{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:09:37Z","timestamp":1791317377964,"version":"4.3.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007512","name":"URV","doi-asserted-by":"publisher","award":["2022PMF-PIPF-06"],"award-info":[{"award-number":["2022PMF-PIPF-06"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009674","name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili","doi-asserted-by":"publisher","award":["PT20\/00197"],"award-info":[{"award-number":["PT20\/00197"]}],"id":[{"id":"10.13039\/100009674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["PI25\/00603"],"award-info":[{"award-number":["PI25\/00603"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["PI21\/01447"],"award-info":[{"award-number":["PI21\/01447"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003741","name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI25\/00603"],"award-info":[{"award-number":["PI25\/00603"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/01447"],"award-info":[{"award-number":["PI21\/01447"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ajcnut.2026.101385","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:32:09Z","timestamp":1780727529000},"page":"101385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study"],"prefix":"10.1016","volume":"124","author":[{"given":"Ailende","family":"Eigbefoh-Addeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-6862","authenticated-orcid":false,"given":"Albert","family":"Salas-Huetos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Ramos-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A","family":"Santos-Calder\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Salas-Salvad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Babio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajcnut.2026.101385_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)00401-9","article-title":"Folate-mediated one-carbon metabolism","volume":"79","author":"Fox","year":"2008","journal-title":"Vitam. Horm."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/nyas.12956","article-title":"One-carbon metabolism and epigenetics: understanding the specificity","volume":"1363","author":"Mentch","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ajcnut.2026.101385_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biochi.2020.01.008","article-title":"Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona birth cohort study","volume":"173","author":"Cavall\u00e9-Busquets","year":"2020","journal-title":"Biochimie."},{"key":"10.1016\/j.ajcnut.2026.101385_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-nutr-043020-091647","article-title":"Folic acid and the prevention of birth defects: 30 years of opportunity and controversies","volume":"42","author":"Crider","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101385_bib5","series-title":"Guideline: daily iron and folic acid supplementation in pregnant women [Internet]","year":"2012"},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101385_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/molehr\/gah204","article-title":"A polymorphism in the MTHFD1 gene increases a mother\u2019s risk of having an unexplained second trimester pregnancy loss","volume":"11","author":"Parle-McDermott","year":"2005","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0002-9378(99)70447-3","article-title":"Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss","volume":"181","author":"Lissak","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.ajcnut.2026.101385_bib8","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/humrep\/17.12.3033","article-title":"The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion","volume":"17","author":"Zetterberg","year":"2002","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cmrp.2016.11.001","article-title":"Association of RFC1 A80G gene polymorphism with advanced maternal age in risk of Down syndrome","volume":"7","author":"Suresh","year":"2017","journal-title":"Curr. Med. Res. Pract."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1086\/303055","article-title":"Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome","volume":"67","author":"Hobbs","year":"2000","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib11","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.4238\/2011.October.25.7","article-title":"A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population","volume":"10","author":"Zeng","year":"2011","journal-title":"Genet. Mol. Res."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/mgme.2000.3034","article-title":"A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia","volume":"70","author":"Chango","year":"2000","journal-title":"Mol. Genet. Metab."},{"issue":"5","key":"10.1016\/j.ajcnut.2026.101385_bib14","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344213","volume":"71","author":"Brody","year":"2002","journal-title":"Am. J. Hum. Genet."},{"issue":"45","key":"10.1016\/j.ajcnut.2026.101385_bib15","doi-asserted-by":"crossref","first-page":"13378","DOI":"10.1021\/bi020536s","article-title":"Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase","volume":"41","author":"Olteanu","year":"2002","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mgme.1999.2879","article-title":"A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida","volume":"67","author":"Wilson","year":"1999","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib17","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1182\/blood.V97.4.1092","article-title":"Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood","volume":"97","author":"Namour","year":"2001","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00013.2015","article-title":"Spermatogenesis: the commitment to meiosis","volume":"96","author":"Griswold","year":"2016","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101385_bib19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.fertnstert.2008.06.010","article-title":"Low folate in seminal plasma is associated with increased sperm DNA damage","volume":"92","author":"Boxmeer","year":"2009","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0015-0282(01)03229-0","article-title":"Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial","volume":"77","author":"Wong","year":"2002","journal-title":"Fertil. Steril."},{"issue":"7257","key":"10.1016\/j.ajcnut.2026.101385_bib21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0140-6736(62)92547-3","article-title":"Seminal vitamin B12 and sterility","volume":"2","author":"Watson","year":"1962","journal-title":"Lancet"},{"issue":"7532","key":"10.1016\/j.ajcnut.2026.101385_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0140-6736(68)90044-5","article-title":"Vitamin B 12 and fertility","volume":"1","author":"Blair","year":"1968","journal-title":"Lancet"},{"issue":"7271","key":"10.1016\/j.ajcnut.2026.101385_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0140-6736(63)91195-4","article-title":"Seminal vitamin B-12 and sterility","volume":"1","author":"Furnass","year":"1963","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101385_bib24","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/humrep\/del081","article-title":"Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple","volume":"21","author":"Ebisch","year":"2006","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae001","article-title":"Ultra-processed food consumption and semen quality parameters in the Led-Fertyl study","volume":"2024","author":"Valle-Hita","year":"2024","journal-title":"Hum. Reprod. Open."},{"key":"10.1016\/j.ajcnut.2026.101385_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0076-6879(97)81007-5","article-title":"Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method","volume":"281","author":"Molloy","year":"1997","journal-title":"Methods Enzymol."