{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:00:47Z","timestamp":1784304047751,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["19-R133-A9089_22145"],"award-info":[{"award-number":["19-R133-A9089_22145"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.ahj.2022.11.016","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:55:12Z","timestamp":1669028112000},"page":"41-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["International randomized trial on the effect of revascularization or optimal medical therapy of chronic total coronary occlusions with myocardial ischemia - ISCHEMIA-CTO trial \u2013 rationale and design"],"prefix":"10.1016","volume":"257","author":[{"given":"Truls","family":"R\u00e5munddal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil Nielsen","family":"Holck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Eftekhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Escaned","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ioanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Spratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Veien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Henrik","family":"Tilsted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Havndrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Thue","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli A.","family":"Kajander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Faurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peep","family":"Lanematt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Jakobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2022.11.016_bib0001","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jacc.2011.12.007","article-title":"Current perspectives on coronary chronic total occlusions: the Canadian multicenter chronic total occlusions registry","volume":"59","author":"Fefer","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0002","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.amjcard.2004.12.065","article-title":"Effect of chronic total coronary occlusion on treatment strategy","volume":"95","author":"Christofferson","year":"2005","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103850","article-title":"Chronic total occlusions in Sweden\u2013a report from the Swedish coronary angiography and angioplasty registry (SCAAR)","volume":"9","author":"Ramunddal","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ahj.2022.11.016_bib0004","first-page":"1535","article-title":"prognostic impact of chronic total occlusions: a report from SCAAR (Swedish coronary angiography and angioplasty registry)","volume":"9","author":"Ramunddal","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2022.11.016_bib0005","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/eurheartj\/ehr471","article-title":"Prognostic impact of a chronic total occlusion in a non-infarct-related artery in patients with ST-segment elevation myocardial infarction: 3-year results from the HORIZONS-AMI trial","volume":"33","author":"Claessen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.11.016_bib0006","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4244\/EIJY14M09_01","article-title":"2014 ESC\/EACTS guidelines on myocardial revascularization","volume":"10","author":"Windecker","year":"2015","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ahj.2022.11.016_bib0007","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIR.0000000000000095","volume":"130","author":"Fihn","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.11.016_bib0008","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/CIRCULATIONAHA.118.031313","article-title":"Randomized trial evaluating percutaneous coronary intervention for the treatment of chronic total occlusion","volume":"139","author":"Lee","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.11.016_bib0009","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/eurheartj\/ehy220","article-title":"A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions","volume":"39","author":"Werner","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.11.016_bib0010","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jacc.2016.07.744","article-title":"Percutaneous intervention for concurrent chronic total occlusions in patients with STEMI: the EXPLORE trial","volume":"68","author":"Henriques","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0011","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jcin.2018.05.041","article-title":"A randomized trial to assess regional left ventricular function after stent implantation in chronic total occlusion: the REVASC trial","volume":"11","author":"Mashayekhi","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2022.11.016_bib0012","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jcin.2011.03.021","article-title":"Long-term outcome of percutaneous coronary intervention for chronic total occlusions","volume":"4","author":"Mehran","year":"2011","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2022.11.016_bib0013","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijcard.2015.03.164","article-title":"Meta-analysis on the impact of percutaneous coronary intervention of chronic total occlusions on left ventricular function and clinical outcome","volume":"187","author":"Hoebers","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0014","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.amjcard.2012.10.034","article-title":"Meta-analysis of effect on mortality of percutaneous recanalization of coronary chronic total occlusions using a stent-based strategy","volume":"111","author":"Pancholy","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/CIRCOUTCOMES.108.825760","article-title":"Quantifying the early health status benefits of successful chronic total occlusion recanalization: results from the flowcardia's approach to chronic total occlusion recanalization (FACTOR) trial","volume":"3","author":"Grantham","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.ahj.2022.11.016_bib0016","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4244\/EIJ-D-16-01014","article-title":"Effects of successful percutaneous coronary intervention of chronic total occlusions on myocardial perfusion and left ventricular function","volume":"13","author":"Stuijfzand","year":"2017","journal-title":"EuroIntervention"},{"key":"10.1016\/j.ahj.2022.11.016_bib0017","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCULATIONAHA.120.046754","article-title":"Definitions and clinical trial design principles for coronary artery chronic total occlusion therapies: CTO-ARC consensus recommendations","volume":"143","author":"Ybarra","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.11.016_bib0018","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.11.016_bib0019","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/eurheartj\/ehs184","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2022.11.016_bib0020","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jacc.2020.08.016","article-title":"Implications of alternative definitions of peri-procedural myocardial infarction after coronary revascularization","volume":"76","author":"Gregson","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2022.11.016_bib0021","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2022.11.016_bib0022","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1136\/heartjnl-2018-314076","article-title":"Risk of cardiac and sudden death with and without revascularisation of a coronary chronic total occlusion","volume":"105","author":"Godino","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2022.11.016_bib0023","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.007877","article-title":"Examining the operator learning curve for percutaneous coronary intervention of chronic total occlusions","volume":"12","author":"Young","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.ahj.2022.11.016_bib0024","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008863","volume":"13","author":"Zein","year":"2020","journal-title":"Circ Cardiovasc Interv"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870322002988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870322002988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:58:58Z","timestamp":1762077538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870322002988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":24,"alternative-id":["S0002870322002988"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2022.11.016","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"International randomized trial on the effect of revascularization or optimal medical therapy of chronic total coronary occlusions with myocardial ischemia - ISCHEMIA-CTO trial \u2013 rationale and design","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2022.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}