{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:31:25Z","timestamp":1793615485675,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ajcnut.2026.101539","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:58:58Z","timestamp":1790348338000},"page":"101539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary interventions for menopausal symptoms: a systematic review"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-6580","authenticated-orcid":false,"given":"Hayley M","family":"O\u2019Neill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J","family":"English","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maci","family":"Polley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bettiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Esper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loai","family":"Albarqouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41569-023-00926-7","article-title":"The menopausal transition period and cardiovascular risk","volume":"21","author":"Mehta","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12978-022-01336-7","article-title":"A review of menopause nomenclature","volume":"19","author":"Ambikairajah","year":"2022","journal-title":"Reprod. Health."},{"key":"10.1016\/j.ajcnut.2026.101539_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-072612","article-title":"Management of perimenopausal and menopausal symptoms","volume":"382","author":"Duralde","year":"2023","journal-title":"BMJ."},{"issue":"10","key":"10.1016\/j.ajcnut.2026.101539_bib4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/GME.0000000000001174","article-title":"Guidelines for the evaluation and treatment of perimenopausal depression: summary and recommendations","volume":"25","author":"Maki","year":"2018","journal-title":"Menopause"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/nu16010027","article-title":"The importance of nutrition in menopause and perimenopause\u2014a review","volume":"16","author":"Erd\u00e9lyi","year":"2023","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101539_bib6","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1177\/00187267221089469","article-title":"Thinking outside Pandora\u2019s box: revealing differential effects of coping with physical and psychological menopause symptoms at work","volume":"76","author":"Steffan","year":"2023","journal-title":"Hum. Relat."},{"issue":"5","key":"10.1016\/j.ajcnut.2026.101539_bib7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1056\/NEJMcp1714787","article-title":"Hormone therapy for postmenopausal women","volume":"382","author":"Pinkerton","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.ajcnut.2026.101539_bib8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.jogc.2021.08.003","article-title":"Guideline No. 422a: menopause: vasomotor symptoms, prescription therapeutic agents, complementary and alternative medicine, nutrition, and lifestyle","volume":"43","author":"Yuksel","year":"2021","journal-title":"J. Obstet. Gynaecol. Can."},{"issue":"10","key":"10.1016\/j.ajcnut.2026.101539_bib9","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1097\/GME.0000000000001812","article-title":"The Women's Study for the Alleviation of Vasomotor Symptoms (WAVS): a randomized, controlled trial of a plant-based diet and whole soybeans for postmenopausal women","volume":"28","author":"Barnard","year":"2021","journal-title":"Menopause"},{"issue":"10","key":"10.1016\/j.ajcnut.2026.101539_bib10","first-page":"4998","article-title":"Quality of life of postmenopausal women receiving plant-based phytoestrogens","volume":"11","author":"Padmapriya","year":"2020","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/gme.0b013e318223b021","article-title":"A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7","volume":"19","author":"Pruthi","year":"2012","journal-title":"Menopause"},{"issue":"11","key":"10.1016\/j.ajcnut.2026.101539_bib12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/GME.0b013e3182896ae5","article-title":"Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review","volume":"20","author":"Dew","year":"2013","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000946","article-title":"Importance of maintaining a low omega\u20136\/omega\u20133 ratio for reducing inflammation","volume":"5","author":"DiNicolantonio","year":"2018","journal-title":"Open Heart"},{"key":"10.1016\/j.ajcnut.2026.101539_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.maturitas.2022.10.012","article-title":"Cognitive decline and dementia in women after menopause: prevention strategies","volume":"168","author":"Stefanowski","year":"2023","journal-title":"Maturitas"},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101539_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu12082333","article-title":"The importance of marine OMEGA-3S for brain development and the prevention and treatment of behavior, mood, and other brain disorders","volume":"12","author":"Dinicolantonio","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib16","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1038\/s41598-021-04258-9","article-title":"Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial","volume":"12","author":"Arjmand","year":"2022","journal-title":"Sci. Rep."