{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:54:07Z","timestamp":1790265247856,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ahj.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T02:45:35Z","timestamp":1500259535000},"page":"23-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Design for the sacubitril\/valsartan (LCZ696) compared with enalapril study of pediatric patients with heart failure due to systemic left ventricle systolic dysfunction (PANORAMA-HF study)"],"prefix":"10.1016","volume":"193","author":[{"given":"Robert","family":"Shaddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Canter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Halnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazaros","family":"Kochilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rossano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kantor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Burch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/CIRCHEARTFAILURE.108.820217","article-title":"Heart failure in children: part I: history, etiology, and pathophysiology","volume":"2","author":"Hsu","year":"2009","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCULATIONAHA.113.007980","article-title":"New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group","volume":"130","author":"Burns","year":"2014","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0015","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1067\/mhj.2001.119423","article-title":"Congestive heart failure in pediatric patients","volume":"142","author":"Kay","year":"2001","journal-title":"Am Heart J"},{"issue":"17","key":"10.1016\/j.ahj.2017.07.006_bb0020","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1056\/NEJMoa021715","article-title":"The incidence of pediatric cardiomyopathy in two regions of the United States","volume":"348","author":"Lipshultz","year":"2003","journal-title":"N Engl J Med"},{"issue":"17","key":"10.1016\/j.ahj.2017.07.006_bb0025","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa021737","article-title":"The epidemiology of childhood cardiomyopathy in Australia","volume":"348","author":"Nugent","year":"2003","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.ahj.2017.07.006_bb0030","first-page":"9","article-title":"New onset heart failure due to heart muscle disease in childhood: A prospective study in the United Kingdom and Ireland","volume":"124","author":"Andrews","year":"2008","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0035","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/CIRCHEARTFAILURE.109.856229","article-title":"Heart failure in children: part II: diagnosis, treatment, and future directions","volume":"2","author":"Hsu","year":"2009","journal-title":"Circ Heart Fail"},{"issue":"Suppl. 2","key":"10.1016\/j.ahj.2017.07.006_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1047951115001353","article-title":"Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute","volume":"25","author":"Jacobs","year":"2015","journal-title":"Cardiol Young"},{"issue":"12","key":"10.1016\/j.ahj.2017.07.006_bb0045","first-page":"1535","article-title":"Presentation, diagnosis, and medical management of heart failure in children: Canadian Cardiovascular Society guidelines","volume":"29","author":"Kantor","year":"2013","journal-title":"Can J Cardiol"},{"issue":"10","key":"10.1016\/j.ahj.2017.07.006_bb0050","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/jama.298.10.1171","article-title":"Carvedilol for children and adolescents with heart failure: a randomized controlled trial","volume":"298","author":"Shaddy","year":"2007","journal-title":"JAMA"},{"issue":"23","key":"10.1016\/j.ahj.2017.07.006_bb0055","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJMoa010713","article-title":"Valsartan Heart Failure Trial I. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure","volume":"345","author":"Cohn","year":"2001","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ahj.2017.07.006_bb0060","first-page":"12","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"370","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0065","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.114.013748","article-title":"Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure","volume":"131","author":"Packer","year":"2015","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2165\/00148581-200608010-00005","article-title":"ACE Inhibitors in Pediatric Patients with Heart Failure","volume":"8","author":"Momma","year":"2006","journal-title":"Pediatr Drugs"},{"issue":"4","key":"10.1016\/j.ahj.2017.07.006_bb0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2459\/JCM.0b013e32832401d6","article-title":"The use of B-type natriuretic peptide in paediatric patients: a review of literature","volume":"10","author":"Favilli","year":"2009","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"20","key":"10.1016\/j.ahj.2017.07.006_bb0080","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World medical association declaration of helsinki: Ethical principles for medical research involving human subjects","volume":"310","author":"World Medical A","year":"2013","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.ahj.2017.07.006_bb0085","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.healun.2014.06.002","article-title":"The