{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:27:41Z","timestamp":1788992861303,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Integrative Medicine"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.aimed.2020.07.011","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T08:42:07Z","timestamp":1596444127000},"page":"192-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effects of vitamin D on acute viral respiratory infections: A rapid review"],"prefix":"10.1016","volume":"7","author":[{"given":"Ryan","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Schloss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deisy","family":"Celis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Finnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Hedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladyslav","family":"Honcharov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci","family":"Pantuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Lauche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amie","family":"Steel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.aimed.2020.07.011_bib0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1172\/JCI111465","article-title":"1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells","volume":"74","author":"Lemire","year":"1984","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.aimed.2020.07.011_bib0010","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.4049\/jimmunol.179.3.1634","article-title":"Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation","volume":"179","author":"Chen","year":"2007","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.aimed.2020.07.011_bib0015","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jcb.10580","article-title":"The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells","volume":"89","author":"Mahon","year":"2003","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0020","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"issue":"3","key":"10.1016\/j.aimed.2020.07.011_bib0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2265.2011.04261.x","article-title":"An update on vitamin D and human immunity","volume":"76","author":"Hewison","year":"2012","journal-title":"Clin. Endocrinol. (Oxf.)"},{"issue":"3","key":"10.1016\/j.aimed.2020.07.011_bib0030","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0029665110001722","article-title":"Mechanisms underlying the effect of vitamin D on the immune system","volume":"69","author":"Cantorna","year":"2010","journal-title":"Proc. Nutr. Soc."},{"issue":"1","key":"10.1016\/j.aimed.2020.07.011_bib0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4049\/jimmunol.1000695","article-title":"The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation","volume":"186","author":"Baeke","year":"2011","journal-title":"J. Immunol."},{"issue":"6 Suppl","key":"10.1016\/j.aimed.2020.07.011_bib0040","doi-asserted-by":"crossref","first-page":"1704S","DOI":"10.1093\/jn\/125.suppl_6.1704S","article-title":"Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions","volume":"125","author":"Lemire","year":"1995","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0045","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.beem.2011.04.009","article-title":"Vitamin D in autoimmune, infectious and allergic diseases: a vital player?","volume":"25","author":"Van Belle","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.aimed.2020.07.011_bib0050","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1074\/jbc.M110.163790","article-title":"Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells","volume":"286","author":"Palmer","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.aimed.2020.07.011_bib0055","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.4049\/jimmunol.167.9.4974","article-title":"1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells","volume":"167","author":"Boonstra","year":"2001","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.aimed.2020.07.011_bib0060","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1017\/S0007114511001991","article-title":"Vitamin D status has a linear association with seasonal infections and lung function in British adults","volume":"106","author":"Berry","year":"2011","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.aimed.2020.07.011_bib0065","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3390\/nu7031933","article-title":"Vitamin D status and acute respiratory infection: cross sectional results from the United States National Health and Nutrition Examination Survey, 2001-2006","volume":"7","author":"Monlezun","year":"2015","journal-title":"Nutrients"},{"issue":"SUPPL. 2","key":"10.1016\/j.aimed.2020.07.011_bib0070","first-page":"A71","article-title":"Vitamin D in the prevention of acute respiratory infection: a systematic review of clinical studies","volume":"67","author":"Jolliffe","year":"2012","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0075","first-page":"240","article-title":"Vitamin d and susceptibility to infection","volume":"40","author":"Zittermann","year":"2015","journal-title":"Aktuelle Ernahrungsmedizin"},{"issue":"9","key":"10.1016\/j.aimed.2020.07.011_bib0080","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s00112-018-0502-6","article-title":"Vitamin D supplementation beyond the second year of life: joint statement of the Nutrition Committee of the German Society for Pediatric and Adolescent Medicine (DGKJ) and the German Society for Pediatric Endocrinology and Diabetology (DGKED)","volume":"166","author":"Reinehr","year":"2018","journal-title":"Monatsschrift fur Kinderheilkunde"},{"key":"10.1016\/j.aimed.2020.07.011_bib0085","doi-asserted-by":"crossref","first-page":"i6583","DOI":"10.1136\/bmj.i6583","article-title":"Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data","volume":"356","author":"Martineau","year":"2017","journal-title":"BMJ (Clin. Res. Ed.)"