{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T14:00:24Z","timestamp":1782828024847,"version":"3.54.5"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ahjo.2026.100721","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:35:27Z","timestamp":1768350927000},"page":"100721","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Initiation, titration, and safety of vericiguat for treatment of heart failure in United States clinical practice"],"prefix":"10.1016","volume":"62","author":[{"given":"Stephen J.","family":"Greene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Lecomte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Manca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsiaryna","family":"Holl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Senni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ahjo.2026.100721_bb0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2333","volume":"24","author":"McDonagh","year":"2022","journal-title":"Eur. J. Heart Fail."},{"issue":"18","key":"10.1016\/j.ahjo.2026.100721_bb0010","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.ahjo.2026.100721_bb0015","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.jacc.2019.02.015","article-title":"Titration of medical therapy for heart failure with reduced ejection fraction","volume":"73","author":"Greene","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100721_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchf.2022.08.009","article-title":"Heart failure drug treatment-inertia, titration, and discontinuation: a multinational observational study (EVOLUTION HF)","volume":"11","author":"Savarese","year":"2023","journal-title":"JACC Heart Fail."},{"issue":"11","key":"10.1016\/j.ahjo.2026.100721_bb0025","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jchf.2023.06.022","article-title":"Clinical inertia among outpatients with heart failure: application of treatment nonintensification taxonomy to EPIC-HF Trial","volume":"11","author":"Swat","year":"2023","journal-title":"JACC Heart Fail."},{"issue":"12","key":"10.1016\/j.ahjo.2026.100721_bb0030","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009237","article-title":"Characteristics and treatments of patients enrolled in the CHAMP-HF registry compared with patients enrolled in the PARADIGM-HF trial","volume":"7","author":"DeVore","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ahjo.2026.100721_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.3699","article-title":"Safety and tolerability of a 5\u2009mg starting dose of vericiguat among patients with heart failure: The VELOCITY study","author":"Greene","year":"2025","journal-title":"Eur. J. Heart Fail."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100721_bb0040","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/ejhf.2283","article-title":"Clinical inertia and medical therapy for heart failure: the unintended harms of \u2018first, do no harm\u2019","volume":"23","author":"Greene","year":"2021","journal-title":"Eur. J. Heart Fail."},{"issue":"21","key":"10.1016\/j.ahjo.2026.100721_bb0045","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.2015.15734","article-title":"Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction: the SOCRATES-REDUCED randomized trial","volume":"314","author":"Gheorghiade","year":"2015","journal-title":"Jama"},{"issue":"20","key":"10.1016\/j.ahjo.2026.100721_bb0050","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1056\/NEJMoa1915928","article-title":"Vericiguat in patients with heart failure and reduced ejection fraction","volume":"382","author":"Armstrong","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ahjo.2026.100721_bb0055","author":"Healthverity"},{"issue":"11","key":"10.1016\/j.ahjo.2026.100721_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13113222","article-title":"Vericiguat use in patients with heart failure in real-world settings during the first year after the drug authorization in Japan","volume":"13","author":"Okami","year":"2024","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.ahjo.2026.100721_bb0065","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00228-024-03654-0","article-title":"Real-world characteristics and use patterns of patients treated with vericiguat: a nationwide longitudinal cohort study in Germany","volume":"80","author":"Kerwagen","year":"2024","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.ahjo.2026.100721_bb0070","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1002\/ehf2.15032","article-title":"Clinical profile, associated events and safety of vericiguat in a real-world cohort: the VERITA study","volume":"11","author":"Galv\u00e1n Ruiz","year":"2024","journal-title":"ESC Heart Fail."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100721_bb0075","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rce.2024.11.005","article-title":"VERICIDuAT: real-life study of vericiguat in patients with heart failure with reduced ejection fraction","volume":"225","author":"Russo Botero","year":"2025","journal-title":"Rev. Clin. Esp. (Barc.)"},{"key":"10.1016\/j.ahjo.2026.100721_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(25)01665-4","article-title":"Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial","author":"Butler","year":"2025","journal-title":"Lancet"},{"issue":"22","key":"10.1016\/j.ahjo.2026.100721_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021094","article-title":"Blood pressure and safety events with vericiguat in the VICTORIA trial","volume":"10","author":"Lam","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"7","key":"10.1016\/j.ahjo.2026.100721_bb0090","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-028750","article-title":"Development of hypotension in patients newly diagnosed with heart failure in UK general practice: retrospective cohort and nested case-control analyses","volume":"9","author":"Mart\u00edn-P\u00e9rez","year":"2019","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100721_bb0095","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jchf.2025.01.013","article-title":"Vericiguat adherence for heart failure with reduced ejection fraction in routine clinical care in the U.S","volume":"13","author":"Ikram","year":"2025","journal-title":"JACC Heart Fail."}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602226000091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602226000091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:30:06Z","timestamp":1769589006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602226000091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":19,"alternative-id":["S2666602226000091"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100721","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Initiation, titration, and safety of vericiguat for treatment of heart failure in United States clinical practice","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100721","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100721"}}