{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:33:41Z","timestamp":1793799221006,"version":"4.6.1"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004637","name":"Nanchang University","doi-asserted-by":"publisher","award":["JZ022"],"award-info":[{"award-number":["JZ022"]}],"id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB20343"],"award-info":[{"award-number":["20242BAB20343"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ahjo.2025.100653","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:24:28Z","timestamp":1761146668000},"page":"100653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Phase-dependent iron dysmetabolism in myocardial ischemia-reperfusion injury: From mechanisms to therapies"],"prefix":"10.1016","volume":"60","author":[{"given":"Yilin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ahjo.2025.100653_bb0010","first-page":"669","article-title":"Report on cardiovascular health and diseases in China 2022: an updated summary","volume":"36","author":"Writing Committee Of The Report On Cardiovascular Health And Diseases In China","year":"2023","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CP9.0000000000000078","article-title":"Pan-vascular disease: what we have done in the past and what we can do in the future?","volume":"9","author":"Wong","year":"2024","journal-title":"Cardiol. Plus"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0020","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbadis.2018.10.011","article-title":"The role of mitochondria in sepsis-induced cardiomyopathy","volume":"1865","author":"Stanzani","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","article-title":"Regulated cell death in myocardial ischemia-reperfusion injury","volume":"35","author":"Xiang","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.ahjo.2025.100653_bb0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"Myocardial ischemia-reperfusion injury and the influence of inflammation","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"issue":"11","key":"10.1016\/j.ahjo.2025.100653_bb0035","first-page":"774","article-title":"The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge","volume":"38","author":"Heusch","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahjo.2025.100653_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155649","article-title":"The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ahjo.2025.100653_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114706","article-title":"Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment","volume":"165","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"19","key":"10.1016\/j.ahjo.2025.100653_bb0050","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","article-title":"Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte Ferroptosis","volume":"147","author":"Cai","year":"2023","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0055","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2016.02.016","article-title":"Macrophages and Iron metabolism","volume":"44","author":"Soares","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.ahjo.2025.100653_bb0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuro.2021.11.003","article-title":"Mitochondrial iron metabolism and neurodegenerative diseases","volume":"88","author":"Cheng","year":"2022","journal-title":"Neurotoxicology"},{"issue":"7","key":"10.1016\/j.ahjo.2025.100653_bb0065","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0080","article-title":"Oxidative stress induces mitochondrial iron overload and ferroptotic cell death","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ahjo.2025.100653_bb0085","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2022.08.018","article-title":"Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes","volume":"190","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ahjo.2025.100653_bb0090","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","article-title":"Hepcidin and Iron in health and disease","volume":"74","author":"Nemeth","year":"2023","journal-title":"Annu. Rev. Med."},{"issue":"40","key":"10.1016\/j.ahjo.2025.100653_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq4469","article-title":"Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow","volume":"8","author":"Bonadonna","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ahjo.2025.100653_bb0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-030-62026-4_4","article-title":"The role of NCOA4-mediated Ferritinophagy in Ferroptosis","volume":"1301","author":"Santana-Codina","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.ahjo.2025.100653_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade9585","article-title":"NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8","volume":"9","author":"Anandhan","year":"2023","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043995","article-title":"Managing the dual nature of Iron to preserve health","volume":"24","author":"Silvestri","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"Supplement_2","key":"10.1016\/j.ahjo.2025.100653_bb0120","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/ehaa946.1578","article-title":"Iron deficiency is associated with larger infarcts and with adverse remodeling in STEMI patients and reduces myocardial tolerance to ischemia\/reperfusion by inhibiting the eNOS\/sGC\/PKG pathway in mice","volume":"41","author":"Barrabes","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ahjo.2025.100653_bb0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2023.06.016","article-title":"Frataxin inhibits the sensitivity of the myocardium to ferroptosis by regulating iron homeostasis","volume":"205","author":"Zhang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70269","article-title":"Interleukin 27 deficiency drives dilated cardiomyopathy by ferroptosis","volume":"15","author":"Zhao","year":"2025","journal-title":"Clin. Transl. Med."