},{"issue":"7","key":"10.1016\/j.aimed.2020.07.011_bib0090","doi-asserted-by":"crossref","first-page":"e0180512","DOI":"10.1371\/journal.pone.0180512","article-title":"Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data","volume":"12","author":"Rejnmark","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/CPM.0000000000000158","article-title":"Vitamin D and lower respiratory tract infection in children: a systematic review and meta-analysis of randomized controlled trials","volume":"23","author":"Jat","year":"2016","journal-title":"Clin. Pulm. Med."},{"issue":"9","key":"10.1016\/j.aimed.2020.07.011_bib0100","doi-asserted-by":"crossref","first-page":"e0162996","DOI":"10.1371\/journal.pone.0162996","article-title":"Effect of vitamin D3 supplementation on respiratory tract infections in healthy individuals: a systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Vuichard Gysin","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.aimed.2020.07.011_bib0105","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1017\/S000711451500207X","article-title":"Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials","volume":"114","author":"Xiao","year":"2015","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0110","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/0976-500X.103685","article-title":"Vitamin D for prevention of respiratory tract infections: a systematic review and meta-analysis","volume":"3","author":"Charan","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"Supplement 3","key":"10.1016\/j.aimed.2020.07.011_bib0115","first-page":"A60","article-title":"Vitamin d supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data","volume":"71","author":"Martineau","year":"2016","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.aimed.2020.07.011_bib0120","first-page":"CD008824","article-title":"Vitamin D supplementation for preventing infections in children under five years of age","volume":"2016","author":"Yakoob","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0125","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/INF.0000000000001452","article-title":"Infant respiratory tract infections or wheeze and maternal vitamin d in pregnancy: a systematic review","volume":"36","author":"Christensen","year":"2017","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"9","key":"10.1016\/j.aimed.2020.07.011_bib0130","doi-asserted-by":"crossref","first-page":"696","DOI":"10.3109\/00365548.2013.803293","article-title":"Vitamin D supplementation and risk of respiratory tract infections: a meta-analysis of randomized controlled trials","volume":"45","author":"Mao","year":"2013","journal-title":"Scand. J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.aimed.2020.07.011_bib0135","doi-asserted-by":"crossref","first-page":"e65835","DOI":"10.1371\/journal.pone.0065835","article-title":"Vitamin d and respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials","volume":"8","author":"Bergman","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.aimed.2020.07.011_bib0140","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4158\/EP09101.ORR","article-title":"Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials","volume":"15","author":"Yamshchikov","year":"2009","journal-title":"Endocrine Pract."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0145","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.dsx.2020.04.015","article-title":"Enhancing immunity in viral infections, with special emphasis on COVID-19: a review","volume":"14","author":"Jayawardena","year":"2020","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"issue":"4","key":"10.1016\/j.aimed.2020.07.011_bib0150","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3390\/nu12040969","article-title":"Role of vitamin D in preventing and treating selected extraskeletal diseases-an umbrella review","volume":"12","author":"Maretzke","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.aimed.2020.07.011_bib0155","article-title":"Vitamin D deficiency and pediatric respiratory infection","volume":"46","author":"Larkin","year":"2013","journal-title":"Commun. Nurs. Res."},{"issue":"12","key":"10.1016\/j.aimed.2020.07.011_bib0160","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S2213-8587(17)30357-1","article-title":"Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials","volume":"5","author":"Autier","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"2","key":"10.1016\/j.aimed.2020.07.011_bib0165","first-page":"159","article-title":"Vitamin D an antimicrobial weapon against acute respiratory tract infections. A systematic review (2006- March 2011)","volume":"60","author":"Moroti","year":"2012","journal-title":"Farmacia"},{"issue":"8","key":"10.1016\/j.aimed.2020.07.011_bib0170","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1210\/jc.2013-3162","article-title":"Impact of vitamin D3 dietary supplement matrix on clinical response","volume":"99","author":"Traub","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Advances in Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212958820301440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212958820301440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:35:53Z","timestamp":1761957353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212958820301440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2212958820301440"],"URL":"https:\/\/doi.org\/10.1016\/j.aimed.2020.07.011","relation":{},"ISSN":["2212-9588"],"issn-type":[{"value":"2212-9588","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of vitamin D on acute viral respiratory infections: A rapid review","name":"articletitle","label":"Article Title"},{"value":"Advances in Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aimed.2020.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}