{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:55:12Z","timestamp":1786560912852,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PP00P3_150531"],"award-info":[{"award-number":["PP00P3_150531"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020083","name":"Cantonal Hospital Aarau","doi-asserted-by":"publisher","award":["1410.000.044"],"award-info":[{"award-number":["1410.000.044"]}],"id":[{"id":"10.13039\/501100020083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020083","name":"Cantonal Hospital Aarau","doi-asserted-by":"publisher","award":["1410.000.058"],"award-info":[{"award-number":["1410.000.058"]}],"id":[{"id":"10.13039\/501100020083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ajcnut.2024.09.020","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T21:33:57Z","timestamp":1726868037000},"page":"1225-1232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex differences in clinical presentation, treatment response, and side effects of nutritional therapy among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-6462","authenticated-orcid":false,"given":"Carla","family":"Wunderle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Endner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Haenggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kaegi-Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Tribolet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Stanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2011.02.001","article-title":"Nutrition and human health from a sex-gender perspective","volume":"32","author":"Marino","year":"2011","journal-title":"Mol. Aspects Med."},{"issue":"4","key":"10.1016\/j.ajcnut.2024.09.020_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1056\/NEJM199107253250408","article-title":"The Yentl syndrome","volume":"325","author":"Healy","year":"1991","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"9","key":"10.1016\/j.ajcnut.2024.09.020_bib3","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIR.0000000000000351","article-title":"Acute myocardial infarction in women: a scientific statement from the American Heart Association","volume":"133","author":"Mehta","year":"2016","journal-title":"Circulation"},{"issue":"5589","key":"10.1016\/j.ajcnut.2024.09.020_bib4","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1126\/science.1076813","article-title":"Ecology and evolution. Sex differences in mortality rate","volume":"297","author":"Owens","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ajcnut.2024.09.020_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.canlet.2019.08.017","article-title":"Sex disparities in cancer","volume":"466","author":"Zhu","year":"2019","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clnu.2009.06.005","article-title":"Prevalence of undernutrition on admission to Swiss hospitals","volume":"29","author":"Imoberdorf","year":"2010","journal-title":"Clin. Nutr."},{"issue":"11\u201312","key":"10.1016\/j.ajcnut.2024.09.020_bib7","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.nut.2015.06.007","article-title":"Association of nutritional risk and adverse medical outcomes across different medical inpatient populations","volume":"31","author":"Felder","year":"2015","journal-title":"Nutrition"},{"key":"10.1016\/j.ajcnut.2024.09.020_bib8","article-title":"Loss of appetite in acutely ill medical inpatients: physiological response or therapeutic target? Swiss","volume":"144","author":"Sch\u00fctz","year":"2014","journal-title":"Med. Wkly."},{"issue":"10188","key":"10.1016\/j.ajcnut.2024.09.020_bib9","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(18)32776-4","article-title":"Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial","volume":"393","author":"Schuetz","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ajcnut.2024.09.020_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/21551197.2020.1725711","article-title":"Association of nutritional status with physical function and disability in community-dwelling older adults: a longitudinal data analysis","volume":"39","author":"Ge","year":"2020","journal-title":"J.\u00a0Nutr. Gerontol. Geriatr."},{"issue":"3","key":"10.1016\/j.ajcnut.2024.09.020_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000444096","article-title":"Unraveling the Link between malnutrition and adverse clinical outcomes: association of acute and chronic malnutrition measures with blood biomarkers from different pathophysiological states","volume":"68","author":"Felder","year":"2016","journal-title":"Ann. Nutr. Metab."},{"issue":"10314","key":"10.1016\/j.ajcnut.2024.09.020_bib12","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(21)01451-3","article-title":"Management of disease-related malnutrition for patients being treated in hospital","volume":"398","author":"Schuetz","year":"2021","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ajcnut.2024.09.020_bib13","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.clnu.2023.06.023","article-title":"ESPEN guideline on nutritional support for polymorbid medical inpatients","volume":"42","author":"Wunderle","year":"2023","journal-title":"Clin. Nutr."},{"issue":"3","key":"10.1016\/j.ajcnut.2024.09.020_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.clnu.2024.01.008","article-title":"ESPEN practical guideline: nutritional support for polymorbid medical inpatients","volume":"43","author":"Wunderle","year":"2024","journal-title":"Clin. Nutr."},{"issue":"6","key":"10.1016\/j.ajcnut.2024.09.020_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00391-013-0535-3","article-title":"[Gender aspects of malnutrition and associated sequelae. Prevention and therapy]","volume":"46","author":"Lechleitner","year":"2013","journal-title":"Z.\u00a0Gerontol. Geriatr."},{"issue":"5","key":"10.1016\/j.ajcnut.2024.09.020_bib16","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.clnu.2019.06.006","article-title":"Disease-related malnutrition in hospitalized chronic patients with complex needs","volume":"39","author":"Burgos","year":"2020","journal-title":"Clin. Nutr."},{"issue":"3","key":"10.1016\/j.ajcnut.2024.09.020_bib17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.18203\/2349-3259.ijct20182085","article-title":"Design and rationale of the effect of early nutritional therapy on frailty, functional\u00a0outcomes and recovery of malnourished medical inpatients trial (EFFORT): a pragmatic, multicenter, randomized-controlled trial","volume":"5","author":"Schuetz","year":"2018","journal-title":"Int. J. Clin. Trials."},{"issue":"3","key":"10.1016\/j.ajcnut.2024.09.020_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0261-5614(02)00214-5","article-title":"Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition\u2014a consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"issue":"4","key":"10.1016\/j.ajcnut.2024.09.020_bib20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.clnu.2022.02.009","article-title":"Validation of modified GLIM criteria to predict adverse clinical outcome and response to nutritional treatment: a secondary analysis of a randomized clinical trial","volume":"41","author":"Kaegi-Braun","year":"2022","journal-title":"Clin. Nutr."