{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:03:40Z","timestamp":1785132220262,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UM1 HL087318"],"award-info":[{"award-number":["UM1 HL087318"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008171","name":"Minneapolis Heart Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ahj.2023.02.004","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T15:21:46Z","timestamp":1676388106000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Microvascular obstruction identifies a subgroup of patients who benefit from stem cell therapy following ST-elevation myocardial infarction"],"prefix":"10.1016","volume":"259","author":[{"given":"Sarah J.","family":"Davidson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Roncalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Surder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Corti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul R.","family":"Chugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Stanberry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lemarchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeau-Paul","family":"Beregi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-0252","authenticated-orcid":false,"given":"Jay H.","family":"Traverse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2023.02.004_bib0001","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1161\/01.CIR.85.5.1699","article-title":"Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction","volume":"85","author":"Ito","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.02.004_bib0002","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.jacc.2009.12.037","article-title":"Microvascular obstruction: underlying pathophysiology and clinical diagnosis","volume":"55","author":"Bekkers","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.02.004_bib0003","doi-asserted-by":"crossref","first-page":"H818","DOI":"10.1152\/ajpheart.00347.2022","article-title":"Increasing myocardial edema is associated with greater microvascular obstruction in ST-segment elevation myocardial infarction","volume":"323","author":"Bonfig","year":"2022","journal-title":"Am J Physiol Heart and Circ"},{"key":"10.1016\/j.ahj.2023.02.004_bib0004","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/CIRCRESAHA.117.311466","article-title":"TIME trial: effect of timing of stem cell delivery following ST-Elevation Myocardial Infarction on the recovery of global and regional left ventricular function: final 2-year analysis","volume":"122","author":"Traverse","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2023.02.004_bib0005","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1093\/eurheartj\/ehx414","article-title":"Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials","volume":"38","author":"de Waha","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2023.02.004_bib0006","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.ejrad.2011.11.053","article-title":"The size does not matter - the presence of microvascular obstruction but not its extent corresponds to larger infarct size in reperfused STEMI","volume":"81","author":"Malek","year":"2012","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ahj.2023.02.004_bib0007","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1532-429X-14-46","article-title":"Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance","volume":"14","author":"Klug","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.ahj.2023.02.004_bib0008","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ejrad.2011.01.069","article-title":"Patterns of myocardial perfusion in the acute and chronic stage after myocardial infarction: a cardiac magnetic resonance study","volume":"81","author":"Trieb","year":"2012","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ahj.2023.02.004_bib0009","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1148\/radiol.2502080739","article-title":"Assessment of microvascular obstruction and prediction of short-term remodeling after acute myocardial infarction: cardiac MR imaging study","volume":"250","author":"Nijveldt","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.ahj.2023.02.004_bib0010","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1001\/jama.2011.1670","article-title":"Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial","volume":"306","author":"Traverse","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2023.02.004_bib0011","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1001\/jama.2012.28726","article-title":"Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial","volume":"308","author":"Traverse","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2023.02.004_bib0012","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ahj.2010.06.009","article-title":"Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction","volume":"160","author":"Traverse","year":"2010","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.02.004_bib0013","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1093\/eurheartj\/ehq455","article-title":"Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial","volume":"32","author":"Roncalli","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2023.02.004_bib0014","unstructured":"Surder D, Manka R, Moccetti T, et\u00a0al. The effect of bone marrow derived mononuclear cell treatment, early or late after acute myocardial infarction: twelve months CMR and long-term clinical results. Circ Res."},{"key":"10.1016\/j.ahj.2023.02.004_bib0015","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1056\/NEJMoa060186","article-title":"Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction","volume":"355","author":"Schachinger","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2023.02.004_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006536.pub3","article-title":"Stem cell treatment for acute myocardial infarction (Review)","volume":"15","author":"Clifford","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ahj.2023.02.004_bib0017","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.112.276519","article-title":"Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up","volume":"112","author":"Vrtovec","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2023.02.004_bib0018","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijcard.2022.07.012","article-title":"Circadian dependence of microvascular obstruction during ST-segment elevation myocardial infarction","volume":"366","author":"Bonfig","year":"2022","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ahj.2023.02.004_bib0019","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(05)67861-0","article-title":"Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial","volume":"367","author":"Janssens","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2023.02.004_bib0020","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00392-013-0595-9","volume":"102","author":"Wohrle","year":"2013","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.ahj.2023.02.004_bib0021","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s00259-015-3279-z","article-title":"Predictors of ventricular remodeling in patients with reperfused acute myocardial infarction and left ventricular dysfunction candidates for bone marrow cell therapy: insights from the BONAMI trial","volume":"43","author":"Manrique","year":"2016","journal-title":"Eur J Nuc Med Mol Imaging"},{"key":"10.1016\/j.ahj.2023.02.004_bib0022","first-page":"1295","article-title":"Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction","volume":"47","author":"Kang","year":"2006","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ahj.2023.02.004_bib0023","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.2967\/jnumed.107.042838","article-title":"Dynamic tracking during intracoronary injection of 18F-FDG-labeled progenitor cell therapy for acute myocardial infarction","volume":"48","author":"Doyle","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ahj.2023.02.004_bib0024","first-page":"837","article-title":"Index of microcirculatory resistance a a tool to characterize microvascular obstruction and\u2003predict infarct size regression in patients with STEMI undergoing primary PCI","volume":"12","author":"Luigi De Maria","year":"2019","journal-title":"J Am Coll Cardiol"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870323000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870323000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:09:53Z","timestamp":1757570993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870323000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":24,"alternative-id":["S0002870323000376"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2023.02.004","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microvascular obstruction identifies a subgroup of patients who benefit from stem cell therapy following ST-elevation myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2023.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}