{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:36:05Z","timestamp":1791239765410,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ahjo.2026.100723","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:25:34Z","timestamp":1768461934000},"page":"100723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cancer therapy-associated Takotsubo cardiomyopathy: A narrative review of mechanisms, drug associations, and clinical implications"],"prefix":"10.1016","volume":"63","author":[{"given":"Michael","family":"Simeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Granado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tochukwu M.","family":"Okwuosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle Santos","family":"Volgman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salaheldin","family":"Abusin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ahjo.2026.100723_bb0005","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical features and outcomes of Takotsubo (stress) cardiomyopathy","volume":"373","author":"Templin","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology","volume":"18","author":"Lyon","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"6","key":"10.1016\/j.ahjo.2026.100723_bb0015","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1002\/ehf2.13741","article-title":"Cancer and Takotsubo syndrome: from rarity to clinical practice","volume":"8","author":"Keramida","year":"2021","journal-title":"ESC Heart Fail."},{"issue":"13","key":"10.1016\/j.ahjo.2026.100723_bb0020","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/eurheartj\/ehl032","article-title":"Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review","volume":"27","author":"Gianni","year":"2006","journal-title":"Eur. Heart J."},{"issue":"13","key":"10.1016\/j.ahjo.2026.100723_bb0025","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/CIRCULATIONAHA.121.055854","article-title":"Takotsubo Syndrome: pathophysiology, emerging concepts, and clinical implications","volume":"145","author":"Singh","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ahjo.2026.100723_bb0030","article-title":"Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis","volume":"43","author":"Khalid Ahmed","year":"2022","journal-title":"IJC Heart Vasc."},{"issue":"5","key":"10.1016\/j.ahjo.2026.100723_bb0035","first-page":"461","article-title":"Does emotion before a chemotherapy course break a heart? Cardiogenic shock complicating Takotsubo cardiomyopathy","volume":"6","author":"Taamallah","year":"2022","journal-title":"Cardiology and Cardiovascular Medicine."},{"issue":"24","key":"10.1016\/j.ahjo.2026.100723_bb0040","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.116.027121","article-title":"Pathophysiology of Takotsubo Syndrome","volume":"135","author":"Pelliccia","year":"2017","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0045","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1089\/jwh.2019.7741","article-title":"Sex differences in Takotsubo Syndrome: a narrative review","volume":"29","author":"Agdamag","year":"2020","journal-title":"J Womens Health (Larchmt)"},{"issue":"16","key":"10.1016\/j.ahjo.2026.100723_bb0050","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.jacc.2018.07.072","article-title":"Stress cardiomyopathy diagnosis and treatment: JACC state-of-the-art review","volume":"72","author":"Medina de Chazal","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0055","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jacc.2009.08.057","article-title":"Natural history and expansive clinical profile of stress (Tako-Tsubo) Cardiomyopathy","volume":"55","author":"Sharkey","year":"2010","journal-title":"JACC"},{"issue":"13","key":"10.1016\/j.ahjo.2026.100723_bb0060","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jacc.2024.05.076","article-title":"Temporal trends in Takotsubo Syndrome: results from the International Takotsubo Registry","volume":"84","author":"Schweiger","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"issue":"13","key":"10.1016\/j.ahjo.2026.100723_bb0065","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jacc.2024.05.076","article-title":"Temporal trends in Takotsubo Syndrome: results from the International Takotsubo Registry","volume":"84","author":"Schweiger","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"issue":"22","key":"10.1016\/j.ahjo.2026.100723_bb0070","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on Takotsubo Syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0075","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2013.12.239","article-title":"Revised clinical diagnostic criteria for Tako-tsubo syndrome: The Tako-tsubo Italian Network proposal","volume":"172","author":"Parodi","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0080","doi-asserted-by":"crossref","DOI":"10.2174\/011573403X273613240125072754","article-title":"Pharmacological triggers of Takotsubo Cardiomyopathy: an updated review of evidence and recommendations","volume":"20","author":"Arunkumar","year":"2024","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.ahjo.2026.100723_bb0085","article-title":"Pathophysiology of stress cardiomyopathy: a comprehensive literature review","volume":"82","author":"Al Houri","year":"2022","journal-title":"Ann. Med. Surg. (Lond.)"