{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:48:44Z","timestamp":1777502924327,"version":"3.51.4"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["17CVD01"],"award-info":[{"award-number":["17CVD01"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL103866"],"award-info":[{"award-number":["R01HL103866"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126827"],"award-info":[{"award-number":["R01HL126827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000439"],"award-info":[{"award-number":["UL1TR000439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ahj.2021.11.014","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T22:08:46Z","timestamp":1639778926000},"page":"78-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Intestinal barrier dysfunction is associated with elevated right atrial pressure in patients with advanced decompensated heart failure"],"prefix":"10.1016","volume":"245","author":[{"given":"Takeshi","family":"Kitai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Nemet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1682-9425","authenticated-orcid":false,"given":"Timothy","family":"Engelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommel","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-0434","authenticated-orcid":false,"given":"Thanat","family":"Chaikijurajai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley L.","family":"Hazen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W.H. Wilson","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2021.11.014_bib0001","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41569-018-0108-7","article-title":"Dietary metabolism, the gut microbiome, and heart failure","volume":"16","author":"Tang","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ahj.2021.11.014_bib0002","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijcard.2010.12.016","article-title":"Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure","volume":"157","author":"Sandek","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2021.11.014_bib0003","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/clinchem\/36.5.797","article-title":"Rapid and simultaneous determination of lactulose and mannitol in urine, by HPLC with pulsed amperometric detection, for use in studies of intestinal permeability","volume":"36","author":"Fleming","year":"1990","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2021.11.014_bib0004","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1136\/gut.35.1_Suppl.S18","article-title":"Intestinal permeability","volume":"35","author":"Bjarnason","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.ahj.2021.11.014_bib0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/gast.2000.8523","article-title":"Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease","volume":"119","author":"Tibble","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ahj.2021.11.014_bib0006","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.clinbiochem.2017.02.014","article-title":"Circulating intestinal fatty acid-binding protein (I-FABP) levels in acute decompensated heart failure","volume":"50","author":"Kitai","year":"2017","journal-title":"Clin Biochem"},{"key":"10.1016\/j.ahj.2021.11.014_bib0007","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ahj.2021.11.014_bib0008","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jacc.2008.02.083","article-title":"Sodium nitroprusside for advanced low-output heart failure","volume":"52","author":"Mullens","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2021.11.014_bib0009","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13567-018-0538-6","article-title":"Biomarkers for monitoring intestinal health in poultry: present status and future perspectives","volume":"49","author":"Ducatelle","year":"2018","journal-title":"Vet Res"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032100466X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032100466X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:07:50Z","timestamp":1757570870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000287032100466X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":9,"alternative-id":["S000287032100466X"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2021.11.014","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal barrier dysfunction is associated with elevated right atrial pressure in patients with advanced decompensated heart failure","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2021.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}