{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:46:29Z","timestamp":1792665989503,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ahj.2019.04.019","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T11:40:31Z","timestamp":1557229231000},"page":"60-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":199,"special_numbering":"C","title":["Rationale and design of DanGer shock: Danish-German cardiogenic shock trial"],"prefix":"10.1016","volume":"214","author":[{"given":"Nanna Junker","family":"Udesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias Greve","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Junker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Wachtell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.ahj.2019.04.019_bb0005","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1093\/eurheartj\/ehs264","article-title":"Improved outcome of cardiogenic shock at the acute stage of myocardial infarction: A report from the USIK 1995, USIC 2000, and FAST-MI French Nationwide Registries","volume":"33","author":"Aissaoui","year":"2012","journal-title":"Eur Heart J Eur Heart J"},{"issue":"9","key":"10.1016\/j.ahj.2019.04.019_bb0010","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/CIRCULATIONAHA.108.814947","article-title":"Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction a population-based perspective","volume":"119","author":"Goldberg","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahj.2019.04.019_bb0015","first-page":"7","article-title":"Risk factors of late cardiogenic shock and mortality in ST-segment elevation myocardial infarction patients","volume":"7","author":"Obling","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"14","key":"10.1016\/j.ahj.2019.04.019_bb0020","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jacc.2014.07.958","article-title":"National trends in the utilization of short-term mechanical circulatory support: Incidence, outcomes, and cost analysis","volume":"64","author":"Stretch","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.ahj.2019.04.019_bb0025","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1208410","article-title":"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock","volume":"367","author":"Thiele","year":"2012","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ahj.2019.04.019_bb0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.ahj.2019.04.019_bb0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jacc.2018.04.051","article-title":"Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction","volume":"72","author":"Levy","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2019.04.019_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-016-1387-1","article-title":"Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality","volume":"20","author":"Tarvasm\u00e4ki","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.ahj.2019.04.019_bb0045","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ijcard.2015.10.063","article-title":"Experience from a randomized controlled trial with Impella 2.5 versus IABP in STEMI patients with cardiogenic pre-shock. Lessons learned from the IMPRESS in STEMI trial","volume":"202","author":"Ouweneel","year":"2016","journal-title":"Int J Cardiol"},{"issue":"9","key":"10.1016\/j.ahj.2019.04.019_bb0050","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1016\/j.ahj.2019.04.019_bb0055","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock","volume":"377","author":"Thiele","year":"2017","journal-title":"N Engl J Med"},{"issue":"0","key":"10.1016\/j.ahj.2019.04.019_bb0060","first-page":"1","article-title":"Integrating the results of the CULPRIT-SHOCK trial in the 2017 ESC ST-elevation myocardial infarction guidelines: viewpoint of the task force","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"19","key":"10.1016\/j.ahj.2019.04.019_bb0065","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2008.05.065","article-title":"A Randomized Clinical Trial to Evaluate the Safety and Efficacy of a Percutaneous Left Ventricular Assist Device Versus Intra-Aortic Balloon Pumping for Treatment of Cardiogenic Shock Caused by Myocardial Infarction","volume":"52","author":"Seyfarth","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.ahj.2019.04.019_bb0070","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","article-title":"Impella CP Versus Intra-Aortic Balloon Pump in Acute Myocardial Infarction Complicated by Cardiogenic Shock: The IMPRESS trial","volume":"69","author":"Ouweneel","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"10.1016\/j.ahj.2019.04.019_bb0075","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33degreeC versus 36degreeC after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"issue":"23","key":"10.1016\/j.ahj.2019.04.019_bb0080","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.jacc.2015.10.017","article-title":"Hemodynamics of Mechanical Circulatory Support","volume":"66","author":"Burkhoff","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2019.04.019_bb0085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jacc.2018.05.038","article-title":"Mechanical Unloading in Heart