},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0090","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1536\/ihj.17-586","article-title":"Novel understanding of Takotsubo Syndrome","volume":"59","author":"Watanabe","year":"2018","journal-title":"Int. Heart J."},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0100","article-title":"Carmustine-induced Takotsubo cardiomyopathy","volume":"15","author":"Khan","year":"2023","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0105","article-title":"The first case of severe Takotsubo cardiomyopathy associated with 5-fluorouracil in a patient with abnormalities of both dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS) genes","volume":"8","author":"Saif","year":"2016","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.ahjo.2026.100723_bb0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/1074248417708618","article-title":"Drug-induced Takotsubo cardiomyopathy","volume":"22","author":"Kido","year":"2017","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.ahjo.2026.100723_bb0115","first-page":"7","article-title":"Takotsubo cardiomyopathy in cancer patients","volume":"5","author":"Desai","year":"2019","journal-title":"Cardiooncology"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytz146","article-title":"Fluorouracil-induced Takotsubo cardiomyopathy causing cardiogenic shock: a case report of clinical and acute cardiac magnetic resonance imaging features","volume":"3","author":"Joy","year":"2019","journal-title":"Eur Heart J Case Rep."},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0125","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/j.amjcard.2017.09.009","article-title":"Stress-induced cardiomyopathy in cancer patients","volume":"120","author":"Giza","year":"2017","journal-title":"Am. J. Cardiol."},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0130","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3390\/cancers15092637","article-title":"Takotsubo cardiomyopathy in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-summary of included cases","volume":"15","author":"Trontzas","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.ahjo.2026.100723_bb0135","article-title":"Takotsubo syndrome during treatment with 5-fluorouracil","volume":"143","author":"Steen","year":"2023","journal-title":"Tidsskr. Nor. Laegeforen."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0140","article-title":"5-fluorouracil induced Takotsubo cardiomyopathy complicated by left ventricular thrombosis","volume":"13","author":"Kumar","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.ahjo.2026.100723_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117312","article-title":"Anthracycline-induced cardiotoxicity: an overview from cellular structural perspective","volume":"179","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0150","article-title":"Chemotherapy induced Takotsubo cardiomyopathy","volume":"7","author":"Bilal","year":"2021","journal-title":"Journal of Hospital & Medical Management."},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0155","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/ccr3.2504","article-title":"Doxorubicin-associated takotsubo cardiomyopathy in a patient with adult T-cell leukemia\/lymphoma","volume":"7","author":"Mubarak","year":"2019","journal-title":"Clin. Case Reports"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1159\/000531389","article-title":"Oxaliplatin-associated Takotsubo cardiomyopathy in a patient with metastatic gastric cancer: a case report","volume":"16","author":"Osorio-Toro","year":"2023","journal-title":"Case Rep Oncol."},{"issue":"10","key":"10.1016\/j.ahjo.2026.100723_bb0165","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.cjco.2024.07.005","article-title":"Takotsubo cardiomyopathy after oxaliplatin chemotherapy exposure: a case report","volume":"6","author":"Veettil","year":"2024","journal-title":"CJC Open."},{"key":"10.1016\/j.ahjo.2026.100723_bb0170","article-title":"Takotsubo syndrome as an acute cardiac complication following combined chemotherapy","volume":"22","author":"Nati-Castillo","year":"2024","journal-title":"Int J Cardiol Cardiovasc Risk Prev."