{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:50:30Z","timestamp":1792212630542,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["ERC-2018-CoG 819775-MATRIX"],"award-info":[{"award-number":["ERC-2018-CoG 819775-MATRIX"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2022034S"],"award-info":[{"award-number":["A2022034S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018967","name":"Universitat Pompeu Fabra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005884","name":"Centro Nacional de Investigaciones Cardiovasculares","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013405","name":"Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"Caixabank SA","doi-asserted-by":"publisher","award":["LCF\/BQ\/DI19\/11730052"],"award-info":[{"award-number":["LCF\/BQ\/DI19\/11730052"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"Caixabank SA","doi-asserted-by":"publisher","award":["LCF\/BQ\/DI22\/11940002"],"award-info":[{"award-number":["LCF\/BQ\/DI22\/11940002"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CPII21\/00007"],"award-info":[{"award-number":["CPII21\/00007"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["CEX2020-001041-S"],"award-info":[{"award-number":["CEX2020-001041-S"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ahj.2024.09.028","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T21:47:25Z","timestamp":1727128045000},"page":"195-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study"],"prefix":"10.1016","volume":"278","author":[{"given":"Catarina","family":"Trist\u00e3o-Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Fuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lopez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00e1ndez-Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Semerano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Fernandez-Nueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Garcia-Lunar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ayuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sanchez-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Ibanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Domingo","family":"Gispert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8802-4338","authenticated-orcid":false,"given":"Marta","family":"Cortes-Canteli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2024.09.028_bib0001","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.ahj.2024.09.028_bib0002","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.ahj.2024.09.028_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105864","article-title":"Emerging concepts in vascular dementia: a review","volume":"30","author":"Bir","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.ahj.2024.09.028_bib0004","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2019.10.062","article-title":"Alzheimer's disease and vascular aging","volume":"75","author":"Cortes-Canteli","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0005","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S1474-4422(16)30029-1","article-title":"Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study","volume":"15","author":"Arvanitakis","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0006","doi-asserted-by":"crossref","first-page":"e1351","DOI":"10.1212\/WNL.0000000000010199","article-title":"Group obotU-SS. Intracranial atherosclerosis on 7T MRI and cognitive functioning: The SMART-MR study","volume":"95","author":"Zwartbol","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ahj.2024.09.028_bib0007","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005349","article-title":"Coronary artery calcium and risk of dementia in MESA (Multi-ethnic study of atherosclerosis)","volume":"10","author":"Fujiyoshi","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2024.09.028_bib0008","doi-asserted-by":"crossref","first-page":"e1248","DOI":"10.1212\/WNL.0000000000005259","article-title":"Arterial stiffness and dementia pathology: atherosclerosis risk in communities (ARIC)-PET Study","volume":"90","author":"Hughes","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.ahj.2024.09.028_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.04592","article-title":"White matter hyperintensities and carotid arterial stiffness in amnestic mild cognitive impairment","volume":"34","author":"Curtis","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.ahj.2024.09.028_bib0010","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3233\/JAD-191073","article-title":"Carotid stiffness is associated with brain amyloid-\u03b2 burden in amnestic mild cognitive impairment","volume":"74","author":"Pasha","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ahj.2024.09.028_bib0011","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1093\/eurheartj\/ehn439","article-title":"Signs of subclinical coronary atherosclerosis in relation to risk factor distribution in the multi-ethnic study of atherosclerosis (MESA) and the heinz nixdorf recall study (HNR)","volume":"29","author":"Erbel","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2024.09.028_bib0012","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics\u20142022 update: a report from the American heart association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2024.09.028_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.673440","article-title":"Atherosclerosis: the culprit and co-victim of vascular dementia","volume":"15","author":"Huang","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.ahj.2024.09.028_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00115","article-title":"Impaired A\u03b2 clearance: a potential link between atherosclerosis and Alzheimer\u2019s disease","volume":"7","author":"Gupta","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.ahj.2024.09.028_bib0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/CIRCRESAHA.123.323921","article-title":"Apolipoprotein E -\u03b52 and Resistance to atherosclerosis in midlife - the PESA observational study","volume":"134","author":"Toribio-Fern\u00e1ndez","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.ahj.2024.09.028_bib0016","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.3390\/ijms23179892","article-title":"Apolipoprotein E in cardiometabolic and neurological health and diseases","volume":"23","author":"Alagarsamy","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ahj.2024.09.028_bib0017","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for primary prevention of Alzheimer's disease: an analysis of population-based