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100653_bb0135","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jacc.2008.06.019","article-title":"Hemoxygenase-1 in cardiovascular disease","volume":"52","author":"Idriss","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100653_bb0140","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9626703","article-title":"Pretreatment with panaxatriol saponin attenuates mitochondrial apoptosis and oxidative stress to facilitate treatment of myocardial ischemia-reperfusion injury via the regulation of Keap1\/Nrf2 activity","volume":"2022","author":"Yao","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"15","key":"10.1016\/j.ahjo.2025.100653_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158300","article-title":"Counteraction of myocardial ferritin heavy chain deficiency by Heme Oxygenase-1","volume":"23","author":"Machado","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ahjo.2025.100653_bb0150","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jacbts.2022.03.012","article-title":"Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury","volume":"7","author":"Miyamoto","year":"2022","journal-title":"JACC Basic Transl. Sci."},{"issue":"5","key":"10.1016\/j.ahjo.2025.100653_bb0155","first-page":"362","article-title":"Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure","volume":"38","author":"Haddad","year":"2017","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100653_bb0160","doi-asserted-by":"crossref","first-page":"21613","DOI":"10.1002\/jcp.28820","article-title":"Iron and the heart: a paradigm shift from systemic to cardiomyocyte abnormalities","volume":"234","author":"Paterek","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ahjo.2025.100653_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122439","article-title":"The molecular mechanisms and potential drug targets of ferroptosis in myocardial ischemia-reperfusion injury","volume":"340","author":"Zhang","year":"2024","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0170","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3892\/ol.2021.12918","article-title":"Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma","volume":"22","author":"Yao","year":"2021","journal-title":"Oncol. Lett."},{"issue":"7","key":"10.1016\/j.ahjo.2025.100653_bb0175","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jacbts.2021.05.004","article-title":"Implications of iron deficiency in STEMI patients and in a murine model of myocardial infarction","volume":"6","author":"Inserte","year":"2021","journal-title":"JACC Basic Transl. Sci."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33277-2","article-title":"Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores","volume":"8","author":"Paterek","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1039\/C4MT00215F","article-title":"Speciation of iron in mouse liver during development, iron deficiency, IRP2 deletion and inflammatory hepatitis","volume":"7","author":"Chakrabarti","year":"2015","journal-title":"Metallomics"},{"issue":"11","key":"10.1016\/j.ahjo.2025.100653_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118830","article-title":"Management versus miscues in the cytosolic labile iron pool: the varied functions of iron chaperones","volume":"1867","author":"Philpott","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.ahjo.2025.100653_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in Ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/jhep.2002.33997","article-title":"Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion","volume":"36","author":"Tacchini","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ahjo.2025.100653_bb0205","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.freeradbiomed.2020.10.307","article-title":"Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53\/TfR1 pathway in the rat hearts after ischemia\/reperfusion","volume":"162","author":"Tang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.ahjo.2025.100653_bb0210","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.ahjo.2025.100653_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22150","article-title":"Protective effect and mechanism of different proportions of \"Danggui-Kushen\" herb pair on ischemic heart disease","volume":"9","author":"Yuan","year":"2023","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0220","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00011-022-01672-1","article-title":"Molecular mechanisms of ferroptosis and relevance to inflammation","volume":"72","author":"Deng","year":"2023","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.ahjo.2025.100653_bb0225","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1089\/ars.2012.4885","article-title":"Lysosomal iron, iron chelation, and cell death","volume":"18","author":"Terman","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0230","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41420-021-00656-0","article-title":"Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia\/reperfusion injury","volume":"7","author":"Li","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ahjo.2025.100653_bb0235","first-page":"10","article-title":"Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice","author":"Ito","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ahjo.2025.100653_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ahjo.2025.100653_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114269","article-title":"cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy","volume":"359","author":"Li","year":"2023","journal-title":"Exp. Neurol."