{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:44:24Z","timestamp":1778798664466,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ahj.2011.09.021","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T04:04:18Z","timestamp":1321934658000},"page":"27-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["A cardiovascular safety study of LibiGel (testosterone gel) in postmenopausal women with elevated cardiovascular risk and hypoactive sexual desire disorder"],"prefix":"10.1016","volume":"163","clinical-trial-number":[{"clinical-trial-number":"nct00612742","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"William B.","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Grady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda C.","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Zborowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Snabes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2011.09.021_bb0005","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1001\/jama.281.6.537","article-title":"Sexual dysfunction in the United States: prevalence and predictors","volume":"281","author":"Laumann","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2011.09.021_bb0010","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/AOG.0b013e3181898cdb","article-title":"Sexual problems and distress in United States women: prevalence and correlates","volume":"112","author":"Shifren","year":"2008","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ahj.2011.09.021_bb0015","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1001\/archinte.168.13.1441","article-title":"Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of US women","volume":"168","author":"West","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0020","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/01.AOG.0000158103.27672.0d","article-title":"Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial","volume":"105","author":"Buster","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ahj.2011.09.021_bb0025","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1210\/jc.2004-1747","article-title":"Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder","volume":"90","author":"Simon","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ahj.2011.09.021_bb0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.ijir.3901481","article-title":"Regulatory perspective on clinical trials and endpoints for female sexual dysfunction, in particular, hypoactive sexual desire disorder: formulating recommendations in an environment of evolving clinical science","volume":"19","author":"Shames","year":"2007","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.ahj.2011.09.021_bb0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa062462","article-title":"Effects if raloxifene on cardiovascular events and breast cancer in postmenopausal women","volume":"355","author":"Barrett-Connor","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0040","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archinte.166.3.357","article-title":"Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative","volume":"166","author":"Hsia","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0045","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progesterone in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2011.09.021_bb0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0895-4356(93)90079-G","article-title":"The Goldilocks dilemma in survey design and its solution","volume":"46","author":"Chappell","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ahj.2011.09.021_bb0055","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1056\/NEJMoa0707302","article-title":"Testosterone for low libido in postmenopausal women not taking estrogen","volume":"359","author":"Davis","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0300-595X(86)80021-4","article-title":"Adrenal and androgen secretion in normal females","volume":"15","author":"Longscope","year":"1986","journal-title":"Clin Endocrinol Metab"},{"key":"10.1016\/j.ahj.2011.09.021_bb0065","doi-asserted-by":"crossref","first-page":"678","DOI":"10.7326\/0003-4819-137-8-200210150-00013","article-title":"Breast cancer in men","volume":"137","author":"Giordano","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0070","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.gme.0000232033.92411.51","article-title":"Testosterone inhibits estrogen\/progestogen-induced breast cell proliferation in postmenopausal women","volume":"14","author":"Hofling","year":"2007","journal-title":"Menopause"},{"key":"10.1016\/j.ahj.2011.09.021_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fertnstert.2007.01.118","article-title":"Safety of testosterone treatment in postmenopausal women","volume":"88","author":"Braunstein","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ahj.2011.09.021_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ahj.2011.09.021_bb0085","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1210\/jc.2007-0195","article-title":"Effects of testosterone therapy on cardiovascular risk markers in androgen-deficient women with hypopituitarism","volume":"92","author":"Miller","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ahj.2011.09.021_bb0090","first-page":"726","article-title":"Fifty-two\u2013week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone","volume":"30","author":"Heufelder","year":"2009","journal-title":"Andrology"},{"key":"10.1016\/j.ahj.2011.09.021_bb0095","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jc.2007-1792","article-title":"Low serum testosterone and mortality in older men","volume":"93","author":"Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ahj.2011.09.021_bb0100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.amjcard.2011.03.093","article-title":"The link between erectile and cardiovascular health: The canary in the coal mine","volume":"108","author":"Meldrum","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2011.09.021_bb0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2164\/jandrol.108.005215","article-title":"The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction","volume":"30","author":"Traish","year":"2009","journal-title":"J Androl."},{"key":"10.1016\/j.ahj.2011.09.021_bb0110","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/eurheartj\/ehm209","article-title":"Cardiovascular safety of drugs not intended for cardiovascular use: need for a new conceptual basis for assessment and approval","volume":"28","author":"Borer","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2011.09.021_bb0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9149(01)02265-2","article-title":"Comparison of thromboembolic events in patients treated with celecoxib, a cyclooxygenase-2 specific inhibitor, versus ibuprofen or diclofenac","volume":"89","author":"White","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2011.09.021_bb0120","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.amjmed.2009.03.005","article-title":"The potential role of nitric oxide in cardiovascular safety when treating patients with osteoarthritis and hypertension","volume":"122","author":"White","year":"2009","journal-title":"Am J Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0125","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","article-title":"Telmisartan, ramipril , or both in patients at high risk for vascular events","volume":"358","author":"ONTARGET Investigators","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2011.09.021_bb0130","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa0706482","article-title":"Prasugrel versus clopidigrel in patients with acute coronary syndromes","volume":"357","author":"Wiviott","year":"2008","journal-title":"N Engl J Med"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287031100706X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287031100706X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:45:00Z","timestamp":1757569500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000287031100706X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S000287031100706X"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2011.09.021","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A cardiovascular safety study of LibiGel (testosterone gel) in postmenopausal women with elevated cardiovascular risk and hypoactive sexual desire disorder","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2011.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}