International Society for Heart and Lung Transplantation Guidelines for the management of pediatric heart failure: Executive summary. [Corrected]","volume":"33","author":"Kirk","year":"2014","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"10.1016\/j.ahj.2017.07.006_bb0090","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.109.927988","article-title":"Enalapril in infants with single ventricle: results of a multicenter randomized trial","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ahj.2017.07.006_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0091270009343932","article-title":"Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)","volume":"50","author":"Gu","year":"2010","journal-title":"J Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0105","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCHEARTFAILURE.109.926030","article-title":"A global rank end point for clinical trials in acute heart failure","volume":"3","author":"Felker","year":"2010","journal-title":"Circ Heart Fail"},{"issue":"6","key":"10.1016\/j.ahj.2017.07.006_bb0110","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/CIRCHEARTFAILURE.112.969154","article-title":"Evaluating treatment efficacy by multiple end points in phase II acute heart failure clinical trials: analyzing data using a global method","volume":"5","author":"Sun","year":"2012","journal-title":"Circ Heart Fail"},{"issue":"2","key":"10.1016\/j.ahj.2017.07.006_bb0115","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1054\/jcaf.2001.25652","article-title":"Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure","volume":"7","author":"Packer","year":"2001","journal-title":"J Card Fail"},{"key":"10.1016\/j.ahj.2017.07.006_bb0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijcard.2015.03.071","article-title":"Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment","volume":"185","author":"Chang","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2017.07.006_bb0125","series-title":"Nomenclature and criteria for diagnosis of diseases of the heart and great vessels","first-page":"253","article-title":"Functional capacity and objective assessment","author":"Criteria Committee of the New York Heart Association","year":"1994"},{"issue":"12","key":"10.1016\/j.ahj.2017.07.006_bb0130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.healun.2004.03.018","article-title":"International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children","volume":"23","author":"Rosenthal","year":"2004","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.ahj.2017.07.006_bb0135","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/BF00798207","article-title":"Grading the severity of congestive heart failure in infants","volume":"13","author":"Ross","year":"1992","journal-title":"Pediatr Cardiol"},{"issue":"4","key":"10.1016\/j.ahj.2017.07.006_bb0140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ahj.2004.12.010","article-title":"Monitoring clinical changes in patients with heart failure: a comparison of methods","volume":"150","author":"Spertus","year":"2005","journal-title":"Am Heart J"},{"issue":"6","key":"10.1016\/j.ahj.2017.07.006_bb0145","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","article-title":"The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity","volume":"3","author":"Varni","year":"2003","journal-title":"Ambul Pediatr"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11136-010-9730-5","article-title":"The PedsQL Infant Scales: feasibility, internal consistency reliability, and validity in healthy and ill infants","volume":"20","author":"Varni","year":"2011","journal-title":"Qual Life Res"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0155","doi-asserted-by":"crossref","first-page":"e1060","DOI":"10.1542\/peds.2006-3778","article-title":"Quality of life in children with heart disease as perceived by children and parents","volume":"121","author":"Uzark","year":"2008","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.ahj.2017.07.006_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/chd.12002","article-title":"The clinical utility of health-related quality of life assessment in pediatric cardiology outpatient practice","volume":"8","author":"Uzark","year":"2013","journal-title":"Congenit Heart Dis"},{"issue":"12","key":"10.1016\/j.ahj.2017.07.006_bb0165","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/jamapediatrics.2014.1600","article-title":"Validity and responsiveness of the pediatric quality of life inventory (PedsQL) 4.0 generic core scales in the pediatric inpatient setting","volume":"168","author":"Desai","year":"2014","journal-title":"JAMA Pediatr"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0170","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.healun.2016.01.1227","article-title":"Outcomes of children implanted with ventricular assist devices in the United States: First analysis of the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS)","volume":"35","author":"Blume","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.ahj.2017.07.006_bb0175","author":"Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS)"},{"key":"10.1016\/j.ahj.2017.07.006_bb0180","series-title":"Quality of life in pediatric transplant