{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:32:29Z","timestamp":1773480749541,"version":"3.50.1"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ahj.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T14:57:13Z","timestamp":1660316233000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Integrating hemodynamics with ventricular and valvular remodeling in aortic stenosis. A paradigm shift in therapeutic decision making"],"prefix":"10.1016","volume":"254","author":[{"given":"Gregory S.","family":"Pavlides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannis S.","family":"Chatzizisis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2022.08.004_bib0001","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic Stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0002","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology. American Heart Association Join Committee on clinical practice Guidelines","volume":"77","author":"Nishimura","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0003","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1161\/CIRCULATIONAHA.111.060319","article-title":"Hemodynamics in the Cardiac Catheterization Laboratory of the 21st century","volume":"125","author":"Nishimura","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0004","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0002-9149(91)90175-K","article-title":"Determination of severity of valvular aortic stenosis by Doppler echocardiography and relation of findings to clinical outcome and agreement with hemodynamic measurements determined at cardiac catheterization","volume":"67","author":"Calan","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0005","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1161\/CIRCULATIONAHA.104.495903","article-title":"Outcome of 622 adults with asymptomatic hemodynamically significant aortic stenosis during prolonged follow-up","volume":"111","author":"Pellikka","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0006","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.109.894170","article-title":"Natural history of very severe aortic stenosis","volume":"121","author":"Rosenhek","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.amjcard.2012.02.056","article-title":"Prognostic value of aortic valve area index in asymptomatic patients with severe aortic stenosis","volume":"110","author":"Sorito","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0008","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.athoracsur.2006.07.043","article-title":"Malignant natural history of asymptomatic severe aortic stenosis: benefit of aortic valve replacement","volume":"82","author":"Pai","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ahj.2022.08.004_bib0009","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1912846","article-title":"Early surgery or conservative care for asymptomatic aortic stenosis","volume":"382","author":"Kang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0010","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0011","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0735-1097(96)00563-3","article-title":"Clinical factors associated with calcific aortic valve disease","volume":"29","author":"Stewart","year":"1997","journal-title":"J AM Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0012","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJM199907153410302","article-title":"Association of Aortic valve stenosis with cardiovascular mortality and morbidity in the elderly","volume":"341","author":"Otto","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0013","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/STROKEAHA.119.028389","article-title":"Incidence of ischemic stroke in individuals with and without aortic valve stenosis","volume":"51","author":"Andreasen","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.ahj.2022.08.004_bib0014","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/eurheartj\/ehi290","article-title":"Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?","volume":"26","author":"Kupari","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0015","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.CIR.79.4.744","article-title":"Left ventricular myocardial structure in aortic valve disease before, intermediate and late after aortic valve replacement","volume":"79","author":"Krayenbuehl","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0016","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J Am Cell Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0017","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","article-title":"Progression from compensated hypertrophy to failure in the pressure-overloaded human heart. Structural deterioration and compensatory mechanisms","volume":"107","author":"Hein","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0018","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/hrt.2005.062422","article-title":"Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: a transthoracic Doppler and myocardial contrast echocardiography study","volume":"92","author":"Galiuto","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0019","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Path"},{"key":"10.1016\/j.ahj.2022.08.004_bib0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00226785","article-title":"Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts","volume":"154","author":"Zhou","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ahj.2022.08.004_bib0021","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-R1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ahj.2022.08.004_bib0022","first-page":"69","article-title":"Transforming growth factor\u2013beta: a key mediator of fibrosis","volume":"117","author":"Muriel","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0023","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMcibr1616598","article-title":"Netting insights into fibrosis","volume":"376","author":"Dimmeler","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0024","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2353\/ajpath.2008.070974","article-title":"Interleukin-1 receptor type 1 signaling critically regulates infarct healing and cardiac remodeling","volume":"173","author":"Bujak","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0025","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMoa043876","article-title":"A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis","volume":"352","author":"Cowell","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0026","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","article-title":"Mutations in NOTCH 1 cause aortic valve disease","volume":"437","author":"Gang","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ahj.2022.08.004_bib0027","first-page":"767","article-title":"Myocyte death and growth in the failing