},{"issue":"29","key":"10.1016\/j.ajcnut.2026.101539_bib17","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1080\/10408398.2021.1925220","article-title":"MIND diet and cognitive performance in older adults: a systematic review","volume":"62","author":"Kheirouri","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"12","key":"10.1016\/j.ajcnut.2026.101539_bib18","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1002\/alz.14277","article-title":"Association of MIND diet with cognitive decline among Black and White older adults","volume":"20","author":"Agarwal","year":"2024","journal-title":"Alzheimers Dementia"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/13697137.2020.1828854","article-title":"Dietary intake and menopausal symptoms in postmenopausal women: a systematic review","volume":"24","author":"Noll","year":"2021","journal-title":"Climacteric"},{"key":"10.1016\/j.ajcnut.2026.101539_bib20","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ajcnut.2026.101539_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jclinepi.2020.01.008","article-title":"A full systematic review was completed in 2 weeks using automation tools: a case study","volume":"121","author":"Clark","year":"2020","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ajcnut.2026.101539_bib22","unstructured":"Veritas Health Innovation. Covidence systematic review software [Internet]. Melbourne, Australia: Veritas Health Innovation; 2024 [cited 2025 Oct 13]. Available from: https:\/\/www.covidence.org"},{"key":"10.1016\/j.ajcnut.2026.101539_bib23","unstructured":"Cochrane Methods. RoB 2: a revised Cochrane risk-of-bias tool for randomized trials [Internet]. London: Cochrane; 2019 [cited 2025 Oct 13]. Available from: https:\/\/methods.cochrane.org\/bias\/resources\/rob-2-revised-cochrane-risk-bias-tool-randomized-trials"},{"key":"10.1016\/j.ajcnut.2026.101539_bib24","unstructured":"GRADEpro GDT: GRADEpro Guideline Development Tool [Internet]. Hamilton (ON): McMaster University and Evidence Prime; 2025 [cited 2025 Oct 13]. Available from: https:\/\/www.gradepro.org"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00394-019-01942-5","article-title":"Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial","volume":"59","author":"Furlong","year":"2020","journal-title":"Eur. J. Nutr."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/GME.0000000000002080","article-title":"A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial","volume":"30","author":"Barnard","year":"2023","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/13697139809085527","article-title":"Effects of dietary phytoestrogens in postmenopausal women","volume":"1","author":"Dalais","year":"1998","journal-title":"Climacteric"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib28","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1210\/jc.2004-1148","article-title":"The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial","volume":"90","author":"Dodin","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib29","first-page":"155","article-title":"The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women","volume":"11","author":"Fournier","year":"2007","journal-title":"J. Nutr. Health Aging"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib30","first-page":"325","article-title":"Effects of a cereal bar with a combination of phytoestrogens on the climacteric symptoms: a placebo-controlled, randomized trial","volume":"41","author":"Frigo","year":"2022","journal-title":"J. Am. Nutr. Assoc."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1479-5868-8-118","article-title":"Dietary weight loss and exercise interventions effects on quality of life in overweight\/obese postmenopausal women: a randomized controlled trial","volume":"8","author":"Imayama","year":"2011","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12966-024-01580-z","article-title":"Effects of combined dietary intervention and physical-cognitive exercise on cognitive function and cardiometabolic health of postmenopausal women with obesity: a randomized controlled trial","volume":"21","author":"Keawtep","year":"2024","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101539_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/01.gme.0000191882.59799.67","article-title":"A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause","volume":"13","author":"Lewis","year":"2006","journal-title":"Menopause (New York, N.Y.)"},{"issue":"1\u20132","key":"10.1016\/j.ajcnut.2026.101539_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.maturitas.2008.09.007","article-title":"Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat","volume":"61","author":"Murkies","year":"2008","journal-title":"Maturitas"},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101539_bib35","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.2174\/1871530319666190528101532","article-title":"Women in LOVe: lacto-ovo-vegetarian diet rich in omega-3 improves vasomotor symptoms in postmenopausal women. an exploratory randomized controlled trial, Endocr. Metab","volume":"19","author":"Rotolo","year":"2019","journal-title":"Immune Disord. Drug Targets"},{"issue":"9","key":"10.1016\/j.ajcnut.2026.101539_bib36","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.nut.2011.11.029","article-title":"A moderate-sodium DASH-type diet improves mood in postmenopausal women","volume":"28","author":"Torres","year":"2012","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/jwh.2006.0207","article-title":"The association between soy nut consumption and decreased menopausal symptoms","volume":"16","author":"Welty","year":"2007","journal-title":"J. Womens Health (Larchmt)"},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101539_bib38","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/oby.2011.76","article-title":"Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women","volume":"20","author":"Foster-Schubert","year":"2012","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/13697137.2018.1430131","article-title":"Vasomotor symptoms: natural history, physiology, and links with cardiovascular health","volume":"21","author":"Thurston","year":"2018","journal-title":"Climacteric"},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101539_bib40","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1001\/jamainternmed.2014.8063","article-title":"Duration of menopausal vasomotor symptoms over the menopause transition","volume":"175","author":"Avis","year":"2015","journal-title":"JAMA Intern. Med."