{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:11:54Z","timestamp":1783123914479,"version":"3.54.6"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ahjo.2025.100535","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T08:56:47Z","timestamp":1743497807000},"page":"100535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of aficamten in obstructive hypertrophic cardiomyopathy: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"53","author":[{"given":"Muhammad Nabeel","family":"Saddique","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Qadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Javaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Iftikhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zain ul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laveeza","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Safiullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Imaz","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"Shamoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-685X","authenticated-orcid":false,"given":"Javed","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ahjo.2025.100535_bb0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/hrt.26.1.16","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"26","author":"Cohen","year":"1964","journal-title":"Heart"},{"key":"10.1016\/j.ahjo.2025.100535_bb0010","first-page":"174","article-title":"Hypertrophic obstructive cardiomyopathy: a review of the patho-anatomic findings and the clinical characteristics including a report of two additional cases","volume":"81A","author":"Simonsen","year":"1973","journal-title":"Acta Pathol. Microbiol. Scand. A"},{"key":"10.1016\/j.ahjo.2025.100535_bb0015","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4103\/ija.IJA_775_18","article-title":"Labour epidural analgesia in hypertrophic obstructive cardiomyopathy","volume":"63","author":"Sivakumar","year":"2019","journal-title":"Indian J. Anaesth."},{"key":"10.1016\/j.ahjo.2025.100535_bb0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.amjcard.2022.01.036","article-title":"Global dissemination and implementation of contemporary management principles for hypertrophic cardiomyopathy and role of the international HCM summit","volume":"172","author":"Maron","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100535_bb0025","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/13696998.2021.1978242","article-title":"Clinical and economic burden of obstructive hypertrophic cardiomyopathy in the United States","volume":"24","author":"Jain","year":"2021","journal-title":"J. Med. Econ."},{"key":"10.1016\/j.ahjo.2025.100535_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s41687-020-00269-8","article-title":"Patient experiences with hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life","volume":"4","author":"Zaiser","year":"2020","journal-title":"J. Patient-Rep. Outcomes"},{"key":"10.1016\/j.ahjo.2025.100535_bb0035","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.3390\/jcm12175710","article-title":"Revisiting diagnosis and treatment of hypertrophic cardiomyopathy: current practice and novel perspectives","volume":"12","author":"Ottaviani","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ahjo.2025.100535_bb0040","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2021.11.021","article-title":"Management of hypertrophic cardiomyopathy","volume":"79","author":"Maron","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100535_bb0045","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/CIRCHEARTFAILURE.112.000122","article-title":"Treatment of obstructive hypertrophic cardiomyopathy symptoms and gradient resistant to first-line therapy with \u03b2-blockade or verapamil","volume":"6","author":"Sherrid","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.ahjo.2025.100535_bb0050","unstructured":"Aficamten looks promising for symptomatic obstructive hypertrophic cardiomyopathy n.d. https:\/\/www.empr.com\/home\/news\/drugs-in-the-pipeline\/aficamten-looks-promising-for-symptomatic-obstructive-hypertrophic-cardiomyopathy\/ (accessed July 30, 2024)."},{"key":"10.1016\/j.ahjo.2025.100535_bb0055","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa2401424","article-title":"Aficamten for symptomatic obstructive hypertrophic cardiomyopathy","volume":"390","author":"Maron","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ahjo.2025.100535_bb0060","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jacc.2022.10.020","article-title":"Phase 2 study of Aficamten in patients with obstructive hypertrophic cardiomyopathy","volume":"81","author":"Maron","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100535_bb0065","unstructured":"Cytokinetics Announces Primary Results From SEQUOIA-HCM Presented in Late Breaking Clinical Trial Session at the European Society of Cardiology Heart Failure 2024 Congress - BioSpace n.d. https:\/\/www.biospace.com\/cytokinetics-announces-primary-results-from-sequoia-hcm-presented-in-late-breaking-clinical-trial-session-at-the-european-society-of-cardiology-heart-failure-2024-congress-and-published-in-the-new-england-journal-of-medicine (accessed July 30, 2024)."},{"key":"10.1016\/j.ahjo.2025.100535_bb0070","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024656","article-title":"Cardiac myosin inhibitors as a novel treatment option for obstructive hypertrophic cardiomyopathy: addressing the core of the matter","volume":"11","author":"Masri","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ahjo.2025.100535_bb0075","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jchf.2023.04.018","article-title":"Cardiac myosin inhibitors for managing obstructive hypertrophic cardiomyopathy","volume":"11","author":"Ostrominski","year":"2023","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.ahjo.2025.100535_bb0080","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ahjo.2025.100535_bb0085","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2019"},{"key":"10.1016\/j.ahjo.2025.100535_bb0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.ahjo.2025.100535_bb0095","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.cardfail.2022.10.022","article-title":"Efficacy and safety of Aficamten in patients with symptomatic obstructive hypertrophic cardiomyopathy: interim results from the randomized evaluation of dosing with Ck-3773274 in hypertrophic cardiomyopathy open label extension study","volume":"29","author":"Masri","year":"2023","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ahjo.2025.100535_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardfail.2024.02.020","article-title":"Efficacy and safety of Aficamten in symptomatic nonobstructive hypertrophic cardiomyopathy: results from the REDWOOD-HCM trial, cohort 4","author":"Masri","year":"2024","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ahjo.2025.100535_bb0105","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0735-1097(24)02346-5","article-title":"Efficacy and safety of Aficamten in the first cohort of patients with symptomatic obstructive hypertrophic cardiomyopathy completing 1-year follow-up: findings from the FOREST-HCM study","volume":"83","author":"Saberi","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100535_bb0110","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ahjo.2025.100535_bb0115","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the sarcomeric human cardiomyopathy registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2025.100535_bb0120","first-page":"142","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","author":"Writing Committee Members","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2025.100535_bb0125","first-page":"124","article-title":"2011 ACCF\/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","author":"Gersh","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2025.100535_bb0130","first-page":"108","article-title":"Hypertrophic cardiomyopathy: a patient perspective","author":"Nishimura","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2025.100535_bb0135","unstructured":"A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy 2023."}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T21:19:19Z","timestamp":1747084759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602225000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":27,"alternative-id":["S2666602225000382"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100535","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of aficamten in obstructive hypertrophic cardiomyopathy: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100535"}}