{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:40:56Z","timestamp":1768466456197,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL157311"],"award-info":[{"award-number":["1R01HL157311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54AG062334"],"award-info":[{"award-number":["1U54AG062334"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ahjo.2025.100696","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:44:16Z","timestamp":1765593856000},"page":"100696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Symptom experience of women with ischemia and no obstructive coronary artery disease: A mixed-methods approach"],"prefix":"10.1016","volume":"61","author":[{"given":"Sneha","family":"Thandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esha","family":"Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Gaignard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura P.","family":"Kimble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ahjo.2025.100696_bb0005","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1161\/CIR.0000000000001303","article-title":"Heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100696_bb0010","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/cvr\/cvaa001","article-title":"Sex differences in non-obstructive coronary artery disease","volume":"116","author":"Waheed","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100696_bb0015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ahj.2013.04.002","volume":"166","author":"Sharaf","year":"2013","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100696_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ahj.2013.03.015","article-title":"Sex differences in clinical outcomes in patients with stable angina and no obstructive coronary artery disease","volume":"166","author":"Sedlak","year":"2013","journal-title":"Am. Heart J."},{"issue":"11","key":"10.1016\/j.ahjo.2025.100696_bb0025","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/CIRCULATIONAHA.116.024534","article-title":"Ischemia and No Obstructive Coronary Artery Disease (INOCA): developing evidence-based therapies and research agenda for the next decade","volume":"135","author":"Bairey Merz","year":"2017","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ahjo.2025.100696_bb0030","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.105.609990","article-title":"The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health--National Heart, Lung, and Blood Institute--sponsored Women\u2019s Ischemia Syndrome Evaluation","volume":"114","author":"Shaw","year":"2006","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100696_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093170","article-title":"Burden of hospital admission and repeat angiography in angina pectoris patients with and without coronary artery disease: a registry-based cohort study","volume":"9","author":"Jespersen","year":"2014","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.ahjo.2025.100696_bb0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12170-019-0611-3","article-title":"Characteristic symptoms in women with ischemic heart disease","volume":"13","author":"Maas","year":"2019","journal-title":"Curr. Cardiovasc. Risk Rep."},{"key":"10.1016\/j.ahjo.2025.100696_bb0045","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ijcard.2016.12.091","article-title":"Depression and chest pain in patients with coronary artery disease","volume":"230","author":"Hayek","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100696_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.atherosclerosis.2022.11.009","article-title":"Ischemia and no obstructive coronary arteries (INOCA): a narrative review","volume":"363","author":"Mehta","year":"2022","journal-title":"Atherosclerosis"},{"issue":"15","key":"10.1016\/j.ahjo.2025.100696_bb0055","doi-asserted-by":"crossref","first-page":"e034644","DOI":"10.1161\/JAHA.124.034644","article-title":"Objective ischemia, subjective angina, and psychological distress in angina with no obstructive coronary disease","volume":"13","author":"Liu","year":"2024","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.ahjo.2025.100696_bb0060","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/smi.2928","article-title":"Psychological stress, cardiac symptoms, and cardiovascular risk in women with suspected ischaemia but no obstructive coronary disease","volume":"36","author":"Gomez","year":"2020","journal-title":"Stress. Health"},{"key":"10.1016\/j.ahjo.2025.100696_bb0065","article-title":"Clinical and psychological characteristics of patients with ischemia and non-obstructive coronary arteries (INOCA) and obstructive coronary artery disease","volume":"27","author":"van Schalkwijk","year":"2023","journal-title":"Am Heart J Plus."