},{"issue":"26","key":"10.1016\/j.ajcnut.2026.101539_bib41","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1021\/jf034427b","article-title":"Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element","volume":"51","author":"Kostelac","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2024.100327","article-title":"Effect of soy isoflavones on measures of estrogenicity: a systematic review and meta-analysis of randomized controlled trials","volume":"16","author":"Viscardi","year":"2025","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101539_bib43","article-title":"Gut microbiota has the potential to improve health of menopausal women by regulating estrogen","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/GME.0000000000001202","article-title":"Inter-relationship between diet, lifestyle habits, gut microflora, and the equol-producer phenotype: baseline findings from a placebo-controlled intervention trial","volume":"26","author":"Yoshikata","year":"2019","journal-title":"Menopause"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13099-024-00625-9","article-title":"Equol: a metabolite of gut microbiota with potential antitumor effects","volume":"16","author":"Lv","year":"2024","journal-title":"Gut Pathog"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/jmf.2018.4265","article-title":"Equol decreases hot flashes in postmenopausal women: a systematic review and meta-analysis of randomized clinical trials","volume":"22","author":"Daily","year":"2019","journal-title":"J. Med. Food."},{"issue":"6","key":"10.1016\/j.ajcnut.2026.101539_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2020.06.039","article-title":"Vasomotor menopausal symptoms and risk of cardiovascular disease: a pooled analysis of six prospective studies","volume":"223","author":"Zhu","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.ajcnut.2026.101539_bib48","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/GME.0000000000001033","article-title":"Vasomotor symptom characteristics: are they risk factors for incident diabetes?","volume":"25","author":"Gray","year":"2018","journal-title":"Menopause"},{"key":"10.1016\/j.ajcnut.2026.101539_bib49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.maturitas.2021.10.001","article-title":"Whole-diet interventions and cardiovascular risk factors in postmenopausal women: a systematic review of controlled clinical trials","volume":"155","author":"Amiri","year":"2022","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12905-017-0487-7","article-title":"Obesity associates with vasomotor symptoms in postmenopause but with physical symptoms in perimenopause: a cross-sectional study","volume":"17","author":"Koo","year":"2017","journal-title":"BMC Women Health"},{"key":"10.1016\/j.ajcnut.2026.101539_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2025.108661","article-title":"Isoflavones and changes in body weight and severe hot flashes in postmenopausal women: a secondary analysis of a randomized clinical trial","volume":"200","author":"Kahleova","year":"2025","journal-title":"Maturitas"},{"issue":"5","key":"10.1016\/j.ajcnut.2026.101539_bib52","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3945\/an.117.015370","article-title":"Effect of soy and soy isoflavones on obesity-related anthropometric measures: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"8","author":"Akhlaghi","year":"2017","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.ajcnut.2026.101539_bib53","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.maturitas.2018.06.012","article-title":"Phytoestrogen supplementation and body composition in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials","volume":"115","author":"Glisic","year":"2018","journal-title":"Maturitas"},{"key":"10.1016\/j.ajcnut.2026.101539_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/frdem.2023.1098693","article-title":"Cognitive trajectories during the menopausal transition","volume":"2","author":"Than","year":"2023","journal-title":"Front. Dement."},{"issue":"21","key":"10.1016\/j.ajcnut.2026.101539_bib55","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1212\/WNL.0b013e3181a71193","article-title":"Effects of the menopause transition and hormone use on cognitive performance in midlife women","volume":"72","author":"Greendale","year":"2009","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101539_bib56","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ajcnut.2025.07.020","article-title":"Dietary patterns and risk of Alzheimer's disease and related dementias across 5 racial and ethnic groups in the Multiethnic Cohort Study","volume":"122","author":"Park","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.ajcnut.2026.101539_bib57","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jamaneurol.2026.0062","article-title":"Dietary patterns and indicators of cognitive function","volume":"83","author":"Chen","year":"2026","journal-title":"JAMA Neurol"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/nu9020145","article-title":"A Mediterranean diet to improve cardiovascular and cognitive health: protocol for a randomised controlled intervention study","volume":"9","author":"Wade","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib59","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41582-024-01036-9","article-title":"Diets to promote healthy brain ageing","volume":"21","author":"Charisis","year":"2025","journal-title":"Nat. Rev. Neurol."