{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:45:32Z","timestamp":1779335132037,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ahj.2010.03.023","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T04:30:55Z","timestamp":1276057855000},"page":"1074-1080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Novel risk factors in long-term hypertension incidence in type 1 diabetes mellitus"],"prefix":"10.1016","volume":"159","author":[{"given":"Karine","family":"Sahakyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.K.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea E.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Y.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2010.03.023_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/01.HYP.19.5.403","article-title":"Diabetes mellitus and hypertension","volume":"19","author":"Epstein","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/bmj.285.6343.685","article-title":"Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy","volume":"285","author":"Mogensen","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.ahj.2010.03.023_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.HYP.0000240331.32352.0c","article-title":"Mechanisms of diabetic nephropathy: role of hypertension","volume":"48","author":"Giunti","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2337\/diacare.11.3.246","article-title":"Incidence of diabetic retinopathy and relationship to baseline plasma glucose and blood pressure","volume":"11","author":"Teuscher","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ahj.2010.03.023_bib5","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1001\/archinte.1989.00390110033008","article-title":"Is blood pressure a predictor of the incidence or progression of diabetic retinopathy?","volume":"149","author":"Klein","year":"1989","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2010.03.023_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00004872-199303000-00012","article-title":"Hypertension in Diabetes Study (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications","volume":"11","year":"1993","journal-title":"J Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/bmj.321.7258.412","article-title":"Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study","volume":"321","author":"Adler","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.ahj.2010.03.023_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2337\/diacare.11.1.17","article-title":"Prevalence of hypertension and associated risk factors among diabetic individuals. The Three-City Study","volume":"11","author":"Sprafka","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ahj.2010.03.023_bib9","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1001\/archinte.1996.00440060042005","article-title":"The incidence of hypertension in insulin-dependent diabetes","volume":"156","author":"Klein","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2010.03.023_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jdiacomp.2007.10.004","article-title":"Incidence and risk factors of hypertension among Saudi type 2 diabetes adult patients: an 11-year prospective randomized study","volume":"23","author":"Salman","year":"2009","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.ahj.2010.03.023_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.diabres.2005.02.017","article-title":"Hypertension in type 2 diabetes mellitus in Isfahan, Iran: incidence and risk factors","volume":"70","author":"Janghorbani","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.ahj.2010.03.023_bib12","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.HYP.0000256956.61872.aa","article-title":"Multiple biomarkers and the risk of incident hypertension","volume":"49","author":"Wang","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib13","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1001\/jama.290.22.2945","article-title":"C-reactive protein and the risk of developing hypertension","volume":"290","author":"Sesso","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2010.03.023_bib14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/01.HYP.0000252664.24294.ff","article-title":"Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women","volume":"49","author":"Sesso","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib15","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1161\/01.CIR.96.6.1745","article-title":"High homocysteine levels are independently related to isolated systolic hypertension in older adults","volume":"96","author":"Sutton-Tyrrell","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.03.023_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1001\/archinte.166.3.345","article-title":"C-reactive protein concentration and incident hypertension in young adults: the CARDIA study","volume":"166","author":"Lakoski","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2010.03.023_bib17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/01.HYP.0000146691.51307.84","article-title":"Inflammation, abdominal obesity, and smoking as predictors of hypertension","volume":"44","author":"Niskanen","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib18","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","article-title":"Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications","volume":"94","author":"Goldberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"5 Suppl","key":"10.1016\/j.ahj.2010.03.023_bib19","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.jacc.2008.09.055","article-title":"The pathologic continuum of diabetic vascular disease","volume":"53","author":"Orasanu","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2010.03.023_bib20","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.96.19.10836","article-title":"Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition","volume":"96","author":"Miyamoto","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ahj.2010.03.023_bib21","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/01.CIR.0000089190.95415.9F","article-title":"New markers of inflammation and endothelial cell activation: part I","volume":"108","author":"Szmitko","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.03.023_bib22","first-page":"297","article-title":"Plasma homocysteine and microvascular complications in type 1 diabetes","volume":"10","author":"Vaccaro","year":"2000","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.ahj.2010.03.023_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1067\/mpd.2000.108103","article-title":"Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy","volume":"137","author":"Chiarelli","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.ahj.2010.03.023_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/oxfordjournals.aje.a113725","article-title":"Prevalence of diabetes mellitus in southern Wisconsin","volume":"119","author":"Klein","year":"1984","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ahj.2010.03.023_bib25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/archopht.1984.01040030398010","article-title":"The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years","volume":"102","author":"Klein","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ahj.2010.03.023_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archopht.1989.01070010243030","article-title":"The Wisconsin Epidemiologic Study of Diabetic Retinopathy. IX. Four-year incidence and progression of diabetic retinopathy when age at diagnosis is less than 30 years","volume":"107","author":"Klein","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ahj.2010.03.023_bib27","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1001\/archopht.1994.01090210105023","article-title":"The