},{"issue":"13","key":"10.1016\/j.ahjo.2025.100653_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137041","article-title":"Beneficial and detrimental roles of Heme Oxygenase-1 in the neurovascular system","volume":"23","author":"Choi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.ahjo.2025.100653_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/cells11142152","article-title":"Iron-induced oxidative stress in human diseases","volume":"11","author":"Kawabata","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ahjo.2025.100653_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102413","article-title":"NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ahjo.2025.100653_bb0265","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6639199","article-title":"Reactive oxygen species and their involvement in red blood cell damage in chronic kidney disease","volume":"2021","author":"Gwozdzinski","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100653_bb0270","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1161\/CIRCULATIONAHA.118.034545","article-title":"Iron regulator Hepcidin impairs macrophage-dependent cardiac repair after injury","volume":"139","author":"Zlatanova","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0275","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3324\/haematol.2019.232124","article-title":"Iron metabolism and iron disorders revisited in the hepcidin era","volume":"105","author":"Camaschella","year":"2020","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.ahjo.2025.100653_bb0280","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep4.1717","article-title":"Hepcidin signaling in health and disease: ironing out the details","volume":"5","author":"Kowdley","year":"2021","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.ahjo.2025.100653_bb0285","first-page":"1","article-title":"Dexmedetomidine inhibits Ferroptosis to alleviate hypoxia\/Reoxygenation-induced cardiomyocyte injury by regulating the HDAC2\/FPN pathway","author":"Fu","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"7831","key":"10.1016\/j.ahjo.2025.100653_bb0290","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-020-2668-z","article-title":"Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms","volume":"586","author":"Billesb\u00f8lle","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ahjo.2025.100653_bb0295","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.gde.2016.02.004","article-title":"Mitochondrial iron overload: causes and consequences","volume":"38","author":"Rouault","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/life11040332","article-title":"Mitochondrial dynamics, ROS, and cell signaling: a blended overview","volume":"11","author":"Brillo","year":"2021","journal-title":"Life"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0305","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0310","doi-asserted-by":"crossref","first-page":"247","DOI":"10.15252\/emmm.201505748","article-title":"Reduction in mitochondrial iron alleviates cardiac damage during injury","volume":"8","author":"Chang","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ahjo.2025.100653_bb0315","article-title":"A novel insight into the fate of cardiomyocytes in ischemia-reperfusion injury: from Iron metabolism to Ferroptosis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"19","key":"10.1016\/j.ahjo.2025.100653_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by Ferroptosis: antioxidants as Mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ahjo.2025.100653_bb0325","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6889278","article-title":"Ischemic preconditioning and postconditioning protect the heart by preserving the mitochondrial network","volume":"2022","author":"Ismail","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"1\u20132","key":"10.1016\/j.ahjo.2025.100653_bb0330","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10495-022-01786-1","article-title":"Regulation of autophagy of the heart in ischemia and reperfusion","volume":"28","author":"Popov","year":"2023","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0335","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13293-021-00392-1","article-title":"Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females","volume":"12","author":"S\u00e1rk\u00f6zy","year":"2021","journal-title":"Biol. Sex Differ."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0340","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-024-03965-0","article-title":"Ischemic preconditioning modulates the DNA methylation process of the rat heart to provide tolerance to withstand ischemia reperfusion injury and its associated mitochondrial dysfunction","volume":"14","author":"Boovarahan","year":"2024","journal-title":"3 Biotech"},{"issue":"1\u20132","key":"10.1016\/j.ahjo.2025.100653_bb0345","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1015923202082","article-title":"Roles of ferritin and iron in ischemic preconditioning of the heart","volume":"234-235","author":"Berenshtein","year":"2002","journal-title":"Mol. Cell. Biochem."