},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101539_bib60","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrendo.2015.82","article-title":"Perimenopause as a neurological transition state","volume":"11","author":"Brinton","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib61","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/physrev.00036.2014","article-title":"Estrogen effects on cognitive and synaptic health over the lifecourse","volume":"95","author":"Hara","year":"2015","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib62","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12974-020-01998-9","article-title":"The peri-menopause in a woman\u2019s life: a systemic inflammatory phase that enables later neurodegenerative disease","volume":"17","author":"McCarthy","year":"2020","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.ajcnut.2026.101539_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbi.2015.03.015","article-title":"Brain morphology links systemic inflammation to cognitive function in midlife adults","volume":"48","author":"Marsland","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ajcnut.2026.101539_bib64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cobeha.2016.05.004","article-title":"Obesity, inflammation and cognition","volume":"9","author":"Spyridaki","year":"2016","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.ajcnut.2026.101539_bib65","first-page":"105","article-title":"Estrogens and cognition: friends or foes?: An evaluation of the opposing effects of estrogens on learning and memory, Horm","volume":"74","author":"Korol","year":"2015","journal-title":"Behav"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","article-title":"Diet and inflammation in cognitive ageing and Alzheimer's disease","volume":"8","author":"McGrattan","year":"2019","journal-title":"Curr. Nutr. Rep."},{"issue":"18","key":"10.1016\/j.ajcnut.2026.101539_bib67","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1002\/1873-3468.13527","article-title":"Compositional and functional features of the female premenopausal and postmenopausal gut microbiota","volume":"593","author":"Zhao","year":"2019","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib68","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00273-22","article-title":"Menopause is associated with an altered gut microbiome and estrobolome, with implications for adverse cardiometabolic risk in the Hispanic Community Health Study\/Study of Latinos","volume":"7","author":"Peters","year":"2022","journal-title":"mSystems"},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib69","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2295432","article-title":"Diets intervene osteoporosis via gut-bone axis","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.ajcnut.2026.101539_bib70","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yhbeh.2012.05.003","article-title":"Estrogens, estrogen receptors, and female cognitive aging: the impact of timing","volume":"63","author":"Daniel","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ajcnut.2026.101539_bib71","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-clinpsy-050718-095557","article-title":"Estrogen, stress, and depression: cognitive and biological interactions","volume":"15","author":"Albert","year":"2019","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62820-7","article-title":"In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology","volume":"14","author":"Mosconi","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ajcnut.2026.101539_bib73","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/jamainternmed.2025.0990","article-title":"Nonhormonal treatment of menopausal vasomotor symptoms","volume":"185","author":"Huang","year":"2025","journal-title":"JAMA Intern. Med."},{"issue":"23","key":"10.1016\/j.ajcnut.2026.101539_bib74","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1001\/jama.2016.8012","article-title":"Use of plant-based therapies and menopausal symptoms: a systematic review and meta-analysis","volume":"315","author":"Franco","year":"2016","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.ajcnut.2026.101539_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001690","article-title":"Intervention synthesis: a missing link between a systematic review and practical treatment(s)","volume":"11","author":"Glasziou","year":"2014","journal-title":"PLOS Med"},{"issue":"5","key":"10.1016\/j.ajcnut.2026.101539_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2025.100418","article-title":"Perspective: isoflavones-intriguing molecules but much remains to be learned about these soybean constituents","volume":"16","author":"Messina","year":"2025","journal-title":"Adv. Nutr."},{"issue":"3","key":"10.1016\/j.ajcnut.2026.101539_bib77","first-page":"230","article-title":"American Cancer Society nutrition and physical activity guideline for cancer survivors","volume":"72","author":"Rock","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.ajcnut.2026.101539_bib78","first-page":"93","article-title":"Precision nutrition for management of cardiovascular disease risk during menopause","volume":"17","author":"Cabre","year":"2024","journal-title":"Lifestyle Genom."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526003485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916526003485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T10:17:15Z","timestamp":1793614635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916526003485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0002916526003485"],"URL":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101539","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary interventions for menopausal symptoms: a systematic review","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajcnut.2026.101539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Nutrition.","name":"copyright","label":"Copyright"}],"article-number":"101539"}}