{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:57Z","timestamp":1776470457441,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.ahj.2003.10.030","type":"journal-article","created":{"date-parts":[[2004,4,9]],"date-time":"2004-04-09T05:21:41Z","timestamp":1081488101000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["The diabetic postoperative mortality and morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery"],"prefix":"10.1016","volume":"147","author":[{"given":"Anne Benedicte","family":"Juul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Kofoed-Enevoldsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Callesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorm","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2003.10.030_BIB1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00000542-199001000-00025","article-title":"Perioperative cardiac morbidity","volume":"72","author":"Mangano","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJM199012273232601","article-title":"Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group","volume":"323","author":"Mangano","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jama.1992.03490020076034","article-title":"In-hospital and long-term mortality in male veterans following noncardiac surgery. The Study of Perioperative Ischemia Research Group","volume":"268","author":"Browner","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.10.030_BIB4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/jama.1992.03490020081035","article-title":"Long-term cardiac prognosis following noncardiac surgery. The Study of Perioperative Ischemia Research Group","volume":"268","author":"Mangano","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.10.030_BIB5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00000542-199801000-00005","article-title":"Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group","volume":"88","author":"Wallace","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0741-5214(92)90105-H","article-title":"Silent myocardial ischemia monitoring predicts late as well as perioperative cardiac events in patients undergoing vascular surgery","volume":"16","author":"Pasternack","year":"1992","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ahj.2003.10.030_BIB7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0735-1097(91)90864-6","article-title":"Perioperative myocardial ischemia in patients undergoing noncardiac surgery\u2014II","volume":"17","author":"Mangano","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.10.030_BIB8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/jama.1992.03490020070033","article-title":"Detection and significance of intraoperative and postoperative myocardial ischemia in peripheral vascular surgery","volume":"268","author":"Raby","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.10.030_BIB9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/00000542-199803000-00005","article-title":"Myocardial infarction after noncardiac surgery","volume":"88","author":"Badner","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJM197710202971601","article-title":"Multifactorial index of cardiac risk in noncardiac surgical procedures","volume":"297","author":"Goldman","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.7326\/0003-4819-110-11-859","article-title":"Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery","volume":"110","author":"Eagle","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB12","first-page":"55","article-title":"Postoperative myocardial infarction","volume":"90","author":"von Knorring","year":"1981","journal-title":"Surgery"},{"key":"10.1016\/j.ahj.2003.10.030_BIB13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00000542-198702000-00027","article-title":"Prevention of intraoperative myocardial ischemia during noncardiac surgery with intravenous diltiazem","volume":"66","author":"Godet","year":"1987","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB14","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1097\/00000542-199910000-00014","article-title":"Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease","volume":"91","author":"Oliver","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000542-198603000-00031","article-title":"Intravenous nitroglycerin dosage to prevent intraoperative myocardial ischemia during noncardiac surgery","volume":"64","author":"Coriat","year":"1986","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00000542-198410000-00005","article-title":"Failure of intravenous nitroglycerin to prevent intraoperative myocardial ischemia during fentanyl-pancuronium anesthesia","volume":"61","author":"Thomson","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2003.10.030_BIB17","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJM199612053352301","article-title":"Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group","volume":"335","author":"Mangano","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB18","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1056\/NEJM199912093412402","article-title":"The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group","volume":"341","author":"Poldermans","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB19","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/00000539-200006000-00001","article-title":"Postoperative prophylactic administration of beta-adrenergic blockers in patients at risk for myocardial ischemia","volume":"90","author":"Urban","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ahj.2003.10.030_BIB20","first-page":"477","article-title":"The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery","volume":"88","author":"Raby","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ahj.2003.10.030_BIB21","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1001\/jama.287.17.2221","article-title":"Preoperative \u03b2-blocker use and mortality and morbidity following CABG