data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0018","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2024.09.028_bib0019","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022846","article-title":"Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis","volume":"9","author":"Peters","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.ahj.2024.09.028_bib0020","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","article-title":"Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease","volume":"14","author":"Kivipelto","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0021","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13195-024-01482-z","article-title":"Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial","volume":"16","author":"Ornish","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.ahj.2024.09.028_bib0022","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/2047487319869400","article-title":"Lifestyle factors and high-risk atherosclerosis: pathways and mechanisms beyond traditional risk factors","volume":"27","author":"Lechner","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0023","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer\u2019s disease continuum","volume":"19","author":"Gustavsson","year":"2022","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"10.1016\/j.ahj.2024.09.028_bib0024","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/ehjci\/jex239","article-title":"Carotid plaque thickness and carotid plaque burden predict future cardiovascular events in asymptomatic adult Americans","volume":"19","author":"Sillesen","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2024.09.028_bib0025","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/gerona\/glz039","article-title":"Carotid intima\u2013media thickness and markers of brain health in a biracial middle-aged cohort: CARDIA brain MRI sub-study","volume":"75","author":"Cermakova","year":"2020","journal-title":"J Gerontol: Series A"},{"key":"10.1016\/j.ahj.2024.09.028_bib0026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ana.22392","article-title":"Carotid atherosclerosis and progression of brain atrophy: The SMART-MR Study","volume":"70","author":"Muller","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0027","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/0271678X221133859","article-title":"Group obotU-SS. Low-grade carotid artery stenosis is associated with progression of brain atrophy and cognitive decline. The SMART-MR study","volume":"43","author":"Ghaznawi","year":"2022","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ahj.2024.09.028_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106388","article-title":"Association of carotid intima-media thickness with brain MRI markers in the atherosclerosis risk in communities neurocognitive study (ARIC-NCS)","volume":"31","author":"Wang","year":"2022","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.ahj.2024.09.028_bib0029","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/HYPERTENSIONAHA.115.06610","article-title":"Association of aortic stiffness with cognition and brain aging in young and middle-aged adults: the framingham third generation cohort study","volume":"67","author":"Pase","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.ahj.2024.09.028_bib0030","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1161\/STROKEAHA.120.032674","article-title":"Association of coronary artery atherosclerosis with brain white matter hyperintensity","volume":"52","author":"Johansen","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.ahj.2024.09.028_bib0031","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.atherosclerosis.2020.10.015","article-title":"Carotid atherosclerosis among middle-aged individuals predicts cognition: A 10-year follow-up study","volume":"314","author":"Lin","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ahj.2024.09.028_bib0032","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020489","article-title":"Association of carotid intima-media thickness and other carotid ultrasound features with incident dementia in the ARIC-NCS","volume":"10","author":"Wang","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ahj.2024.09.028_bib0033","doi-asserted-by":"crossref","first-page":"e1454","DOI":"10.1212\/WNL.0000000000206825","article-title":"Premature cardiovascular disease and brain health in midlife: the CARDIA study","volume":"100","author":"Jiang","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.ahj.2024.09.028_bib0034","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.ahj.2013.08.024","article-title":"The progression and early detection of subclinical atherosclerosis (PESA) study: rationale and design","volume":"166","author":"Fern\u00e1ndez-Ortiz","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.ahj.2024.09.028_bib0035","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.114.014310","article-title":"ar distribution, and multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (progression of early subclinical atherosclerosis) study","volume":"131","author":"Fernandez-Friera","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ahj.2024.09.028_bib0036","first-page":"681","article-title":"Plaque burden as a measure of subclinical atherosclerosis","volume":"5","author":"Sillesen","year":"2012","journal-title":"JACC: Cardiovasc Imaging"},{"key":"10.1016\/j.ahj.2024.09.028_bib0037","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jacc.2017.05.033","article-title":"Subclinical atherosclerosis burden by 3d ultrasound in mid-life: the PESA study","volume":"70","author":"Lopez-Melgar","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0038","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.jacc.2023.09.814","article-title":"Determinants of progression and regression of subclinical atherosclerosis over 6 years","volume":"82","author":"Mendieta","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0039","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jacc.2020.12.027","article-title":"Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study","volume":"77","author":"Cortes-Canteli","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0040","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1016\/S2666-7568(23)00134-4","article-title":"Longitudinal interplay between subclinical atherosclerosis, cardiovascular risk factors, and cerebral glucose metabolism in midlife: results from the PESA prospective cohort study","volume":"4","author":"Trist\u00e3o-Pereira","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.ahj.2024.09.028_bib0041","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13024-021-00430-x","article-title":"Moving