heart","volume":"78","author":"Anversa","year":"1998","journal-title":"Lab Invest"},{"key":"10.1016\/j.ahj.2022.08.004_bib0028","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1006\/jmcc.2000.1125","article-title":"Unresolved issues regarding the role of apoptosis in the pathogenesis of ischemic injury and heart failure","volume":"32","author":"Elanner","year":"2000","journal-title":"J Mol Cell Card"},{"key":"10.1016\/j.ahj.2022.08.004_bib0029","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/01.CIR.102.12.1342","article-title":"Targeting pathological remodeling: concepts of cardio protection and reparation","volume":"102","author":"Weber","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0030","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jcmg.2016.10.007","article-title":"Myocardial fibrosis and cardiac decompensation in aortic stenosis","volume":"10","author":"Chin","year":"2017","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0031","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.108.847772","article-title":"Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis","volume":"120","author":"Weidemann","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0032","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jtcvs.2011.11.024","article-title":"Prognostic valve of myocardia fibrosis in patients with severe aortic valve stenosis","volume":"144","author":"Milano","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ahj.2022.08.004_bib0033","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jacc.2011.04.045","article-title":"Is Ventricular arrhythmia a possible mediator of the association between aortic stenosis-related mid-wall fibrosis and mortality","volume":"58","author":"Nazariam","year":"2011","journal-title":"J AM Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0034","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1093\/eurheartj\/ehx653","article-title":"Calcific aortic valve stenosis. Heart disease in the heart","volume":"39","author":"Peeters","year":"2018","journal-title":"E Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0035","article-title":"Progression of hypertrophy and myocardial fibrosis in aortic stenosis. A multicenter cardiac magnetic resonance study","volume":"11","author":"Everet","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2022.08.004_bib0036","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jcmg.2009.11.019","article-title":"Impact of pressure recovery on echocardiographic assessment of asymptomatic aortic stenosis: A SEAS Substudy","volume":"3","author":"Bahlmann","year":"2010","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0037","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.echo.2019.10.007","article-title":"Clinical usefulness of pressure recovery adjustment in patients with predominantly severe aortic stenosis: Asian Valve Registry data","volume":"33","author":"Heo","year":"2020","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ahj.2022.08.004_bib0038","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.114.002917","article-title":"Effect of left ventricular ejection fractionon post-operative outcome in patients with severe aortic stenosis undergoing aortic valve replacement","volume":"8","author":"Dahl","year":"2015","journal-title":"Circ Cardiovasc Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0039","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/icvts\/ivt171","article-title":"Emerging role of echocardiographic strain\/strain rate imaging and twist in systolic function evaluation and operative procedure in patients with aortic stenosis","volume":"17","author":"Wang","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.ahj.2022.08.004_bib0040","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1136\/heartjnl-2019-316215","article-title":"Global longitudinal strain: clinical use and prognostic implications in contemporary practice","volume":"106","author":"Abou","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0041","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1093\/eurheartj\/ehr084","article-title":"Alterations in multidirectional myocardial functions in patients with aortic stenosis and preserved ejection fraction: a two \u2013dimensional speckle tracking analysis","volume":"32","author":"Ng","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0042","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ehjci\/jes115","article-title":"Global longitudinal strain is strong independent predictor of all-cause mortality in patients with aortic stenosis","volume":"13","author":"Kearny","year":"2012","journal-title":"E Heart J Cardiovasc Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0043","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/CIRCIMAGING.112.977348","article-title":"Association of myocardial deformation with outcome in asymptomatic aortic stenosis with normal ejection fraction","volume":"5","author":"Yingchoncharoen","year":"2012","journal-title":"Cir Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2022.08.004_bib0044","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jcmg.2014.12.009","article-title":"Prognostic value of LV deformation parameters using 2D and 3D speckle tracking echocardiography in asymptomatic patients with severe aortic stenosis and preserved ejection fraction","volume":"8","author":"Nagata","year":"2015","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0045","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1540-8175.2011.01419.x","article-title":"Global longitudinal strain in relation to the severity of aortic stenosis: a 2-D speckle-tracking study","volume":"28","author":"Miyazaki","year":"2011","journal-title":"Echocardiography"},{"key":"10.1016\/j.ahj.2022.08.004_bib0046","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1253\/circj.CJ-16-1105","article-title":"Impact of mitral annular displacement on LV diastolic function improvement after TAVR","volume":"81","author":"Utsunomiya","year":"2017","journal-title":"Circ J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0047","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009958","article-title":"Left ventricular global longitudinal strain is associated with long-term outcomes in moderate aortic stenosis","volume":"13","author":"Zhu","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2022.08.004_bib0048","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic functionby echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocard"},{"key":"10.1016\/j.ahj.2022.08.004_bib0049","unstructured":"Garbi M, Chambers J, Vannan MA, et\u00a0al. Valve Stress Echocardiography: A Practical Guide for Referral, Procedure, Reporting, and Clinical Implementation of Results From the HAVEC Group"},{"key":"10.1016\/j.ahj.2022.08.004_bib0050","first-page":"1133","article-title":"Resting Aortic Valve Area at Normal Transaortic Flow Rate Reflects True Valve Area