{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:57:15Z","timestamp":1793105835809,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.ahj.2008.11.007","type":"journal-article","created":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T09:14:01Z","timestamp":1231924441000},"page":"589-595","source":"Crossref","is-referenced-by-count":41,"title":["Heparin\/PF4 antibodies formation after heparin treatment: Temporal aspects and long-term follow-up"],"prefix":"10.1016","volume":"157","author":[{"given":"Anna Vittoria","family":"Mattioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Zennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2008.11.007_bib1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood.V96.5.1703","article-title":"Impact of the patient population on the risk for heparin-induced thrombocytopenia","volume":"96","author":"Warkentin","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ahj.2008.11.007_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ahj.2005.10.005","article-title":"Heparin-induced thrombocytopenia and cardiovascular diseases","volume":"152","author":"Das","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2008.11.007_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-2004-831041","article-title":"Prevalence of Anti-PF4\/heparin antibodies and the HIT syndrome in cardiovascular medicine","volume":"30","author":"Mattioli","year":"2004","journal-title":"Sem Thromb Hemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1517\/14656566.7.3.267","article-title":"Treatment of heparin-induced thrombocytopenia in cardiovascular patients","volume":"7","author":"Mattahi","year":"2006","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ahj.2008.11.007_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-0037-1615864","article-title":"Heparin-induced thrombocytopenia: a clinicopathologic syndrome","volume":"82","author":"Warkentin","year":"1999","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.ahj.2008.11.007_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archinternmed.2007.65","article-title":"Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy","volume":"168","author":"Oliveira","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.CIR.0000066696.57519.AF","article-title":"Anti\u2013platelet factor 4\/heparin antibodies: an independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes","volume":"107","author":"Williams","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2008.11.007_bib8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0002-9343(96)00258-6","article-title":"A 14-year study of heparin-induced thrombocytopenia","volume":"101","author":"Warkentin","year":"1996","journal-title":"Am J Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJM198010023031404","article-title":"Heparin-associated thrombocytopenia","volume":"303","author":"Cines","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib10","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM200104263441704","article-title":"Temporal aspects of heparin-induced thrombocytopenia","volume":"334","author":"Warkentin","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib11","first-page":"148","article-title":"Laboratory diagnosis of immune heparin-induced thrombocytopenia","volume":"2","author":"Warkentin","year":"2003","journal-title":"Curr Hematol Rep"},{"key":"10.1016\/j.ahj.2008.11.007_bib12","first-page":"39","article-title":"Heparin-induced thrombocytopenia in patients treated with unfractionated heparin: prevalence of thrombosis in a 1 year follow-up","volume":"1","author":"Mattioli","year":"2000","journal-title":"Ital Heart J"},{"key":"10.1016\/j.ahj.2008.11.007_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1010-7940(99)00134-7","article-title":"European System for Cardiac Operative Risk Evaluation (EuroSCORE)","volume":"16","author":"Nashef","year":"1999","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2008.11.007_bib14","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1111\/j.1538-7836.2004.01039.x","article-title":"Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia","volume":"2","author":"Zwicker","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11239-005-0850-7","volume":"19","author":"Ohman","year":"2005","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.ahj.2008.11.007_bib16","doi-asserted-by":"crossref","first-page":"311S","DOI":"10.1378\/chest.126.3_suppl.311S","article-title":"Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Warkentin","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ahj.2008.11.007_bib17","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1016\/j.amjmed.2005.06.005","article-title":"Heparin-induced thrombocytopenia: clinical manifestations and management strategies","volume":"118","author":"Menajovsky","year":"2005","journal-title":"Am J Med"},{"issue":"Suppl 2","key":"10.1016\/j.ahj.2008.11.007_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-2002-32313","article-title":"Selective inhibition of coagulation factors: advances in antithrombotic therapy","volume":"28","author":"Bauer","year":"2002","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib19","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1055\/s-0037-1615969","article-title":"A new approach in the study of the molecular and cellular events implicated in heparin-induced thrombocytopenia. Formation of leukocyte-platelet aggregates","volume":"85","author":"Khairy","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1056\/NEJM200008173430718","article-title":"Use of heparin during cardiopulmonary bypass in patients with a history of heparin-induced thrombocytopenia","volume":"343","author":"Potzsch","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.7326\/0003-4819-136-3-200202050-00009","article-title":"Delayed onset heparin-induced thrombocytopenia","volume":"136","author":"Rice","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib22","doi-asserted-by":"crossref","first-page":"502","DOI":"10.7326\/0003-4819-135-7-200110020-00009","article-title":"Delayed-onset heparin-induced thrombocytopenia and thrombosis","volume":"135","author":"Warkentin","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2008.11.007_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/j.jvca.2006.05.002","article-title":"Heparin-induced thrombocytopenia following cardiac surgery is associated with poor outcome","volume":"21","author":"Kuitunen","year":"2007","journal-title":"J Cardiothorac Vasc Anest"},{"key":"10.1016\/j.ahj.2008.11.007_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1365-2141.2005.05381.x","article-title":"Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies","volume":"128","author":"Pouplard","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ahj.2008.11.007_bib25","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jtcvs.2005.07.052","article-title":"Preoperative anti-PF4\/heparin antibody level predicts adverse outcome after cardiac surgery","volume":"130","author":"Bennett-Guerrero","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ahj.2008.11.007_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1160\/TH04-12-0825","article-title":"Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis: a retrospective analysis of 408 patients","volume":"94","author":"Greinacher","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib27","first-page":"9","article-title":"Clinical presentation of heparin-induced thrombocytopenia","volume":"35","author":"Warkentin","year":"1998","journal-title":"Semin Hematol"},{"key":"10.1016\/j.ahj.2008.11.007_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0037-1614206","article-title":"Heparin-induced thrombocytopenia: towards consensus","volume":"79","author":"Warkentin","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.ahj.2008.11.007_bib29","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/jcp.6.4.320","article-title":"Observations on cases of thrombocytopenic purpura due to quinidine, sulphamezathine, and quinidine","volume":"6","author":"Bolton","year":"1953","journal-title":"J Clin Pathol"}],"updated-by":[{"DOI":"10.1016\/j.ahj.2009.07.019","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000}}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870308009848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870308009848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T16:24:26Z","timestamp":1589473466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870308009848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0002870308009848"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2008.11.007","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}