{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:03:30Z","timestamp":1771063410382,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.ahj.2003.07.003","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T16:48:52Z","timestamp":1072111732000},"page":"42-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE)"],"prefix":"10.1016","volume":"147","author":[{"given":"Mark I","family":"Furman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M","family":"Gore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrick A","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Budaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun G","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1varo","family":"Avezum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Send\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim A","family":"Eagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar H","family":"Dabbous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2003.07.003_BIB1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB2","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1001\/jama.279.18.1477","article-title":"Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease","volume":"279","author":"Danesh","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.07.003_BIB3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM199408183310701","article-title":"The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina","volume":"331","author":"Liuzzo","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB5","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1161\/01.CIR.96.12.4204","article-title":"Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. FRISC Study Group","volume":"96","author":"Toss","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJM200010193431602","article-title":"Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group","volume":"343","author":"Lindahl","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB7","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/hc3701.095949","article-title":"Circulating cell adhesion molecules and death in patients with coronary artery disease","volume":"104","author":"Blankenberg","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB8","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1001\/jama.1987.03390170074031","article-title":"Leukocytes and the risk of ischemic diseases","volume":"257","author":"Ernst","year":"1987","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.07.003_BIB9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/01.CIR.89.1.36","article-title":"Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology","volume":"89","author":"van der Wal","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/01.CIR.83.3.836","article-title":"Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease","volume":"83","author":"Yarnell","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1056\/NEJM197406062902302","article-title":"The leukocyte count as a predictor of myocardial infarction","volume":"290","author":"Friedman","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJM198102193040806","article-title":"Leukocyte count, smoking, and myocardial infarction","volume":"304","author":"Zalokar","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.07.003_BIB13","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1055\/s-0038-1660101","article-title":"White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction","volume":"54","author":"Lowe","year":"1985","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ahj.2003.07.003_BIB14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9149(96)00473-0","article-title":"Effect of elevated leukocyte count on in-hospital mortality following acute myocardial infarction","volume":"78","author":"Furman","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/oxfordjournals.eurheartj.a060141","article-title":"Haematological prognostic indices after myocardial infarction","volume":"13","author":"Burr","year":"1992","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2003.07.003_BIB16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1055\/s-0038-1665316","article-title":"Haemostatic variables and the outcome of myocardial infarction","volume":"50","author":"Haines","year":"1983","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ahj.2003.07.003_BIB17","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0735-1097(01)01613-8","article-title":"The association between white blood cell count and acute myocardial infarction mortality in patients \u226565 years of age","volume":"38","author":"Barron","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB18","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1161\/01.CIR.102.19.2329","article-title":"Association between white blood cell count, epicardial blood flow, myocardial perfusion, and clinical outcomes in the setting of acute myocardial infarction","volume":"102","author":"Barron","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0002-8703(00)90314-4","article-title":"Neutrophilia and congestive heart failure after acute myocardial infarction","volume":"139","author":"Kyne","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2003.07.003_BIB20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0735-1097(01)01721-1","article-title":"Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction","volume":"39","author":"Maekawa","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB21","doi-asserted-by":"crossref","unstructured":"Rationale and design of the GRACE (Global Registry of Acute Coronary Events) Project: a multinational registry of patients hospitalized with acute coronary syndromes. Am Heart J 2001;141:190\u20139","DOI":"10.1067\/mhj.2001.112404"},{"key":"10.1016\/j.ahj.2003.07.003_BIB22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0002-9149(02)02489-X","article-title":"Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE)","volume":"90","author":"Steg","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0140-6736(02)07595-5","article-title":"Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction","volume":"359","author":"Eagle","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2003.07.003_BIB24","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/01.CIR.90.4.2126","article-title":"Conner Memorial Lecture","volume":"90","author":"Fuster","year":"1994","journal-title":"Circulation"},{"issue":"Suppl 1","key":"10.1016\/j.ahj.2003.07.003_BIB25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2362.1994.tb02426.x","article-title":"Markers of platelet activation in coronary heart disease patients","volume":"24","author":"Nurden","year":"1994","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ahj.2003.07.003_BIB26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1161\/hh2101.099270","article-title":"Novel clinical markers of vascular wall inflammation","volume":"89","author":"Blake","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2003.07.003_BIB27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0735-1097(97)00510-X","article-title":"Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease","volume":"31","author":"Furman","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB28","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.CIR.94.6.1239","article-title":"Increased neutrophil-platelet adhesion in patients with unstable angina","volume":"94","author":"Ott","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB29","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1067\/mhj.2001.119128","article-title":"Leukocyte-platelet aggregation, platelet surface P-selectin, and platelet surface glycoprotein IIIa after percutaneous coronary intervention","volume":"142","author":"Furman","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2003.07.003_BIB30","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.95.10.2387","article-title":"Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets","volume":"95","author":"Neumann","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB31","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0735-1097(01)01485-1","article-title":"Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction","volume":"38","author":"Furman","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB32","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/hc3801.095588","article-title":"Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin","volume":"104","author":"Michelson","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.07.003_BIB33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0735-1097(96)00164-7","article-title":"Leukocyte activation with platelet adhesion after coronary angioplasty","volume":"28","author":"Mickelson","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB34","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0002-9149(00)01444-2","article-title":"Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris","volume":"87","author":"Cannon","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB35","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-9149(00)00963-2","article-title":"Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris","volume":"86","author":"Zouridakis","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0002-8703(00)90019-X","article-title":"Effect of leukocytosis at initial examination on prognosis in patients with primary unstable angina","volume":"139","author":"Lloyd-Jones","year":"2000","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2003.07.003_BIB37","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/cvr\/28.9.1301","article-title":"Postreperfusion inflammation","volume":"28","author":"Entman","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ahj.2003.07.003_BIB38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0002-9149(97)00482-7","article-title":"Insights into the pathophysiology of unstable coronary artery disease","volume":"80","author":"Kristensen","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2003.07.003_BIB39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1527-5299.2002.00724.x","article-title":"Immune and neurohormonal pathways in chronic heart failure","volume":"8","author":"Sharma","year":"2002","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.ahj.2003.07.003_BIB40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc Res"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870303005921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870303005921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T04:52:56Z","timestamp":1757566376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870303005921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0002870303005921"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2003.07.003","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the Global Registry of Acute Coronary Events (GRACE)","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2003.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}