fluid biomarkers for Alzheimer's disease from research tools to routine clinical diagnostics","volume":"16","author":"Zetterberg","year":"2021","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.ahj.2024.09.028_bib0042","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jacc.2021.05.011","article-title":"Progression of early subclinical atherosclerosis (PESA) study: JACC focus seminar 7\/8","volume":"78","author":"Ibanez","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0043","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.fob.2015.10.006","article-title":"Association between apolipoprotein E polymorphism and myocardial infarction risk: a systematic review and meta-analysis","volume":"5","author":"Wang","year":"2015","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.ahj.2024.09.028_bib0044","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","article-title":"Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies","volume":"15","author":"Yamazaki","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0045","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/arclin\/acp038","article-title":"Spanish multicenter normative studies (NEURONORMA Project): norms for verbal span, visuospatial span, letter and number sequencing, trail making test, and symbol digit modalities test","volume":"24","author":"Pena-Casanova","year":"2009","journal-title":"Arch Clin Neuropsychol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0046","first-page":"82","article-title":"The ALFA project: a research platform to identify early pathophysiological features of Alzheimer's disease","volume":"2","author":"Molinuevo","year":"2016","journal-title":"Alzheimers Dementia"},{"key":"10.1016\/j.ahj.2024.09.028_bib0047","doi-asserted-by":"crossref","unstructured":"Cumplido-Mayoral I, Brugulat-Serrat A, S\u00e1nchez-Benavides G, et al. The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study. Lancet Healthy Longev. 2024;5:e276-e286. doi: 10.1016\/S2666-7568(24)00025-4.","DOI":"10.2139\/ssrn.4604778"},{"key":"10.1016\/j.ahj.2024.09.028_bib0048","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1177\/0271678X17702156","article-title":"Variability of physiological brain perfusion in healthy subjects \u2013 A systematic review of modifiers. Considerations for multi-center ASL studies","volume":"38","author":"Clement","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ahj.2024.09.028_bib0049","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81067","article-title":"Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer\u2019s disease and neurodegeneration stratified by sex","volume":"12","author":"Cumplido-Mayoral","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.ahj.2024.09.028_bib0050","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1109\/TMI.2015.2419072","article-title":"Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation","volume":"34","author":"Sudre","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.ahj.2024.09.028_bib0051","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/mrm.25083","article-title":"Time-encoded pseudocontinuous arterial spin labeling: basic properties and timing strategies for human applications: Basic Properties and Requirements of te-pCASL","volume":"72","author":"Teeuwisse","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ahj.2024.09.028_bib0052","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1002\/alz.14059","article-title":"Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum","volume":"20","author":"Falcon","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ahj.2024.09.028_bib0053","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1093\/cercor\/bhac239","article-title":"Genotypic effects of APOE-\u03b54 on resting-state connectivity in cognitively intact individuals support functional brain compensation","volume":"33","author":"Cacciaglia","year":"2023","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.ahj.2024.09.028_bib0054","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.2967\/jnumed.116.188029","article-title":"Forward to the past: the case for quantitative PET imaging","volume":"58","author":"Lammertsma","year":"2017","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ahj.2024.09.028_bib0055","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.jacc.2016.08.073","article-title":"A\u03b2 amyloid pathology affects the hearts of patients with alzheimer's disease","volume":"68","author":"Troncone","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ahj.2024.09.028_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3941\/jrcr.v13i8.3633","article-title":"Intracranial calcifications on CT: an updated review","volume":"13","author":"Saade","year":"2019","journal-title":"J Radiol Case Rep"},{"key":"10.1016\/j.ahj.2024.09.028_bib0057","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/NI:5:1:11","article-title":"The extensible neuroimaging archive toolkit: an informatics platform for managing, exploring, and sharing neuroimaging data","volume":"5","author":"Marcus","year":"2007","journal-title":"Neuroinformatics"},{"key":"10.1016\/j.ahj.2024.09.028_bib0058","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nn.4478","article-title":"Building better biomarkers: brain models in translational neuroimaging","volume":"20","author":"Woo","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ahj.2024.09.028_bib0059","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0146645314558019","article-title":"ICRP publication 128: radiation dose to patients from radiopharmaceuticals: a compendium of current information related to frequently used substances","volume":"44","author":"Mattsson","year":"2015","journal-title":"Ann ICRP"},{"key":"10.1016\/j.ahj.2024.09.028_bib0060","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1093\/eurheartj\/ehac378","article-title":"Effects of a comprehensive lifestyle intervention on cardiovascular health: the TANSNIP-PESA trial","volume":"43","author":"Garcia-Lunar","year":"2022","journal-title":"Eur Heart J"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324002618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324002618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:17Z","timestamp":1777392857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870324002618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"alternative-id":["S0002870324002618"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2024.09.028","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2024.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}