{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:06:46Z","timestamp":1790701606213,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016867","name":"ZOLL Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ahjo.2026.100852","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:13:27Z","timestamp":1785708807000},"page":"100852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rationale and design of a pilot randomized control trial of permissive hypotension after cardiac surgery: The PHACS trial"],"prefix":"10.1016","volume":"70","author":[{"given":"David W.","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham","family":"Makarem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Liquori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Galvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranya","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan P.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Rabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"D'Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serguei","family":"Melnitchouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arminder S.","family":"Jassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel B.","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahar","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Kreso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thoralf M.","family":"Sundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asishana A.","family":"Osho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ahjo.2026.100852_bb0005","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1053\/j.jvca.2020.11.032","article-title":"Vasopressor therapy in cardiac surgery\u2014an experts\u2019 consensus statement","volume":"35","author":"Guarracino","year":"2021","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.ahjo.2026.100852_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s44158-022-00045-8","article-title":"Perioperative hypotension: causes and remedies","volume":"2","author":"Guarracino","year":"2022","journal-title":"J. Anesth. Analg. Crit. Care"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100852_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5152\/eurasianjmed.2022.20394","article-title":"Vasoplegia: mechanism and management following cardiopulmonary bypass","volume":"54","author":"Muhammad","year":"2022","journal-title":"Eurasian J. Med."},{"issue":"8","key":"10.1016\/j.ahjo.2026.100852_bb0020","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1177\/0885066620917630","article-title":"Vasopressor and inotrope therapy in cardiac critical care","volume":"36","author":"Jentzer","year":"2021","journal-title":"J. Intensive Care Med."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100852_bb0025","doi-asserted-by":"crossref","first-page":"120","DOI":"10.54912\/jci.2024.0030","article-title":"Optimal inotrope and vasopressor therapy in cardiogenic shock","volume":"4","author":"Bae","year":"2025","journal-title":"J. Cardiovasc. Interv."},{"issue":"1","key":"10.1016\/j.ahjo.2026.100852_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13613-023-01130-z","article-title":"Microcirculatory dysfunction in cardiogenic shock","volume":"13","author":"Merdji","year":"2023","journal-title":"Ann. Intensive Care"},{"issue":"6","key":"10.1016\/j.ahjo.2026.100852_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304227","article-title":"The REPERFUSE study protocol: the effects of vasopressor therapy on renal perfusion in patients with septic shock\u2014a mechanistically focused randomised control trial","volume":"19","author":"McDonald","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ahjo.2026.100852_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-016-1373-6","article-title":"Perfusion pressure cerebral infarct (PPCI) trial - the importance of mean arterial pressure during cardiopulmonary bypass to prevent cerebral complications after cardiac surgery: study protocol for a randomised controlled trial","volume":"17","author":"Vedel","year":"2016","journal-title":"Trials"},{"issue":"17","key":"10.1016\/j.ahjo.2026.100852_bb0045","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/CIRCULATIONAHA.118.033197","article-title":"Preventing brain injury after cardiopulmonary bypass will require more than just dialing up the pressure","volume":"137","author":"Cheung","year":"2018","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ahjo.2026.100852_bb0050","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bja.2018.12.019","article-title":"Vasoactive-inotropic score and the prediction of morbidity and mortality after cardiac surgery","volume":"122","author":"Koponen","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ahjo.2026.100852_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-023-02403-1","article-title":"The association of vasoactive-inotropic score and surgical patients\u2019 outcomes: a systematic review and meta-analysis","volume":"13","author":"Sun","year":"2024","journal-title":"Syst. Rev."},{"issue":"10","key":"10.1016\/j.ahjo.2026.100852_bb0060","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/jama.2020.0930","article-title":"Effect of reduced exposure to vasopressors on 90-day mortality in older critically ill patients with vasodilatory hypotension: a randomized clinical trial","volume":"323","author":"Lamontagne","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ahjo.2026.100852_bb0065","series-title":"Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT [Internet]","article-title":"Methods","author":"Mouncey","year":"2021"},{"issue":"2","key":"10.1016\/j.ahjo.2026.100852_bb0070","doi-asserted-by":"crossref","first-page":"127","DOI":"10.17085\/apm.24103","article-title":"Permissive strategies in intensive care units (ICUs): actual trends?","volume":"20","author":"Domi","year":"2025","journal-title":"Anesth. Pain Med."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100852_bb0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1513\/AnnalsATS.202108-997ED","article-title":"Should we be permissive with hypercapnia?","volume":"19","author":"Nassar","year":"2022","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.ahjo.2026.100852_bb0080","author":"Yartsev"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100852_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00134-017-4849-2","article-title":"Permissive hypotension during shock resuscitation: equipoise in all patients?","volume":"44","author":"Lamontagne","year":"2018","journal-title":"Intensive Care Med."},{"issue":"17","key":"10.1016\/j.ahjo.2026.100852_bb0090","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/CIRCULATIONAHA.117.030308","article-title":"High-target versus low-target blood pressure management during cardiopulmonary bypass to prevent cerebral injury in cardiac surgery patients","volume":"137","author":"Vedel","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ahjo.2026.100852_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-024-03962-4","article-title":"Mortality, morbidity & clinical outcome with different types of vasopressors in out of hospital cardiac arrest patients- a systematic review and meta-analysis","volume":"24","author":"Chander","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"issue":"3","key":"10.1016\/j.ahjo.2026.100852_bb0100","first-page":"565","article-title":"Early vasopressor use in critical injury is associated with mortality independent from volume status","volume":"71","author":"Plurad","year":"2011","journal-title":"J. Trauma"},{"issue":"10","key":"10.1016\/j.ahjo.2026.100852_bb0105","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/CCM.0000000000004476","article-title":"Evaluation of vasopressor exposure and mortality in patients with septic shock","volume":"48","author":"Roberts","year":"2020","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100852_bb0110","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/CCM.0000000000005736","article-title":"Lower versus higher exposure to vasopressor therapy in vasodilatory hypotension: a systematic review with meta-analysis*","volume":"51","author":"Richards-Belle","year":"2023","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.ahjo.2026.100852_bb0115","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00134-016-4237-3","article-title":"Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial","volume":"42","author":"Lamontagne","year":"2016","journal-title":"Intensive Care Med."},{"issue":"4S","key":"10.1016\/j.ahjo.2026.100852_bb0120","first-page":"S117","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2024","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.ahjo.2026.100852_bb0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"issue":"10","key":"10.1016\/j.ahjo.2026.100852_bb0130","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1053\/j.jvca.2020.09.117","article-title":"Vasoactive-inotropic score: evolution, clinical utility, and pitfalls","volume":"35","author":"Belletti","year":"2021","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"issue":"5","key":"10.1016\/j.ahjo.2026.100852_bb0135","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the treatment of vasodilatory shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N. Engl. J. Med."}],"container-title":["American Heart Journal Plus: Cardiology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602226001412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666602226001412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:36:09Z","timestamp":1790699769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666602226001412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"alternative-id":["S2666602226001412"],"URL":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100852","relation":{},"ISSN":["2666-6022"],"issn-type":[{"value":"2666-6022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationale and design of a pilot randomized control trial of permissive hypotension after cardiac surgery: The PHACS trial","name":"articletitle","label":"Article Title"},{"value":"American Heart Journal Plus: Cardiology Research and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ahjo.2026.100852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100852"}}