{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:03:13Z","timestamp":1791194593931,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.ahj.2004.05.058","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T07:11:39Z","timestamp":1110006699000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Erythrocyte adhesiveness\/aggregation: A novel biomarker for the detection of low-grade internal inflammation in individuals with atherothrombotic risk factors and proven vascular disease"],"prefix":"10.1016","volume":"149","author":[{"given":"Shlomo","family":"Berliner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Rogowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Aharonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Mardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Tolshinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirav","family":"Rozenblat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Justo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varda","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Serov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zeltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2004.05.058_bib1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/circ.105.1.2","article-title":"On evolutionary biology, inflammation, infection, and the causes of atherosclerosis","volume":"105","author":"Ridker","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/01.CIR.0000021112.29409.A2","article-title":"Need to test arterial inflammation hypothesis","volume":"106","author":"Bhatt","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib4","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1161\/01.CIR.0000017822.82512.62","article-title":"Inflammatory biomarkers, statins, and the risk of stroke: cracking a clinical conundrum","volume":"105","author":"Ridker","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.CIR.103.9.1191","article-title":"Rapid reduction in C-reactive protein with cervistatin among 785 patients with primary hypercholesterolemia","volume":"103","author":"Ridker","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0735-1097(99)00574-4","article-title":"Serum amyloid A predicts early mortality in acute coronary syndromes: a TIMI 11A substudy","volume":"35","author":"Morrow","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahj.2004.05.058_bib7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/euhj.2001.2905","article-title":"Tumour necrosis factor-alpha, inflammatory biomarker, and atherogenesis","volume":"23","author":"Blake","year":"2002","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahj.2004.05.058_bib8","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0735-1097(01)01613-8","article-title":"The association between white blood cell count and acute myocardial infarction mortality in patients \u226565 years of age: findings from the cooperative cardiovascular project","volume":"38","author":"Barron","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahj.2004.05.058_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/euhj.1999.1923","article-title":"Blood viscosity and the risk of death from coronary heart disease","volume":"21","author":"Froom","year":"2000","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahj.2004.05.058_bib10","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/S0140-6736(02)09093-1","article-title":"Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study","volume":"359","author":"Brown","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2004.05.058_bib11","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1001\/jama.286.17.2107","article-title":"Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy","volume":"17","author":"Lindmark","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2004.05.058_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.CIR.0000020546.30940.92","article-title":"Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina","volume":"106","author":"Blankenberg","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib13","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.ATV.19.6.1368","article-title":"Measuring plasma fibrinogen to predict stroke and myocardial infarction: an update","volume":"19","author":"Maresca","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ahj.2004.05.058_bib14","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1053\/euhj.2000.2148","article-title":"Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease and mortality","volume":"21","author":"Erikssen","year":"2000","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahj.2004.05.058_bib15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1053\/euhj.2001.2661","article-title":"Cell adhesion molecules and inflammation in acute coronary syndromes: markers and emerging risk factors","volume":"22","author":"Best","year":"2001","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahj.2004.05.058_bib16","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1161\/01.CIR.0000017327.69909.FF","article-title":"Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men","volume":"105","author":"Engstrom","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib17","first-page":"307","article-title":"Increased erythrocyte adhesiveness and aggregation in peripheral venous blood of women with pregnancy-induced hypertension","volume":"98","author":"Gamzu","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ahj.2004.05.058_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0002-9149(02)02539-0","article-title":"Red blood cell adhesiveness\/aggregation, C-reactive protein, fibrinogen and erythrocyte sedimentation rate in healthy adults and in those with atherosclerotic risk factors","volume":"90","author":"Fusman","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ahj.2004.05.058_bib19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0021-9150(02)00250-2","article-title":"The erythrocyte adhesiveness\/aggregation test (EAAT). A new biomarker to reveal the low grade subclinical smoldering inflammation individuals with atherosclerotic risk factors","volume":"165","author":"Rotstein","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ahj.2004.05.058_bib20","first-page":"H2346","article-title":"Influence of acute-phase proteins on erythrocyte aggregation","volume":"271","author":"Weng","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ahj.2004.05.058_bib21","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1055\/s-0037-1615386","article-title":"Contribution of acute-phase proteins and cardiovascular risk factors to erythrocyte aggregation in