"},{"key":"10.1016\/j.afos.2025.04.003_bib78","article-title":"Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp","volume":"6","author":"Zhong","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.afos.2025.04.003_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122335","article-title":"Complementary modulation of BMP signaling improves bone healing efficiency","volume":"302","author":"Fan","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.afos.2025.04.003_bib80","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/jcb.25241","article-title":"Inhibition of GSK3\u03b2 stimulates BMP signaling and decreases SOST expression which results in enhanced osteoblast differentiation","volume":"116","author":"Schoeman","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.afos.2025.04.003_bib81","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1002\/jcb.26907","article-title":"Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells","volume":"119","author":"Gao","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.afos.2025.04.003_bib82","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00441-023-03791-5","article-title":"The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation","volume":"393","author":"Chen","year":"2023","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.afos.2025.04.003_bib83","doi-asserted-by":"crossref","first-page":"270","DOI":"10.5582\/ddt.2023.01026","article-title":"Apolipoprotein E deficiency attenuated osteogenesis via down-regulating osterix","volume":"17","author":"Qi","year":"2023","journal-title":"Drug Discov Ther"},{"key":"10.1016\/j.afos.2025.04.003_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.740783","article-title":"Mesenchymal stem cells may explain the protein's role in osteosarcomagenesis","volume":"9","author":"Xu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.afos.2025.04.003_bib85","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2174\/0929867327666200330142432","article-title":"Osteoporosis: mechanism, molecular target and current status on drug development","volume":"28","author":"Li","year":"2021","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.afos.2025.04.003_bib86","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13323","article-title":"Senescent cells: a therapeutic target for osteoporosis","volume":"55","author":"Wang","year":"2022","journal-title":"Cell Prolif"},{"key":"10.1016\/j.afos.2025.04.003_bib87","first-page":"84","article-title":"Human umbilical cord mesenchymal stem cell-induced osterix, bone morphogenetic protein-2, and tartrate-resistant acid phosphatase expression in osteoporotic mandibular bone","volume":"15","author":"Hendrijantini","year":"2021","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.afos.2025.04.003_bib88","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/biomedicines12081635","article-title":"Mechanistic insights and therapeutic strategies in osteoporosis: a comprehensive review","volume":"12","author":"Elahmer","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.afos.2025.04.003_bib89","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jcb.24439","article-title":"Genetic and molecular control of osterix in skeletal formation","volume":"114","author":"Sinha","year":"2013","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.afos.2025.04.003_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.582670","article-title":"Chronic intermittent hypobaric hypoxia enhances bone fracture healing","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.afos.2025.04.003_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052948","article-title":"Synergistic inhibition of Wnt pathway by HIF-1\u03b1 and osteoblast-specific transcription factor osterix (Osx) in osteoblasts","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.afos.2025.04.003_bib92","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s42255-019-0053-8","article-title":"The long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts","volume":"1","author":"Sun","year":"2019","journal-title":"Nat Metab"},{"key":"10.1016\/j.afos.2025.04.003_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101107","article-title":"Osteoporosis remission and new bone formation with mesoporous silica nanoparticles","volume":"8","author":"Mora-Raimundo","year":"2021","journal-title":"Adv Sci"},{"key":"10.1016\/j.afos.2025.04.003_bib94","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1007\/s11999-014-4073-0","article-title":"Cationic nanogel-mediated Runx2 and osterix siRNA delivery decreases mineralization in MC3T3 cells","volume":"473","author":"Shrivats","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.afos.2025.04.003_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133502","article-title":"Chitosan composite with mesenchymal stem cells: properties, mechanism, and its application in bone regeneration","volume":"275","author":"Kudiyarasu","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.afos.2025.04.003_bib96","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/ten.tea.2016.0315","article-title":"In situ release of VEGF enhances osteogenesis in 3D porous scaffolds engineered with osterix-modified adipose-derived stem cells","volume":"23","author":"Xu","year":"2017","journal-title":"Tissue Eng"},{"key":"10.1016\/j.afos.2025.04.003_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.111202","article-title":"Porous PLGA\/MBG scaffold enhanced bone regeneration through osteoimmunomodulation","volume":"272","author":"Liu","year":"2024","journal-title":"Compos B Eng"},{"key":"10.1016\/j.afos.2025.04.003_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.593310","article-title":"The smad dependent TGF-\u03b2 and BMP signaling pathway in bone remodeling and therapies","volume":"8","author":"Zou","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.afos.2025.04.003_bib99","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11914-022-00735-w","article-title":"Single-cell RNA sequencing: unravelling the bone one cell at a time","volume":"20","author":"Chai","year":"2022","journal-title":"Curr Osteoporos Rep"}],"container-title":["Osteoporosis and Sarcopenia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405525525000251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405525525000251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:30:49Z","timestamp":1762623049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405525525000251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2405525525000251"],"URL":"https:\/\/doi.org\/10.1016\/j.afos.2025.04.003","relation":{},"ISSN":["2405-5255"],"issn-type":[{"value":"2405-5255","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential","name":"articletitle","label":"Article Title"},{"value":"Osteoporosis and Sarcopenia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.afos.2025.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}