surgery in North America","volume":"287","author":"Ferguson","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2003.10.030_BIB22","doi-asserted-by":"crossref","unstructured":"Guidelines for assessing and managing the perioperative risk from coronary artery disease associated with major noncardiac surgery. Ann Intern Med 1997;127:309\u201312","DOI":"10.7326\/0003-4819-127-4-199708150-00011"},{"key":"10.1016\/j.ahj.2003.10.030_BIB23","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/00000539-200205000-00002","volume":"94","author":"Eagle","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ahj.2003.10.030_BIB24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2337\/diacare.2.2.120","article-title":"Diabetes and glucose tolerance as risk factors for cardiovascular disease","volume":"2","author":"Kannel","year":"1979","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ahj.2003.10.030_BIB25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0735-1097(92)90033-J","article-title":"Acute myocardial infarction in the diabetic patient","volume":"20","author":"Jacoby","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2003.10.030_BIB26","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1161\/01.CIR.0000013955.34262.AF","article-title":"Prevention Conference VI","volume":"105","author":"Redberg","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2003.10.030_BIB27","unstructured":"ICH harmonised tripartite guideline for good clinical practice. 3rd ed. Brookwood Medical Publications Ltd; 2002"},{"key":"10.1016\/j.ahj.2003.10.030_BIB28","doi-asserted-by":"crossref","unstructured":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2000;284:3043\u20135","DOI":"10.1001\/jama.284.23.3043"},{"issue":"Suppl","key":"10.1016\/j.ahj.2003.10.030_BIB29","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1007\/BF00578409","article-title":"Controlled-release metoprolol compared with atenolol in asthmatic patients","volume":"33","author":"Lofdahl","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.ahj.2003.10.030_BIB30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7326\/0003-4819-135-9-200111060-00010","article-title":"Unrecognized myocardial infarction","volume":"135","author":"Sheifer","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/oxfordjournals.eurheartj.a061212","article-title":"Electrocardiographic findings and their association with mortality in the Copenhagen City Heart Study","volume":"2","author":"Ostor","year":"1981","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2003.10.030_BIB32","unstructured":"Juul AB, Wetterslev J, Kofoed-Enevoldsen A. Reducing postoperative mortality and cardiovascular morbidity after noncardiac surgery [abstract]. Presented at the Angelo-Danish-Dutch-diabetes-Group meeting, 1998, UK"},{"key":"10.1016\/j.ahj.2003.10.030_BIB33","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF03011261","article-title":"Study design in clinical research","volume":"43","author":"Lerman","year":"1996","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.ahj.2003.10.030_BIB34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1067\/mhj.2001.111547","article-title":"Perioperative beta-blocker withdrawal and mortality in vascular surgical patients","volume":"141","author":"Shammash","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2003.10.030_BIB35","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/bmj.321.7259.504","article-title":"Statistics notes","volume":"321","author":"Day","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ahj.2003.10.030_BIB36","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7326\/0003-4819-134-8-200104170-00012","article-title":"The revised CONSORT statement for reporting randomized trials","volume":"134","author":"Altman","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2003.10.030_BIB37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1023\/A:1022146721098","article-title":"Beta-blockers and diabetes","volume":"16","author":"Cruickshank","year":"2002","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.ahj.2003.10.030_BIB38","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s00125-003-1106-8","article-title":"ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy","volume":"46","author":"Gross","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.ahj.2003.10.030_BIB39","first-page":"33","article-title":"Data validity and coverage in the Danish National Health Registry","volume":"164","author":"Nickelsen","year":"2001","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.ahj.2003.10.030_BIB40","doi-asserted-by":"crossref","unstructured":"Als-Nielsen B, Chen W, Gluud C, et al. Association of funding and conclusions in randomized drug trials. JAMA 2003;290:921\u20138","DOI":"10.1001\/jama.290.7.921"},{"key":"10.1016\/j.ahj.2003.10.030_BIB41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/bmj.325.7358.249","article-title":"Association between competing interests and authors' conclusions","volume":"325","author":"Kjaergard","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.ahj.2003.10.030_BIB42","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.289.4.454","article-title":"Scope and impact of financial conflicts of interest in biomedical research","volume":"289","author":"Bekelman","year":"2003","journal-title":"JAMA"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870303007750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870303007750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:06:25Z","timestamp":1757567185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870303007750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0002870303007750"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2003.10.030","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The diabetic postoperative mortality and morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2003.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}