{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:28:18Z","timestamp":1789370898921,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.ahj.2012.11.010","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T04:38:47Z","timestamp":1359002327000},"page":"371-378.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Risk stratification in patients with unstable angina using absolute serial changes of 3 high-sensitive troponin assays"],"prefix":"10.1016","volume":"165","clinical-trial-number":[{"clinical-trial-number":"nct00470587","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Tobias","family":"Reichlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Maushart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Moehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrin","family":"Balmelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rubini","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Hoeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Sakarikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Haaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.ahj.2012.11.010_bb0005","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1161\/CIRCULATIONAHA.107.187397","article-title":"Universal definition of myocardial infarction","volume":"116","author":"Thygesen","year":"2007","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.ahj.2012.11.010_bb0010","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1161\/CIR.0b013e318212bb8b","volume":"123","author":"Anderson","year":"2011","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.ahj.2012.11.010_bb0015","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.109.192663","article-title":"2009 Focused updates: ACC\/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"120","author":"Kushner","year":"2009","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.ahj.2012.11.010_bb0020","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/jama.295.13.joc60034","article-title":"Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial","volume":"295","author":"Kastrati","year":"2006","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ahj.2012.11.010_bb0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0735-1097(96)00447-0","article-title":"Troponin T identifies patients with unstable coronary artery disease who benefit from long-term antithrombotic protection. Fragmin in Unstable Coronary Artery Disease Study Group","volume":"29","author":"Lindahl","year":"1997","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"10.1016\/j.ahj.2012.11.010_bb0030","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1001\/jama.286.19.2405","article-title":"Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non\u2013ST elevation myocardial infarction: results from a randomized trial","volume":"286","author":"Morrow","year":"2001","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ahj.2012.11.010_bb0035","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ahj.2007.10.016","article-title":"The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing","volume":"155","author":"Wu","year":"2008","journal-title":"Am Heart J"},{"issue":"2","key":"10.1016\/j.ahj.2012.11.010_bb0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.ahj.2012.11.010_bb0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1373\/clinchem.2008.107391","article-title":"Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice","volume":"55","author":"Wu","year":"2009","journal-title":"Clin Chem"},{"issue":"13","key":"10.1016\/j.ahj.2012.11.010_bb0050","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jacc.2009.05.051","article-title":"Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia","volume":"54","author":"Venge","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.ahj.2012.11.010_bb0055","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa0900428","article-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","volume":"361","author":"Reichlin","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ahj.2012.11.010_bb0060","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCULATIONAHA.111.023937","article-title":"Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction","volume":"124","author":"Reichlin","year":"2011","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.ahj.2012.11.010_bb0065","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/eurheartj\/ehq251","article-title":"Recommendations for the use of cardiac troponin measurement in acute cardiac care","volume":"31","author":"Thygesen","year":"2010","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.ahj.2012.11.010_bb0070","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1067\/mhj.2002.124048","article-title":"European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials","volume":"144","author":"Apple","year":"2002","journal-title":"Am Heart J"},{"issue":"13","key":"10.1016\/j.ahj.2012.11.010_bb0075","first-page":"e352","article-title":"National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes","volume":"115","author":"Apple","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ahj.2012.11.010_bb0080","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1373\/clinchem.2010.159350","article-title":"Sources of variability in measurements of cardiac troponin T in a community-based sample: the atherosclerosis risk in communities study","volume":"57","author":"Agarwal","year":"2011","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.ahj.2012.11.010_bb0085","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1309\/LR7FC0LUGLHT8X6J","article-title":"The effect of freezing and long-term storage on the stability of cardiac troponin T","volume":"128","author":"Basit","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"10.1016\/j.ahj.2012.11.010_bb0090","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.ahj.2012.11.010_bb0095","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1373\/clinchem.2008.114728","article-title":"Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events","volume":"55","author":"Apple","year":"2009","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.ahj.2012.11.010_bb0100","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ahj.2009.06.011","article-title":"Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: observations from the PROTECT-TIMI 30 Trial","volume":"158","author":"Wilson","year":"2009","journal-title":"Am Heart J"},{"issue":"4","key":"10.1016\/j.ahj.2012.11.010_bb0105","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1373\/clinchem.2009.134460","article-title":"High-sensitivity cardiac troponin T for early prediction of evolving non\u2013ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin Chem"},{"issue":"13","key":"10.1016\/j.ahj.2012.11.010_bb0110","first-page":"e356","article-title":"National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes","volume":"115","author":"Morrow","year":"2007","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.ahj.2012.11.010_bb0115","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1056\/NEJMoa0807986","article-title":"Early versus delayed invasive intervention in acute coronary syndromes","volume":"360","author":"Mehta","year":"2009","journal-title":"N Engl J Med"},{"issue":"9001","key":"10.1016\/j.ahj.2012.11.010_bb0120","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0140-6736(96)91270-2","article-title":"Low-molecular-weight heparin during instability in coronary artery disease. Fragmin during Instability in Coronary Artery Disease (FRISC) study group","volume":"347","year":"1996","journal-title":"Lancet"},{"issue":"25","key":"10.1016\/j.ahj.2012.11.010_bb0125","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1056\/NEJM200106213442501","article-title":"Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb\/IIIa inhibitor tirofiban","volume":"344","author":"Cannon","year":"2001","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ahj.2012.11.010_bb0130","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jacc.2006.05.056","article-title":"Troponin-T and N-terminal pro\u2013B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy","volume":"48","author":"James","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"10.1016\/j.ahj.2012.11.010_bb0135","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1161\/01.CIR.103.24.2891","article-title":"Benefit of glycoprotein IIb\/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy","volume":"103","author":"Newby","year":"2001","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ahj.2012.11.010_bb0140","first-page":"e148","article-title":"ACC\/AHA 2007 guidelines for the management of patients with unstable angina\/non ST-elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"116","author":"Anderson","year":"2007","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.ahj.2012.11.010_bb0145","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/eurheartj\/ehm161","article-title":"Guidelines for the diagnosis and treatment of non\u2013ST-segment elevation acute coronary syndromes","volume":"28","author":"Bassand","year":"2007","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.ahj.2012.11.010_bb0150","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/01.CIR.0000121360.31954.1F","article-title":"Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial","volume":"109","author":"Hambrecht","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahj.2012.11.010_bb0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/eurheartj\/ehn504","article-title":"Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35","volume":"30","author":"Sabatine","year":"2009","journal-title":"Eur Heart J"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870312008381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870312008381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:49:44Z","timestamp":1757569784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870312008381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0002870312008381"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2012.11.010","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk stratification in patients with unstable angina using absolute serial changes of 3 high-sensitive troponin assays","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2012.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}