{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:12:25Z","timestamp":1774674745828,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015237","name":"Medicines Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ahj.2019.04.017","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T11:40:24Z","timestamp":1557229224000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Rationale and design of the Onyx ONE global randomized trial: A randomized controlled trial of high-bleeding risk patients after stent placement with 1\u202fmonth of dual antiplatelet therapy"],"prefix":"10.1016","volume":"214","author":[{"given":"Elvin","family":"Kedhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Abizaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kandzari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Worthley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azfar","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Brar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2019.04.017_bb0005","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1161\/01.CIR.103.15.1967","article-title":"Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials","volume":"103","author":"Cutlip","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.017_bb0010","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0002-9149(99)00005-3","article-title":"Timing of coronary stent thrombosis in patients treated with ticlopidine and aspirin","volume":"83","author":"Wilson","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0015","first-page":"e574","article-title":"2011 ACCF\/AHA\/SCAI Guideline for Percutaneous Coronary Intervention: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions","volume":"124","author":"Levine","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.017_bb0020","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.jacc.2014.09.008","article-title":"Second-generation drug-eluting stent implantation followed by 6- versus 12-month dual antiplatelet therapy: the SECURITY randomized clinical trial","volume":"64","author":"Colombo","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0025","first-page":"2510","article-title":"Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial","volume":"310","author":"Feres","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2019.04.017_bb0030","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.111.059022","article-title":"Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience\/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study","volume":"125","author":"Gwon","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.017_bb0035","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.jacc.2012.06.043","article-title":"A new strategy for discontinuation of dual antiplatelet therapy: the RESET Trial (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation)","volume":"60","author":"Kim","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0040","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1161\/CIR.0000000000000404","volume":"134","author":"Levine","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.017_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehx419","volume":"39","author":"Valgimigli","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2019.04.017_bb0050","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/S0140-6736(15)60263-X","article-title":"Mortality in patients treated with extended duration dual antiplatelet therapy after drug-eluting stent implantation: a pairwise and Bayesian network meta-analysis of randomised trials","volume":"385","author":"Palmerini","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2019.04.017_bb0055","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jacc.2014.11.053","article-title":"Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates","volume":"65","author":"Valgimigli","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0060","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1056\/NEJMoa1503943","article-title":"Polymer-free drug-coated coronary stents in patients at high bleeding risk","volume":"373","author":"Urban","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2019.04.017_bb0065","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ahj.2013.07.033","volume":"166","author":"Valgimigli","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2019.04.017_bb0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ahj.2013.01.008","article-title":"Rationale and design of the LEADERS FREE trial: a randomized double-blind comparison of the BioFreedom drug-coated stent vs the Gazelle bare metal stent in patients at high bleeding risk using a short (1 month) course of dual antiplatelet therapy","volume":"165","author":"Urban","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2019.04.017_bb0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijcard.2017.04.079","article-title":"Drug-coated versus bare-metal stents for elderly patients: a predefined sub-study of the LEADERS FREE trial","volume":"243","author":"Morice","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00392-018-1308-1","article-title":"Polymer-free drug-coated coronary stents in diabetic patients at high bleeding risk: a pre-specified sub-study of the LEADERS FREE trial","volume":"108","author":"Richardt","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0085","first-page":"961","article-title":"Biolimus-A9 polymer-free coated stent in high bleeding risk patients with acute coronary syndrome: a Leaders Free ACS sub-study","volume":"38","author":"Naber","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2019.04.017_bb0090","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.jcin.2017.05.033","article-title":"Safety and efficacy of polymer-free biolimus a9-coated versus bare-metal stents in orally anticoagulated patients: 2-year results of the LEADERS FREE oral anticoagulation substudy","volume":"10","author":"Carrie","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2019.04.017_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(17)32713-7","article-title":"Drug-eluting stents in elderly patients with coronary artery disease (SENIOR): a randomised single-blind trial","volume":"391","author":"Varenne","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2019.04.017_bb0100","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.jcin.2017.05.004","article-title":"First report of the Resolute Onyx 2.0-mm zotarolimus-eluting stent for the treatment of coronary lesions with very small reference vessel diameter","volume":"10","author":"Price","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2019.04.017_bb0105","first-page":"253","article-title":"Safety and efficacy of the next generation Resolute Onyx zotarolimus-eluting stent: primary outcome of the RESOLUTE ONYX core trial","volume":"92","author":"Price","year":"2018","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2019.04.017_bb0110","first-page":"247","article-title":"5-Year safety and efficacy of resolute zotarolimus-eluting stent: the RESOLUTE Global Clinical Trial Program the SECURITY randomized clinical trial","volume":"10","author":"Yeh","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0115","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1093\/eurheartj\/ehu026","article-title":"Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation","volume":"35","author":"Silber","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2019.04.017_bb0120","article-title":"Short-term stent coverage of second generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study","author":"Roleder","year":"2019","journal-title":"Adv Interv Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4244\/EIJV6I1A6","article-title":"Consensus from the 5th European Bifurcation Club meeting","volume":"6","author":"Hildick-Smith","year":"2010","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ahj.2019.04.017_bb0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4244\/EIJV12I1A7","article-title":"Percutaneous coronary intervention for coronary bifurcation disease: 11th consensus document from the European Bifurcation Club","volume":"12","author":"Lassen","year":"2016","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ahj.2019.04.017_bb0135","first-page":"137","article-title":"The next generation Endeavor Resolute Stent: role of the BioLinx Polymer System","volume":"3","author":"Udipi","year":"2007","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ahj.2019.04.017_bb0140","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","article-title":"Third universal definition of myocardial infarction","volume":"60","author":"Thygesen","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.017_bb0145","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.017_bb0150","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870319301061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870319301061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:57:02Z","timestamp":1762077422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870319301061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":30,"alternative-id":["S0002870319301061"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2019.04.017","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of the Onyx ONE global randomized trial: A randomized controlled trial of high-bleeding risk patients after stent placement with 1\u202fmonth of dual antiplatelet therapy","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2019.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}