{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:53:15Z","timestamp":1789890795759,"version":"4.0.1"},"reference-count":11,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.ajem.2009.04.005","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T05:37:38Z","timestamp":1267162658000},"page":"798-802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Early anion gap metabolic acidosis in acetaminophen overdose"],"prefix":"10.1016","volume":"28","author":[{"given":"Joe G.","family":"Zein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kinasewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagib","family":"Toubia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kakoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2009.04.005_bib1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0196-0644(84)80674-5","article-title":"Anion gap acidosis with hypoglycemia in acetaminophen toxicity","volume":"13","author":"Zabrodski","year":"1984","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.ajem.2009.04.005_bib2","doi-asserted-by":"crossref","first-page":"872S","DOI":"10.1378\/chest.126.4_MeetingAbstracts.872S-b","article-title":"Early high anion gap metabolic acidosis in patients with acetaminophen overdose: clinical significance","volume":"126","author":"Zein","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ajem.2009.04.005_bib3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0196-0644(99)70312-4","article-title":"Early metabolic acidosis and coma after acetaminophen ingestion","volume":"33","author":"Roth","year":"1999","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.ajem.2009.04.005_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/bmj.285.6345.851","article-title":"Severe metabolic acidosis early in paracetamol poisoning","volume":"285","author":"Zezulka","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.ajem.2009.04.005_bib5","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0022-3476(87)80220-2","article-title":"Metabolic acidosis after acute ibuprofen overdosage","volume":"111","author":"Linden","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.ajem.2009.04.005_bib6","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1016\/S0021-9258(19)67754-9","article-title":"Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes","volume":"266","author":"Burcham","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajem.2009.04.005_bib7","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/0006-2952(89)90481-4","article-title":"Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI)","volume":"38","author":"Esterline","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajem.2009.04.005_bib8","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/clinchem\/44.7.1497","article-title":"Transient 5-oxoprolinuria and high anion gap metabolic acidosis: clinical and biochemical findings in eleven subjects","volume":"44","author":"Pitt","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.ajem.2009.04.005_bib9","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1097\/00003246-199811000-00019","article-title":"Anion gap and hypoalbuminemia","volume":"26","author":"Figge","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2009.04.005_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/096032718600500305","article-title":"Coma and metabolic acidosis early in severe acute paracetamol poisoning","volume":"5","author":"Flanagan","year":"1986","journal-title":"Hum Toxicol"},{"key":"10.1016\/j.ajem.2009.04.005_bib11","first-page":"811","article-title":"Hyperlactataemia and metabolic acidosis following paracetamol overdose","volume":"65","author":"Gray","year":"1987","journal-title":"Q J Med"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675709001880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675709001880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:13:31Z","timestamp":1760022811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675709001880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0735675709001880"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2009.04.005","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early anion gap metabolic acidosis in acetaminophen overdose","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2009.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}