},{"issue":"21","key":"10.1016\/j.ahjo.2025.100653_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217889","article-title":"The molecular mechanisms of Iron metabolism and its role in cardiac dysfunction and Cardioprotection","volume":"21","author":"Ravingerov\u00e1","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ahjo.2025.100653_bb0355","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.yjmcc.2008.08.011","article-title":"Heart protection by ischemic preconditioning: a novel pathway initiated by iron and mediated by ferritin","volume":"45","author":"Chevion","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"7","key":"10.1016\/j.ahjo.2025.100653_bb0360","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ahjo.2025.100653_bb0365","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","article-title":"Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury","volume":"160","author":"Li","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.ahjo.2025.100653_bb0370","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/iub.1616","article-title":"Iron and ferroptosis: a still ill-defined liaison","volume":"69","author":"Doll","year":"2017","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0375","first-page":"195","article-title":"Combined intravenous treatment with ascorbic acid and desferrioxamine to reduce myocardial reperfusion injury in an experimental model resembling the clinical setting of primary PCI","volume":"53","author":"Chatziathanasiou","year":"2012","journal-title":"Hellenic J. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100653_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173999","article-title":"Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis","volume":"898","author":"Tu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ahjo.2025.100653_bb0385","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev-pharmtox-010715-103335","article-title":"Mitochondrial dysfunction and myocardial ischemia-reperfusion: implications for novel therapies","volume":"57","author":"Lesnefsky","year":"2017","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.ahjo.2025.100653_bb0390","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10534-017-0039-5","article-title":"Triphenylphosphonium-desferrioxamine as a candidate mitochondrial iron chelator","volume":"30","author":"Alta","year":"2017","journal-title":"Biometals"},{"issue":"9","key":"10.1016\/j.ahjo.2025.100653_bb0395","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1158\/0008-5472.CAN-20-1628","article-title":"Targeting mitochondrial Iron metabolism suppresses tumor growth and metastasis by inducing mitochondrial dysfunction and Mitophagy","volume":"81","author":"Sandoval-Acu\u00f1a","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0400","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12951-025-03197-1","article-title":"Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models","volume":"23","author":"Zhu","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0405","first-page":"190","article-title":"Polydopamine nanoparticles-encapsulated Ferroptosis inhibitor Ferstatin-1 promotes GPX4 expression by Down-regulating NOX4 to alleviate myocardial ischemia-reperfusion injury","volume":"54","author":"Hong","year":"2024","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"Pt 5","key":"10.1016\/j.ahjo.2025.100653_bb0410","article-title":"Myocardial cell mitochondria-targeted mesoporous polydopamine nanoparticles eliminate inflammatory damage in cardiovascular disease","volume":"282","author":"Zheng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"29","key":"10.1016\/j.ahjo.2025.100653_bb0415","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/eurheartj\/ehy232","article-title":"Nitric oxide for inhalation in ST-elevation myocardial infarction (NOMI): a multicentre, double-blind, randomized controlled trial","volume":"39","author":"Janssens","year":"2018","journal-title":"Eur. Heart J."},{"issue":"25","key":"10.1016\/j.ahjo.2025.100653_bb0420","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/j.jacc.2013.03.050","article-title":"Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models","volume":"61","author":"Ingram","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0425","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/eurheartj\/ehi028","article-title":"Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance","volume":"26","author":"Paraskevaidis","year":"2005","journal-title":"Eur. Heart J."},{"issue":"1\u20132","key":"10.1016\/j.ahjo.2025.100653_bb0430","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10495-024-02040-6","article-title":"Melatonin ameliorates inflammation and improves outcomes of ischemia\/reperfusion injury in patients undergoing coronary artery bypass grafting surgery: a randomized placebo-controlled study","volume":"30","author":"Casper","year":"2025","journal-title":"Apoptosis"},{"key":"10.1016\/j.ahjo.2025.100653_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118004","article-title":"Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat","volume":"257","author":"Tang","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100653_bb0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00228-003-0564-8","article-title":"Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysis, results of the ATTenuation by adenosine of cardiac complications (ATTACC) study","volume":"59","author":"Quintana","year":"2003","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0445","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0022-5223(03)00209-5","article-title":"Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study","volume":"126","author":"Boyce","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0450","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezae306","article-title":"Protective effects of fructose-1,6-bisphosphate postconditioning on myocardial ischaemia-reperfusion injury in patients undergoing valve replacement: a randomized, double-blind, placebo-controlled clinical trial","volume":"66","author":"Xu","year":"2024","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"15","key":"10.1016\/j.ahjo.2025.100653_bb0455","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2021.02.049","article-title":"Randomized trial of Interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction","volume":"77","author":"Broch","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.ahjo.2025.100653_bb0460","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/cpdd.1443","article-title":"Safety and pharmacokinetics of a combined antioxidant therapy against myocardial reperfusion injury: a phase 1 randomized clinical trial in healthy humans","volume":"13","author":"Gajardo Cortez","year":"2024","journal-title":"Clin. Pharmacol. Drug Dev."},{"issue":"6","key":"10.1016\/j.ahjo.2025.100653_bb0465","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2024.5434","article-title":"Curcumin pretreatment attenuates myocardial ischemia\/reperfusion injury by inhibiting ferroptosis, autophagy and apoptosis via HES1","volume":"54","author":"Yuan","year":"2024","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100653_bb0470","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2025.5492","article-title":"Curcumin attenuates myocardial ischemia-reperfusion-induced autophagy-dependent ferroptosis via Sirt1\/AKT\/FoxO3a signaling","volume":"55","author":"Zhao","year":"2025","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.ahjo.2025.100653_bb0475","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2023.5312","article-title":"Tanshinone IIA confers protection against myocardial ischemia\/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1","volume":"52","author":"Hu","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ahjo.2025.100653_bb0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.05.012","article-title":"Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2\/HO-1\/SLC7a11\/GPX4 axis in mice","volume":"221","author":"Yao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ahjo.2025.100653_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154999","article-title":"EGCG attenuated acute myocardial infarction by inhibiting ferroptosis via miR-450b-5p\/ACSL4 axis","volume":"119","author":"Yu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ahjo.2025.100653_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155365","article-title":"Salidroside pretreatment alleviates ferroptosis induced by myocardial ischemia\/reperfusion through mitochondrial superoxide-dependent AMPK\u03b12 activation","volume":"128","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0495","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70223","article-title":"Apelin-13 protects against myocardial hypoxia\/Reoxygenation (H\/R) injury by inhibiting Ferroptosis via Nrf2 activation","volume":"39","author":"Liang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0500","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1080\/21655979.2021.1995994","article-title":"Naringenin alleviates myocardial ischemia\/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)\/System xc-\/glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis","volume":"12","author":"Xu","year":"2021","journal-title":"Bioengineered"},{"issue":"2","key":"10.1016\/j.ahjo.2025.100653_bb0505","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11626-024-00995-z","article-title":"Melatonin inhibits ferroptosis through the ATF3\/GPX4 signaling pathway to relieve myocardial ischemia-reperfusion injury in rats","volume":"61","author":"He","year":"2025","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.ahjo.2025.100653_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177599","article-title":"Combined administration of dexmedetomidine and propofol mitigates myocardial ischemia\/reperfusion injury by modulating the Akt\/mTOR\/Nrf2 axis to suppress ferroptosis","volume":"997","author":"Yang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100653_bb0515","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/CP9.0000000000000098","article-title":"Time to rename the \u201cischemia\/reperfusion injury\u201d model to \u201cischemia\/delayed reperfusion injury\u201d model?","volume":"9","author":"Liu","year":"2024","journal-title":"Cardiol. Plus"}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225001569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225001569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:19:25Z","timestamp":1793798365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602225001569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":102,"alternative-id":["S2666602225001569"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100653","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase-dependent iron dysmetabolism in myocardial ischemia-reperfusion injury: From mechanisms to therapies","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100653"}}