{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:13:25Z","timestamp":1793340805336,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ajem.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T09:03:02Z","timestamp":1407402182000},"page":"1259-1262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Red cell distribution width is an independent predictor of mortality in necrotizing fasciitis"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-0139","authenticated-orcid":false,"given":"Chia-Lung","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Yu","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung-Pin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-3594","authenticated-orcid":false,"given":"Hong-Mo","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2014.08.001_bb0185","first-page":"416","article-title":"Necrotizing fasciitis","volume":"18","author":"Wilson","year":"1952","journal-title":"Am Surg"},{"key":"10.1016\/j.ajem.2014.08.001_bb0010","first-page":"917","article-title":"Clinical manifestations, microbiology and prognosis of 42 patients with necrotizing fasciitis","volume":"95","author":"Hung","year":"1996","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.ajem.2014.08.001_bb0015","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/01.prs.0000259040.71478.27","article-title":"Mortality in patients with necrotizing fasciitis","volume":"119","author":"Golger","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ajem.2014.08.001_bb0020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ajem.2007.04.023","article-title":"Predictors of mortality in patients with necrotizing fasciitis","volume":"26","author":"Hsiao","year":"2008","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2334-11-5","article-title":"Prognostic factors and monomicrobial necrotizing fasciitis: gram-positive versus gram-negative pathogens","volume":"11","author":"Lee","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ajem.2014.08.001_bb0030","first-page":"467","article-title":"Independent predictors of mortality for necrotizing fasciitis: a retrospective analysis in a single institution","volume":"71","author":"Huang","year":"2011","journal-title":"J Trauma"},{"key":"10.1016\/j.ajem.2014.08.001_bb0035","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/bjs.1800800943","article-title":"Role of early and extensive surgery in the treatment of severe necrotizing soft tissue infection","volume":"80","author":"Voros","year":"1993","journal-title":"Br J Surg"},{"key":"10.1016\/j.ajem.2014.08.001_bb0040","first-page":"890","article-title":"Necrotizing fasciitis. Role of early surgical intervention","volume":"25","author":"Qazi","year":"2004","journal-title":"Saudi Med J"},{"key":"10.1016\/j.ajem.2014.08.001_bb0045","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00134-008-1373-4","article-title":"Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management","volume":"35","author":"Boyer","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.amjsurg.2012.08.008","article-title":"Impact of timing of surgery on outcome of Vibrio vulnificus\u2013related necrotizing fasciitis","volume":"206","author":"Chao","year":"2013","journal-title":"Am J Surg"},{"key":"10.1016\/j.ajem.2014.08.001_bb0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jacc.2007.02.067","article-title":"Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank","volume":"50","author":"Felker","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajem.2014.08.001_bb0060","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.amjcard.2009.09.027","article-title":"Relation between red cell distribution width and clinical outcomes after acute myocardial infarction","volume":"105","author":"Dabbah","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ajem.2014.08.001_bb0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cardfail.2009.11.003","article-title":"Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure","volume":"16","author":"Allen","year":"2010","journal-title":"J Card Fail"},{"key":"10.1016\/j.ajem.2014.08.001_bb0070","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0003319712461931","article-title":"Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction","volume":"64","author":"Akin","year":"2013","journal-title":"Angiology"},{"key":"10.1016\/j.ajem.2014.08.001_bb0075","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.ijcard.2012.12.091","article-title":"Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure","volume":"168","author":"Aung","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ajem.2014.08.001_bb0080","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/cc10355","article-title":"Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia","volume":"15","author":"Braun","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.ajem.2014.08.001_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/SHK.0b013e31825e2a85","article-title":"Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia","volume":"38","author":"Ku","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.ajem.2014.08.001_bb0090","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ajem.2012.10.017","article-title":"Red cell distribution width is a prognostic factor in severe sepsis and septic shock","volume":"31","author":"Jo","year":"2013","journal-title":"Am J Emerg Med"},{"issue":"4","key":"10.1016\/j.ajem.2014.08.001_bb0095","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ajem.2012.12.015","article-title":"Red cell distribution width as a predictor of mortality in acute pancreatitis","volume":"31","author":"\u015eenol","year":"2013","journal-title":"Am J Emerg Med"},{"issue":"277","key":"10.1016\/j.ajem.2014.08.001_bb0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jns.2008.10.024","article-title":"Elevated red blood cell distribution width predicts mortality in persons with known stroke","volume":"15","author":"Ani","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajem.2014.08.001_bb0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1191\/0267659105pf793oa","article-title":"Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device","volume":"20","author":"Pierce","year":"2005","journal-title":"Perfusion"},{"key":"10.1016\/j.ajem.2014.08.001_bb0190","doi-asserted-by":"crossref","first-page":"S651","DOI":"10.1097\/01.CCM.0000098036.90796.ED","article-title":"Red blood cell physiology in critical illness","volume":"31","author":"Scharte","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1532-5415.1995.tb07047.x","article-title":"Influence of acute inflammation on iron and nutritional status indexes in older inpatients","volume":"43","author":"Chiari","year":"1995","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ajem.2014.08.001_bb0125","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI28111","article-title":"Oxidative stress in sepsis: a redox redux","volume":"116","author":"Kolls","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajem.2014.08.001_bb0130","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1089\/ars.2008.2142","article-title":"Oxidative stress in the regulation of normal and neoplastic hematopoiesis","volume":"10","author":"Ghaffari","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajem.2014.08.001_bb0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1001\/jama.1995.03520260039030","article-title":"The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study","volume":"273","author":"Rangel-Frausto","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2014.08.001_bb0140","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/jama.1994.03510270072043","article-title":"Multiple organ failure syndrome in the 1990s: systemic inflammatory response and organ dysfunction","volume":"271","author":"Beal","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.ajem.2014.08.001_bb0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s001340000790","article-title":"The endothelial response to oxygen deprivation: biology and clinical implications","volume":"27","author":"Karimova","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0195","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM199902113400601","article-title":"A multicenter, randomized, controlled clinical trial of transfusion in critical care. Tansfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group","volume":"340","author":"H\u00e9bert","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0160","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2407-5-144","article-title":"The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: a clinical study of 19 cases","volume":"5","author":"Ozkalemkas","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajem.2014.08.001_bb0165","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cdp.2003.10.002","article-title":"The value of a complete blood count in predicting cancer of the colon","volume":"28","author":"Spell","year":"2004","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.ajem.2014.08.001_bb0170","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jacc.2004.05.070","article-title":"Anemia as a risk factor and therapeutic target in heart failure","volume":"44","author":"Felker","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajem.2014.08.001_bb0175","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1097\/CCM.0b013e31821b85c6","article-title":"Red cell distribution width and all cause mortality in critically ill patients","volume":"39","author":"Bazick","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2014.08.001_bb0180","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.resuscitation.2012.01.038","article-title":"Red blood cell distribution width as an independent predictor of all-cause mortality in out of hospital cardiac arrest","volume":"83","author":"Kim","year":"2012","journal-title":"Resuscitation"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675714005294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675714005294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:25:16Z","timestamp":1760023516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675714005294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0735675714005294"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2014.08.001","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Red cell distribution width is an independent predictor of mortality in necrotizing fasciitis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}