{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:01:46Z","timestamp":1774584106416,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.ahj.2005.04.025","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T10:33:28Z","timestamp":1138358008000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":125,"title":["Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials"],"prefix":"10.1016","volume":"151","member":"78","reference":[{"key":"10.1016\/j.ahj.2005.04.025_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nm0496-386","article-title":"Homocysteine and vascular disease","volume":"2","author":"McCully","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.ahj.2005.04.025_bib2","series-title":"The metabolic and molecular bases of inherited disease","first-page":"2007","article-title":"Disorders of transulfuration","author":"Mudd","year":"2001"},{"key":"10.1016\/j.ahj.2005.04.025_bib3","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.1993.03510220049033","article-title":"Vitamin status and intake as primary determinants of homocysteinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2005.04.025_bib4","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2005.04.025_bib5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","article-title":"Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials","volume":"316","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.ahj.2005.04.025_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2005.04.025_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/hq0302.105369","article-title":"Total homocysteine lowering treatment among coronary artery disease patients in the era of folic acid\u2013fortified cereal grain flour","volume":"22","author":"Bostom","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2005.04.025_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00043798-199808000-00007","article-title":"Can dietary supplements with folic acid or vitamin B-6 reduce cardiovascular risk? Design of clinical trials to test the homocysteine hypothesis of vascular disease","volume":"5","author":"Clarke","year":"1998","journal-title":"J Cardiovasc Risk"},{"key":"10.1016\/j.ahj.2005.04.025_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2005.04.025_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00043798-199808000-00004","article-title":"Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies","volume":"5","author":"Danesh","year":"1998","journal-title":"J Cardiovasc Risk"},{"key":"10.1016\/j.ahj.2005.04.025_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.ahj.2005.04.025_bib12","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1001\/jama.288.16.2023","article-title":"MTHFR 677C\u2192T polymorphism and risk of coronary heart disease: a meta-analysis","volume":"288","author":"Klerk","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2005.04.025_bib13","first-page":"A3642","article-title":"Blinded comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial","author":"Baker","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2005.04.025_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000054753","article-title":"Vitamin Intervention for Stroke Prevention (VISP) trial: rationale and design","volume":"20","author":"Spence","year":"2001","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ahj.2005.04.025_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2005.04.025_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000047761","article-title":"The VITATOPS (Vitamins to Prevent Stroke) trial: rationale and design of an international large, simple, randomized trial of homocysteine-lowering multivitamin therapy in patients with recent transient ischemic attack or stroke","volume":"13","year":"2002","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.ahj.2005.04.025_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/154099904322836519","article-title":"The Women's Antioxidant Cardiovascular Study: design and baseline characteristics of participants","volume":"13","author":"Bassuk","year":"2004","journal-title":"J Women's Health"},{"key":"10.1016\/j.ahj.2005.04.025_bib18","first-page":"430","volume":"6","author":"Galan","year":"2003","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.ahj.2005.04.025_bib19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ajcn\/80.3.641","article-title":"Changes in basal and post-methionine load concentrations of total homocysteine and cystathionine after B vitamin intervention","volume":"80","author":"Bleie","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ahj.2005.04.025_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00007890-199509000-00008","article-title":"Ischemic heart disease: major cause of death and graft loss after renal transplantation in Scandinavia","volume":"60","author":"Lindholm","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.ahj.2005.04.025_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1681\/ASN.V71158","article-title":"Cardiovascular disease after renal transplantation","volume":"7","author":"Kasiske","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ahj.2005.04.025_bib22","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/ndt\/12.8.1672","article-title":"Patient survival after renal transplantation; more than 25 years of follow-up","volume":"12","author":"Arend","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ahj.2005.04.025_bib23","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1161\/01.ATV.19.12.2918","article-title":"Enhanced reduction of fasting total homocysteine levels with supraphysiological versus standard multivitamin dose folic acid supplementation in renal transplant recipients","volume":"19","author":"Beaulieu","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2005.04.025_bib24","series-title":"Statistical tables for the design of clinical trials","author":"Machin","year":"1997"},{"key":"10.1016\/j.ahj.2005.04.025_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(02)09327-3","article-title":"MRC\/BHF heart protection study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomized placebo-controlled trial","volume":"360","year":"2002","journal-title":"Lancet"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870305004448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870305004448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:16:44Z","timestamp":1757567804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870305004448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0002870305004448"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2005.04.025","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2005.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}