{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:26:24Z","timestamp":1791332784896,"version":"4.3.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.ahj.2014.01.003","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T03:31:17Z","timestamp":1389756677000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Improving diagnosis and treatment of women with angina pectoris and microvascular disease: The iPOWER study design and rationale"],"prefix":"10.1016","volume":"167","author":[{"given":"Eva","family":"Prescott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Zabell","family":"Abildstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel Bairey","family":"Merz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Halcox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Steen","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Riis","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kastrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Michelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naja Dam","family":"Mygind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Sechtem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"S\u00f8gaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Suppl","key":"10.1016\/j.ahj.2014.01.003_bb0005","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jacc.2004.12.084","volume":"47","author":"Bairey Merz","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"10.1016\/j.ahj.2014.01.003_bb0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.jacc.2009.04.098","article-title":"Women and ischemic heart disease: evolving knowledge","volume":"54","author":"Shaw","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.ahj.2014.01.003_bb0015","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","article-title":"Low diagnostic yield of elective coronary angiography","volume":"362","author":"Patel","year":"2010","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.ahj.2014.01.003_bb0020","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurheartj\/ehr331","article-title":"Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events","volume":"33","author":"Jespersen","year":"2012","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.ahj.2014.01.003_bb0025","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archinternmed.2009.50","article-title":"Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project","volume":"169","author":"Gulati","year":"2009","journal-title":"Arch Intern Med"},{"issue":"8","key":"10.1016\/j.ahj.2014.01.003_bb0030","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00392-013-0568-z","article-title":"Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris","volume":"102","author":"Jespersen","year":"2013","journal-title":"Clin Res Cardiol"},{"issue":"6","key":"10.1016\/j.ahj.2014.01.003_bb0035","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1161\/01.CIR.0000116206.77324.5B","article-title":"Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2\u20134, 2002: Section 1: diagnosis of stable ischemia and ischemic heart disease","volume":"109","author":"Pepine","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahj.2014.01.003_bb0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ahj.2007.10.019","article-title":"Angina with \"normal\" coronary arteries: sex differences in outcomes","volume":"155","author":"Humphries","year":"2008","journal-title":"Am Heart J"},{"issue":"7","key":"10.1016\/j.ahj.2014.01.003_bb0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jacc.2011.11.015","article-title":"High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries)","volume":"59","author":"Ong","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.ahj.2014.01.003_bb0050","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.105.609990","article-title":"The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health\u2013National Heart, Lung, and Blood Institute\u2013sponsored Women's Ischemia Syndrome Evaluation","volume":"114","author":"Shaw","year":"2006","journal-title":"Circulation"},{"issue":"42","key":"10.1016\/j.ahj.2014.01.003_bb0055","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1093\/eurheartj\/eht395","article-title":"Symptoms of angina pectoris increase the probability of disability pension and premature exit from the workforce even in the absence of obstructive coronary artery disease","volume":"34","author":"Jespersen","year":"2013","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.ahj.2014.01.003_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/cvr\/cvq394","article-title":"Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology","volume":"90","author":"Vaccarino","year":"2011","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0065","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1067\/mhj.2001.114198","article-title":"Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study","volume":"141","author":"Reis","year":"2001","journal-title":"Am Heart J"},{"issue":"10","key":"10.1016\/j.ahj.2014.01.003_bb0070","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jacc.2009.03.080","article-title":"Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms","volume":"54","author":"Cannon","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0075","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.amjcard.2008.10.033","article-title":"Additive prognostic value of coronary flow reserve in patients with chest pain syndrome and normal or near-normal coronary arteries","volume":"103","author":"Sicari","year":"2009","journal-title":"Am J Cardiol"},{"issue":"25","key":"10.1016\/j.ahj.2014.01.003_bb0080","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.jacc.2010.01.054","article-title":"Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study","volume":"55","author":"Pepine","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.ahj.2014.01.003_bb0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ahj.2005.03.008","article-title":"The additional prognostic value of coronary flow reserve on left anterior descending artery in patients with negative stress echo by wall motion criteria. A Transthoracic Vasodilator Stress Echocardiography Study.","volume":"151","author":"Rigo","year":"2006","journal-title":"Am Heart J"},{"issue":"3","key":"10.1016\/j.ahj.2014.01.003_bb0090","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1549-8719.2009.00015.x","article-title":"Microvascular responses to cardiovascular risk factors","volume":"17","author":"Granger","year":"2010","journal-title":"Microcirculation"},{"issue":"2","key":"10.1016\/j.ahj.2014.01.003_bb0095","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.atherosclerosis.2012.05.034","article-title":"Coronary microvascular dysfunction is associated with higher frequency of thin-cap fibroatheroma","volume":"223","author":"Dhawan","year":"2012","journal-title":"Atherosclerosis"},{"issue":"14","key":"10.1016\/j.ahj.2014.01.003_bb0100","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1001\/jama.2009.425","article-title":"Persistent chest pain and no obstructive coronary artery