{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:08:05Z","timestamp":1793916485718,"version":"4.8.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"am","delay-in-days":288,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014930","name":"Arbor Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL105561"],"award-info":[{"award-number":["U01HL105561"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56HL1555528"],"award-info":[{"award-number":["R56HL1555528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL105462"],"award-info":[{"award-number":["U01HL105462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL105565"],"award-info":[{"award-number":["U01HL105565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL105907"],"award-info":[{"award-number":["U01HL105907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL165208"],"award-info":[{"award-number":["R01HL165208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ahj.2023.08.007","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T17:04:00Z","timestamp":1692464640000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Biomarkers and cardiovascular events in patients with stable coronary disease in the ISCHEMIA Trials"],"prefix":"10.1016","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-7305","authenticated-orcid":false,"given":"Jonathan D.","family":"Newman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Anthopolos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly V.","family":"Ruggles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macintosh","family":"Cornwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmony R.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kreton","family":"Mavromatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wallentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikar J.","family":"Kullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"McManus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Kristin K\uff0e","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Hochman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2023.08.007_bib0001","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics\u20142019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0002","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1161\/CIRCULATIONAHA.109.904029","article-title":"Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group","volume":"121","author":"Eagle","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0003","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001646","article-title":"Traditional risk factors versus biomarkers for prediction of secondary events in patients with stable coronary heart disease: from the heart and soul study","volume":"4","author":"Beatty","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2023.08.007_bib0004","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/CIRCULATIONAHA.121.054567","article-title":"International observational analysis of evolution and outcomes of chronic stable angina: the multinational CLARIFY study","volume":"144","author":"Mesnier","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0005","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCULATIONAHA.115.019861","article-title":"Atherothrombotic risk stratification and the efficacy and safety of vorapaxar in patients with stable ischemic heart disease and previous myocardial infarction","volume":"134","author":"Bohula","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0006","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1136\/heartjnl-2013-303640","article-title":"Development and validation of a prediction rule for recurrent vascular events based on a cohort study of patients with arterial disease: the SMART risk score","volume":"99","author":"Dorresteijn","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.ahj.2023.08.007_bib0007","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jacc.2019.08.012","article-title":"From subclinical atherosclerosis to plaque progression and acute coronary events: JACC state-of-the-art review","volume":"74","author":"Ahmadi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0008","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ahj.2017.10.016","article-title":"Biomarkers in stable coronary artery disease","volume":"196","author":"McCarthy","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0009","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.amjcard.2017.03.265","article-title":"Usefulness of multiple biomarkers for predicting incident major adverse cardiac events in patients undergoing diagnostic coronary angiography (from the catheter sampled blood archive in cardiovascular diseases [CASABLANCA] study)","volume":"120","author":"McCarthy","year":"2017","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1415921","article-title":"Troponin and cardiac events in stable ischemic heart disease and diabetes","volume":"373","author":"Everett","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0011","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jcmg.2016.11.021","article-title":"Association between high-sensitivity cardiac troponin levels and myocardial ischemia during mental stress and conventional stress","volume":"11","author":"Hammadah","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2023.08.007_bib0012","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/ATVBAHA.115.306818","article-title":"Effect of coronary atherosclerosis and myocardial ischemia on plasma levels of high-sensitivity troponin T and NT-proBNP in patients with stable angina","volume":"36","author":"Caselli","year":"2016","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0013","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1093\/eurheartj\/ehs164","article-title":"Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score","volume":"33","author":"Goliasch","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/joim.12189","article-title":"Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score","volume":"276","author":"Kleber","year":"2014","journal-title":"J