},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101385_bib27","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/jcp.44.7.592","article-title":"Microbiological assay for vitamin B12 performed in 96-well microtitre plates","volume":"44","author":"Kelleher","year":"1991","journal-title":"J. Clin. Pathol."},{"issue":"21","key":"10.1016\/j.ajcnut.2026.101385_bib28","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1021\/acs.analchem.6b02325","article-title":"Combined measurement of 6 fat-soluble vitamins and 26 water-soluble functional vitamin markers and amino acids in 50 \u03bcL of serum or plasma by high-throughput mass spectrometry","volume":"88","author":"Midttun","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ajcnut.2026.101385_bib29","series-title":"Folates and Pterins, Nutritional, Pharmacological and Physiological Aspects","first-page":"75","author":"Blakley","year":"1986"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101385_bib30","article-title":"Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies","volume":"29","author":"De Benoist","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.ajcnut.2026.101385_bib31","article-title":"Vitamin B12 deficiency","volume":"3","author":"Green","year":"2017","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.ajcnut.2026.101385_bib32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-60327-411-1_20","article-title":"Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MassARRAY)","volume":"578","author":"Oeth","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ajcnut.2026.101385_bib33","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","year":"2021"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101385_bib35","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.21037\/tau-21-276","article-title":"The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review","volume":"10","author":"Finelli","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.ajcnut.2026.101385_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2025.101217","article-title":"Prevalent low Mediterranean diet adherence and low folate status in a Spanish Km 0 Mediterranean coast population","volume":"11","author":"Eigbefoh-Addeh","year":"2025","journal-title":"Curr. Res. Food Sci."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/jama.2019.18714","article-title":"Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: a randomized clinical trial","volume":"323","author":"Schisterman","year":"2020","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101385_bib38","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0950-3536(05)80216-1","article-title":"DNA damage in folate deficiency","volume":"8","author":"Blount","year":"1995","journal-title":"Baillieres. Clin. Haematol."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib40","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/cclm-2012-0639","article-title":"Red cell or serum folate: what to do in clinical practice?","volume":"51","author":"Farrell","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101385_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2257.1994.tb00397.x","article-title":"Guidelines on the investigation and diagnosis of cobalamin and folate deficiencies. A publication of the British Committee for Standards in Haematology. BCSH General Haematology Test Force","volume":"16","author":"Amos","year":"1994","journal-title":"Clin. Lab. Haematol."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib42","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2164\/jandrol.106.001982","article-title":"Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures","volume":"28","author":"Boxmeer","year":"2007","journal-title":"J. Androl."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101385_bib43","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/and.12003","article-title":"Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA","volume":"45","author":"Abad","year":"2013","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101385_bib44","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","article-title":"S-adenosylmethionine and methylation","volume":"10","author":"Chiang","year":"1996","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.rbmo.2021.04.009","article-title":"Association of homocysteine with IVF\/ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study","volume":"43","author":"Chen","year":"2021","journal-title":"Reprod. Biomed. Online."},{"key":"10.1016\/j.ajcnut.2026.101385_bib46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejogrb.2025.03.038","article-title":"The impact of serum homocysteine levels in women and men on pregnancy outcomes in fresh IVF\/ICSI cycles: a retrospective cohort study","volume":"309","author":"Zhan","year":"2025","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s43043-025-00223-y","article-title":"Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case-control study on Algerian population","volume":"30","author":"Bousnane","year":"2025","journal-title":"Middle East Fertil. Soc. J."},{"issue":"6","key":"10.1016\/j.ajcnut.2026.101385_bib48","first-page":"586","article-title":"Detection of polymorphisms in MTHFD1 G1958A and its possible association with idiopathic male infertility","volume":"16","author":"Khaki","year":"2019","journal-title":"Urol. J."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fertnstert.2013.09.014","article-title":"Polymorphisms in folate-metabolizing genes and risk of idiopathic male infertility: a study on a Russian population and a meta-analysis","volume":"101","author":"Weiner","year":"2014","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101385_bib50","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/humu.20830","article-title":"The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects","volume":"30","author":"Christensen","year":"2009","journal-title":"Hum. Mutat."},{"issue":"26","key":"10.1016\/j.ajcnut.2026.101385_bib51","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.ajcnut.2026.101385_bib52","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM199911113412001","article-title":"Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention","volume":"341","author":"Berry","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ajcnut.2026.101385_bib53","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1038\/ncomms3889","article-title":"Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes","volume":"4","author":"Lambrot","year":"2013","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101385_bib54","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41598-023-45091-6","article-title":"Sperm DNA fragmentation index affect pregnancy outcomes and offspring safety in assisted reproductive technology","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101385_bib55","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/andr.13395","article-title":"Sperm DNA fragmentation and idiopathic recurrent pregnancy loss: results from a multicenter case-control study","volume":"11","author":"Busnelli","year":"2023","journal-title":"Andrology"},{"issue":"6","key":"10.1016\/j.ajcnut.2026.101385_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat. Rev. Urol."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526001942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526001942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:58:34Z","timestamp":1785873514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916526001942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0002916526001942"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101385","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101385"}}