{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:09:23Z","timestamp":1792681763162,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ahj.2025.04.013","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:23:18Z","timestamp":1744892598000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Atrial fibrillation is associated with higher oxygen extraction in the human heart"],"prefix":"10.1016","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-6254","authenticated-orcid":false,"given":"Lee","family":"Bockus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1082-8858","authenticated-orcid":false,"given":"Ahmad","family":"Kassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaacoub","family":"Chahine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Chamoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romanos","family":"Haykal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nona","family":"Sotoodehnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ordovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazem","family":"Akoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ahj.2025.04.013_bib0001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/j.2040-4603.2015.tb00626.x","article-title":"Atrial fibrillation: mechanisms, therapeutics, and future directions","volume":"5","author":"Pellman","year":"2015","journal-title":"Compr Physiol"},{"issue":"15","key":"10.1016\/j.ahj.2025.04.013_bib0002","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009218","article-title":"Myocardial perfusion is impaired and relates to cardiac dysfunction in patients with atrial fibrillation both before and after successful catheter ablation","volume":"7","author":"Wijesurendra","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"10.1016\/j.ahj.2025.04.013_bib0003","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jchf.2019.03.005","article-title":"Heart failure and atrial fibrillation, like fire and fury","volume":"7","author":"Carlisle","year":"2019","journal-title":"JACC Heart Fail"},{"issue":"4","key":"10.1016\/j.ahj.2025.04.013_bib0004","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jjcc.2018.12.011","article-title":"Impact of stroke volume on prognostic outcome in patients with atrial fibrillation and concomitant heart failure with preserved ejection fraction","volume":"73","author":"Hayashi","year":"2019","journal-title":"J Cardiol"},{"issue":"8","key":"10.1016\/j.ahj.2025.04.013_bib0005","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4065\/75.8.790","article-title":"Tachycardia-related cardiomyopathy: a common cause of ventricular dysfunction in patients with atrial fibrillation referred for atrioventricular ablation","volume":"75","author":"Redfield","year":"2000","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0006","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10840-016-0131-8","article-title":"Changes in left ventricular filling parameters following catheter ablation of atrial fibrillation","volume":"47","author":"Krezowski","year":"2016","journal-title":"J Interv Card Electrophysiol"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0007","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1540-8167.2006.00653.x","article-title":"Reversal of left ventricular dysfunction following ablation of atrial fibrillation","volume":"18","author":"Gentlesk","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"22","key":"10.1016\/j.ahj.2025.04.013_bib0008","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/01.CIR.0000039327.11661.16","article-title":"Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke","volume":"106","author":"Cai","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0009","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3349\/ymj.2016.57.1.64","article-title":"Left ventricular filling pressure as assessed by the E\/e\u2019 Ratio is a determinant of atrial fibrillation recurrence after cardioversion","volume":"57","author":"Chung","year":"2016","journal-title":"Yonsei Med J"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0010","first-page":"29","article-title":"The relationship between coronary microvascular dysfunction, atrial fibrillation and heart failure with preserved ejection fraction","volume":"11","author":"Ozcan","year":"2021","journal-title":"Am J Cardiovasc Dis"},{"issue":"5","key":"10.1016\/j.ahj.2025.04.013_bib0011","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.amjmed.2005.10.057","article-title":"Quality of life in patients with atrial fibrillation: a systematic review","volume":"119","author":"Thrall","year":"2006","journal-title":"Am J Med"},{"issue":"7","key":"10.1016\/j.ahj.2025.04.013_bib0012","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/europace\/eut395","article-title":"The European Heart Rhythm Association symptom classification for atrial fibrillation: validation and improvement through a simple modification","volume":"16","author":"Wynn","year":"2014","journal-title":"Europace"},{"issue":"253","key":"10.1016\/j.ahj.2025.04.013_bib0013","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01621459.1951.10500769","article-title":"The Kolmogorov-Smirnov test for goodness of fit","volume":"46","author":"Massey","year":"1951","journal-title":"J Am Stat Assoc"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0014","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/cvr\/cvt239","article-title":"Atrial supply\u2013demand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation","volume":"101","author":"van