{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:37:11Z","timestamp":1793839031406,"version":"4.6.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD011721"],"award-info":[{"award-number":["R01MD011721"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD016595"],"award-info":[{"award-number":["R01MD016595"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["K99ES035109"],"award-info":[{"award-number":["K99ES035109"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES031259"],"award-info":[{"award-number":["R01ES031259"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajcnut.2025.05.029","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T05:51:03Z","timestamp":1748670663000},"page":"413-423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999\u20132002"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-5767","authenticated-orcid":false,"given":"Anne K","family":"Bozack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Khodasevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamaji C","family":"Nwanaji-Enwerem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gladish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saher","family":"Daredia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda L","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Rehkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Cardenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/cells11020214","article-title":"One-carbon metabolism: pulling the strings behind aging and neurodegeneration","volume":"11","author":"Lionaki","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mam.2016.11.004","article-title":"Interaction between excess folate and low vitamin B12 status","volume":"53","author":"Paul","year":"2017","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00043798-199808000-00003","article-title":"Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry","volume":"5","author":"Scott","year":"1998","journal-title":"J. Cardiovasc. Risk."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-nutr-082117-051757","article-title":"Nutritional influences on one-carbon metabolism: effects on arsenic methylation and toxicity","volume":"38","author":"Bozack","year":"2018","journal-title":"Annu. Rev. Nutr."},{"issue":"3","key":"10.1016\/j.ajcnut.2025.05.029_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tem.2023.11.001","article-title":"Methylmalonic acid in aging and disease","volume":"35","author":"Tejero","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.arr.2015.04.005","article-title":"Folates and aging: role in mild cognitive impairment, dementia and depression","volume":"22","author":"Ara\u00fajo","year":"2015","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ageing\/afg109","article-title":"Vitamin B12 and folate deficiency in later life","volume":"33","author":"Clarke","year":"2004","journal-title":"Age Ageing"},{"issue":"7352","key":"10.1016\/j.ajcnut.2025.05.029_bib11","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/bmj.324.7352.1512","article-title":"Folic acid, ageing, depression, and dementia","volume":"324","author":"Reynolds","year":"2002","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.ajcnut.2025.05.029_bib12","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41430-021-01057-3","article-title":"Low folate predicts accelerated cognitive decline: 8-year follow-up of 3140 older adults in Ireland","volume":"76","author":"O\u2019Connor","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"issue":"7 Suppl","key":"10.1016\/j.ajcnut.2025.05.029_bib13","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.3945\/jn.114.206599","article-title":"Biomarkers of nutrition for development\u2014folate review","volume":"145","author":"Bailey","year":"2015","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.ajcnut.2025.05.029_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/09637486.2013.866641","article-title":"Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies","volume":"65","author":"He","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"issue":"8","key":"10.1016\/j.ajcnut.2025.05.029_bib15","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1111\/j.1538-7836.2005.01364.x","article-title":"Mechanisms of homocysteine-induced atherothrombosis","volume":"3","author":"Lentz","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"11","key":"10.1016\/j.ajcnut.2025.05.029_bib16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4065\/83.11.1203","article-title":"Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis","volume":"83","author":"Humphrey","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-nutr-071715-050947","article-title":"Homocysteine, B vitamins, and cognitive impairment","volume":"36","author":"Smith","year":"2016","journal-title":"Annu. Rev. Nutr."},{"issue":"10","key":"10.1016\/j.ajcnut.2025.05.029_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"issue":"10","key":"10.1016\/j.ajcnut.2025.05.029_bib19","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.18632\/aging.101508","article-title":"Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies","volume":"10","author":"Horvath","year":"2018","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging"},{"issue":"23","key":"10.1016\/j.ajcnut.2025.05.029_bib21","first-page":"9484","article-title":"DNA methylation GrimAge version 2","volume":"14","author":"Lu","year":"2022","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54870","article-title":"Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm","volume":"9","author":"Belsky","year":"2020","journal-title":"eLife"},{"issue":"9","key":"10.1016\/j.ajcnut.2025.05.029_bib24","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.18632\/aging.101020","article-title":"DNA methylation-based measures of biological age: meta-analysis predicting time to death","volume":"8","author":"Chen","year":"2016","journal-title":"Aging"},{"issue":"6","key":"10.1016\/j.ajcnut.2025.05.029_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","article-title":"A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450K DNA methylation data","volume":"29","author":"Teschendorff","year":"2013","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol. Cell."