in Suspected Low-Gradient Severe Aortic Stenosis","volume":"8","author":"Chahal","year":"2015","journal-title":"JACC Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0051","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/eurheartj\/ehx353","article-title":"Reappraising myocardial fibrosis in severe AS: an invasive and non-invasive study in 133 patients","volume":"39","author":"Treibel","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0052","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2009.12.074","article-title":"Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease","volume":"56","author":"Azevedo","year":"2010","journal-title":"J AM Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0053","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/hrt.2005.079392","article-title":"Delayed hyperenhancement in magnetic resonance imaging of left ventricular hypertrophy caused by aortic stenosis and hypertrophic cardiomyopathy: visualisation of focal fibrosis","volume":"92","author":"Debl","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0054","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jacc.2017.12.035","article-title":"Reverse myocardial remodeling following valve replacement in patients with AS","volume":"71","author":"Treibel","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0055","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jacc.2011.03.064","article-title":"Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis","volume":"58","author":"Dweck","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0056","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/eurheartj\/ehv525","article-title":"A clinical risk score of myocardial fibrosis predicts adverse outcomes in AS","volume":"37","author":"Chin","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0057","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/heartjnl-2012-303052","article-title":"Human non-contrast T1 values and correlation with histology in diffuse fibrosis","volume":"99","author":"Bull","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0058","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jacc.2019.11.032","article-title":"Extracellular myocardial volume in patients with aortic stenosis","volume":"75","author":"Everett","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0059","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2021.05.047","article-title":"Markers of myocardial damage predict mortality in patients with aortic stenosis","volume":"78","author":"Kwak","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0060","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"Genereux","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0061","article-title":"Prevalence and prognostic significance of right ventricular systolic dysfunctionin patients undergoing transcatheter aortic valve implantation","volume":"9","author":"Lindsay","year":"2016","journal-title":"Circ Cardiovsc Interv"},{"key":"10.1016\/j.ahj.2022.08.004_bib0062","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.119.009802","article-title":"Impact of right ventricular systolic dysfunction on outcome in aortic stenosis","volume":"13","author":"Bohbot","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2022.08.004_bib0063","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1161\/CIRCULATIONAHA.114.011085","article-title":"Left ventricular hypertrophy with strain and aortic stenosis","volume":"130","author":"Shah","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0064","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/jcmm.14129","article-title":"Molecular biomarkers in cardiac hypertrophy","volume":"23","author":"Zhu","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ahj.2022.08.004_bib0065","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/eurheartj\/ehu189","article-title":"High sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with AS","volume":"35","author":"Chin","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0066","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1161\/01.CIR.0000060533.79248.0C","article-title":"Increased plasma natriuretic peptide level reflect symptom onset in aortic stenosis","volume":"107","author":"Gerber","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0067","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.0000126825.50903.18","article-title":"Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis","volume":"109","author":"Bergler-Klein","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0068","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.ehj.2004.09.033","article-title":"Predictors of outcome in severe aortic stenosis with normal left ventricular functions role of B-type natriuretic peptide","volume":"25","author":"Lim","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0069","first-page":"384","article-title":"B-type natriuretic peptide in patients with asymptomatic severe aortic stenosis","volume":"105","author":"Nakatsuma","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0070","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1161\/CIRCULATIONAHA.106.654210","article-title":"B-Type natriuretic peptide in low-flow, low-gradient aortic stenosis: relationship to hemodynamics and clinical outcome: result from the multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) study","volume":"115","author":"Bergler-Klein","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0071","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/icvts\/ivt186","article-title":"B-type natriuretic peptide as a biochemical marker of left ventricular diastolic function: assessment in asymptomatic patients 1 year after valve replacement for aortic stenosis","volume":"17","author":"Mannacio","year":"2013","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.ahj.2022.08.004_bib0072","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.ijcard.2012.11.116","article-title":"Pro B-type natriuretic peptide plasma valve: a new criterion for the prediction of short-and long-term outcomes after transcatheter aortic valve implantation","volume":"168","author":"Lopez-Oten","year":"2013","journal-title":"Int J cardiol"},{"issue":"10_Supplement","key":"10.1016\/j.ahj.2022.08.004_bib0073","doi-asserted-by":"crossref","first-page":"A87.E821","DOI":"10.1016\/S0735-1097(10)60822-4","article-title":"Correlation of N terminal pro B-type natriuretic peptide and speckle tracking derived longitudinal strain in sever asymptomatic aortic stenosis","volume":"55","author":"Bergler-Klein","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0074","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/CIRCULATIONAHA.108.808857","article-title":"Risk score for predicting outcome in patients with asymptomatic aortic stenosis","volume":"120","author":"Monin","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.08.004_bib0075","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.jacc.2014.02.581","article-title":"B-Type