disease","volume":"301","author":"Phan","year":"2009","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ahj.2014.01.003_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1475-2840-11-97","article-title":"Insulin resistance and exercise tolerance in heart failure patients: linkage to coronary flow reserve and peripheral vascular function","volume":"11","author":"Snoer","year":"2012","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"10.1016\/j.ahj.2014.01.003_bb0110","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/ehjci\/jes269","article-title":"Coronary flow reserve as a link between diastolic and systolic function and exercise capacity in heart failure","volume":"14","author":"Snoer","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.ahj.2014.01.003_bb0115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2459\/JCM.0b013e32820588dd","article-title":"Factors predicting coronary flow reserve impairment in patients evaluated for chest pain: an ultrasound study","volume":"9","author":"Tuccillo","year":"2008","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"8","key":"10.1016\/j.ahj.2014.01.003_bb0120","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1097\/01.hjh.0000239294.17636.27","article-title":"Endothelial dysfunction, intima-media thickness and coronary reserve in relation to risk factors and Framingham score in patients without clinical atherosclerosis","volume":"24","author":"Campuzano","year":"2006","journal-title":"J Hypertens"},{"issue":"12","key":"10.1016\/j.ahj.2014.01.003_bb0125","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.amjcard.2008.02.055","article-title":"Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography","volume":"101","author":"Ahmari","year":"2008","journal-title":"Am J Cardiol"},{"issue":"10","key":"10.1016\/j.ahj.2014.01.003_bb0130","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jcmg.2010.07.008","article-title":"Prognostic value of global MR myocardial perfusion imaging in women with suspected myocardial ischemia and no obstructive coronary disease: results from the NHLBI-sponsored WISE (Women's Ischemia Syndrome Evaluation) study","volume":"3","author":"Doyle","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.ahj.2014.01.003_bb0135","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJM200002173420702","article-title":"Effect of exercise on coronary endothelial function in patients with coronary artery disease","volume":"342","author":"Hambrecht","year":"2000","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ahj.2014.01.003_bb0140","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/ejechocard\/jen004","article-title":"Non-invasive assessment of coronary flow and coronary flow reserve by transthoracic Doppler echocardiography: a magic tool for the real world","volume":"9","author":"Meimoun","year":"2008","journal-title":"Eur J Echocardiogr"},{"issue":"4","key":"10.1016\/j.ahj.2014.01.003_bb0145","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0735-1097(99)00342-3","article-title":"Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire","volume":"34","author":"Caiati","year":"1999","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.ahj.2014.01.003_bb0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1046\/j.1365-2281.2001.00296.x","article-title":"Coronary flow reserve: measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography","volume":"21","author":"Saraste","year":"2001","journal-title":"Clin Physiol"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0155","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0735-1097(98)00389-1","article-title":"Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique","volume":"32","author":"Hozumi","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"10.1016\/j.ahj.2014.01.003_bb0160","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.jacc.2009.10.074","article-title":"Predicting ischemic heart disease in women: the value of endothelial function","volume":"55","author":"Lian","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"10.1016\/j.ahj.2014.01.003_bb0165","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jacc.2009.10.073","article-title":"Digital assessment of endothelial function and ischemic heart disease in women","volume":"55","author":"Matsuzawa","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2014.01.003_bb0170","doi-asserted-by":"crossref","unstructured":"Manginas A, Gatzov P, Chasikidis C, et al. Estimation of coronary flow reserve using the Thrombolysis In Myocardial Infarction (TIMI) frame count method. Am J Cardiol 1999;83(11):1562\u20135, A7.","DOI":"10.1016\/S0002-9149(99)00149-6"},{"issue":"2","key":"10.1016\/j.ahj.2014.01.003_bb0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ejechocard\/jep188","article-title":"Reproducibility in echocardiographic assessment of the left ventricular global and regional function, the HUNT study","volume":"11","author":"Thorstensen","year":"2010","journal-title":"Eur J Echocardiogr"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0180","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/ejechocard\/jer051","article-title":"Recommendations of the European Association of Echocardiography: how to use echo-Doppler in clinical trials: different modalities for different purposes","volume":"12","author":"Galderisi","year":"2011","journal-title":"Eur J Echocardiogr"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0185","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/1741826711398430","article-title":"Effects of statins on coronary and peripheral endothelial function in humans: a systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Reriani","year":"2011","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"issue":"4","key":"10.1016\/j.ahj.2014.01.003_bb0190","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1017\/S0029665111001674","article-title":"Endothelial dysfunction associated with obesity and the effect of weight loss interventions","volume":"70","author":"Kerr","year":"2011","journal-title":"Proc Nutr Soc"},{"issue":"5","key":"10.1016\/j.ahj.2014.01.003_bb0195","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2165\/00003495-200868050-00002","article-title":"Beta-blockers and coronary flow reserve: the importance of a vasodilatory action","volume":"68","author":"Galderisi","year":"2008","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.ahj.2014.01.003_bb0200","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ahj.2011.07.011","volume":"162","author":"Pauly","year":"2011","journal-title":"Am Heart J"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870314000222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870314000222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:51:55Z","timestamp":1757569915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870314000222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0002870314000222"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2014.01.003","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving diagnosis and treatment of women with angina pectoris and microvascular disease: The iPOWER study design and rationale","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2014.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}