Failure","volume":"72","author":"Uriel","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2019.04.019_bb0090","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jacc.2018.05.034","article-title":"Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction","volume":"72","author":"Esposito","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2019.04.019_bb0095","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004397","article-title":"Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs","volume":"11","author":"Saku","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ahj.2019.04.019_bb0100","doi-asserted-by":"crossref","unstructured":"Basir M.B, Schreiber T, Patel K, Almany S, et al. Feasibility of early mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock: The Detroitcardiogenic shock initiative. Catheter Cardiovasc Interv 2018;91(3): pp. 454\u2013461;","DOI":"10.1002\/ccd.27427"},{"issue":"1","key":"10.1016\/j.ahj.2019.04.019_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/joic.12080","article-title":"The current use of impella 2.5 in acute myocardial infarction complicated by cardiogenic shock: Results from the USpella Registry","volume":"27","author":"O'Neill","year":"2014","journal-title":"J Interv Cardiol"},{"key":"10.1016\/j.ahj.2019.04.019_bb0110","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","article-title":"Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock","volume":"139","author":"Schrage","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2019.04.019_bb0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCULATIONAHA.118.038269","article-title":"Unloading the Left Ventricle Before Reperfusion in Patients with Anterior ST-Segment Elevation Myocardial Infarction: A Pilot Study Using the Impella CP \u00ae","volume":"139","author":"Kapur","year":"2018","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.ahj.2019.04.019_bb0120","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.jacc.2015.02.043","article-title":"2015 SCAI\/ACC\/HFSA\/STS Clinical Expert Consensus Statement on the Use of Percutaneous Mechanical Circulatory Support Devices in Cardiovascular Care","volume":"65","author":"Rihal","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ahj.2019.04.019_bb0125","doi-asserted-by":"crossref","first-page":"R164","DOI":"10.1186\/cc9253","article-title":"Clinical correlates of arterial lactate levels in patients with ST-segment elevation myocardial infarction at admission: A descriptive study","volume":"14","author":"Vermeulen","year":"2010","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.ahj.2019.04.019_bb0130","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/SHK.0000000000001191","article-title":"Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction","volume":"51","author":"Frydland","year":"2019","journal-title":"Shock"},{"issue":"24","key":"10.1016\/j.ahj.2019.04.019_bb0135","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1056\/NEJMra1309483","article-title":"Lactic Acidosis","volume":"371","author":"Kraut","year":"2014","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ahj.2019.04.019_bb0140","first-page":"201","article-title":"Differences in symptoms, first medical contact and pre-hospital delay times between patients with ST- and non-ST-elevation myocardial infarction","volume":"8","author":"\u00c4ngerud","year":"2019","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"1","key":"10.1016\/j.ahj.2019.04.019_bb0145","first-page":"38","article-title":"Altered mental status predicts mortality in cardiogenic shock \u2013 results from the CardShock study","volume":"7","author":"Kataja","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"1","key":"10.1016\/j.ahj.2019.04.019_bb0150","first-page":"53","article-title":"Single-centre experience with the Impella CP, 5.0 and RP in 109 consecutive patients with profound cardiogenic shock","volume":"7","author":"Jensen","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.ahj.2019.04.019_bb0155","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ahj.2015.11.006","article-title":"Multivessel versus culprit lesion only percutaneous revascularization plus potential staged revascularization in patients with acute myocardial infarction complicated by cardiogenic shock: Design and rationale of CULPRIT-SHOCK trial","volume":"172","author":"Thiele","year":"2016","journal-title":"Am Heart J"},{"issue":"10124","key":"10.1016\/j.ahj.2019.04.019_bb0160","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(18)30315-5","article-title":"Out-of-hospital cardiac arrest: in-hospital intervention strategies","volume":"391","author":"Hassager","year":"2018","journal-title":"Lancet"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870319301085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870319301085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:02:56Z","timestamp":1757570576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870319301085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":32,"alternative-id":["S0002870319301085"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2019.04.019","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of DanGer shock: Danish-German cardiogenic shock trial","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2019.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}