{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:15:31Z","timestamp":1777414531149,"version":"3.51.4"},"reference-count":12,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ajem.2015.06.023","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T06:31:12Z","timestamp":1434436272000},"page":"341.e1-341.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["An uncommon complication of hyperosmolar hyperglycemic state: bilateral above knee amputations"],"prefix":"10.1016","volume":"34","author":[{"given":"Alyssa","family":"Milano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ara","family":"Tadevosyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5278","authenticated-orcid":false,"given":"Regina","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Luizza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2015.06.023_bb0060","article-title":"The management of the hyperosmolar hyperglycemic state (HHS) in adults with diabetes","author":"Scott","year":"2012"},{"issue":"9","key":"10.1016\/j.ajem.2015.06.023_bb0005","first-page":"1723","article-title":"Hyperosmolar hyperglycemic state","volume":"71","author":"Stoner","year":"2005","journal-title":"Am Fam Physician"},{"issue":"6","key":"10.1016\/j.ajem.2015.06.023_bb0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0828-282X(09)70113-8","article-title":"Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia","volume":"25","author":"Roberts","year":"2009","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ajem.2015.06.023_bb0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/bmj.1.5740.85","article-title":"Hyperosmolar non-ketotic diabetic coma: with particular reference to vascular complications","volume":"1","author":"Whelton","year":"1971","journal-title":"Br Med J"},{"issue":"2","key":"10.1016\/j.ajem.2015.06.023_bb0025","first-page":"214","article-title":"Acute limb ischemia in a septic patient with diabetic ketoacidosis","volume":"60","author":"Alfred","year":"2011","journal-title":"West Indian Med J"},{"key":"10.1016\/j.ajem.2015.06.023_bb0030","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1538-7836.2007.02553.x","article-title":"High risk of venous thromboembolism in diabetics with hyperosmolar state: comparison with other acute medical illnesses","volume":"5","author":"Keenan","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ajem.2015.06.023_bb0035","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db05-1543","article-title":"Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans","volume":"55","author":"Stegenga","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.ajem.2015.06.023_bb0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S1056-8727(00)00132-X","article-title":"Diabetes mellitus: a hypercoagulable state","volume":"15","author":"Carr","year":"2001","journal-title":"J Diabetes Complicat"},{"issue":"8","key":"10.1016\/j.ajem.2015.06.023_bb0045","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00019501-200512000-00003","article-title":"Abnormalities of coagulation, platelet function, and fibrinolysis associated with syndromes of insulin resistance","volume":"16","author":"Schneider","year":"2005","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.ajem.2015.06.023_bb0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.diabet.2006.11.010","article-title":"Acute lower limb ischemia is a frequent complication of severe diabetic hyperosmolarity","volume":"33","author":"Megarbane","year":"2007","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.ajem.2015.06.023_bb0055","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4088\/JCP.08m04905","article-title":"Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trail","volume":"70","author":"Nakamura","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.ajem.2015.06.023_bb0065","author":"Seroquel (quetiapine fumarate)","year":"1997"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675715005008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675715005008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:27:01Z","timestamp":1744255621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675715005008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0735675715005008"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2015.06.023","relation":{},"ISSN":["0735-6757"],"issn-type":[{"value":"0735-6757","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An uncommon complication of hyperosmolar hyperglycemic state: bilateral above knee amputations","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2015.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}