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0175","article-title":"Takotsubo syndrome in a cancer patient treated with a combination of anti-cancer drugs including immune checkpoint inhibitors: a case report","volume":"8","author":"Yamada","year":"2024","journal-title":"Eur Heart J Case Rep."},{"key":"10.1016\/j.ahjo.2026.100723_bb0180","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular mechanism of doxorubicin-induced cardiomyopathy \u2013 an update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ahjo.2026.100723_bb0185","first-page":"bcr","article-title":"Heart of the matter: reverse takotsubo syndrome in an anthracycline-exposed oncology patient","volume":"2018","author":"Voit","year":"2018","journal-title":"Case Reports."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0190","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10741-019-09773-6","article-title":"Malignancies and outcome in Takotsubo syndrome: a meta-analysis study on cancer and stress cardiomyopathy","volume":"24","author":"Brunetti","year":"2019","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ahjo.2026.100723_bb0195","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-213783","article-title":"5-Fluorouracil-induced acute reversible heart failure not explained by coronary spasms, myocarditis or takotsubo: lessons from MRI","volume":"2016","author":"Fakhri","year":"2016","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.ahjo.2026.100723_bb0200","article-title":"FOLFOX induced Takotsubo cardiomyopathy treated with impella assist device","volume":"2017","author":"Sundaravel","year":"2017","journal-title":"Case Rep. Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0205","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1592\/phco.31.2.226","article-title":"5-Fluorouracil-induced Tako-Tsubo-like syndrome","volume":"31","author":"Basselin","year":"2011","journal-title":"Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0210","first-page":"55","article-title":"Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen","volume":"8","author":"Cerny","year":"2009","journal-title":"Clin. Colorectal Cancer"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0215","doi-asserted-by":"crossref","first-page":"244","DOI":"10.14740\/cr728w","article-title":"Takotsubo cardiomyopathy-induced cardiac free wall rupture: a case report and review of literature","volume":"9","author":"Iskander","year":"2018","journal-title":"Cardiol Res."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0220","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.ijcard.2014.09.154","article-title":"A case of Takotsubo syndrome following 5-fluorouracil chemotherapy","volume":"177","author":"Knott","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0225","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/MBC.0b013e3283597605","article-title":"Takotsubo syndrome: an underdiagnosed complication of 5-fluorouracil mimicking acute myocardial infarction","volume":"24","author":"Ozturk","year":"2013","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0230","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1445-5994.2009.02144.x","article-title":"Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina","volume":"40","author":"Stewart","year":"2010","journal-title":"Intern. Med. J."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0235","article-title":"Takotsubo cardiomyopathy and 5-fluorouracil: getting to the heart of the matter","volume":"2013","author":"Lim","year":"2013","journal-title":"Case Rep. Oncol. Med."},{"key":"10.1016\/j.ahjo.2026.100723_bb0240","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-0716-3056-3_8","article-title":"Culturing human lung adenocarcinoma cells in a serum-free environment","volume":"2645","author":"Chary","year":"2023","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.ahjo.2026.100723_bb0245","first-page":"208","article-title":"Autopsy and cardiac magnetic resonance image case of bevacizumab-related cardiomyopathy","volume":"9","author":"Hashimoto","year":"2022","journal-title":"J Cardiovasc Dev Dis."},{"issue":"6","key":"10.1016\/j.ahjo.2026.100723_bb0250","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2147\/TCRM.S3960","article-title":"Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer","volume":"4","author":"Franco","year":"2008","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.ahjo.2026.100723_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1060813","article-title":"Takotsubo cardiomyopathy Afatinib-related in a non-small cell lung cancer patient: case report","volume":"9","author":"Ramos","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0260","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1634\/theoncologist.2018-0285","article-title":"Takotsubo cardiomyopathy during anti-HER2 therapy for metastatic breast cancer","volume":"24","author":"Lees","year":"2019","journal-title":"Oncologist"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13691-019-00396-0","article-title":"Takotsubo cardiomyopathy caused by infusion reaction to trastuzumab","volume":"9","author":"Matsumoto","year":"2020","journal-title":"Int Cancer Conf J."