{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:08:58Z","timestamp":1793833738484,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA013696"],"award-info":[{"award-number":["P30CA013696"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["5R01AT009273"],"award-info":[{"award-number":["5R01AT009273"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES009089"],"award-info":[{"award-number":["P30ES009089"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES033719"],"award-info":[{"award-number":["P42ES033719"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["5UH3AT009149"],"award-info":[{"award-number":["5UH3AT009149"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["2UH3AT009150"],"award-info":[{"award-number":["2UH3AT009150"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ahj.2024.04.005","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T13:40:27Z","timestamp":1713188427000},"page":"72-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2)"],"prefix":"10.1016","volume":"273","author":[{"given":"Ana","family":"Navas-Acien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M.","family":"Santella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie R.","family":"Joubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Lokhnygina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Ujueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Gurvich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-2844","authenticated-orcid":false,"given":"Nancy J.","family":"LoIacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ravalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-4143","authenticated-orcid":false,"given":"Cynthia D.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery M.","family":"Jarrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonsina De Leon","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Boineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa L.Z.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Anstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gervasio A.","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2024.04.005_bib0001","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association\/American College of Cardiology Joint Committee on clinical practice guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2024.04.005_bib0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/CIRCOUTCOMES.113.000663","article-title":"The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT)","volume":"7","author":"Escolar","year":"2014","journal-title":"Circulat Cardiovasc Qual Outcom"},{"key":"10.1016\/j.ahj.2024.04.005_bib0003","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2013.2107","article-title":"Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial","volume":"309","author":"Lamas","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2024.04.005_bib0004","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2337\/dci20-0053","article-title":"Social determinants of health and diabetes: a scientific review","volume":"44","author":"Hill-Briggs","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ahj.2024.04.005_bib0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029852","article-title":"Contaminant metals as cardiovascular risk factors: a scientific statement from the American Heart Association","volume":"12","author":"Lamas","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2024.04.005_bib0006","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40572-023-00402-x","article-title":"A state-of-the-science review on metal biomarkers","volume":"10","author":"Martinez-Morata","year":"2023","journal-title":"Curr Environ Health Rep"},{"key":"10.1016\/j.ahj.2024.04.005_bib0007","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfab026","article-title":"Low-level metal contamination and chelation in cardiovascular disease-a ripe area for toxicology research","volume":"181","author":"Ujueta","year":"2021","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.ahj.2024.04.005_bib0008","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024648","article-title":"Chelation therapy in patients with cardiovascular disease: a systematic review","volume":"11","author":"Ravalli","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2024.04.005_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17134684","article-title":"Urinary metal levels after repeated edetate disodium infusions: preliminary findings","volume":"17","author":"Alam","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.ahj.2024.04.005_bib0010","first-page":"1","article-title":"Metallomics and the cell: some definitions and general comments","volume":"12","author":"Banci","year":"2013","journal-title":"Met Ions Life Sci"},{"key":"10.1016\/j.ahj.2024.04.005_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ahj.2022.05.013","article-title":"The trial to assess chelation therapy 2 (TACT2): rationale and design","volume":"252","author":"Lamas","year":"2022","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2024.04.005_bib0012","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.talanta.2016.09.060","article-title":"Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures","volume":"162","author":"Jones","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.ahj.2024.04.005_bib0013","series-title":"Laboratory procedure manual - analytes: cadmium, lead, manganese, mercury, and selenium, Matrix: whole blood. Method: blood multi-element analysis by ICP-DRC-MS. cdc.gov: centers for disease control","year":"2018"},{"key":"10.1016\/j.ahj.2024.04.005_bib0014","first-page":"1","article-title":"Inductively coupled plasma mass spectrometry to measure multiple toxic elements in urine in NHANES 1999-2000","volume":"26","author":"Caldwell","year":"2005","journal-title":"Atomic Spectroscopy"},{"key":"10.1016\/j.ahj.2024.04.005_bib0015","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1039\/b801927d","article-title":"Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS","volume":"23","author":"Jarrett","year":"2008","journal-title":"J Analyt Atom Spectromet"},{"key":"10.1016\/j.ahj.2024.04.005_bib0016","year":"2019"},{"key":"10.1016\/j.ahj.2024.04.005_bib0017","year":"2019"},{"key":"10.1016\/j.ahj.2024.04.005_bib0018","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s40572-016-0117-9","article-title":"Environmental metals and cardiovascular disease in adults: a systematic review beyond lead and cadmium","volume":"3","author":"Nigra","year":"2016","journal-title":"Curr Environ Health Rep"},{"key":"10.1016\/j.ahj.2024.04.005_bib0019","doi-asserted-by":"crossref","first-page":"91303","DOI":"10.1289\/EHP12382","article-title":"Invited perspective: an argument for changing the reporting units for lead in blood","volume":"131","author":"Caravanos","year":"2023","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ahj.2024.04.005_bib0020","series-title":"cdc.gov: centers for disease control and prevention","article-title":"Lead - understanding blood lead levels, (NIOSH) TNIfOSaH","year":"2023"},{"key":"10.1016\/j.ahj.2024.04.005_bib0021","unstructured":"OSHA. Occupational safety and health standards 1910 subpart z, toxic and hazardous substances 1910.1027, cadmium. www.osha.gov: U.S. Department of Labor: https:\/\/www.osha.gov\/laws-regs\/regulations\/standardnumber\/1910\/1910.1027 Occupational Safety and Health Administration: Washington, DC"},{"key":"10.1016\/j.ahj.2024.04.005_bib0022","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40557-015-0086-8","article-title":"Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication","volume":"28","author":"Ye","year":"2016","journal-title":"Ann Occup Environ Med"},{"key":"10.1016\/j.ahj.2024.04.005_bib0023","series-title":"NHANES survey methods and analytic guidelines","year":"2022"},{"key":"10.1016\/j.ahj.2024.04.005_bib0024","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jacc.2018.11.001","article-title":"Long-term survival following multivessel revascularization in patients with diabetes: the FREEDOM follow-on study","volume":"73","author":"Farkouh","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.04.005_bib0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jama.1994.03520040046039","article-title":"The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES)","volume":"272","author":"Pirkle","year":"1994","journal-title":"Jama"},{"key":"10.1016\/j.ahj.2024.04.005_bib0026","series-title":"Lead and cardiovascular mortality: evidence supports lead as an independent cardiovascular risk factor","author":"Navas-Acien","year":"2021"},{"key":"10.1016\/j.ahj.2024.04.005_bib0027","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/092986705774462987","article-title":"Chelators as antidotes of metal toxicity: therapeutic and experimental aspects","volume":"12","author":"Blanusa","year":"2005","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.ahj.2024.04.005_bib0028","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1038\/s41467-022-35185-6","article-title":"Nationwide geospatial analysis of county racial and ethnic composition and public drinking water arsenic and uranium","volume":"13","author":"Martinez-Morata","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ahj.2024.04.005_bib0029","series-title":"Diabetes in america","author":"Cowie","year":"2018"},{"key":"10.1016\/j.ahj.2024.04.005_bib0030","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.2337\/dc24-S010","article-title":"Cardiovascular disease and risk management: standards of care in diabetes-2024","volume":"47","year":"2024","journal-title":"Diabetes Care"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324000929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324000929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T02:36:46Z","timestamp":1721356606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870324000929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":30,"alternative-id":["S0002870324000929"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2024.04.005","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2)","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2024.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}