{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:52:37Z","timestamp":1786391557084,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ahj.2015.05.013","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T21:02:42Z","timestamp":1432328562000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":137,"title":["Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"170","clinical-trial-number":[{"clinical-trial-number":"nct01915615","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-7731","authenticated-orcid":false,"given":"Christopher M.","family":"Kramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Desvigne-Nickens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"DiMarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahfaye","family":"Heckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Y.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jerosch-Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Ivey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianna","family":"Keleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kolm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Y.","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Schulz-Menger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Piechnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2015.05.013_bb0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/CIRCULATIONAHA.109.878579","article-title":"Contemporary insights and strategies for risk stratification and prevention of sudden death in hypertrophic cardiomyopathy","volume":"121","author":"Maron","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2015.05.013_bb0010","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jacc.2015.01.019","article-title":"New perspectives on the prevalence of hypertrophic cardiomyopathy","volume":"65","author":"Semsarian","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.ahj.2015.05.013_bb0015","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/j.ahj.2015.05.013_bb0020","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJMra0902923","article-title":"Inherited cardiomyopathies","volume":"364","author":"Watkins","year":"2011","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ahj.2015.05.013_bb0025","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/jama.298.4.405","article-title":"Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy","volume":"298","author":"Maron","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ahj.2015.05.013_bb0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1532-429X-14-13","article-title":"Clinical utility of cardiovascular magnetic resonance in hypertrophic cardiomyopathy","volume":"14","author":"Maron","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.ahj.2015.05.013_bb0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jcmg.2011.11.021","article-title":"Prognostic value of cardiac magnetic resonance late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy","volume":"5","author":"Green","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.ahj.2015.05.013_bb0040","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.113.007094","article-title":"Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy","volume":"130","author":"Chan","year":"2014","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ahj.2015.05.013_bb0045","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jcmg.2012.09.018","article-title":"Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR","volume":"6","author":"Moravsky","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"10.1016\/j.ahj.2015.05.013_bb0050","doi-asserted-by":"crossref","first-page":"H1234","DOI":"10.1152\/ajpheart.00429.2008","article-title":"Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy","volume":"295","author":"Jerosch-Herold","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.ahj.2015.05.013_bb0055","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.109.930636","article-title":"Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis","volume":"122","author":"Flett","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahj.2015.05.013_bb0060","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCIMAGING.112.000333","article-title":"T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy","volume":"6","author":"Ho","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"issue":"39","key":"10.1016\/j.ahj.2015.05.013_bb0065","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"issue":"25","key":"10.1016\/j.ahj.2015.05.013_bb0070","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1016\/j.jacc.2011.10.825","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary","volume":"58","author":"Gersh","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2015.05.013_bb0075","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.108.821314","article-title":"Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy","volume":"2","author":"Kaski","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"10.1016\/j.ahj.2015.05.013_bb0080","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0025-6196(11)60890-2","article-title":"Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy","volume":"83","author":"Olivotto","year":"2008","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"10.1016\/j.ahj.2015.05.013_bb0085","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.ahj.2015.05.013_bb0090","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jacc.2011.05.018","article-title":"Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations","volume":"58","author":"Olivotto","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.ahj.2015.05.013_bb0095","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1532-429X-12-69","article-title":"Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold","volume":"12","author":"Piechnik","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.ahj.2015.05.013_bb0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1532-429X-15-35","article-title":"Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing","volume":"15","author":"Schulz-Menger","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"issue":"11","key":"10.1016\/j.ahj.2015.05.013_bb0105","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1373\/clinchem.2007.091181","article-title":"Ultrasensitive flow-based immunoassays using single-molecule counting","volume":"53","author":"Todd","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2015.05.013_bb0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/eurheartj\/ehn504","article-title":"Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35","volume":"30","author":"Sabatine","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2015.05.013_bb0115","series-title":"Regression modeling strategies with applications to linear models, logistic regression and survival analysis","author":"Harrell","year":"2001"},{"issue":"12","key":"10.1016\/j.ahj.2015.05.013_bb0120","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0895-4356(95)00048-8","article-title":"Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates","volume":"48","author":"Peduzzi","year":"1995","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ahj.2015.05.013_bb0125","first-page":"986","article-title":"Testing significance of features by lassoed principal components","volume":"3","author":"Witten","year":"2008","journal-title":"Ann Appl Stat"},{"key":"10.1016\/j.ahj.2015.05.013_bb0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/biomet\/69.1.239","article-title":"Partial residuals for the proportional hazards regression model","volume":"69","author":"Schoenfeld","year":"1982","journal-title":"Biometrical"},{"issue":"1","key":"10.1016\/j.ahj.2015.05.013_bb0135","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/bimj.200900028","article-title":"L1 penalized estimation in the Cox Proportional Hazards Model","volume":"52","author":"Goeman","year":"2010","journal-title":"Biom J"},{"issue":"11-12","key":"10.1016\/j.ahj.2015.05.013_bb0140","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/sim.4371","article-title":"An evaluation of penalised survival methods for developing prognostic models with rare events","volume":"31","author":"Ambler","year":"2012","journal-title":"Stat Med"},{"key":"10.1016\/j.ahj.2015.05.013_bb0145","series-title":"Missing data in clinical studies","author":"Molenberghs","year":"2007"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870315003646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870315003646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:54:21Z","timestamp":1757570061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870315003646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0002870315003646"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2015.05.013","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2015.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}