},{"key":"10.1016\/j.ahjo.2026.100723_bb0270","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ijcard.2016.07.291","article-title":"Apical takotsubo syndrome in a patient with metastatic breast carcinoma on novel immunotherapy","volume":"222","author":"Anderson","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"10.1016\/j.ahjo.2026.100723_bb0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.clon.2012.12.007","article-title":"Tako-Tsubo syndrome after trastuzumab - an unusual complication of chemotherapy for breast cancer","volume":"25","author":"Khanji","year":"2013","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0280","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1200\/JCO.2013.48.7280","article-title":"Association between Takotsubo cardiomyopathy and axitinib: case report and review of the literature","volume":"33","author":"Ovadia","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0285","first-page":"45","article-title":"Typical variant of takotsubo cardiomyopathy in oncological patients. Two case reports and review of the literature","volume":"60","author":"St\u0119pie\u0144","year":"2020","journal-title":"Folia Med. Cracov."},{"issue":"16","key":"10.1016\/j.ahjo.2026.100723_bb0290","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2217\/imt-2022-0013","article-title":"Takotsubo syndrome in a patient with metastatic renal cell carcinoma treated with pembrolizumab plus axitinib","volume":"14","author":"Air\u00f2","year":"2022","journal-title":"Immunotherapy"},{"key":"10.1016\/j.ahjo.2026.100723_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152281","article-title":"Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: running title: Sunitinib and oxidative stress in hearts","volume":"426","author":"Bouitbir","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.ahjo.2026.100723_bb0300","first-page":"82","article-title":"Association of cancer and anticancer therapy with stress cardiomyopathy","author":"Sun","year":"2020","journal-title":"IJPS"},{"key":"10.1016\/j.ahjo.2026.100723_bb0305","article-title":"Takotsubo cardiomyopathy in a patient with undiscovered sigmoid colon cancer","volume":"2017","author":"Po-Yen","year":"2017","journal-title":"Case Rep. Cardiol."},{"issue":"15","key":"10.1016\/j.ahjo.2026.100723_bb0310","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010881","article-title":"Clinical features and outcomes of patients with malignancy and Takotsubo syndrome: observations from the International Takotsubo Registry","volume":"8","author":"Cammann","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ahjo.2026.100723_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.634291","article-title":"Anti-cancer therapy leads to increased cardiovascular susceptibility to COVID-19","volume":"8","author":"Lozahic","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ahjo.2026.100723_bb0320","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2021.12.013","article-title":"Hypoxia signaling and oxygen metabolism in cardio-oncology","volume":"165","author":"Baik","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ahjo.2026.100723_bb0325","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijcard.2021.02.074","article-title":"Indications of beta-adrenoceptor blockers in Takotsubo syndrome and theoretical reasons to prefer agents with vasodilating activity","volume":"333","author":"Aimo","year":"2021","journal-title":"Int. J. Cardiol."},{"issue":"13","key":"10.1016\/j.ahjo.2026.100723_bb0330","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1136\/heartjnl-2015-308712","article-title":"Early \u03b2-blocker use and in-hospital mortality in patients with Takotsubo cardiomyopathy","volume":"102","author":"Isogai","year":"2016","journal-title":"Heart"},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0335","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006990","article-title":"Left ventricular thrombi in Takotsubo Syndrome: incidence, predictors, and management: results from the GEIST (German Italian Stress Cardiomyopathy) Registry","volume":"6","author":"Santoro","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"11","key":"10.1016\/j.ahjo.2026.100723_bb0340","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/clc.20957","article-title":"Cardiac rupture in takotsubo cardiomyopathy: a systematic review","volume":"34","author":"Kumar","year":"2011","journal-title":"Clin. Cardiol."