Wisconsin Epidemiologic Study of diabetic retinopathy. XIV. Ten-year incidence and progression of diabetic retinopathy","volume":"112","author":"Klein","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ahj.2010.03.023_bib28","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0161-6420(98)91020-X","article-title":"The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes","volume":"105","author":"Klein","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ahj.2010.03.023_bib29","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.ophtha.2008.08.023","article-title":"The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII. The twenty-five-year progression of retinopathy in persons with type 1 diabetes","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ahj.2010.03.023_bib30","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/archinte.164.17.1917","article-title":"Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy","volume":"164","author":"Klein","year":"2004","journal-title":"Arch Intern Med"},{"issue":"7 Pt 1","key":"10.1016\/j.ahj.2010.03.023_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0895-7061(00)01321-2","article-title":"A pilot study of homocyst(e)ine levels in essential hypertension: relationship to von Willebrand factor, an index of endothelial damage","volume":"14","author":"Lip","year":"2001","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/ajcn\/72.2.315","article-title":"Homocysteine and cardiovascular disease: cause or effect?","volume":"72","author":"Brattstrom","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ahj.2010.03.023_bib33","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1046\/j.1523-1755.1999.0550031028.x","article-title":"Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus","volume":"55","author":"Wollesen","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.ahj.2010.03.023_bib34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/aje\/kwf157","article-title":"Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994","volume":"156","author":"Lim","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ahj.2010.03.023_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2010.03.023_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.HYP.38.3.399","article-title":"Blood pressure and inflammation in apparently healthy men","volume":"38","author":"Chae","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2010.03.023_bib37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.jhh.1001537","article-title":"Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence","volume":"17","author":"Bautista","year":"2003","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00004872-200105000-00004","article-title":"Is C-reactive protein an independent risk factor for essential hypertension?","volume":"19","author":"Bautista","year":"2001","journal-title":"J Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.jhh.1001785","article-title":"Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension","volume":"19","author":"Bautista","year":"2005","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archinte.163.1.93","article-title":"C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998","volume":"163","author":"Thorand","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2010.03.023_bib41","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1161\/01.ATV.0000160351.95181.d0","article-title":"Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality","volume":"25","author":"Smith","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2010.03.023_bib42","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1139\/y92-069","article-title":"Hypertensive structural changes in blood vessels: do endothelial cells hold the key?","volume":"70","author":"Todd","year":"1992","journal-title":"Can J Physiol Pharmacol"},{"issue":"Suppl 12","key":"10.1016\/j.ahj.2010.03.023_bib43","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1097\/00005344-199204002-00054","article-title":"Endothelium-dependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension","volume":"20","author":"Taddei","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.ahj.2010.03.023_bib44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2362.1996.1780527.x","article-title":"The pathogenesis of vascular complications of diabetes mellitus: one voice or many?","volume":"26","author":"Stehouwer","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ahj.2010.03.023_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4149\/endo_2010_01_17","article-title":"Plasma levels of ICAM-1 and circulating endothelial cells are elevated in unstable types 1 and 2 diabetes","volume":"44","author":"El Amine","year":"2010","journal-title":"Endocr Regul"},{"key":"10.1016\/j.ahj.2010.03.023_bib46","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1097\/00004872-200208000-00019","article-title":"Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy","volume":"20","author":"Malmqvist","year":"2002","journal-title":"J Hypertens"},{"key":"10.1016\/j.ahj.2010.03.023_bib47","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1161\/01.ATV.17.11.2646","article-title":"Soluble vascular cell adhesion molecule-1 as a biohumoral correlate of atherosclerosis","volume":"17","author":"De Caterina","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2010.03.023_bib48","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1177\/0091270003258190","article-title":"Homocysteine and essential hypertension","volume":"43","author":"Rodrigo","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.ahj.2010.03.023_bib49","doi-asserted-by":"crossref","first-page":"F671","DOI":"10.1152\/ajprenal.2000.279.4.F671","article-title":"Effects of homocysteine on endothelial nitric oxide production","volume":"279","author":"Zhang","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ahj.2010.03.023_bib50","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/01.ATV.19.5.1263","article-title":"Enhanced in vivo lipid peroxidation at elevated plasma total homocysteine levels","volume":"19","author":"Voutilainen","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2010.03.023_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-2000-8472","article-title":"Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction","volume":"26","author":"van Guldener","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.ahj.2010.03.023_bib52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/030006059902700105","article-title":"Association between hyperhomocysteinaemia and hypertension in Sri Lankans","volume":"27","author":"Mendis","year":"1999","journal-title":"J Int Med Res"},{"key":"10.1016\/j.ahj.2010.03.023_bib53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0021-9150(95)05522-X","article-title":"Net uptake of plasma homocysteine by the rat kidney in vivo","volume":"116","author":"Bostom","year":"1995","journal-title":"Atherosclerosis"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870310002498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870310002498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:41:41Z","timestamp":1757569301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870310002498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0002870310002498"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2010.03.023","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel risk factors in long-term hypertension incidence in type 1 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2010.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}