{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:32:19Z","timestamp":1777498339809,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ahj.2024.10.003","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T02:14:39Z","timestamp":1728612879000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Methylprednisolone for acute type A aortic dissection patients undergoing total arch replacement: Design and rationale of the Medal trial"],"prefix":"10.1016","volume":"279","author":[{"given":"Shujie","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shifu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengbin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahj.2024.10.003_bib0001","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/jamacardio.2022.2718","article-title":"Early mortality in type A acute aortic dissection: insights from the international registry of acute aortic dissection","volume":"7","author":"Harris","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.ahj.2024.10.003_bib0002","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/CM9.0000000000001459","article-title":"Clinical profiles and outcomes of acute type A aortic dissection and intramural hematoma in the current era: lessons from the first registry of aortic dissection in China","volume":"134","author":"Duan","year":"2021","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.ahj.2024.10.003_bib0003","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jtcvs.2021.04.053","article-title":"2021 The American Association for Thoracic Surgery expert consensus document: surgical treatment of acute type A aortic dissection","volume":"162","author":"Malaisrie","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2015.07.026","article-title":"Knowledge, attitudes, and practice preferences of Canadian cardiac surgeons toward the management of acute type A aortic dissection","volume":"150","author":"Peterson","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0005","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/ejcts\/ezu284","article-title":"Current trends in cannulation and neuroprotection during surgery of the aortic arch in Europe","volume":"47","author":"De Paulis","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0006","doi-asserted-by":"crossref","first-page":"156","DOI":"10.21037\/acs.2016.05.06","article-title":"Hemiarch versus total aortic arch replacement in acute type A dissection: a systematic review and meta-analysis","volume":"5","author":"Poon","year":"2016","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0007","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13019-019-1027-3","article-title":"Severe systemic inflammatory response syndrome in patients following Total aortic arch replacement with deep hypothermic circulatory arrest","volume":"14","author":"Li","year":"2019","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0008","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1010-7940(01)01099-5","article-title":"Cardiopulmonary bypass induced inflammation: pathophysiology and treatment","volume":"21","author":"Paparella","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0009","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic mechanisms of glucocorticoids","volume":"29","author":"Vandewalle","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ahj.2024.10.003_bib0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1010-7940(00)00336-5","article-title":"Preoperative high dose methylprednisolone attenuates the cerebral response to deep hypothermic circulatory arrest","volume":"17","author":"Langley","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0011","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.athoracsur.2003.09.067","article-title":"Preoperative glucocorticoids decrease pulmonary hypertension in piglets after cardiopulmonary bypass and circulatory arrest","volume":"77","author":"Pearl","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0012","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1010-7940(03)00164-7","article-title":"Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone","volume":"24","author":"Shum-Tim","year":"2003","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0013","first-page":"25","article-title":"Current conduct of deep hypothermic circulatory arrest in China","volume":"5","author":"Augoustides","year":"2013","journal-title":"HSR Proc Intensive Care Cardiovasc Anesth"},{"key":"10.1016\/j.ahj.2024.10.003_bib0014","first-page":"43","article-title":"Practice variations in the conduct of hypothermic circulatory arrest for adult aortic arch repair: focus on an emerging European paradigm","volume":"6","author":"Gutsche","year":"2014","journal-title":"Heart Lung Vessel"},{"key":"10.1016\/j.ahj.2024.10.003_bib0015","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1046\/j.1365-2044.2002.02787.x","article-title":"Pharmacological agents as cerebral protectants during deep hypothermic circulatory arrest in adult thoracic aortic surgery. A survey of current practice","volume":"57","author":"Dewhurst","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ahj.2024.10.003_bib0016","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/ejcts\/ezt182","article-title":"Intraoperative neuroprotective drugs without beneficial effects? Results of the German registry for acute aortic dissection type A (GERAADA)","volume":"44","author":"Kr\u00fcger","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0017","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.ahj.2024.10.003_bib0018","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/HCO.0000000000000667","article-title":"Type A aortic dissection complicated by malperfusion syndrome","volume":"34","author":"Norton","year":"2019","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.ahj.2024.10.003_bib0019","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(15)00273-1","article-title":"methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomized, double-blind, placebo-controlled trial","volume":"386","author":"Whitlock","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ahj.2024.10.003_bib0020","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1001\/jama.2012.14144","article-title":"Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial","volume":"308","author":"Dieleman","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2024.10.003_bib0021","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1001\/jama.2020.8133","article-title":"Effect of intraoperative dexamethasone on major complications and mortality among infants undergoing cardiac surgery: the DECISION randomized clinical trial","volume":"323","author":"Lomivorotov","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ahj.2024.10.003_bib0022","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0003-4975(90)90359-E","article-title":"Cerebrospinal fluid drainage and steroids provide better spinal cord protection during aortic cross-clamping than does either treatment alone","volume":"49","author":"Woloszyn","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0023","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1213\/01.ANE.0000180206.95542.76","article-title":"Large-dose pretreatment with methylprednisolone fails to attenuate neuronal injury after deep hypothermic circulatory arrest in a neonatal piglet model","volume":"101","author":"Schubert","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ahj.2024.10.003_bib0024","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1378\/chest.10-2639","article-title":"Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy","volume":"141","author":"Kerr","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.ahj.2024.10.003_bib0025","article-title":"Steroids for acute spinal cord injury","volume":"1","author":"Bracken","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ahj.2024.10.003_bib0026","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12931-022-02186-4","article-title":"Safety and efficacy of corticosteroids in ARDS patients: a systematic review and meta-analysis of RCT data","volume":"23","author":"Chang","year":"2022","journal-title":"Respir Res"},{"key":"10.1016\/j.ahj.2024.10.003_bib0027","doi-asserted-by":"crossref","first-page":"S289","DOI":"10.33549\/physiolres.934818","article-title":"Effect of methylprednisolone on experimental brain edema in rats - own experience reviewed","volume":"70","author":"Kozler","year":"2021","journal-title":"Physiol Res"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324002655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870324002655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:05:02Z","timestamp":1733130302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870324002655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":27,"alternative-id":["S0002870324002655"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2024.10.003","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylprednisolone for acute type A aortic dissection patients undergoing total arch replacement: Design and rationale of the Medal trial","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2024.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}