{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:11:34Z","timestamp":1791803494159,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.ahj.2010.09.018","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T09:33:44Z","timestamp":1292492024000},"page":"68-75","source":"Crossref","is-referenced-by-count":78,"title":["Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin"],"prefix":"10.1016","volume":"161","author":[{"given":"Gjin","family":"Ndrepepa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegmund","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julinda","family":"Mehilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Anette","family":"Birkmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"H\u00f6sl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Pache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchior","family":"Seyfarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Sch\u00f6mig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2010.09.018_bb0005","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1373\/clinchem.2006.084194","article-title":"National Academy of Clinical Biochemistry laboratory medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes","volume":"53","author":"Morrow","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCULATIONAHA.105.570762","article-title":"Troponin I as a predictor of coronary heart disease and mortality in 70-year-old men: a community-based cohort study","volume":"113","author":"Zethelius","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0015","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1161\/CIRCULATIONAHA.107.708529","article-title":"Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality","volume":"116","author":"Eggers","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0020","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJMoa0903515","article-title":"Sensitive troponin I assay in early diagnosis of acute myocardial infarction","volume":"361","author":"Keller","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0025","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa0900428","article-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","volume":"361","author":"Reichlin","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0030","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1373\/clinchem.2007.097162","article-title":"Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome","volume":"54","author":"Apple","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0035","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cca.2007.12.016","article-title":"Use of the bioMerieux VIDAS troponin I ultra assay for the diagnosis of myocardial infarction and detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome","volume":"390","author":"Apple","year":"2008","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ahj.2010.09.018_bb0040","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1309\/AJCP0CMZ6UJZHLKA","article-title":"Impact of ultrasensitive cardiac troponin I dynamic changes in the new universal definition of myocardial infarction","volume":"130","author":"Casals","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0045","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1373\/clinchem.2008.116020","article-title":"Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury","volume":"55","author":"Kavsak","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1309\/Q9W5HJTT24GQCXXX","article-title":"Earlier detection of myocardial injury in a preliminary evaluation using a new troponin I assay with improved sensitivity","volume":"128","author":"Melanson","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0060","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1258\/acb.2007.007209","article-title":"Performance of the Advia Centaur second-generation troponin assay TnI-Ultra compared with the first-generation cTnI assay","volume":"45","author":"van de Kerkhof","year":"2008","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1373\/clinchem.2008.106500","article-title":"Clinical performance of two highly sensitive cardiac troponin I assays","volume":"55","author":"Venge","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0070","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1515\/CCLM.2008.292","article-title":"Troponin revisited 2008: assay performance","volume":"46","author":"Tate","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0009-8981(99)00079-0","article-title":"Clinical insights on the use of highly sensitive cardiac troponin assays","volume":"284","author":"Missov","year":"1999","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ahj.2010.09.018_bb0080","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/CIRCULATIONAHA.106.655076","article-title":"Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure","volume":"116","author":"Latini","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0085","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1373\/clinchem.2009.127241","article-title":"Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population","volume":"55","author":"Kavsak","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0090","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1056\/NEJMoa0805299","article-title":"A sensitive cardiac troponin T assay in stable coronary artery disease","volume":"361","author":"Omland","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0095","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCULATIONAHA.109.192667","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0100","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1056\/NEJM199905273402103","article-title":"Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators","volume":"340","author":"Hamm","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.ahj.2010.09.018_bb0110","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.ahj.2010.09.018_bb0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0120","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1093\/eurheartj\/ehn327","article-title":"Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects","volume":"29","author":"Eggers","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2010.09.018_bb0125","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1161\/CIRCULATIONAHA.105.609974","article-title":"Prevalence and determinants of troponin T elevation in the general population","volume":"113","author":"Wallace","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0130","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jacc.2009.05.051","article-title":"Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia","volume":"54","author":"Venge","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0135","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/0735-1097(95)00282-8","article-title":"Gender differences and aging: effects on the human heart","volume":"26","author":"Olivetti","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ahj.2010.09.018_bb0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1373\/clinchem.2007.101683","article-title":"Value of cardiac troponin I cutoff concentrations below the 99th percentile for clinical decision-making","volume":"55","author":"Eggers","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0150","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/clinchem\/37.8.1405","article-title":"S-troponin T in suspected ischemic myocardial injury compared with mass and catalytic concentrations of S-creatine kinase isoenzyme MB","volume":"37","author":"Gerhardt","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/01.CIR.0000109483.45211.8F","article-title":"Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients","volume":"109","author":"Diris","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2010.09.018_bb0160","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.med.53.082901.104057","article-title":"Lipotoxic diseases","volume":"53","author":"Unger","year":"2002","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0165","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/clinchem\/44.9.1912","article-title":"Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage","volume":"44","author":"Bleier","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2010.09.018_bb0170","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/0002-9149(91)90466-X","article-title":"Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction","volume":"67","author":"Katus","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0175","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yexmp.2008.07.002","article-title":"Release kinetics of intact and degraded troponin I and T after irreversible cell damage","volume":"85","author":"Hessel","year":"2008","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.ahj.2010.09.018_bb0180","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.RES.71.1.159","article-title":"Permeability of rat atrial endocardium, epicardium, and myocardium to large molecules. Stretch-dependent effects","volume":"71","author":"Page","year":"1992","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2010.09.018_bb0185","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJMra0901217","article-title":"Cell death","volume":"361","author":"Hotchkiss","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2010.09.018_bb0190","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cca.2009.12.009","article-title":"Cardiac troponin may be released by ischemia alone, without necrosis","volume":"411","author":"Hickman","year":"2010","journal-title":"Clin Chim Acta"}],"updated-by":[{"DOI":"10.1016\/j.ahj.2013.03.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000}}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870310008872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870310008872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T18:53:04Z","timestamp":1592160784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870310008872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0002870310008872"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2010.09.018","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}