},{"issue":"2","key":"10.1016\/j.ajcnut.2024.09.020_bib21","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/ajcn\/nqab042","article-title":"Value of handgrip strength to predict clinical outcomes and therapeutic response in malnourished medical inpatients: secondary analysis of a randomized controlled trial","volume":"114","author":"Kaegi-Braun","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2024.09.020_bib22","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fendo.2019.00850","article-title":"Validity of dietary assessment methods when compared to the method of doubly labeled water: a systematic review in adults","volume":"10","author":"Burrows","year":"2019","journal-title":"Front. Endocrinol (Lausanne)."},{"issue":"5","key":"10.1016\/j.ajcnut.2024.09.020_bib23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/ajcn\/nqaa370","article-title":"Investigating sex differences in the accuracy of dietary assessment methods to measure energy intake in adults: a systematic review and meta-analysis","volume":"113","author":"McKenzie","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.ajcnut.2024.09.020_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/nu11020266","article-title":"Dietary intake and associated factors in long-term care homes in southeast Spain","volume":"11","author":"Rodr\u00edguez-Rej\u00f3n","year":"2019","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.ajcnut.2024.09.020_bib25","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41430-022-01129-y","article-title":"Recent and current low food intake\u2014prevalence and associated factors in hospital patients from different medical specialities","volume":"76","author":"B\u00f6hne","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2024.09.020_bib26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clnesp.2021.02.020","article-title":"The nutritional status and dietary intake of free-living seniors: a cross-sectional study","volume":"43","author":"O\u2019Connell","year":"2021","journal-title":"Clin. Nutr. Espen"},{"issue":"8","key":"10.1016\/j.ajcnut.2024.09.020_bib27","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.3390\/nu11081891","article-title":"Anthropometry, body composition and resting energy expenditure in human","volume":"11","author":"Tur","year":"2019","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.ajcnut.2024.09.020_bib28","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41430-018-0220-0","article-title":"Resting energy expenditure and body composition: critical aspects for clinical nutrition","volume":"72","author":"Soares","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2024.09.020_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-319-70178-3_2","article-title":"Sex differences in body composition","volume":"1043","author":"Bredella","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"18","key":"10.1016\/j.ajcnut.2024.09.020_bib30","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1042\/CS20160006","article-title":"Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity","volume":"130","author":"Hopkins","year":"2016","journal-title":"Clin. Sci (Lond)."},{"issue":"9","key":"10.1016\/j.ajcnut.2024.09.020_bib31","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41574-018-0062-9","article-title":"Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies","volume":"14","author":"Batsis","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib32","first-page":"25","article-title":"Physical activity and hormonal regulation of appetite: sex differences and weight control, Exerc","volume":"38","author":"Hagobian","year":"2010","journal-title":"Sport Sci. Rev."},{"key":"10.1016\/j.ajcnut.2024.09.020_bib33","doi-asserted-by":"crossref","DOI":"10.3402\/fnr.v55i0.7028","article-title":"Determinants of appetite ratings: the role of age, gender, BMI, physical activity, smoking habits, and diet\/weight concern","volume":"55","author":"Gregersen","year":"2011","journal-title":"Food Nutr. Res."},{"issue":"2","key":"10.1016\/j.ajcnut.2024.09.020_bib34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1467-789X.2008.00529.x","article-title":"Stock Conference 2008 Working Group, Sex differences in obesity and the regulation of energy homeostasis","volume":"10","author":"Lovejoy","year":"2009","journal-title":"Obes. Rev."},{"issue":"4","key":"10.1016\/j.ajcnut.2024.09.020_bib35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cger.2021.05.008","article-title":"The science of frailty: sex differences","volume":"37","author":"Park","year":"2021","journal-title":"Clin. Geriatr. Med."},{"issue":"4","key":"10.1016\/j.ajcnut.2024.09.020_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41569-022-00797-4","article-title":"Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes","volume":"20","author":"Regitz-Zagrosek","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/19485565.2016.1262238","article-title":"Gender and health behavior clustering among U.S. young adults","volume":"63","author":"Olson","year":"2017","journal-title":"Biodemography Soc. Biol."},{"issue":"10250","key":"10.1016\/j.ajcnut.2024.09.020_bib38","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","article-title":"Sex and gender: modifiers of health, disease, and medicine","volume":"396","author":"Mauvais-Jarvis","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2022-001518","article-title":"Lower geriatric nutritional risk index is associated with a higher risk of all-cause mortality in patients with chronic\u00a0obstructive pulmonary disease: a cohort study from the National\u00a0Health\u00a0and Nutrition Examination Survey 2013\u20132018","volume":"10","author":"Chai","year":"2023","journal-title":"BMJ Open. Respir. Res."},{"issue":"6","key":"10.1016\/j.ajcnut.2024.09.020_bib40","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/ajcn\/nqab292","article-title":"Association between protein intake and mortality in older patients receiving parenteral nutrition: a retrospective observational study","volume":"114","author":"Tamiya","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.ajcnut.2024.09.020_bib41","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13098-023-01060-7","article-title":"Geriatric Nutrition Risk Index as a predictor of cardiovascular and all-cause mortality in older Americans with diabetes","volume":"15","author":"Shen","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"issue":"1\u20132","key":"10.1016\/j.ajcnut.2024.09.020_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpharm.2011.04.069","article-title":"Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery","volume":"415","author":"Freire","year":"2011","journal-title":"Int. J. Pharm."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916524007524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916524007524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:42:12Z","timestamp":1762029732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916524007524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0002916524007524"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2024.09.020","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in clinical presentation, treatment response, and side effects of nutritional therapy among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2024.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}