normolipidemic and hyperlipidemic individuals","volume":"80","author":"Weng","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ahj.2004.05.058_bib22","first-page":"569","article-title":"Effect of immunoglobulins and IgG-fragments on the human erythrocyte aggregation, studied by rheoscope combined with image analyzer","volume":"20","author":"Imaizumi","year":"1983","journal-title":"Biorheology"},{"key":"10.1016\/j.ahj.2004.05.058_bib23","first-page":"235","article-title":"Recommendation of measurement of erythrocyte sedimentation rate of human blood","volume":"2","year":"1965","journal-title":"Immunochemistry"},{"key":"10.1016\/j.ahj.2004.05.058_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","article-title":"Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol. (Basel)"},{"key":"10.1016\/j.ahj.2004.05.058_bib25","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/clinchem\/45.12.2136","article-title":"Clinical efficacy of an automated high-sensitivity C-reactive protein assay","volume":"45","author":"Rifai","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ahj.2004.05.058_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000046598","article-title":"The picture of inflammation: a new concept that combines the white blood cell count and erythrocyte sedimentation rate into a new hematologic diagnostic modality","volume":"106","author":"Rotstein","year":"2001","journal-title":"Acta Haematol."},{"key":"10.1016\/j.ahj.2004.05.058_bib27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/01.HDX.0000074516.58801.7a","article-title":"Inflammation at a glance: erythrocyte adhesiveness\/aggregation to reveal the presence of inflammation in individuals with atherothrombosis","volume":"5","author":"Sharshun","year":"2003","journal-title":"Heart Dis."},{"key":"10.1016\/j.ahj.2004.05.058_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ahj.2004.05.058_bib29","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1001\/jama.285.19.2481","article-title":"Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease","volume":"285","author":"Ridker","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2004.05.058_bib30","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.162.11.1286","article-title":"Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults","volume":"162","author":"Abramson","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ahj.2004.05.058_bib31","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/hc0502.103331","article-title":"Weight loss reduces C-reactive protein levels in obese postmenopausal women","volume":"105","author":"Tchernof","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2004.05.058_bib32","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJM200106283442601","article-title":"Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events","volume":"344","author":"Ridker","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ahj.2004.05.058_bib33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0037-1614066","article-title":"Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study","volume":"84","author":"Lowe","year":"2000","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ahj.2004.05.058_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0953-6205(00)00108-4","article-title":"INFLAMET: an image analyzer to display erythrocyte adhesiveness\/aggregation","volume":"11","author":"Fusman","year":"2000","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.ahj.2004.05.058_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.1526-0968.2002.00364.x","article-title":"The erythrocyte adhesiveness\/aggregation test to reveal real-time information of rheological relevance in patients with familial and primary hypercholesterolemia before and following plasma exchange","volume":"6","author":"Hershcovici","year":"2002","journal-title":"Ther. Apher."},{"key":"10.1016\/j.ahj.2004.05.058_bib36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1515\/arh-2000-0014","article-title":"The erythrocyte adhesiveness\/aggregation (EAAT) in the peripheral blood of patients with ischemic heart and brain disease with normal fibrinogen concentrations","volume":"10","author":"Zeltser","year":"2000","journal-title":"Appl. Rheol."},{"key":"10.1016\/j.ahj.2004.05.058_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/hrt.2003.014753","article-title":"Sex differences in the expression of haemorheological determinants in individuals with atherothrombotic risk factors and apparently health people","volume":"90","author":"Zeltser","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2004.05.058_bib38","first-page":"297","article-title":"Comparison of three optical methods to study erythrocyte aggregation","volume":"21","author":"Zhao","year":"1999","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.ahj.2004.05.058_bib39","doi-asserted-by":"crossref","first-page":"H1982","DOI":"10.1152\/ajpheart.2001.280.5.H1982","article-title":"Parameters of red blood cell aggregation as correlates of the inflammatory state","volume":"280","author":"Ben Ami","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ahj.2004.05.058_bib40","first-page":"99","article-title":"100 mg acetylsalicylic acid acutely decreases red cell aggregation in women taking oral contraceptives","volume":"22","author":"El Bouhmadi","year":"2000","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.ahj.2004.05.058_bib41","first-page":"159","article-title":"Rheological action of aspirin on human erythrocytes","volume":"20","author":"Bilto","year":"1999","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.ahj.2004.05.058_bib42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/13547500410001670303","article-title":"Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones","volume":"9","author":"Rogowski","year":"2004","journal-title":"Biomarkers"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870304005897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870304005897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:14:12Z","timestamp":1757567652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870304005897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0002870304005897"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2004.05.058","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Erythrocyte adhesiveness\/aggregation: A novel biomarker for the detection of low-grade internal inflammation in individuals with atherothrombotic risk factors and proven vascular disease","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2004.05.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}