natriuretic peptide clinical activation in aortic stenosis","volume":"63","author":"Clavel","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0076","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0077","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jacc.2013.07.087","article-title":"Head to head comparison of 2 myocardial Fibrosis biomarkers for long-term heart failure risk stratification","volume":"63","author":"Baynes-Genis","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0078","first-page":"260","article-title":"Biomarkers of mycardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure","volume":"2","author":"Ahmed","year":"2014","journal-title":"J Am Coll Cardiol HF"},{"key":"10.1016\/j.ahj.2022.08.004_bib0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/heartasia-2017-010980","article-title":"Prognostic value of soluble ST2 post-aortic valve replacement in a meta-analysis","volume":"10","author":"Tse","year":"2018","journal-title":"Heart Asia"},{"key":"10.1016\/j.ahj.2022.08.004_bib0080","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ijcard.2014.10.010","article-title":"Galectin-3 predicts short- and long-term outcome in patients undergoing transcatheter aortic valve implantation (TAVI)","volume":"177","author":"Baldenhofer","year":"2014","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0081","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1136\/heartjnl-2015-307742","article-title":"Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement","volume":"101","author":"Lindman","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.08.004_bib0082","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.jcin.2018.07.039","article-title":"Multimarker approach to identify patients with higher mortality and rehospitalization rate after surgical aortic valve replacement for aortic stenosis","volume":"11","author":"Lindman","year":"2018","journal-title":"J Am Coll Cardiol Intv"},{"key":"10.1016\/j.ahj.2022.08.004_bib0083","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ejhf.2361","article-title":"Plasma biomarkers associated with adverse outcomes in patients with calcific aortic stenosis","volume":"23","author":"Vidula","year":"2021","journal-title":"E J Heart F"},{"key":"10.1016\/j.ahj.2022.08.004_bib0084","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jacc.2015.05.066","article-title":"Calcification in aortic stenosis: The skeleton key","volume":"66","author":"Pawade","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0085","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007146","article-title":"Computed tomography aortic valve calcium scoring in patients with aortic stenosis","volume":"11","author":"Pawade","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2022.08.004_bib0086","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jcmg.2019.01.045","article-title":"Why and how to measure aortic valve calcification in patients with aortic stenosis","volume":"12","author":"Pawadi","year":"2019","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0087","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijcard.2011.11.091","article-title":"Aortic valve calcium score as a predictor for outcome after TAVI, using the Corevalve revalving system","volume":"166","author":"Leber","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0088","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmg.2020.02.034","article-title":"Sex differences in valve-calcification activity and calcification progression in aortic stenosis","author":"Peeters","year":"2020","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0089","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ehjci\/jew013","article-title":"Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study","volume":"18","author":"Testet","year":"2017","journal-title":"Eur Heart J Cardiovasc Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0090","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/HYPERTENSIONAHA.109.147520","article-title":"Blood pressure and vascular calcification","volume":"55","author":"Jensky","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2022.08.004_bib0091","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jcmg.2019.01.036","article-title":"Management of asymptomatic severe aortic stenosis. Evolving concepts in timing of valve replacement","volume":"13","author":"Lindman","year":"2020","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0092","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Echo Heart Survey on valvular heart disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0093","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/eurheartj\/ehq076","article-title":"Usefulness of exercise-stress echocardiography for risk stratification of true asymptomatic patients with aortic valve stenosis","volume":"31","author":"Marechaux","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.08.004_bib0094","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jacc.2020.02.046","article-title":"Transvalvular flow rate determines prognostic value of aortic valve area in aortic stenosis","volume":"75","author":"Namasivayam","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0095","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jcmg.2018.01.011","article-title":"Low transvalvular flow rate predicts mortality in patients with low gradient aortic stenosis following aortic valve intervention","volume":"12","author":"Vamvakidou","year":"2019","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.ahj.2022.08.004_bib0096","first-page":"549","article-title":"Association of time between left ventricular and aortic systolic pressure peaks with severity of aortic stenosis and calcification of aortic valve","volume":"4","author":"Sato","year":"2019","journal-title":"JAMACardiol"},{"key":"10.1016\/j.ahj.2022.08.004_bib0097","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/CIRCULATIONAHA.116.023997","article-title":"Medical treatment of aortic stenosis","volume":"134","author":"Marquis-Gravel","year":"2016","journal-title":"Circulation"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032200165X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000287032200165X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T13:03:30Z","timestamp":1672059810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000287032200165X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":97,"alternative-id":["S000287032200165X"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2022.08.004","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating hemodynamics with ventricular and valvular remodeling in aortic stenosis. A paradigm shift in therapeutic decision making","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2022.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}