{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:37Z","timestamp":1790401477042,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.ahj.2007.05.010","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T08:05:20Z","timestamp":1187942720000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy"],"prefix":"10.1016","volume":"154","author":[{"given":"Mamoru","family":"Satoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonari","family":"Akatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2007.05.010_bib1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0140-6736(86)91837-4","article-title":"Detection of coxsackie-B-virus\u2013specific RNA sequence in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy","volume":"1","author":"Bowles","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2007.05.010_bib2","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1161\/01.CIR.89.6.2582","article-title":"Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy","volume":"89","author":"Why","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/labinvest.3700031","article-title":"Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy","volume":"84","author":"Satoh","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.ahj.2007.05.010_bib4","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1006\/jmcc.2001.1416","article-title":"Persistent expression of cytokines in the chronic stage of CVB3-induced myocarditis in NMRI mice","volume":"33","author":"Gluck","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ahj.2007.05.010_bib5","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1161\/01.CIR.99.25.3260","article-title":"Tumor necrosis factor-\u03b1\u2013converting enzyme and tumor necrosis factor-\u03b1 in human dilated cardiomyopathy","volume":"99","author":"Satoh","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ahj.2007.05.010_bib7","doi-asserted-by":"crossref","first-page":"11313","DOI":"10.1128\/JVI.78.20.11313-11320.2004","article-title":"Coxsackievirus B4\u2013induced cytokine production in pancreatic cells is mediated through toll-like receptor 4","volume":"78","author":"Triantafilou","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.ahj.2007.05.010_bib8","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8","volume":"303","author":"Heil","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ahj.2007.05.010_bib9","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA","volume":"303","author":"Diebold","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ahj.2007.05.010_bib10","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1462-5822.2005.00537.x","article-title":"Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8\u2013dependent","volume":"7","author":"Triantafilou","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ahj.2007.05.010_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies","volume":"93","author":"Richardson","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ahj.2007.05.010_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jmv.1890410208","article-title":"Attenuation of a reactivated cardiovirulent coxsackievirus B3: the 5\u2032-nontranslated region does not contain major attenuation determinants","volume":"41","author":"Zhang","year":"1993","journal-title":"J Med Virol"},{"key":"10.1016\/j.ahj.2007.05.010_bib14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.amjcard.2004.05.023","article-title":"Evidence of viral infection in the myocardium of American and Japanese patients with idiopathic dilated cardiomyopathy","volume":"94","author":"Fujioka","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2007.05.010_bib15","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1172\/JCI1972","article-title":"Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy","volume":"102","author":"Wessely","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ahj.2007.05.010_bib16","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0735-1097(00)00955-4","article-title":"Evaluation of viral infection in the myocardium of patients with idiopathic dilated cardiomyopathy","volume":"36","author":"Fujioka","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2007.05.010_bib17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.CIR.0000155616.07901.35","article-title":"High prevalence of viral genomes and multiple viral infections in the myocardium of adults with \u201cidiopathic\u201d left ventricular dysfunction","volume":"111","author":"K\u00fchl","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/01.CIR.101.3.231","article-title":"Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy","volume":"101","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib19","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ahj.2007.05.010_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ahj.2007.05.010_bib21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/ni1223","article-title":"Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1\u2013polarizing program in dendritic cells","volume":"6","author":"Napolitani","year":"2005","journal-title":"Nat Immun"},{"key":"10.1016\/j.ahj.2007.05.010_bib22","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/CIRCULATIONAHA.105.536433","article-title":"Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of coxsackievirus B3\u2013induced myocarditis and influences type I interferon production","volume":"112","author":"Fuse","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2007.05.010_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF00199511","article-title":"Expression of cytokine genes and presence of enteroviral genomic RNA in endomyocardial biopsy tissues of myocarditis and dilated cardiomyopathy","volume":"427","author":"Satoh","year":"1996","journal-title":"Virchow Arch"},{"key":"10.1016\/j.ahj.2007.05.010_bib24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/01.RES.81.4.627","article-title":"Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-\u03b1","volume":"81","author":"Kubota","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2007.05.010_bib25","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1161\/01.CIR.97.14.1375","article-title":"Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-\u03b1","volume":"97","author":"Bryant","year":"1998","journal-title":"Circulation"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870307004279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870307004279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:33:11Z","timestamp":1757568791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870307004279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0002870307004279"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2007.05.010","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2007.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}