recipients. NCT00678002","author":"ClinicalTrials.gov","year":"2008"},{"key":"10.1016\/j.ahj.2017.07.006_bb0185","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/19012276.2013.824204","article-title":"The reliability of the Pediatric Quality of Life Inventory 3.0 Cardiac Module\u2122 for Swedish children with congenital heart defects","volume":"65","author":"Sand","year":"2013","journal-title":"Nord Psychol"},{"issue":"6","key":"10.1016\/j.ahj.2017.07.006_bb0190","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.healun.2012.01.867","article-title":"Quality of life in pediatric heart transplant recipients: a comparison with children with and without heart disease","volume":"31","author":"Uzark","year":"2012","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"10.1016\/j.ahj.2017.07.006_bb0195","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/jpc.12296","article-title":"Health-related quality of life and congenital heart disease in Australia","volume":"49","author":"Eagleson","year":"2013","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.ahj.2017.07.006_bb0200","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1198\/sbr.2010.10007","article-title":"Stratified multivariate Mann\u2013Whitney estimators for the comparison of two treatments with randomization based covariance adjustment","volume":"3","author":"Kawaguchi","year":"2011","journal-title":"Stat Biopharm Res"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/adc.70.1.35","article-title":"Efficacy and dosage of enalapril in congenital and acquired heart disease","volume":"70","author":"Leversha","year":"1994","journal-title":"Arch Dis Child"},{"issue":"5","key":"10.1016\/j.ahj.2017.07.006_bb0210","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0002-9149(00)01452-1","article-title":"Angiotensin-converting enzyme inhibitors in adults after the Mustard procedure","volume":"87","author":"Hechter","year":"2001","journal-title":"Am J Cardiol"},{"issue":"16","key":"10.1016\/j.ahj.2017.07.006_bb0215","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.105.543470","article-title":"Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial","volume":"112","author":"Dore","year":"2005","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahj.2017.07.006_bb0220","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCULATIONAHA.112.135392","article-title":"Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial","volume":"127","author":"van der Bom","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahj.2017.07.006_bb0225","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.CIR.83.2.523","article-title":"Acute hemodynamic effects of captopril in children with a congestive or restrictive cardiomyopathy","volume":"83","author":"Bengur","year":"1991","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0230","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00794837","article-title":"The effect of treatment with angiotensin-converting enzyme inhibitors on survival of pediatric patients with dilated cardiomyopathy","volume":"14","author":"Lewis","year":"1993","journal-title":"Pediatr Cardiol"},{"issue":"6","key":"10.1016\/j.ahj.2017.07.006_bb0235","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jacc.2004.09.078","article-title":"Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy","volume":"45","author":"Duboc","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.ahj.2017.07.006_bb0240","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ahj.2007.05.014","article-title":"Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up","volume":"154","author":"Duboc","year":"2007","journal-title":"Am Heart J"},{"issue":"1","key":"10.1016\/j.ahj.2017.07.006_bb0245","first-page":"8","article-title":"Innovative approaches to clinical development and trial design","volume":"47","author":"Orloff","year":"2011","journal-title":"Ann Ist Super Sanita"},{"key":"10.1016\/j.ahj.2017.07.006_bb0250","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1745-6215-13-145","article-title":"Adaptive trial designs: a review of barriers and opportunities","volume":"13","author":"Kairalla","year":"2012","journal-title":"Trials"},{"key":"10.1016\/j.ahj.2017.07.006_bb0255","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1750-1172-6-79","article-title":"Benefits, challenges and obstacles of adaptive clinical trial designs","volume":"6","author":"Chow","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.ahj.2017.07.006_bb0260","series-title":"Applied Clinical Trials Advanstar Communications","article-title":"Improving Oncology Trials Through Adapative Designs","author":"Reitsma","year":"2015"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870317302053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870317302053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:59:24Z","timestamp":1757570364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870317302053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":51,"alternative-id":["S0002870317302053"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2017.07.006","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design for the sacubitril\/valsartan (LCZ696) compared with enalapril study of pediatric patients with heart failure due to systemic left ventricle systolic dysfunction (PANORAMA-HF study)","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2017.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}