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4065\/76.1.79","article-title":"Anteroapical stunning and left ventricular outflow tract obstruction","volume":"76","author":"Villareal","year":"2001","journal-title":"Mayo Clin. Proc."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0350","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/1755-5922.12182","article-title":"Hemodynamic effects, safety, and feasibility of Intravenous Esmolol infusion during Takotsubo cardiomyopathy with left ventricular outflow tract obstruction: results from a Multicenter Registry","volume":"34","author":"Santoro","year":"2016","journal-title":"Cardiovasc. Ther."},{"issue":"11","key":"10.1016\/j.ahjo.2026.100723_bb0355","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jchf.2018.05.015","article-title":"Short- and long-term prognostic relevance of cardiogenic shock in Takotsubo Syndrome: results from the RETAKO Registry","volume":"6","author":"Almendro-Delia","year":"2018","journal-title":"JACC Heart Fail."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0360","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/ATVBAHA.119.313491","article-title":"Intraventricular Thrombus formation and embolism in Takotsubo Syndrome: insights from the International Takotsubo Registry","volume":"40","author":"Ding","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ahjo.2026.100723_bb0365","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4137\/CMC.S38151","article-title":"Prevalence, clinical characteristics, and predictors of patients with Thromboembolic events in Takotsubo cardiomyopathy","volume":"10","author":"El-Battrawy","year":"2016","journal-title":"Clin Med Insights Cardiol."},{"issue":"11","key":"10.1016\/j.ahjo.2026.100723_bb0370","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.jacc.2019.01.017","article-title":"Anticoagulation strategies in patients with cancer: JACC review topic of the week","volume":"73","author":"Mosarla","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0375","article-title":"A cycle of complications: a case report on trastuzumab-induced takotsubo cardiomyopathy causing left ventricular thrombosis complicated by thromboembolic stroke","volume":"9","author":"Patel","year":"2025","journal-title":"Eur Heart J Case Rep."},{"key":"10.1016\/j.ahjo.2026.100723_bb0380","article-title":"A contemporary update on cancer and takotsubo syndrome","volume":"10","author":"Tini","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"10166","key":"10.1016\/j.ahjo.2026.100723_bb0385","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0390","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaccao.2022.07.005","article-title":"Permissive cardiotoxicity: the clinical crucible of cardio-oncology","volume":"4","author":"Porter","year":"2022","journal-title":"JACC CardioOncol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0395","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/biomedicines10020464","article-title":"Pretreatment with betablockers, a potential predictor of adverse cardiovascular events in Takotsubo syndrome","volume":"10","author":"Topf","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ahjo.2026.100723_bb0400","article-title":"A case of stress cardiomyopathy with nab-paclitaxel infusion","volume":"11","author":"Singh","year":"2023","journal-title":"J. Investig. Med. High Impact Case Rep."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0405","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jaccao.2024.02.004","article-title":"Dexrazoxane to prevent cardiotoxicity in adults treated with anthracyclines: JACC: CardioOncology Controversies in Cardio-Oncology","volume":"6","author":"Upshaw","year":"2024","journal-title":"JACC CardioOncol."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0410","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1272\/jnms.76.27","article-title":"A case of Takotsubo cardiomyopathy during 5-fluorouracil treatment for rectal adenocarcinoma","volume":"76","author":"Kobayashi","year":"2009","journal-title":"J. Nippon Med. Sch."},{"issue":"10","key":"10.1016\/j.ahjo.2026.100723_bb0415","article-title":"Acute reversible atypical takotsubo cardiomyopathy following trastuzumab and 5-fluorouracil in a young patient","volume":"16","author":"Lafaras","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ahjo.2026.100723_bb0420","series-title":"Capecitabine Caused Cardiogenic Shock through Induction of Global Takotsubo Syndrome","volume":"Vol 14","year":"2013"},{"issue":"5","key":"10.1016\/j.ahjo.2026.100723_bb0425","doi-asserted-by":"crossref","first-page":"e1188","DOI":"10.1097\/MJT.0000000000000134","article-title":"Capecitabine-induced Takotsubo cardiomyopathy: a case report and literature review","volume":"23","author":"Qasem","year":"2016","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.ahjo.2026.100723_bb0430","first-page":"23","article-title":"Capecitabine-induced Takotsubo cardiomyopathy: a case report","author":"Bhardwaj","year":"2019","journal-title":"Perm. J."