Bragt","year":"2014","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.ahj.2025.04.013_bib0015","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41569-024-01038-6","article-title":"Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications","volume":"21","author":"Bode","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"17","key":"10.1016\/j.ahj.2025.04.013_bib0016","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1161\/circ.104.17.2118","volume":"104","author":"Members","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0017","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0008-6363(01)00453-9","article-title":"Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort","volume":"53","author":"Schotten","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.ahj.2025.04.013_bib0018","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.hroo.2020.05.002","article-title":"Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease","volume":"1","author":"Jansen","year":"2020","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.ahj.2025.04.013_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.hroo.2025.01.002","article-title":"Atrial FDG uptake and Atrial fibrillation: a systematic review and meta-analysis","author":"Kassar","year":"2025","journal-title":"Heart Rhythm O2"},{"issue":"11","key":"10.1016\/j.ahj.2025.04.013_bib0020","first-page":"euae258","article-title":"Atrial fibrillation substrate and impaired left atrial function: a cardiac MRI study","volume":"26","author":"Chahine","year":"2024","journal-title":"EP Eur"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0021","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12968-021-00790-9","article-title":"Prognostic value of resting coronary sinus flow determined by phase-contrast cine cardiovascular magnetic resonance in patients with known or suspected coronary artery disease","volume":"23","author":"Kato","year":"2021","journal-title":"J Cardiovasc Magn Reson"},{"issue":"5","key":"10.1016\/j.ahj.2025.04.013_bib0022","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2214\/ajr.177.5.1771161","article-title":"Assessing coronary sinus blood flow in patients with coronary artery disease","volume":"177","author":"Koskenvuo","year":"2001","journal-title":"Am J Roentgenol"},{"issue":"4","key":"10.1016\/j.ahj.2025.04.013_bib0023","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1253\/jcj.42.417","article-title":"Effect of atrial fibrillation on coronary circulation and blood flow distribution across the left ventricular wall in anesthetized open-chest dogs","volume":"42","author":"Saito","year":"1978","journal-title":"Jpn Circ J"},{"issue":"9","key":"10.1016\/j.ahj.2025.04.013_bib0024","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/euhj.2001.2894","article-title":"Effect of acute atrial fibrillation on phasic coronary blood flow pattern and flow reserve in humans","volume":"23","author":"Kochiadakis","year":"2002","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2025.04.013_bib0025","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.25.1.47","article-title":"Decreased affinity of blood for oxygen in patients with low-output heart failure","volume":"25","author":"Metcalfe","year":"1969","journal-title":"Circ Res"},{"issue":"8","key":"10.1016\/j.ahj.2025.04.013_bib0026","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/clc.22564","article-title":"Cardiogenic shock: failure of oxygen delivery and oxygen utilization","volume":"39","author":"Lim","year":"2016","journal-title":"Clin Cardiol"},{"issue":"1","key":"10.1016\/j.ahj.2025.04.013_bib0027","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41598-022-04897-6","article-title":"A computational analysis of atrial fibrillation effects on coronary perfusion across the different myocardial layers","volume":"12","author":"Saglietto","year":"2022","journal-title":"Sci Rep"},{"issue":"18","key":"10.1016\/j.ahj.2025.04.013_bib0028","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/eurheartj\/ehm246","article-title":"Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation","volume":"28","author":"Range","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ahj.2025.04.013_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.763933","article-title":"Influence of high hemoglobin-oxygen affinity on humans during hypoxia","volume":"12","author":"Webb","year":"2022","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.ahj.2025.04.013_bib0030","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/CIRCRESAHA.116.308925","article-title":"Myocardial ischemia: lack of coronary blood flow or Myocardial oxygen supply\/demand imbalance?","volume":"119","author":"Heusch","year":"2016","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.ahj.2025.04.013_bib0031","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCULATIONAHA.117.029058","article-title":"Exercise intolerance in heart failure with preserved ejection fraction: diagnosing and ranking its causes using personalized O2 pathway analysis","volume":"137","author":"Houstis","year":"2018","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.ahj.2025.04.013_bib0032","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.jacc.2017.08.012","article-title":"Exercise testing: what is its value?","volume":"70","author":"Guazzi","year":"2017","journal-title":"J Am Coll Cardiol"}],"container-title":["American Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870325001292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002870325001292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:21:13Z","timestamp":1748319673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002870325001292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"alternative-id":["S0002870325001292"],"URL":"https:\/\/doi.org\/10.1016\/j.ahj.2025.04.013","relation":{},"ISSN":["0002-8703"],"issn-type":[{"value":"0002-8703","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atrial fibrillation is associated with higher oxygen extraction in the human heart","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2025.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ahj.2025.04.014","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}