},{"issue":"16","key":"10.1016\/j.ajcnut.2025.05.029_bib31","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.18632\/aging.102173","article-title":"DNA methylation-based estimator of telomere length","volume":"11","author":"Lu","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1471-2458-8-383","article-title":"The non-linear risk of mortality by income level in a healthy population: US National Health and Nutrition Examination Survey mortality follow-up cohort, 1988-2001","volume":"8","author":"Rehkopf","year":"2008","journal-title":"BMC Public Health"},{"issue":"19","key":"10.1016\/j.ajcnut.2025.05.029_bib53","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C\u2013based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.ajcnut.2025.05.029_bib54","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1016\/j.cell.2023.08.003","article-title":"Biomarkers of aging for the identification and evaluation of longevity interventions","volume":"186","author":"Moqri","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib55","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2105-13-86","article-title":"DNA methylation arrays as surrogate measures of cell mixture distribution","volume":"13","author":"Houseman","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib56","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12859-016-0943-7","article-title":"Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)","volume":"17","author":"Koestler","year":"2016","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib57","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13059-018-1448-7","article-title":"An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray","volume":"19","author":"Salas","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib58","author":"Lumley"},{"issue":"101","key":"10.1016\/j.ajcnut.2025.05.029_bib59","first-page":"1","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley","year":"2004","journal-title":"J. Stat. Softw."},{"issue":"101","key":"10.1016\/j.ajcnut.2025.05.029_bib60","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.21105\/joss.06610","article-title":"jtools: analysis and presentation of social scientific data","volume":"9","author":"Long","year":"2024","journal-title":"J. Open Source Softw."},{"issue":"1-2","key":"10.1016\/j.ajcnut.2025.05.029_bib61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2006.08.028","article-title":"Monitoring micronutrients in cigarette smokers","volume":"377","author":"Northrop-Clewes","year":"2007","journal-title":"Clin. Chim. Acta."},{"issue":"8","key":"10.1016\/j.ajcnut.2025.05.029_bib62","doi-asserted-by":"crossref","first-page":"2367S","DOI":"10.1093\/jn\/132.8.2367S","article-title":"Metabolic interactions of alcohol and folate","volume":"132","author":"Halsted","year":"2002","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.ajcnut.2025.05.029_bib63","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/s41440-024-01690-y","article-title":"Is renal function the key to disease risk management in elevated homocysteine levels?","volume":"47","author":"Hirata","year":"2024","journal-title":"Hypertens. Res."},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib64","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3390\/nu14051054","article-title":"Reduced kidney function Is associated with increasing red blood cell folate concentration and changes in folate form distributions (NHANES 2011\u20132018)","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib65","doi-asserted-by":"crossref","DOI":"10.1177\/03000605231223064","article-title":"Folic acid: friend or foe in cancer therapy","volume":"52","author":"Thabet","year":"2024","journal-title":"J. Int. Med. Res."},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib66","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.62.4.641","article-title":"Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons","volume":"62","author":"Morris","year":"2005","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ajcn\/nqx076","article-title":"Folate and cancer: a tale of Dr. Jekyll and Mr. Hyde?","volume":"107","author":"Kim","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib68","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1158\/1055-9965.EPI-17-1136","article-title":"Elevated vitamin B12 levels and dancer risk in UK primary care: a THIN database cohort study","volume":"28","author":"Arendt","year":"2019","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib69","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canep.2015.12.007","article-title":"Elevated plasma vitamin B12 levels and cancer prognosis: a population-based cohort study","volume":"40","author":"Arendt","year":"2016","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib70","series-title":"Hyperhomocysteinemia. StatPearls. Treasure Island (FL)","author":"Son","year":"2024"},{"issue":"3","key":"10.1016\/j.ajcnut.2025.05.029_bib71","first-page":"1","article-title":"mice: multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib72","series-title":"R: a language and environment for statistical computing","year":"2024"},{"issue":"6","key":"10.1016\/j.ajcnut.2025.05.029_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002036","article-title":"Strengthening the reporting of observational studies in epidemiology-nutritional epidemiology (STROBE-nut): an extension of the STROBE statement","volume":"13","author":"Lachat","year":"2016","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib75","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1038\/s41598-022-08160-w","article-title":"Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults","volume":"12","author":"Cardenas","year":"2022","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.ajcnut.2025.05.029_bib76","first-page":"10938","article-title":"Alcohol consumption and epigenetic age acceleration across human adulthood","volume":"15","author":"Wang","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.ajcnut.2025.05.029_bib77","article-title":"Sex-specific and generational effects of alcohol and tobacco use on epigenetic age acceleration in the Michigan longitudinal study, Drug Alcohol Depend","volume":"4","author":"Carter","year":"2022","journal-title":"Rep"},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib78","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s11357-022-00540-4","article-title":"Accelerated epigenetic aging and inflammatory\/immunological profile (ipAGE) in patients with chronic kidney disease","volume":"44","author":"Yusipov","year":"2022","journal-title":"Geroscience"},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib79","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1186\/s12872-024-04317-9","article-title":"Association between homocysteine levels and mortality in CVD: a cohort study based on NHANES database","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"issue":"12","key":"10.1016\/j.ajcnut.2025.05.029_bib80","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/ki.2012.301","article-title":"Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients","volume":"82","author":"Liabeuf","year":"2012","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.ajcnut.2025.05.029_bib81","doi-asserted-by":"crossref","first-page":"E309","DOI":"10.1073\/pnas.1115083109","article-title":"Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt\/\u03b2-catenin signaling","volume":"109","author":"Egea","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib82","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tcb.2022.08.005","article-title":"Cut loose TIMP-1: an emerging cytokine in inflammation","volume":"33","author":"Schoeps","year":"2023","journal-title":"Trends Cell Biol"},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib83","article-title":"Adrenomedullin and cardiovascular diseases","volume":"1","author":"Wong","year":"2012","journal-title":"JRSM Cardiovasc. Dis."