},{"issue":"17","key":"10.1016\/j.ahjo.2025.100696_bb0070","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.jacc.2023.08.028","article-title":"Psychosocial factors of women presenting with myocardial infarction with or without obstructive coronary arteries","volume":"82","author":"Hausvater","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"issue":"17","key":"10.1016\/j.ahjo.2025.100696_bb0075","doi-asserted-by":"crossref","first-page":"e021722","DOI":"10.1161\/JAHA.121.021722","article-title":"Anxiety disorders are associated with coronary endothelial dysfunction in women with chest pain and nonobstructive coronary artery disease","volume":"10","author":"Sara","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100696_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008126","article-title":"Ischemia and no obstructive coronary artery disease","volume":"12","author":"Ford","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.ahjo.2025.100696_bb0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijcard.2022.09.047","article-title":"Ischemia with no obstructive coronary artery disease (INOCA): a patient self-report quality of life survey from INOCA international","volume":"371","author":"Gulati","year":"2023","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ahjo.2025.100696_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcin.2019.11.001","article-title":"1-Year outcomes of angina management guided by invasive coronary function testing (CorMicA)","volume":"13","author":"Ford","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"issue":"10","key":"10.1016\/j.ahjo.2025.100696_bb0095","first-page":"1600","article-title":"One-year prospective follow-up of women with INOCA and MINOCA at a Canadian Women\u2019s Heart Centre","volume":"38","author":"Parvand","year":"2022","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ahjo.2025.100696_bb0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","article-title":"International standardization of diagnostic criteria for microvascular angina","volume":"250","author":"Ong","year":"2018","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100696_bb0105","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0735-1097(94)00397-9","article-title":"Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease","volume":"25","author":"Spertus","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100696_bb0110","first-page":"383","article-title":"Duke Activity Status Index for cardiovascular diseases: validation of the Portuguese translation","volume":"102","author":"Coutinho-Myrrha","year":"2014","journal-title":"Arq. Bras. Cardiol."},{"issue":"1\u20133","key":"10.1016\/j.ahjo.2025.100696_bb0115","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2008.06.026","article-title":"The PHQ-8 as a measure of current depression in the general population","volume":"114","author":"Kroenke","year":"2009","journal-title":"J. Affect. Disord."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100696_bb0120","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.cjco.2024.08.013","article-title":"Unveiling the longitudinal journey: 3-year follow-up of women with MINOCA and INOCA in a Specialized Heart Centre","volume":"6","author":"Th\u00e9berge","year":"2024","journal-title":"CJC Open."},{"issue":"8","key":"10.1016\/j.ahjo.2025.100696_bb0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00392-013-0568-z","article-title":"Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris","volume":"102","author":"Jespersen","year":"2013","journal-title":"Clin. Res. Cardiol."},{"issue":"7","key":"10.1016\/j.ahjo.2025.100696_bb0130","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jcmg.2021.01.041","article-title":"Functional and economic impact of INOCA and influence of coronary microvascular dysfunction","volume":"14","author":"Schumann","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"23","key":"10.1016\/j.ahjo.2025.100696_bb0135","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1093\/eurheartj\/ehy185","article-title":"Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis","volume":"39","author":"Radico","year":"2018","journal-title":"Eur Heart J."},{"key":"10.1016\/j.ahjo.2025.100696_bb0140","series-title":"Summary Health Statistics Tables for U.S. Adults: National Health Interview Survey. 6 April 2018","year":"2015"},{"issue":"17","key":"10.1016\/j.ahjo.2025.100696_bb0145","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008868","article-title":"Ischemia and No Obstructive Coronary Artery Disease (INOCA): what is the risk?","volume":"7","author":"Herscovici","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"2 Suppl 1","key":"10.1016\/j.ahjo.2025.100696_bb0150","first-page":"S31","article-title":"Symptom recognition and healthcare experiences of young women with acute myocardial infarction","volume":"8","author":"Lichtman","year":"2015","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"issue":"5","key":"10.1016\/j.ahjo.2025.100696_bb0155","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/JCN.0000000000000381","article-title":"A qualitative study of symptom experiences of women with acute coronary syndrome","volume":"32","author":"Davis","year":"2017","journal-title":"J. Cardiovasc. Nurs."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100696_bb0160","doi-asserted-by":"crossref","first-page":"e005948","DOI":"10.1161\/CIRCOUTCOMES.119.005948","article-title":"Sex differences in symptom phenotypes among patients with acute myocardial infarction","volume":"13","author":"Brush","year":"2020","journal-title":"Circ. Cardiovasc. Qual. Outcomes"}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T21:19:25Z","timestamp":1768425565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602225001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"alternative-id":["S2666602225001995"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100696","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptom experience of women with ischemia and no obstructive coronary artery disease: A mixed-methods approach","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100696"}}