{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:13:24Z","timestamp":1760026404186,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Emergency Medicine"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ajem.2015.06.037","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T04:46:38Z","timestamp":1434689198000},"page":"676.e5-676.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A centrally acting antihypertensive, clonidine, combined to a venous dilator, nitroglycerin, to handle severe pulmonary edema"],"prefix":"10.1016","volume":"34","author":[{"given":"Philippe","family":"Schraub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Matthys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Lecomte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ghignone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Quintin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajem.2015.06.037_bb0005","doi-asserted-by":"crossref","first-page":"370","DOI":"10.7326\/0003-4819-101-3-370","article-title":"The neurohumoral axis in congestive heart failure","volume":"101","author":"Francis","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-2999(91)90842-E","article-title":"Effect of clonidine on the catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study","volume":"204","author":"Mermet","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ajem.2015.06.037_bb0015","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/01.HYP.26.5.719","article-title":"Suppressing sympathetic activation in congestive heart failure: a new therapeutic strategy","volume":"26","author":"Manolis","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.ajem.2015.06.037_bb0020","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/01.CCM.0000055402.68581.DC","article-title":"Low stretch ventilation strategy in acute respiratory distress syndrome: eight years of clinical experience in a single center","volume":"31","author":"Page","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0025","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/000331978703800707","article-title":"Acute and short-term effects of clonidine in heart failure","volume":"38","author":"Giles","year":"1987","journal-title":"Angiology"},{"key":"10.1016\/j.ajem.2015.06.037_bb0030","first-page":"433","article-title":"The role of clonidine in hypertensive heart disease. Influence on myocardial contractility and left ventricular afterload","volume":"83","author":"Motz","year":"1983","journal-title":"Chest"},{"key":"10.1016\/j.ajem.2015.06.037_bb0035","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1540\/jsmr.42.63","article-title":"Clonidine induced endothelium-dependent tonic contraction in circular muscle of the rat hepatic portal vein","volume":"42","author":"Shimamura","year":"2006","journal-title":"J Smooth Muscle Res"},{"key":"10.1016\/j.ajem.2015.06.037_bb0040","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/sj.jhh.1001243","article-title":"Acute effect of clonidine on left ventricular pressure-volume relation in hypertensive patients with diastolic heart dysfunction","volume":"15","author":"Stefanadis","year":"2001","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.ajem.2015.06.037_bb0045","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00003246-198604000-00073","article-title":"Clonidine: a new pulmonary vasodilator","volume":"14","author":"Ghignone","year":"1986","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0050","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00000542-199102000-00008","article-title":"Oxygen uptake after major abdominal surgery: effect of clonidine","volume":"74","author":"Quintin","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ajem.2015.06.037_bb0055","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/BF03015364","article-title":"Oral clonidine premedication decreases energy expenditure in human volunteers","volume":"44","author":"Takahashi","year":"1997","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.ajem.2015.06.037_bb0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00134-008-1251-0","article-title":"Respiratory, metabolic and hemodynamic effects of clonidine in ventilated patients presenting with withdrawal syndrome","volume":"35","author":"Liatsi","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0065","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0022-3565(25)32224-X","article-title":"Clonidine-induced diuresis in the rat: evidence for a renal site of action","volume":"214","author":"Miller","year":"1980","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajem.2015.06.037_bb0070","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/hep.21355","article-title":"Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system","volume":"44","author":"Lenaerts","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ajem.2015.06.037_bb0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0885066610396815","article-title":"Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting?","volume":"27","author":"Pichot","year":"2012","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0080","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1046\/j.1365-2044.1999.01114.x","article-title":"Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit","volume":"54","author":"Venn","year":"1999","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ajem.2015.06.037_bb0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1213\/ane.0b013e3181732dc2","article-title":"The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study","volume":"107","author":"Akada","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ajem.2015.06.037_bb0090","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1152\/jappl.1985.58.4.1189","article-title":"Determinants of cardiac augmentation by elevations in intrathoracic pressure","volume":"58","author":"Pinsky","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajem.2015.06.037_bb0095","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1164\/rccm.200402-226OC","article-title":"Physiologic effects of noninvasive ventilation during acute lung injury","volume":"172","author":"L'Her","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajem.2015.06.037_bb0100","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1172\/JCI111065","article-title":"Regional blood flow distribution in dog during induced hypotension and low cardiac output. Spontaneous breathing versus artificial ventilation","volume":"72","author":"Viires","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajem.2015.06.037_bb0105","first-page":"61","article-title":"Spontaneous breathing during mechanical ventilation in ARDS","volume":"8","author":"Freebairn","year":"2005","journal-title":"Crit Care Shock"},{"key":"10.1016\/j.ajem.2015.06.037_bb0110","first-page":"109","article-title":"Swift recovery of severe hypoxemic pneumonia upon morbid obesity","volume":"65","author":"Galland","year":"2014","journal-title":"Acta Anaesthesiol Belg"},{"key":"10.1016\/j.ajem.2015.06.037_bb0115","first-page":"69","article-title":"Spontaneous breathing in mild and moderate versus severe acute respiratory distress syndrome","volume":"20","author":"Guldner","year":"2014","journal-title":"Curr Opin Crit Care"}],"container-title":["The American Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675715005161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735675715005161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T15:30:20Z","timestamp":1760023820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735675715005161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0735675715005161"],"URL":"https:\/\/doi.org\/10.1016\/j.ajem.2015.06.037","relation":{},"ISSN":["0735-6757"],"issn-type":[{"type":"print","value":"0735-6757"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A centrally acting antihypertensive, clonidine, combined to a venous dilator, nitroglycerin, to handle severe pulmonary edema","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Emergency Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajem.2015.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}