Intern Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jacc.2013.03.072","article-title":"Aggregate risk score based on markers of inflammation, cell stress, and coagulation is an independent predictor of adverse cardiovascular outcomes","volume":"62","author":"Eapen","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0016","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/CIRCULATIONAHA.105.590927","article-title":"Comparative impact of multiple biomarkers and n-terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the heart outcomes prevention evaluation (HOPE) study","volume":"114","author":"Blankenberg","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ahj.2015.11.010","article-title":"Clinical benefit of high-sensitivity cardiac troponin I in the detection of exercise-induced myocardial ischemia","volume":"173","author":"Lee","year":"2016","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0018","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/jamacardio.2019.0014","article-title":"Baseline characteristics and risk profiles of participants in the ISCHEMIA randomized clinical trial","volume":"4","author":"Hochman","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0019","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial invasive or conservative strategy for stable coronary disease","volume":"382","author":"Maron","year":"2020","journal-title":"New Engl J Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0020","doi-asserted-by":"crossref","first-page":"124<-135","DOI":"10.1016\/j.ahj.2018.04.011","article-title":"International study of comparative health effectiveness with medical and invasive approaches (ISCHEMIA) trial: rationale and design","volume":"201","author":"Maron","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmg.2020.11.012","article-title":"Coronary CT angiography followed by invasive angiography in patients with moderate or severe ischemia-insights from the ISCHEMIA trial","author":"Mancini","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2023.08.007_bib0022","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ahj.2018.07.023","article-title":"International study of comparative health effectiveness with medical and invasive approaches- chronic kidney disease (ISCHEMIA-CKD): rationale and design","volume":"205","author":"Bangalore","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0023","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa1915925","article-title":"Management of coronary disease in patients with advanced kidney disease","volume":"382","author":"Bangalore","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0024","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005077","article-title":"Inflammatory biomarkers interleukin-6 and c-reactive protein and outcomes in stable coronary heart disease: experiences from the STABILITY (stabilization of atherosclerotic plaque by initiation of darapladib therapy) trial","volume":"6","author":"Held","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2023.08.007_bib0025","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jacc.2017.06.030","article-title":"Biomarker-based risk model to predict cardiovascular mortality in patients with stable coronary disease","volume":"70","author":"Lindholm","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0026","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0895-4356(95)00048-8","article-title":"Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates","volume":"48","author":"Peduzzi","year":"1995","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0027","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0028","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","article-title":"Relaxing the rule of ten events per variable in logistic and Cox regression","volume":"165","author":"Vittinghoff","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0029","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1093\/eurheartj\/ehq322","article-title":"Multiple marker approach to risk stratification in patients with stable coronary artery disease","volume":"31","author":"Schnabel","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0030","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1161\/01.CIR.0000103681.04726.9C","article-title":"B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the heart and soul study","volume":"108","author":"Bibbins-Domingo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0031","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1001\/jama.297.2.169","article-title":"N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease","volume":"297","author":"Bibbins-Domingo","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2023.08.007_bib0032","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0033","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1002\/sim.6152","article-title":"Calibration plots for risk prediction models in the presence of competing risks","volume":"33","author":"Gerds","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0034","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/EDE.0b013e3181a39056","article-title":"Prognostic models with competing risks: methods and application to coronary risk prediction","volume":"20","author":"Wolbers","year":"2009","journal-title":"Epidemiology"},{"key":"10.1016\/j.ahj.2023.08.007_bib0035","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/clinchem\/hvaa332","article-title":"Growth differentiation factor (GDF)-15 and cardiometabolic outcomes among older adults: the atherosclerosis risk in communities study","volume":"67","author":"Echouffo-Tcheugui","year":"2021","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2023.08.007_bib0036","unstructured":"Team RC. R: A language and