{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:36:31Z","timestamp":1774931791573,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ahj.2017.10.021","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T04:34:20Z","timestamp":1509770060000},"page":"56-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Duration of ischemia and treatment effects of pre- versus in-hospital ticagrelor in patients with ST-segment elevation myocardial infarction: Insights from the ATLANTIC study"],"prefix":"10.1016","volume":"196","author":[{"given":"Akshay","family":"Bagai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun G.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren J.","family":"Cantor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Vicaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Bolognese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Cequier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Chettibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Hammett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Janzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lapostolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Flensted","family":"Lassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurri\u00ebn M.","family":"ten Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdourahmane","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tsatsaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad","family":"El Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnoud W.","family":"van't Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9030","key":"10.1016\/j.ahj.2017.10.021_bb0005","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(96)02514-7","article-title":"Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour","volume":"348","author":"Boersma","year":"1996","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ahj.2017.10.021_bb0010","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.CIR.0000121424.76486.20","article-title":"Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts","volume":"109","author":"De Luca","year":"2004","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.ahj.2017.10.021_bb0015","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.jacc.2005.12.072","article-title":"Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction","volume":"47","author":"McNamara","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2017.10.021_bb0020","doi-asserted-by":"crossref","first-page":"b1807","DOI":"10.1136\/bmj.b1807","article-title":"Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study","volume":"338","author":"Rathore","year":"2009","journal-title":"BMJ"},{"issue":"23","key":"10.1016\/j.ahj.2017.10.021_bb0025","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.jacc.2009.08.024","article-title":"Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: insight from cardiovascular magnetic resonance","volume":"54","author":"Francone","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"6 Suppl. A","key":"10.1016\/j.ahj.2017.10.021_bb0030","first-page":"3A","volume":"12","year":"1988","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.ahj.2017.10.021_bb0035","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ahj.2010.08.039","article-title":"The golden hour of prehospital reperfusion with triple antiplatelet therapy: a sub-analysis from the Ongoing Tirofiban in Myocardial Evaluation 2 (On-TIME 2) trial early initiation of triple antiplatelet therapy","volume":"160","author":"Heestermans","year":"2010","journal-title":"Am Heart J"},{"issue":"10","key":"10.1016\/j.ahj.2017.10.021_bb0040","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jcin.2009.06.018","article-title":"Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals","volume":"2","author":"Herrmann","year":"2009","journal-title":"JACC Cardiovasc Interv"},{"issue":"14","key":"10.1016\/j.ahj.2017.10.021_bb0045","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1093\/eurheartj\/ehq143","article-title":"Use of glycoprotein IIb\/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial","volume":"31","author":"Huber","year":"2010","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.ahj.2017.10.021_bb0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00392-011-0393-1","article-title":"Efficacy and safety of a high loading dose of clopidogrel administered prehospitally to improve primary percutaneous coronary intervention in acute myocardial infarction: the randomized CIPAMI trial","volume":"101","author":"Zeymer","year":"2012","journal-title":"Clin Res Cardiol"},{"issue":"23","key":"10.1016\/j.ahj.2017.10.021_bb0055","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1001\/jama.2012.50788","article-title":"Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis","volume":"308","author":"Bellemain-Appaix","year":"2012","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.ahj.2017.10.021_bb0060","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1056\/NEJMoa1407024","article-title":"Prehospital ticagrelor in ST-segment elevation myocardial infarction","volume":"371","author":"Montalescot","year":"2014","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.ahj.2017.10.021_bb0065","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcin.2015.12.024","article-title":"Effect of Pre-Hospital Ticagrelor During the First 24 h After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: The ATLANTIC-H(2)(4) Analysis","volume":"9","author":"Montalescot","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"issue":"4","key":"10.1016\/j.ahj.2017.10.021_bb0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ahj.2012.12.015","volume":"165","author":"Montalescot","year":"2013","journal-title":"Am Heart J"},{"issue":"4","key":"10.1016\/j.ahj.2017.10.021_bb0075","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ahj.2009.01.003","article-title":"Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial","volume":"157","author":"James","year":"2009","journal-title":"Am Heart J"},{"issue":"12","key":"10.1016\/j.ahj.2017.10.021_bb0080","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.amjcard.2007.01.047","article-title":"Impact of time to treatment on myocardial reperfusion and infarct size with primary percutaneous coronary intervention for acute myocardial infarction (from the EMERALD Trial)","volume":"99","author":"Brodie","year":"2007","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2017.10.021_bb0085","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1253\/circj.72.716","article-title":"Clinical and procedural predictors of no-reflow phenomenon after primary percutaneous coronary interventions: experience at a single center","volume":"72","author":"Kirma","year":"2008","journal-title":"Circ J"},{"issue":"9638","key":"10.1016\/j.ahj.2017.10.021_bb0090","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0140-6736(08)61235-0","article-title":"Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial","volume":"372","author":"Van't Hof","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ahj.2017.10.021_bb0095","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.CIR.0000022691.71708.94","article-title":"Integrated analysis of myocardial blush and ST-segment elevation recovery after successful primary angioplasty: Real-time grading of microvascular reperfusion and prediction of early and late recovery of left ventricular function","volume":"106","author":"Poli","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahj.2017.10.021_bb0100","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/hc0302.103588","article-title":"TIMI myocardial perfusion grade and ST segment resolution: association with infarct size as assessed by single photon emission computed tomography imaging","volume":"105","author":"Angeja","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahj.2017.10.021_bb0105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2006.04.082","article-title":"Combination of electrocardiographic and angiographic markers of reperfusion in the prediction of infarct size in patients with ST-segment elevation myocardial infarction undergoing successful primary angioplasty","volume":"117","author":"De Luca","year":"2007","journal-title":"Int J Cardiol"},{"issue":"8","key":"10.1016\/j.ahj.2017.10.021_bb0110","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/jama.293.8.979","article-title":"Pharmacological facilitation of primary percutaneous coronary intervention for acute myocardial infarction: is the slope of the curve the shape of the future?","volume":"293","author":"Gersh","year":"2005","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.ahj.2017.10.021_bb0115","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jcin.2012.06.013","article-title":"Predictors of early, late, and very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction","volume":"5","author":"Brodie","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"issue":"16","key":"10.1016\/j.ahj.2017.10.021_bb0120","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1161\/CIRCULATIONAHA.110.981688","article-title":"Frequency and predictors of stent thrombosis after percutaneous coronary intervention in acute myocardial infarction","volume":"123","author":"Dangas","year":"2011","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.ahj.2017.10.021_bb0125","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.jacc.2010.09.077","article-title":"Composition of coronary thrombus in acute myocardial infarction","volume":"57","author":"Silvain","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ahj.2017.10.021_bb0130","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/CIRCULATIONAHA.105.551705","article-title":"Images in cardiovascular medicine. Architecture of intracoronary thrombi in ST-elevation acute myocardial infarction: time makes the difference","volume":"113","author":"Beygui","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahj.2017.10.021_bb0135","first-page":"369","article-title":"P2Y12 receptor inhibition and effect of morphine in patients undergoing primary PCI for ST-segment elevation myocardial infarction. The PRIVATE-ATLANTIC study","volume":"116","author":"Silvain","year":"2016","journal-title":"Thromb Haemost"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870317303514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870317303514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:59:42Z","timestamp":1757570382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870317303514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"alternative-id":["S0002870317303514"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2017.10.021","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Duration of ischemia and treatment effects of pre- versus in-hospital ticagrelor in patients with ST-segment elevation myocardial infarction: Insights from the ATLANTIC study","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2017.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}