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2021.100854","article-title":"Cardio-oncology: capecitabine can sometimes be heatbreaking capecitabine-induced takotsubo cardiomyopathy case report and literature review","volume":"46","author":"Abdelmaseih","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ahjo.2026.100723_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.991886","article-title":"Case report: acute toxic myocardial damage caused by 5-fluorouracil-from enigma to success","volume":"9","author":"Lasica","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"10","key":"10.1016\/j.ahjo.2026.100723_bb0445","doi-asserted-by":"crossref","first-page":"565","DOI":"10.12998\/wjcc.v2.i10.565","article-title":"Chemotherapy induced Takotsubo cardiomyopathy","volume":"2","author":"Goel","year":"2014","journal-title":"World J. Clin. Cases"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0450","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12885-017-3384-4","article-title":"Chemotherapy-induced Takotsubo cardiomyopathy, a case report and review of the literature","volume":"17","author":"Coen","year":"2017","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0455","first-page":"E338","article-title":"Chemotherapy-induced takotsubo cardiomyopathy","volume":"20","author":"Kim","year":"2008","journal-title":"J. Invasive Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0460","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hfc.2012.12.009","article-title":"Chemotherapy-induced takotsubo cardiomyopathy","volume":"9","author":"Smith","year":"2013","journal-title":"Heart Fail. Clin."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0465","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00392-013-0636-4","article-title":"Epicardial coronary artery spasm as cause of capecitabine-induced tako tsubo cardiomyopathy","volume":"103","author":"Klag","year":"2014","journal-title":"Clin. Res. Cardiol."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0470","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1097\/MJT.0000000000000030","article-title":"Ergotamine-induced Takotsubo Cardiomyopathy","volume":"23","author":"Ozpelit","year":"2016","journal-title":"Am. J. Ther."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0475","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/omcr\/omv072","article-title":"Successful capecitabine rechallenge following 5-fluorouracil-induced Takotsubo syndrome","volume":"2016","author":"Abdelrahman","year":"2016","journal-title":"Oxf. Med. Case Reports"},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0480","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1200\/JCO.2011.38.5278","article-title":"Takotsubo cardiomyopathy and Fluorouracil: case report and review of the literature","volume":"30","author":"Grunwald","year":"2012","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0485","article-title":"Takotsubo cardiomyopathy in a patient undergoing 5-fluorouracil infusion: considerations for folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) cardiotoxicity and rechallenge","volume":"17","author":"Sami","year":"2025","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0490","article-title":"The first case of severe takotsubo cardiomyopathy associated with 5-fluorouracil in a patient with abnormalities of both dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS) genes","volume":"8","author":"Saif","year":"2016","journal-title":"Cureus"},{"key":"10.1016\/j.ahjo.2026.100723_bb0495","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12887-016-0628-4","article-title":"Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma","volume":"16","author":"De Pasquale","year":"2016","journal-title":"BMC Pediatr."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0500","first-page":"291","article-title":"Multiple myeloma complicated with Takotsubo cardiomyopathy","volume":"51","author":"Mitsumori","year":"2010","journal-title":"Rinsho Ketsueki"},{"issue":"2","key":"10.1016\/j.ahjo.2026.100723_bb0505","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.amjms.2021.03.014","article-title":"When too many hits break the heart: a case of radiation induced Takotsubo cardiomyopathy","volume":"362","author":"Giyanani","year":"2021","journal-title":"Am. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0510","article-title":"Fulminant immune checkpoint inhibitor-associated myocarditis bridged to recovery with a temporary left ventricular assist device: a case report","volume":"9","author":"Mallery","year":"2025","journal-title":"Eur Heart J Case Rep."