},{"issue":"3","key":"10.1016\/j.ajcnut.2025.05.029_bib84","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3121\/cmr.4.3.236","article-title":"Megaloblastic anemia and other causes of macrocytosis","volume":"4","author":"Aslinia","year":"2006","journal-title":"Clin. Med. Res."},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib85","doi-asserted-by":"crossref","first-page":"628","DOI":"10.5858\/133.4.628","article-title":"Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients","volume":"133","author":"Lippi","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib86","first-page":"241","article-title":"Relationship between red cell distribution width and oxidative stress indexes in patients with coronary artery disease","volume":"12","author":"Namazi","year":"2023","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"10.1016\/j.ajcnut.2025.05.029_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2019.100644","article-title":"The emerging role of red blood cells in cytokine signalling and modulating immune cells","volume":"41","author":"Karsten","year":"2020","journal-title":"Blood Rev"},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/nu11020383","article-title":"Folic acid and vitamin B12 administration in CKD, why not?","volume":"11","author":"Capelli","year":"2019","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.ajcnut.2025.05.029_bib89","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ndt\/gfw090","article-title":"Association of serum vitamin B12 and folate with mortality in incident hemodialysis patients","volume":"32","author":"Soohoo","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.ajcnut.2025.05.029_bib90","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0885-3924(00)00169-X","article-title":"Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years","volume":"20","author":"Geissb\u00fchler","year":"2000","journal-title":"J. Pain Symptom Manage."},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib91","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1532-5415.2005.53278_7.x","article-title":"High vitamin B12 level: a strong predictor of mortality in elderly inpatients","volume":"53","author":"Salles","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib92","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/gerona\/glaa257","article-title":"Associations of plasma folate and vitamin B6 with blood DNA methylation age: an analysis of one-carbon metabolites in the VA normative aging study","volume":"76","author":"Nwanaji-Enwerem","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"10","key":"10.1016\/j.ajcnut.2025.05.029_bib93","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14255","article-title":"Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment","volume":"23","author":"Holmes","year":"2024","journal-title":"Aging Cell"},{"issue":"17","key":"10.1016\/j.ajcnut.2025.05.029_bib94","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial","volume":"299","author":"Albert","year":"2008","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ajcnut.2025.05.029_bib95","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"issue":"37","key":"10.1016\/j.ajcnut.2025.05.029_bib96","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017095","article-title":"The effect of folic acid in patients with cardiovascular disease: a systematic review and meta-analysis","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine"},{"issue":"8","key":"10.1016\/j.ajcnut.2025.05.029_bib97","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003768","article-title":"Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials","volume":"5","author":"Li","year":"2016","journal-title":"J. Am. Heart Assoc."},{"issue":"9557","key":"10.1016\/j.ajcnut.2025.05.029_bib98","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(07)60109-3","article-title":"Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial","volume":"369","author":"Durga","year":"2007","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.ajcnut.2025.05.029_bib99","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1212\/WNL.0b013e3181f962c4","article-title":"Vitamins B12, B6, and folic acid for cognition in older men","volume":"75","author":"Ford","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.ajcnut.2025.05.029_bib100","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ajcn\/nqaa373","article-title":"Positive effects of folic acid supplementation on cognitive aging are dependent on \u03c9-3 fatty acid status: a post hoc analysis of the FACIT trial","volume":"113","author":"van Soest","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"issue":"10","key":"10.1016\/j.ajcnut.2025.05.029_bib101","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s43587-024-00683-3","article-title":"Challenges and recommendations for the translation of biomarkers of aging","volume":"4","author":"Herzog","year":"2024","journal-title":"Nat. Aging."},{"issue":"1","key":"10.1016\/j.ajcnut.2025.05.029_bib102","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-statistics-011516-012958","article-title":"Are survey weights needed? A review of diagnostic tests in regression analysis","volume":"3","author":"Bollen","year":"2016","journal-title":"Annu. Rev. Stat. Appl."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652500317X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652500317X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:34:21Z","timestamp":1754044461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291652500317X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S000291652500317X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2025.05.029","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.06.25320074","asserted-by":"object"}]},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999\u20132002","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2025.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}]}}