environment for statistical computing.; 2018. Available at: https:\/\/www.R-project.org\/"},{"key":"10.1016\/j.ahj.2023.08.007_bib0037","doi-asserted-by":"crossref","first-page":"440","DOI":"10.32614\/RJ-2017-062","article-title":"risk regression: predicting the risk of an event using cox regression models","volume":"9","author":"Ozenne","year":"2017","journal-title":"The R Journal"},{"key":"10.1016\/j.ahj.2023.08.007_bib0038","series-title":"Medical Risk Prediction: With Ties to Machine Learning","author":"Gerds","year":"2021"},{"key":"10.1016\/j.ahj.2023.08.007_bib0039","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/CIRCULATIONAHA.121.054439","article-title":"Outcomes of participants with diabetes in the ISCHEMIA trials","volume":"26","author":"Newman","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jacc.2020.11.063","article-title":"Association of NT-ProBNP, blood pressure, and cardiovascular events: the ARIC study","volume":"77","author":"Hussain","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0041","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/CIRCULATIONAHA.118.038772","article-title":"High-sensitivity troponin I and incident coronary events, stroke, heart failure hospitalization, and mortality in the ARIC study","volume":"139","author":"Jia","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0042","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/CIRCULATIONAHA.112.129437","article-title":"Prognostic utility of novel biomarkers of cardiovascular stress: the framingham heart study","volume":"126","author":"Wang","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0043","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/CIRCULATIONAHA.116.025505","article-title":"High-sensitive cardiac troponin t as an early biochemical signature for clinical and subclinical heart failure: MESA (multi-ethnic study of atherosclerosis)","volume":"135","author":"Seliger","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2023.08.007_bib0044","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ahj.2013.09.013","article-title":"Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (the heart and soul study)","volume":"167","author":"Schopfer","year":"2014","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2023.08.007_bib0045","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa1415516","article-title":"Outcomes of anatomical versus functional testing for coronary artery disease","volume":"372","author":"Douglas","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0046","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jacc.2018.10.065","article-title":"Single-molecule hsTnI and short-term risk in stable patients with chest pain","volume":"73","author":"Januzzi","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0047","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jcmg.2018.01.021","article-title":"High-sensitivity troponin I and coronary computed tomography in symptomatic outpatients with suspected CAD: insights from the PROMISE trial","volume":"12","author":"Januzzi","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2023.08.007_bib0048","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/j.jcct.2020.06.169","article-title":"Relationship Of myocardial necrosis, inflammation and coronary atherosclerosis to cardiovascular outcomes in patients with stable chest pain: results from the promise trial","volume":"14","author":"Ferencik","year":"2020","journal-title":"J Cardiovasc Comp Tomogr"},{"key":"10.1016\/j.ahj.2023.08.007_bib0049","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pcad.2004.07.003","article-title":"Biology of the troponin complex in cardiac myocytes","volume":"47","author":"Parmacek","year":"2004","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.ahj.2023.08.007_bib0050","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1056\/NEJMoa042330","article-title":"N-terminal Pro\u2013B-type natriuretic peptide and long-term mortality in stable coronary heart disease","volume":"352","author":"Kragelund","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ahj.2023.08.007_bib0051","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1373\/clinchem.2016.255174","article-title":"Growth differentiation factor 15 as a biomarker in cardiovascular disease","volume":"63","author":"Wollert","year":"2017","journal-title":"Clin Chem"},{"key":"10.1016\/j.ahj.2023.08.007_bib0052","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jacc.2009.03.076","article-title":"The CD40\/CD40 Ligand System","volume":"54","author":"Antoniades","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2023.08.007_bib0053","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024516","article-title":"Association of high-sensitivity troponin T and I blood concentrations with all-cause mortality and cardiovascular outcome in stable patients\u2014results from the INTERCATH cohort","volume":"11","author":"Bay","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2023.08.007_bib0054","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.118.038529","article-title":"Cardiac troponin T and troponin I in the general population","volume":"139","author":"Welsh","year":"2019","journal-title":"Circulation"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870323002041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870323002041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:17:18Z","timestamp":1778638638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870323002041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":54,"alternative-id":["S0002870323002041"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2023.08.007","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers and cardiovascular events in patients with stable coronary disease in the ISCHEMIA Trials","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2023.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}