{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:19:54Z","timestamp":1768015194617,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ahjo.2025.100699","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:34:43Z","timestamp":1765931683000},"page":"100699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mortality trends in heart failure and colon cancer: Insights into gender, ethnic, and regional disparities in the United States (1999\u20132020)"],"prefix":"10.1016","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-4230","authenticated-orcid":false,"given":"Hafsah Alim Ur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1280-9432","authenticated-orcid":false,"given":"Nimrah","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1468-4388","authenticated-orcid":false,"given":"Muhammad Ahmed Ali","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-9601","authenticated-orcid":false,"given":"Fayza","family":"Salman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Hassan","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4937-0639","authenticated-orcid":false,"given":"Omama","family":"Asim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Mansoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zain","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-2030","authenticated-orcid":false,"given":"Muhammad Sohaib","family":"Asghar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.ahjo.2025.100699_bb0005","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/heartjnl-2021-320131","article-title":"Prevalence, incidence and survival of heart failure: a systematic review","volume":"108","author":"Emmons-Bell","year":"2022","journal-title":"Heart"},{"issue":"7899","key":"10.1016\/j.ahjo.2025.100699_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-022-04437-2","article-title":"Effective drug combinations in breast, colon and pancreatic cancer cells","volume":"603","author":"Jaaks","year":"2022","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.ahjo.2025.100699_bb0015","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.ahjo.2025.100699_bb0020","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.ahjo.2025.100699_bb0025","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cardfail.2023.07.006","article-title":"Heart failure epidemiology and outcomes statistics: a report of the Heart Failure Society of America","volume":"29","author":"Bozkurt","year":"2023","journal-title":"J. Card. Fail."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100699_bb0030","first-page":"313","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018 Nov;68(6):394\u2013424. doi: 10.3322\/caac.21492. Epub 2018 Sep 12. Erratum in","volume":"70","author":"Bray","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ahjo.2025.100699_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100794","article-title":"Association between cardiovascular risk factors and colorectal cancer: a systematic review and meta-analysis of prospective cohort studies","volume":"34","author":"Zhang","year":"2021","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ahjo.2025.100699_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103346","article-title":"Risk factors of fluoropyrimidine induced cardiotoxicity among cancer patients: a systematic review and meta-analysis","volume":"162","author":"Li","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"4","key":"10.1016\/j.ahjo.2025.100699_bb0045","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.6687","article-title":"Black representation in the primary care physician workforce and its association with population life expectancy and mortality rates in the US","volume":"6","author":"Snyder","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ahjo.2025.100699_bb0050","author":"Centers for Disease Control and Prevention"},{"key":"10.1016\/j.ahjo.2025.100699_bb0055","first-page":"1","article-title":"2013 NCHS urban-rural classification scheme for counties","volume":"166","author":"Ingram","year":"2014","journal-title":"Vital Health Stat. Ser. 2 Data Eval. Methods Res."},{"key":"10.1016\/j.ahjo.2025.100699_bb0060","series-title":"Geographic Division or Region","author":"Centers for Disease Control and Prevention","year":"2024"},{"issue":"9","key":"10.1016\/j.ahjo.2025.100699_bb0065","first-page":"e139","article-title":"Heart disease and stroke statistics\u20142020 update: a report from the American Heart Association","volume":"141","author":"Benjamin","year":"2020","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahjo.2025.100699_bb0070","first-page":"145","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.ahjo.2025.100699_bb0075","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics\u20142021 update","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2025.100699_bb0080","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1158\/1055-9965.EPI-05-0879","article-title":"Emerging and widening colorectal carcinoma disparities between Blacks and Whites in the United States (1975\u20132002)","volume":"15","author":"Irby","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.ahjo.2025.100699_bb0085","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1158\/1055-9965.EPI-12-0023","article-title":"Contribution of screening and survival differences to racial disparities in colorectal cancer rates","volume":"21","author":"Lansdorp-Vogelaar","year":"2012","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"12","key":"10.1016\/j.ahjo.2025.100699_bb0090","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1093\/jnci\/djab131","article-title":"Annual report to the nation on the status of cancer, part 1: national cancer statistics","volume":"113","author":"Islami","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ahjo.2025.100699_bb0095","series-title":"Rural Health Report","article-title":"Health disparities in rural America: current challenges and future solutions","author":"Centers for Disease Control and Prevention (CDC)","year":"2023"},{"issue":"4","key":"10.1016\/j.ahjo.2025.100699_bb0100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.14740\/gr1631","article-title":"Trends in colorectal cancer mortality in the United States, 1999\u20132020","volume":"16","author":"Kusnik","year":"2023","journal-title":"Gastroenterol. Res."},{"issue":"11","key":"10.1016\/j.ahjo.2025.100699_bb0105","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jchf.2022.06.012","article-title":"Trends in heart failure-related mortality among older adults in the United States from 1999 to 2019","volume":"10","author":"Siddiqi","year":"2022","journal-title":"JACC Heart Fail."},{"issue":"10","key":"10.1016\/j.ahjo.2025.100699_bb0110","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1200\/JCO.2015.64.0409","article-title":"Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study","volume":"34","author":"Armenian","year":"2016","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100699_bb0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.annonc.2019.10.023","article-title":"Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations","volume":"31","author":"Curigliano","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ahjo.2025.100699_bb0120","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ahjo.2025.100699_bb0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ahjo.2025.100699_bb0130","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/CIRCHEARTFAILURE.112.000178","article-title":"Temporal trends in treatment and outcomes for advanced heart failure with reduced ejection fraction from 1993\u20132010: findings from a university referral center","volume":"6","author":"Loh","year":"2013","journal-title":"Circ. Heart Fail."},{"issue":"2","key":"10.1016\/j.ahjo.2025.100699_bb0135","first-page":"89","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. Gastroenterol."},{"key":"10.1016\/j.ahjo.2025.100699_bb0140","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225002022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602225002022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:34:39Z","timestamp":1767990879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602225002022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S2666602225002022"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100699","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mortality trends in heart failure and colon cancer: Insights into gender, ethnic, and regional disparities in the United States (1999\u20132020)","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2025.100699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100699"}}