},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0515","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1159\/000365536","article-title":"Takotsubo cardiomyopathy after systemic consolidation therapy with high-dose intravenous cytarabine in a patient with acute myeloid leukemia","volume":"37","author":"Baumann","year":"2014","journal-title":"Oncol. Res. Treat."},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0520","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2459\/JCM.0000000000000204","article-title":"Midventricular Takotsubo cardiomyopathy after oxaliplatin infusion: an unreported side effect","volume":"16","author":"Coli","year":"2015","journal-title":"J. Cardiovasc. Med. (Hagerstown)"},{"issue":"7","key":"10.1016\/j.ahjo.2026.100723_bb0525","article-title":"Atypical Takotsubo cardiomyopathy secondary to combination of chemo-immunotherapy in a patient with non-small cell lung cancer","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100723_bb0530","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.12669\/pjms.344.15293","article-title":"Germ cell tumor and Takotsubo cardiomyopathy: a treatment dilemma","volume":"34","author":"Hannan","year":"2018","journal-title":"Pak J Med Sci."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0535","article-title":"Cardiac angiosarcoma in the right atrium treated by surgical resection","volume":"vol. 60","author":"Dragicevic-Antonic","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.ahjo.2026.100723_bb0540","article-title":"Paclitaxel-induced acute fibrinous and organizing pneumonitis in early breast cancer: a case report","volume":"48","author":"Limpawittayakul","year":"2024","journal-title":"Respir. Med. Case. Rep."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100723_bb0545","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-243863","article-title":"Takotsubo cardiomyopathy caused by infusion reaction to paclitaxel","volume":"14","author":"Micho Ulbeh","year":"2021","journal-title":"BMJ Case Rep."},{"issue":"12","key":"10.1016\/j.ahjo.2026.100723_bb0550","doi-asserted-by":"crossref","first-page":"E80","DOI":"10.1002\/clc.20685","article-title":"Myocardial stunning following combined modality combretastatin-based chemotherapy: two case reports and review of the literature","volume":"32","author":"Bhakta","year":"2009","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.ahjo.2026.100723_bb0555","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.875391","article-title":"Takotsubo Syndrome (TTS) in onco-hematologic patients: retrospective analysis and focus on the correlation or not with anticancer drugs. Case reports and review of the literature","volume":"12","author":"Monti","year":"2022","journal-title":"Front Oncol."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0560","article-title":"Rapid onset of Takotsubo cardiomyopathy induced by an infusion reaction to pembrolizumab in a patient with NSCLC","volume":"1","author":"Okamatsu","year":"2020","journal-title":"JTO Clin Res Rep."},{"issue":"9","key":"10.1016\/j.ahjo.2026.100723_bb0565","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.6279","article-title":"Reoccurrence of takotsubo cardiomyopathy induced by osimertinib: a case report","volume":"10","author":"Fukuda","year":"2022","journal-title":"Clin. Case Reports"},{"issue":"7","key":"10.1016\/j.ahjo.2026.100723_bb0570","first-page":"3579","article-title":"First report of trastuzumab treatment after postoperative Takotsubo cardiomyopathy","volume":"34","author":"Burgy","year":"2014","journal-title":"Anticancer Res"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100723_bb0575","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12010179","article-title":"Takotsubo syndrome during Pertuzumab and Trastuzumab therapy for HER2-positive metastatic breast cancer","volume":"12","author":"Irelli","year":"2024","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.ahjo.2026.100723_bb0580","first-page":"88","article-title":"Pembrolizumab-induced broken heart syndrome, pneumonitis, and hypophysitis occurring concurrently; a deadly triad","volume":"13","author":"Khan","year":"2023","journal-title":"J. Community Hosp. Intern. Med. Perspect."}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266660222600011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266660222600011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:26:33Z","timestamp":1775766393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266660222600011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":115,"alternative-id":["S266660222600011X"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100723","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer therapy-associated Takotsubo cardiomyopathy: A narrative review of mechanisms, drug associations, and clinical implications","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100723"}}