{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:00:04Z","timestamp":1791874804969,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["2024NSCQ-MSX3470"],"award-info":[{"award-number":["2024NSCQ-MSX3470"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1069"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1069"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX1233"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX1233"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2017YFC1309200"],"award-info":[{"award-number":["2017YFC1309200"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012397","name":"Army Medical University","doi-asserted-by":"publisher","award":["2024YQB033"],"award-info":[{"award-number":["2024YQB033"]}],"id":[{"id":"10.13039\/501100012397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304131"],"award-info":[{"award-number":["82304131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ajcnut.2025.01.006","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T02:53:52Z","timestamp":1736304832000},"page":"535-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-2680","authenticated-orcid":false,"given":"Liangyu","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongliang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajcnut.2025.01.006_bib1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41571-023-00734-5","article-title":"Cancer-associated cachexia\u2014understanding the tumour macroenvironment and microenvironment to improve management","volume":"20","author":"Argiles","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jgo.2017.08.013","article-title":"Pearls of optimizing nutrition and physical performance of older adults undergoing cancer therapy","volume":"8","author":"Vigano","year":"2017","journal-title":"J.\u00a0Geriatr. Oncol."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib3","first-page":"340","article-title":"Molecular pathways leading to cancer cachexia","volume":"20","author":"Tisdale","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jcsm.12167","article-title":"Prevalence and clinical impact of cachexia in chronic illness in Europe, USA, and Japan: facts and numbers update 2016","volume":"7","author":"von Haehling","year":"2016","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jcsm.12524","article-title":"Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced-stage ovarian cancer","volume":"11","author":"Huang","year":"2020","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/jcsm.12633","article-title":"Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?","volume":"11","author":"Dolly","year":"2020","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188359","article-title":"Advances in cancer cachexia: intersection between affected organs, mediators, and pharmacological interventions","volume":"1873","author":"Siddiqui","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.trecan.2018.10.001","article-title":"Cancer cachexia: more than skeletal muscle wasting","volume":"4","author":"Schmidt","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib13","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/ajcn\/nqac251","article-title":"Identifying cancer cachexia\u00a0in patients without weight loss information: machine learning approaches to address a real-world challenge","volume":"116","author":"Yin","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib14","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/jcsm.13156","article-title":"Triceps skinfold-albumin index significantly predicts the prognosis of cancer cachexia: a multicentre cohort study","volume":"14","author":"Yin","year":"2023","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/PPO.0000000000000100","article-title":"Cancer cachexia, recent advances, and future directions","volume":"21","author":"Penet","year":"2015","journal-title":"Cancer J."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib16","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.clnu.2016.07.001","article-title":"ESPEN guideline on ethical aspects of artificial nutrition and hydration","volume":"35","author":"Bozzetti","year":"2016","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib17","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of cancer cachexia: ASCO guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/jama.1987.03390090067026","article-title":"High-dose megestrol acetate. A possible treatment for cachexia","volume":"257","author":"Tchekmedyian","year":"1987","journal-title":"JAMA"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1525-8610(04)70052-3","article-title":"Incidence of venous thromboembolism in megestrol acetate users","volume":"5","author":"Thomas","year":"2004","journal-title":"J.\u00a0Am. Med. Dir. Assoc."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcsm.12246","article-title":"Serum and urine metabolomics study reveals a distinct diagnostic model for cancer cachexia","volume":"9","author":"Yang","year":"2018","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib21","first-page":"551","article-title":"Anthropometric equation for estimation of appendicular skeletal muscle mass in Chinese adults","volume":"20","author":"Wen","year":"2011","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib22","first-page":"2725","article-title":"Clinical significance of weight changes at diagnosis in solid tumours","volume":"27","author":"O'Donoghue","year":"2019","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib23","article-title":"Extension protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China (INSCOC) study: 2021 update","volume":"1","author":"Xu","year":"2022","journal-title":"Precision Nutrition"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0261-5614(03)00098-0","article-title":"Educational, Clinical Practice Committee ESoP, Enteral N. ESPEN guidelines for nutrition screening 2002","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib25","first-page":"770","article-title":"Rethinking nutritional support of the cancer patient: the new field of nutritional oncology","volume":"21","author":"Ottery","year":"1994","journal-title":"Semin. Oncol."},{"issue":"Suppl","key":"10.1016\/j.ajcnut.2025.01.006_bib26","first-page":"1","article-title":"Department of Disease Control Ministry of Health PRC, The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Chen","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J.\u00a0Am. Med. Dir. Assoc."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib28","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.3390\/s22114132","article-title":"A\u00a0model for predicting cervical cancer using machine learning algorithms","volume":"22","author":"Al Mudawi","year":"2022","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib29","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s11427-022-2255-4","article-title":"Ensemble learning\u00a0system to identify nutritional risk and malnutrition in cancer patients\u00a0without weight loss information","volume":"66","author":"Yin","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib30","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1016\/j.clnu.2021.06.028","article-title":"A\u00a0fusion decision system to identify and grade malnutrition in cancer patients: machine learning reveals feasible workflow from representative real-world data","volume":"40","author":"Yin","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0272989X06295361","article-title":"Decision curve analysis: a novel method for evaluating prediction models","volume":"26","author":"Vickers","year":"2006","journal-title":"Med. Decis. Making."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib32","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/jcsm.12776","article-title":"Prevalence and prognostic impact of cachexia among older patients with cancer: a nationwide cross-sectional survey (NutriAgeCancer)","volume":"12","author":"Poisson","year":"2021","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib33","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: a new definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition\u2014a consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00001648-199501000-00012","article-title":"The validity of self-reports of past body weights by U.S. adults","volume":"6","author":"Perry","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.ijo.802195","article-title":"The accuracy of long-term recall of past body weight in Japanese adult men","volume":"27","author":"Tamakoshi","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.annepidem.2007.06.009","article-title":"Ability and accuracy of long-term weight recall by elderly males: the Manitoba follow-up study","volume":"18","author":"Bayomi","year":"2008","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib38","first-page":"1871","article-title":"A\u00a0cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer","volume":"26","author":"Vagnildhaug","year":"2018","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ajcnut.2025.01.006_bib39","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/sj.bjc.6605578","article-title":"Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres","volume":"102","author":"Pressoir","year":"2010","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.ajcnut.2025.01.006_bib40","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/jcsm.12954","article-title":"Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research","volume":"13","author":"Orsso","year":"2022","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916525000061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916525000061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:08:29Z","timestamp":1772327309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916525000061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0002916525000061"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2025.01.006","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2025.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}