{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:36:35Z","timestamp":1787319395650,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ahj.2021.05.008","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T03:59:43Z","timestamp":1621828783000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Rationale and design of the intravenous iron for treatment of anemia before cardiac surgery trial"],"prefix":"10.1016","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-5456","authenticated-orcid":false,"given":"Paul S.","family":"Myles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica M.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Heritier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McGiffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Zavarsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe K.","family":"McQuilten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Karkouti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2021.05.008_bib0001","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.athoracsur.2012.04.042","article-title":"Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis","volume":"94","author":"Ranucci","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ahj.2021.05.008_bib0002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12630-014-0302-y","article-title":"Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study","volume":"62","author":"Karkouti","year":"2015","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.ahj.2021.05.008_bib0003","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.athoracsur.2013.03.015","article-title":"Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery","volume":"96","author":"Ranucci","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ahj.2021.05.008_bib0004","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1056\/NEJMoa1606424","article-title":"Tranexamic acid in patients undergoing coronary-artery surgery","volume":"376","author":"Myles","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2021.05.008_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ejcts\/ezx325","article-title":"2017 EACTS\/EACTA Guidelines on patient blood management for adult cardiac surgery","volume":"53","author":"Pagano","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2021.05.008_bib0006","first-page":"517","article-title":"Bone marrow iron depletion is common in patients with coronary artery disease","volume":"182c","author":"Jankowska","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0007","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/EJA.0b013e32834ad97b","article-title":"Preoperative iron deficiency increases transfusion requirements and fatigue in cardiac surgery patients: a prospective observational study","volume":"28","author":"Piednoir","year":"2011","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fphar.2014.00083","article-title":"Iron deficiency in the elderly population, revisited in the hepcidin era","volume":"5","author":"Busti","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0009","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2021.05.008_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/heartjnl-2014-305856","article-title":"A prospective observational cohort study to identify the causes of anaemia and association with outcome in cardiac surgical patients","volume":"101","author":"Hung","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2021.05.008_bib0011","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1182\/asheducation-2010.1.338","article-title":"Clinical use of intravenous iron: administration, efficacy, and safety","volume":"2010","author":"Auerbach","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.ahj.2021.05.008_bib0012","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/S0140-6736(18)32555-8","article-title":"Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial","volume":"393","author":"Spahn","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2021.05.008_bib0013","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/anae.14358","article-title":"An international consensus statement on the management of postoperative anaemia after major surgical procedures","volume":"73","author":"Mu\u00f1oz","year":"2018","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ahj.2021.05.008_bib0014","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/01.anes.0000291441.10704.82","article-title":"Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study","volume":"107","author":"Theusinger","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2021.05.008_bib0015","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1111\/j.1572-0241.2005.00250.x","article-title":"Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease\u2014a randomized, controlled, open-label, multicenter study","volume":"100","author":"Schroder","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0016","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/bjs.6688","article-title":"Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery","volume":"96","author":"Edwards","year":"2009","journal-title":"Br J Surg"},{"key":"10.1016\/j.ahj.2021.05.008_bib0017","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jacc.2006.07.015","article-title":"Intravenous iron alone for the treatment of anemia in patients with chronic heart failure","volume":"48","author":"Bolger","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0018","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(20)31539-7","article-title":"Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial","volume":"396","author":"Richards","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2021.05.008_bib0019","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(20)32339-4","article-title":"Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial","volume":"396","author":"Ponikowski","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2021.05.008_bib0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14740\/jh696","article-title":"The impact of preoperative intravenous iron therapy on perioperative outcomes in cardiac surgery: a systematic review","volume":"9","author":"Tankard","year":"2020","journal-title":"J Hematol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0021","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jacc.2009.12.046","article-title":"Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury","volume":"55","author":"Haase","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0022","doi-asserted-by":"crossref","first-page":"f4822","DOI":"10.1136\/bmj.f4822","article-title":"Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials","volume":"347","author":"Litton","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.ahj.2021.05.008_bib0023","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jtcvs.2012.04.014","article-title":"Implications and management of anemia in cardiac surgery: current state of knowledge","volume":"144","author":"Loor","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ahj.2021.05.008_bib0024","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/bja\/83.6.833","article-title":"Why we need large randomized studies in anaesthesia","volume":"83","author":"Myles","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ahj.2021.05.008_bib0025","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.290.12.1624","article-title":"Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy","volume":"290","author":"Tunis","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2021.05.008_bib0026","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-015828","article-title":"Validation of days at home as an outcome measure after surgery: a prospective cohort study in Australia","author":"Myles","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.ahj.2021.05.008_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2019.04.011","article-title":"Days at home after surgery: an integrated and efficient outcome measure for clinical trials and quality assurance","author":"Bell","year":"2019","journal-title":"EClinical Med"},{"key":"10.1016\/j.ahj.2021.05.008_bib0028","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1097\/ALN.0b013e318289b84b","article-title":"Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15","volume":"118","author":"Stark","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2021.05.008_bib0029","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00435980","article-title":"An improved questionnaire for assessing quality of life after acute myocardial infarction","volume":"5","author":"Valenti","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ahj.2021.05.008_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","article-title":"EuroQol\u2014a new facility for the measurement of health-related quality of life","volume":"16","author":"Group","year":"1990","journal-title":"Health Policy"},{"key":"10.1016\/j.ahj.2021.05.008_bib0031","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/ALN.0000000000000586","article-title":"Measurement of disability-free survival after surgery","volume":"122","author":"Shulman","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ahj.2021.05.008_bib0032","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/bjh.13623","article-title":"British Committee for Standards in Haematology Guidelines on the identification and management of pre-operative anaemia","volume":"171","author":"Kotz\u00e9","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0033","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"issue":"5","key":"10.1016\/j.ahj.2021.05.008_bib0034","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/bcp.14643","article-title":"Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside-a systematic review and meta-analysis","volume":"87","author":"Schaefer","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ahj.2021.05.008_bib0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ehf2.12006","article-title":"Rationale and design of the CONFIRM-HF study: a double-blind, randomized, placebo-controlled study to assess the effects of intravenous ferric carboxymaltose on functional capacity in patients with chronic heart failure and iron deficiency","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.ahj.2021.05.008_bib0036","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s40264-020-01022-2","article-title":"Frequency and associated costs of anaphylaxis- and hypersensitivity-related adverse events for intravenous iron products in the USA: an analysis using the US Food and Drug Administration adverse event reporting system","volume":"44","author":"Trumbo","year":"2021","journal-title":"Drug safety"},{"key":"10.1016\/j.ahj.2021.05.008_bib0037","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/S0140-6736(99)03464-9","article-title":"The agonising negative trend in monitoring of clinical trials","volume":"354","author":"DeMets","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2021.05.008_bib0038","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bja.2019.11.023","article-title":"Preoperative intravenous iron before cardiac surgery: a prospective multicentre feasibility study","volume":"124","author":"Klein","year":"2020","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ahj.2021.05.008_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/763576","article-title":"Intravenous iron therapy in patients with iron deficiency anemia: dosing considerations","volume":"2015","author":"Koch","year":"2015","journal-title":"Anemia"},{"key":"10.1016\/j.ahj.2021.05.008_bib0040","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/j.1471-0528.2006.01062.x","article-title":"Intravenous versus oral iron therapy for postpartum anaemia","volume":"113","author":"Bhandal","year":"2006","journal-title":"BJOG"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032100137X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032100137X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:07:06Z","timestamp":1757570826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000287032100137X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":40,"alternative-id":["S000287032100137X"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2021.05.008","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of the intravenous iron for treatment of anemia before cardiac surgery trial","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2021.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}